Reign Posted December 18, 2021 Share Posted December 18, 2021 Hello, I was wondering which antipsychotic is best suited for tapering? Regarding tapering dosages and also regarding the neurotransmitters they block. I read on holisticpsychiatrist.com that halperidol is the best to taper off regarding the amount of receptors it blocks. But I'm also struggling with the practicality of the tapering process with liquid forms etc. I was on Quetiapine before while I tapered. The tapering wasn't too difficult, but became unwell and now am on Risperdal. So deciding if I should switch to an antipsychotic that is best suited for my next tapering attempt. Thank you Reign 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Moderator Emeritus manymoretodays Posted December 20, 2021 Moderator Emeritus Share Posted December 20, 2021 Hi there Reign and welcome aboard, Personally, I don't have a opinion on which antipsychotic is easier to taper than another. But did want to get your first post approved and started today. Are you interested in tapering a drug or drug(s)? And if so, what are you on now? Please see: How to summarize your drug history in your signature and note that this is different from any of the confidential information you may have already provided. It will, when done, appear below all of your posts, and give us a brief synopsis of your drug or drugs, and drug and tapering history. Please include all of your drug(s). And do your best to cover for the last 2 years or so. Thank you. On 12/17/2021 at 5:24 PM, Reign said: But I'm also struggling with the practicality of the tapering process with liquid forms etc. I was on Quetiapine before while I tapered. The tapering wasn't too difficult, but became unwell and now am on Risperdal. So deciding if I should switch to an antipsychotic that is best suited for my next tapering attempt. I don't think it would be a great idea to switch to another antipsychotic to taper. I'm of the "taper off what you are on" opinion I guess. And good that you are now wanting to learn a bit more about tapering prior to beginning. Excellent. And how are you doing right now? Do you feel like you are in a good place to begin a taper? And then here is some more information for you, so you'll have it here, in your topic, to peruse. We go with a harm reduction model of tapering here. Why taper by 10% of my dosage? Tips for tapering off Risperdal(risperidone) When we take medications, the CNS (central nervous system) responds by making changes over the months and years we take the drug(s). When the medication is discontinued, the CNS has to undo all the changes it made. The CNS likes stability. Rebuilding the neurotransmitter production and reactivating the receptor and transporter cells takes time -- during that rebuilding process symptoms occur. I'll stop there for today. This is your introduction/journal page where you have now introduced yourself to the community, you can ask questions here regarding your case, and tapering, give updates, communicate with staff and other members, and just keep a record of your journey. And best. Love, peace, healing, and growth, moderator manymoretodays(mmt) Late 2023- gone to emeritus status, inactive, don't @ me, I can check who I've posted on, and I'm not really here like I used to be......thanks. Started with psycho meds/psychiatric care circa 1988. In retrospect, and on contemplation, situational overwhelm. Rounding up to 30 years of medications(30 medication trials, poly-pharmacy maximum was 3 at one time). 5/28/2015-off Adderal salts 2.5mg. (I had been on that since hospital 10/2014) 12/2015---just holding, holding, holding, with trileptal/oxcarb at 75 mg. 1/2 tab at hs. My last psycho med ever! Tapered @ 10% every 4 weeks, sometimes 2 weeks to 2016 Dec 16, medication free!! Longer signature post here, with current supplements. Herb and alcohol free since 5/15/2016. And.....I quit smoking 11/2021. Lapsed. Redo of quit smoking 9/28/2022, and again finally 5/25/24. Can you say Hallelujah?(took me long enough)💜 None of my posts are intended as medical advice. Please discuss any decisions about your medical care with a knowledgeable medical provider. My success story: Blue skies ahead, clear sailing Link to comment
Reign Posted December 21, 2021 Author Share Posted December 21, 2021 Hello, So at the moment they are trialling different antipsychotics on me. I started on Quetiapine in 2013 and was on this medication until recently. I was tapering and got unwell. So now they've started me on Risperidone a month ago, but I can't tolerate the side effects (restlessness, unbearable muscle tension in face). Tomorrow they will discuss putting me either on Amisulpride or Aripiprazole. 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Moderator Emeritus manymoretodays Posted December 22, 2021 Moderator Emeritus Share Posted December 22, 2021 (edited) Hi Reign, 2 hours ago, Reign said: but I can't tolerate the side effects (restlessness, unbearable muscle tension in face). Tomorrow they will discuss putting me either on Amisulpride or Aripiprazole. Oh okay, those are not great side effects. Are you able to function okay most days at present? I mean things like hygiene, work, eating, exercise, socialize, etc. How much Risperidone are you on now? I wonder if you could take less than what you are on now of the Risperdone. You might ask about that. Negotiate a little. It's a pretty powerful AP(antipsychotic). With a lower dose you might not experience the side effects that you have now. Sorry you are having to go through this. What an ordeal. How did you taper the Quetiapine? To the best of your recollection? What was the last dose you were doing well on? I can't really speculate on exactly what you should try next, but perhaps others will have some ideas for you too. Are you in hospital or doing Outpatient services with your prescriber? And then do give a try at the Signature when you can. No other medications/drugs right now? And best, L, P, H, and G, mmt Edited December 22, 2021 by manymoretodays added quote, additional 1 Late 2023- gone to emeritus status, inactive, don't @ me, I can check who I've posted on, and I'm not really here like I used to be......thanks. Started with psycho meds/psychiatric care circa 1988. In retrospect, and on contemplation, situational overwhelm. Rounding up to 30 years of medications(30 medication trials, poly-pharmacy maximum was 3 at one time). 5/28/2015-off Adderal salts 2.5mg. (I had been on that since hospital 10/2014) 12/2015---just holding, holding, holding, with trileptal/oxcarb at 75 mg. 1/2 tab at hs. My last psycho med ever! Tapered @ 10% every 4 weeks, sometimes 2 weeks to 2016 Dec 16, medication free!! Longer signature post here, with current supplements. Herb and alcohol free since 5/15/2016. And.....I quit smoking 11/2021. Lapsed. Redo of quit smoking 9/28/2022, and again finally 5/25/24. Can you say Hallelujah?(took me long enough)💜 None of my posts are intended as medical advice. Please discuss any decisions about your medical care with a knowledgeable medical provider. My success story: Blue skies ahead, clear sailing Link to comment
Reign Posted December 22, 2021 Author Share Posted December 22, 2021 Thanks so much for your fast reply. Really appreciate your advice. I'll give a try with the signature when I can. I'm back at home as a compulsory outpatient. It's pretty full on as we have two toddlers to look after as well. When I tapered the Quetiapine I did this alongside a micronutrient treatment. The University of Canterbury in New Zealand have been trialing mental health with these. It really worked for me and I started feeling so much better on them. I reduced about 10% every 3 weeks and got down to 87.5 mg. Things got quite stressful in my family plus I had an upset stomach for three weeks, and then I lost touch with reality... I think my dopamine levels must have been way to high. So now I'm still grieving that time and wish I could have tapered more slowly. I'm struggling a bit with accepting that I'll be on meds again, how they affect me and quite anxious about it. Really also not wanting to go down the road of polypharmacy. But maybe now this is just the way it is. Thanks for your advice about Risperidone and asking to go on a lower dose. I'll see if that works, the side effects really have been unbearable. 1 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Reign Posted December 22, 2021 Author Share Posted December 22, 2021 Oh and on Quetiapine the last dose I was doing well on, probably was around 150 mg. 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Moderator Emeritus Shep Posted December 22, 2021 Moderator Emeritus Share Posted December 22, 2021 5 hours ago, Reign said: I reduced about 10% every 3 weeks and got down to 87.5 mg. 5 hours ago, Reign said: Oh and on Quetiapine the last dose I was doing well on, probably was around 150 mg. Thank you for this information. Please note that quetiapine changes from a drug that effects dopamine at higher doses to a drug that affects histamine at lower doses (under 150 - 200 mg). It may be that you had reached the point where the drug was changing mechanisms and you would have benefited from a much slower taper, perhaps 3 - 5% a month. When were you last on 150 mg Quetiapine? How did you transition over to Risperdal? Please add a signature so we don't bombard you with questions on your drug history and can get right to giving you the information you're asking for. How to summarize your drug history in your signature A direct link to your signature is here: Account Settings - Create or Update Your Signature 5 hours ago, Reign said: I'm struggling a bit with accepting that I'll be on meds again, how they affect me and quite anxious about it. Really also not wanting to go down the road of polypharmacy. But maybe now this is just the way it is. I don't think you'll have to stay on meds forever. You wrote you're on compulsory outpatient status, so you don't have a lot of choice right now. But it really looks like a large part of the problem is in the tapering and switching of drugs. If you haven't already, you may want to read Robert Whitaker's book Anatomy of an Epidemic. It explains how these drugs effect us and cause so many problems that are labeled so-called "mental illness." Here is the book trailer: Robert Whitaker, author Anatomy of an Epidemic video (11 minutes) 1 Link to comment
Moderator Emeritus hayduke Posted December 23, 2021 Moderator Emeritus Share Posted December 23, 2021 Hey there @Reign Tough position you're in there, sorry to hear. If risperidone agitates you, aripiprazole is likely to be even more activating. Amisulpride we don't know that much about, although it seems reasonable that you can taper successfully from it, it doesn't sound like a good one to jump to. Can you please fill out your drug history in your signature as mmt asked in the first reply here. Also please respond to the question about how much risperidone you are taking now and when you cut over from the quetiapine. 1 I am not a health professional - your actions are your own. Please do not seek tapering support via private message - "Any reason to hold is a good one" My taper visualised as a graph | My intro thread Backdrop: 2003 10mg olanzapine | 2004 2-3mg risperidone | end 2014 3wks aripiprazole 2015: olanzapine 10 -> 7½ -> 6⅔ -> 5mg by crude pill cutter 2018: Mar 5.00mg -> water titrated taper -> Aug2.5mg tablet and hold Jan 2019 2.50mg water titration -> Jan 2020 1.214 -> Jan 2021 0.44 -> 2 Oct 0.205 ->3 Oct ZERO🥂 Jun 2023 💉150mg paliperidone "loading" depot shot, 100mg 1wk after Jul 100mg Aug-Dec 75mg/4wks Jul 2023 2.50mg aripiprazole/day attempt to lower prolactin^ Jan-Feb 2024 cross taper off shots to 1mg risperidone Ask not what you can do for your country, but what your country did to you" -- KMFDM Link to comment
Moderator Emeritus manymoretodays Posted December 23, 2021 Moderator Emeritus Share Posted December 23, 2021 Hi Reign, Good job on the signature! I copied a portion here: May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg Did you jump from the 87.5 mg of quetiapine then? If you have actual dates for your November changes in the risperidone, that will be helpful to add to your signature. Just use Account Settings/signature to make any edits. Don't forget to hit SAVE at the bottom. Thanks. Hoping things went okay at your appointment too. I think yesterday? Okay, and best. Wow.....2 little ones to care for and keep after! Just keep on keeping on and hopefully this round we can perhaps save you from polypharmacy. And then later, a really harm reduction taper too. Happy Holidays. L, P, H, and G, mmt Late 2023- gone to emeritus status, inactive, don't @ me, I can check who I've posted on, and I'm not really here like I used to be......thanks. Started with psycho meds/psychiatric care circa 1988. In retrospect, and on contemplation, situational overwhelm. Rounding up to 30 years of medications(30 medication trials, poly-pharmacy maximum was 3 at one time). 5/28/2015-off Adderal salts 2.5mg. (I had been on that since hospital 10/2014) 12/2015---just holding, holding, holding, with trileptal/oxcarb at 75 mg. 1/2 tab at hs. My last psycho med ever! Tapered @ 10% every 4 weeks, sometimes 2 weeks to 2016 Dec 16, medication free!! Longer signature post here, with current supplements. Herb and alcohol free since 5/15/2016. And.....I quit smoking 11/2021. Lapsed. Redo of quit smoking 9/28/2022, and again finally 5/25/24. Can you say Hallelujah?(took me long enough)💜 None of my posts are intended as medical advice. Please discuss any decisions about your medical care with a knowledgeable medical provider. My success story: Blue skies ahead, clear sailing Link to comment
Moderator Emeritus hayduke Posted December 24, 2021 Moderator Emeritus Share Posted December 24, 2021 10 hours ago, manymoretodays said: Nov 2021 Risperidone 4mg-1mg Have you cut from 4mg to 1mg within just a month or so? Akathisia would be expected from such a drastic drop, or at least comparable discomfort to what you mention. Especially after your previous quetiapine taper. With the quetiapine taper, did you calculate each 10% drop from the previous dose, or was it 10% of the starting dose each cut all the way down? If you can, it would help to list each cut you've made in the last year or two as well as the ranges. Thanks I am not a health professional - your actions are your own. Please do not seek tapering support via private message - "Any reason to hold is a good one" My taper visualised as a graph | My intro thread Backdrop: 2003 10mg olanzapine | 2004 2-3mg risperidone | end 2014 3wks aripiprazole 2015: olanzapine 10 -> 7½ -> 6⅔ -> 5mg by crude pill cutter 2018: Mar 5.00mg -> water titrated taper -> Aug2.5mg tablet and hold Jan 2019 2.50mg water titration -> Jan 2020 1.214 -> Jan 2021 0.44 -> 2 Oct 0.205 ->3 Oct ZERO🥂 Jun 2023 💉150mg paliperidone "loading" depot shot, 100mg 1wk after Jul 100mg Aug-Dec 75mg/4wks Jul 2023 2.50mg aripiprazole/day attempt to lower prolactin^ Jan-Feb 2024 cross taper off shots to 1mg risperidone Ask not what you can do for your country, but what your country did to you" -- KMFDM Link to comment
Moderator Emeritus Shep Posted December 24, 2021 Moderator Emeritus Share Posted December 24, 2021 On 12/22/2021 at 3:39 AM, Reign said: When I tapered the Quetiapine I did this alongside a micronutrient treatment. Please let us know the ingredients in the micronutrient treatment. Are you still taking them? Link to comment
Administrator Altostrata Posted December 24, 2021 Administrator Share Posted December 24, 2021 On 12/21/2021 at 3:32 PM, Reign said: I was tapering and got unwell. Hello, @Reign What symptoms occurred when you were tapering quetiapine? That suggests your following "feeling unwell" was withdrawal from quetiapine. Your last quetiapine dosage was 150mg? Why not reinstate a low dose of quetiapine, such as 25mg, and see if that helps? We have seen reinstating "hair of the dog that bit you" is most effective for withdrawal symptoms. We would not randomly try other antipsychotics, each drug trial is wearing on your nervous system. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment
Moderator Emeritus manymoretodays Posted January 2, 2022 Moderator Emeritus Share Posted January 2, 2022 Hi there Reign, Hope the New Year is bringing some new stability. And am wondering how it is going? Thanks. L, P, H, and G, mmt 1 Late 2023- gone to emeritus status, inactive, don't @ me, I can check who I've posted on, and I'm not really here like I used to be......thanks. Started with psycho meds/psychiatric care circa 1988. In retrospect, and on contemplation, situational overwhelm. Rounding up to 30 years of medications(30 medication trials, poly-pharmacy maximum was 3 at one time). 5/28/2015-off Adderal salts 2.5mg. (I had been on that since hospital 10/2014) 12/2015---just holding, holding, holding, with trileptal/oxcarb at 75 mg. 1/2 tab at hs. My last psycho med ever! Tapered @ 10% every 4 weeks, sometimes 2 weeks to 2016 Dec 16, medication free!! Longer signature post here, with current supplements. Herb and alcohol free since 5/15/2016. And.....I quit smoking 11/2021. Lapsed. Redo of quit smoking 9/28/2022, and again finally 5/25/24. Can you say Hallelujah?(took me long enough)💜 None of my posts are intended as medical advice. Please discuss any decisions about your medical care with a knowledgeable medical provider. My success story: Blue skies ahead, clear sailing Link to comment
Reign Posted January 10, 2022 Author Share Posted January 10, 2022 Hello everyone, Thanks for your messages. Wishing you a Happy New Year! So regarding a question, when I tapered Quetiapine at around 87,5 mg my Dopamine levels went through the roof but I also had a very upset stomach for 3 weeks which would have rendered the micronutrients useless and contributed to my relapse. I also had had quite a few issues with my family which magnified. I didn't feel safe and called the police. My thoughts at this stage were based in reality but delusional. Then I was hospitalized. I'm still really disappointed that the tapering didn't work, as the micronutrient treatment I had been on really was doing wonders (also according to my family) and allowed me to taper to quite a low dose without any issues, until it didn't. You asked which micronutrients. The micronutrient treatment is from Hardy Nutritionals. I came across them through the University of Canterbury (Julia Rucklidge) in New Zealand. They don't publicly talk about who supplies them unless they are contacted directly. The latest is that I am currently being put back on 300 mg of Quetiapine. I will also be starting the micronutrient treatment again. Regarding tapering on Quetiapine I would greatly appreciate your input. I'm planning on tapering 10% of the last dose approx. every 4 weeks. At what dose does Quetiapine stop being an antipsychotic? Was it 200 mg? Then I might hold it there for a while? I'm wanting to be safe and take my time, although I acknowledge that I've rushed in the past and think that contributed to my relapses. At this stage my family definitely wouldn't support me tapering off completely and I'm also still too traumatized after this last episode and the way one gets treated in hospital. The psychiatrist said he would be ok for me to taper down to 250 mg. I guess it is a bit of a negotiation. He said he doesn't know about micronutrients but might look into it. I hope he does. Here is a link to a study regarding psychosis and micronutrients: https://pubmed.ncbi.nlm.nih.gov/28103052/ https://www.scientificwellness.com/blog-view/micronutrients-help-adults-with-psychosis-601 The micronutrient treatment enhances the effects and side effects of the medication, so this requires tapering to reduce these effects. Last time I got to 150 mg at which stage I didn't notice any side effects. So my goal would be to taper to 150mg and stay there. Would you suggest me to hold for longer periods of time in between and at which dosages? Thanks Reign 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Administrator Altostrata Posted January 12, 2022 Administrator Share Posted January 12, 2022 We do not endorse Hardy Nutritionals or any other supplement program to substitute for gradual tapering. We have not seen them to be of any help. Please let us know if you should need assistance tapering. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment
Reign Posted January 12, 2022 Author Share Posted January 12, 2022 Hi Altostrata, Right, sorry I didn't know. Yes, it would be great to have some help still. I've been looking up various posts on your site regarding Quetiapine withdrawal and just for support in general. Also I'm wondering as I'm just now being put onto 300 mg of Quetiapine to wait for my body to adjust? After having had been hospitalized and having had been put on Risperidone which gave me Akathisia and symptoms I'm still struggling. The symptoms were so severe that two weeks ago I attempted to overdose on lorazepam, sleeping tablets and quetiapine. Apologies if I shouldn't mention this. What is helping me now for the sideeffects is Clonazepam. It really helps with the akathisia and tardive dyskinesia symptoms. I'm relieved as I thought this was going to be my life. The doctor says my body is still taking time to get rid of the remaining Risperidone which brought on these symptoms in the first place. As I've had fairly good experiences in the past with Quetiapine the hope is that the akathisia and dyskinesia will subside in the next week or so. 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Administrator Altostrata Posted January 12, 2022 Administrator Share Posted January 12, 2022 What times o'clock are you taking each drug, with their dosages? I am sorry you are in this situation. You can pretty much expect if you go to the hospital, you will come out on more drugs. If you're feeling poorly from drug reactions, this may not be a good time to taper quetiapine. Are you having any adverse reaction to quetiapine, that you can tell? This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment
Reign Posted January 12, 2022 Author Share Posted January 12, 2022 Hi, I'm taking 300 mg of Quetiapine in the evening and 0.5 mg Clonazepam morning, lunch, afternoon. The Clonazepam makes me a bit dopey, but it's better than the alternative of tardive dyskinesia/akathisia symptoms. I've ordered gingko biloba as I've read it could potentially help as well. No drug reactions from Quetiapine so far. 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Administrator Altostrata Posted January 12, 2022 Administrator Share Posted January 12, 2022 Do you currently have akathisia or tardive dyskinesia? What are the symptoms? If you've been on 300mg quetiapine for only a couple of weeks, you're probably not adapted to it yet, you might go down to 250mg, as your psychiatrist suggested, then after a couple of weeks to 200mg and then 150mg. If I were you, I'd stay at 150mg for some months to stabilize further. Since you've already triggered withdrawal from neuroleptics several times by too-fast tapering, and ended up in the hospital repeatedly, how about doing something different to taper after you've been taking 150mg for a while? Such as tapering much more gradually -- see Tips for tapering off quetiapine (Seroquel) Please discuss this with your psychiatrist and get him informed about careful, slow tapering to lowest effective dosage. That's what you're paying him to do. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment
Reign Posted January 12, 2022 Author Share Posted January 12, 2022 Hi, That sounds like great advice thank you. The psychiatrist said he wouldn't go lower than 250mg as that would be too risky. But I will ask him if we could stabilize on 250mg. 150mg would be a dream dose for me. 1 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Moderator Emeritus Shep Posted January 12, 2022 Moderator Emeritus Share Posted January 12, 2022 9 hours ago, Reign said: I'm taking 300 mg of Quetiapine in the evening and 0.5 mg Clonazepam morning, lunch, afternoon. The Clonazepam makes me a bit dopey, but it's better than the alternative of tardive dyskinesia/akathisia symptoms. Please let us know how long you've been taking clonazepam. Also please add it to your signature. A direct link is here: Account Settings - Create or Update Your Signature. 9 hours ago, Reign said: I've ordered gingko biloba as I've read it could potentially help as well. Here is how members reported their experiences: Gingko and Ginseng We don't recommend a lot of supplements, as many members report their nervous systems are simply too fragile to handle them. However, magnesium and fish oil tend to be calming to the nervous system and many people report they do help. Please only add in one supplement at a time and at a small dose. For more, please see: King of supplements: Omega-3 fatty acids (fish oil) Magnesium, nature's calcium channel blocker You may want to try a bit of fish oil or magnesium before adding in gingko. Magnesium and fish oil have a better track record for people with destabilized nervous systems. Again, one supplement at a time, though. The rule of 3KIS: Keep it simple. Keep it slow. Keep it stable. Link to comment
Moderator Emeritus manymoretodays Posted January 13, 2022 Moderator Emeritus Share Posted January 13, 2022 (edited) Oh, and hey Reign, I am glad to see you posting again. And very sorry to hear that it got so bad and tough. And yes, do update with the date clonazepam was started, as asked. Here is a very helpful link for you too: Important topics about tests, supplements, treatments, and diet and it then goes to more indexed topics and then this topic too: https://www.survivingantidepressants.org/topic/12664-dont-waste-your-money-on-truehope-the-road-back-point-of-return-label-me-sane-hardy-nutritionals/ Oh man, I too, went on True Hope way back when, on the suggest of my then psychiatrist. Based on one article published at that time by some Doctor about it. I was also on medications then, I am thinking possibly 2 medications, maybe 3, and one was quite likely Seroquel. You see they had me pegged or labeled as a Bipolar something by then. I was responding so nicely to Seroquel, that they then needed to give me something else to try to suppress, the horrible sedation and mucked up ness that I experienced from it. My experience with True Hope/Empower Plus or something else it was called too, was a lot of time, and money was wasted, and furthermore I got phone suggests/advice from them too. The company support system. I did a much too rapid taper then as well, based on what they suggested. Kept on adding more supplements and tapering too rapidly to boot. My then psychiatrist just defaulted to that it was "my illness" and never once mentioned WD. Nor was I privy to information or much in the way of education then.....as far as deprescribing and the reality of WD from too fast tapers, which had been already done to me- with psychiatrist instructions. That was a not so great time period in my own what I call my "psychiatric career" or maybe better said "psychiatric patient career". Gee whiz, too bad I was not able to hone in on my own career for so many wasted years. Ugh. Anyway.....do stick around if you will. With a goal of eventually tapering. Do try to share information with your psychiatrist too, as Alto suggested. Or maybe if they won't listen, you could get on with someone new? Also see: How to talk to a doctor about tapering and withdrawal? What to expect? and do try to take in the first couple of posts there if you can.......I think you'll find them helpful, and also much less alone right now Best, L, P, H, and G, mmt Edited January 13, 2022 by manymoretodays more, always more..... Late 2023- gone to emeritus status, inactive, don't @ me, I can check who I've posted on, and I'm not really here like I used to be......thanks. Started with psycho meds/psychiatric care circa 1988. In retrospect, and on contemplation, situational overwhelm. Rounding up to 30 years of medications(30 medication trials, poly-pharmacy maximum was 3 at one time). 5/28/2015-off Adderal salts 2.5mg. (I had been on that since hospital 10/2014) 12/2015---just holding, holding, holding, with trileptal/oxcarb at 75 mg. 1/2 tab at hs. My last psycho med ever! Tapered @ 10% every 4 weeks, sometimes 2 weeks to 2016 Dec 16, medication free!! Longer signature post here, with current supplements. Herb and alcohol free since 5/15/2016. And.....I quit smoking 11/2021. Lapsed. Redo of quit smoking 9/28/2022, and again finally 5/25/24. Can you say Hallelujah?(took me long enough)💜 None of my posts are intended as medical advice. Please discuss any decisions about your medical care with a knowledgeable medical provider. My success story: Blue skies ahead, clear sailing Link to comment
Reign Posted January 13, 2022 Author Share Posted January 13, 2022 Thank you again very much for all your input. I'll update my signature as well. I've been on Clonazepam for maybe 4 days as they cover up my side effects and will be tapering as sooon as they get better. My side effects have been almost uncontrollable need for head shaking, wanting to move the muscles around the mouth, a lot of tension around the mouth, and almost the need to shout or groan. Embarrassing. A bit of restless legs. Thankfully today I only needed 0.5 mg of clonazepam and these side effects seem to be getting better each day. I spoke to the psychiatrist today and he's reduced my Quetiapine down to 200 mg to see if that helps further with reducing the side effects. I'm hoping at some stage I can discuss tapering with him, and I will read the links you sent. But for now I will just hold. I was also wondering how supportive were your families during your tapering journeys? With me they are becoming supportive again I think but have a very medicalized view and mostly listen to the doctors and their views. So some conversations can be challenging. 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Moderator Emeritus ChessieCat Posted January 13, 2022 Moderator Emeritus Share Posted January 13, 2022 1 hour ago, Reign said: was also wondering how supportive were your families during your tapering journeys? With me they are becoming supportive again I think but have a very medicalized view and mostly listen to the doctors and their views. So some conversations can be challenging. Check out the topics in this area of the site: relationships-and-social-life * NO LONGER ACTIVE on SA * MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment
Moderator Emeritus hayduke Posted January 28, 2022 Moderator Emeritus Share Posted January 28, 2022 On 1/13/2022 at 5:10 PM, Reign said: I was also wondering how supportive were your families during your tapering journeys? With me they are becoming supportive again I think but have a very medicalized view and mostly listen to the doctors and their views. So some conversations can be challenging. Mine have been terrible, while superficially appearing reasonable until lately. I eventually found it was necessary to find my own therapists and professional health support, because so many problems originate in the nuclear family - typically unconsciously, ancestral trauma etc - more nuanced than just "they are bad people". But I have never got any validation in my family, and when my clinical psychologists started providing that, things started improving a whole lot. I found the concept of "identified patient" applied to me, where the others did not want to face their own (Jungian) shadow work and just projected it onto me - not at all healthy. Stepping back and working outside of the nuclear family is gradually evening that imbalance out. If you can find a supportive clinical psychologist, you might find that disentangling from the family's already-made-up minds provides a lot more space to heal. I am not a health professional - your actions are your own. Please do not seek tapering support via private message - "Any reason to hold is a good one" My taper visualised as a graph | My intro thread Backdrop: 2003 10mg olanzapine | 2004 2-3mg risperidone | end 2014 3wks aripiprazole 2015: olanzapine 10 -> 7½ -> 6⅔ -> 5mg by crude pill cutter 2018: Mar 5.00mg -> water titrated taper -> Aug2.5mg tablet and hold Jan 2019 2.50mg water titration -> Jan 2020 1.214 -> Jan 2021 0.44 -> 2 Oct 0.205 ->3 Oct ZERO🥂 Jun 2023 💉150mg paliperidone "loading" depot shot, 100mg 1wk after Jul 100mg Aug-Dec 75mg/4wks Jul 2023 2.50mg aripiprazole/day attempt to lower prolactin^ Jan-Feb 2024 cross taper off shots to 1mg risperidone Ask not what you can do for your country, but what your country did to you" -- KMFDM Link to comment
Reign Posted May 17, 2022 Author Share Posted May 17, 2022 (edited) Liquid taper 200 mg pill Quetiapine immediate rel Hello, I would like to start tapering from 200 mg of Quetiapine pill (immediate release). For the last days I've been reading up on the different tapering methods on SA and I've decided to do a liquid taper. So I would mix 200 mg of Quetiapine tablet with 200 ml of water. I thought I'd take that for a few days to get used to the change to liquid form. Then I will start tapering by taking the percentage for example 5 ml / 5 mg out of the container with a syringe and drinking the rest. Does that sound correct? Should I be looking out for anything else when changing to liquid? Thank you Also I would like to do a very slow taper as I've experienced psychosis during too fast tapers in the past. I've read about the brass monkey taper where it was suggested to taper 2.5 % per week for 4 weeks and then hold another 2 weeks. I'm thinking of tapering a bit slower so 2.5% per two weeks, and then again 2.5% per two weeks and then holding for four weeks. Does that sound slow enough? Thank you so much if you've read so far. I'm grateful for any advice. Oh, also. I'm also taking 0.5 mg of Clonazepam for mild tardive dyskinesia, which has been improving. I think it's probably best not to taper two medications, so best to keep on taking the Clonazepam. Reign Edited May 17, 2022 by ChessieCat added topic title before merging with intro topic 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Moderator Emeritus ChessieCat Posted May 17, 2022 Moderator Emeritus Share Posted May 17, 2022 cross-over-changing-form-eg-tablet-to-liquid-of-drug-or-changing-brand-of-same-drug Taking multiple psych drugs? Which drug to taper first? If you're not having an adverse reaction from the other medications, taper the most activating drug first. This is usually an antidepressant or stimulant (ADHD drug).Taper more than one drug at a time? Try this only if you know your withdrawal symptom pattern and know how to control your taper with various tapering techniques. * NO LONGER ACTIVE on SA * MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment
Reign Posted May 17, 2022 Author Share Posted May 17, 2022 Thank you ChessieCat Then I will definitely only taper the Quetiapine and keep on taking 0.5mg of Clonazepam Also what brassmonkey tapering rate would people suggest? In the past I redu ed to fast and ended up with psychosis. So wondering if I should reduce even only 1% per week and then hold for a few. Any suggestions appreciated. Thank you. 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Reign Posted May 18, 2022 Author Share Posted May 18, 2022 Hi, sorry I have another question. I've just put the 200 mg tablet into 200 ml water and noticing that 200 ml is quite a lot of water. Should I be using less water? And also if you don't mind explaining how the calculation would be then as I struggle a bit with numbers. Thanks 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Moderator Emeritus ChessieCat Posted May 18, 2022 Moderator Emeritus Share Posted May 18, 2022 4 hours ago, Reign said: Also what brassmonkey tapering rate would people suggest? It's up to you to decide what rate to taper at. Unless you need to get off the drug quickly due to bad side effects/drug interaction, then generally you can go as slow as you feel comfortable doing. 1 hour ago, Reign said: I've just put the 200 mg tablet into 200 ml water and noticing that 200 ml is quite a lot of water. Should I be using less water? Putting a 200mg tablet into 200mL water gives a liquid where 1mL of the solution will give you a 1mg dose. The more water you use the more accurately you can measure your dose; which is helpful when you get to lower doses. However because you are currently at 200mg and only reducing by a small amount (of the liquid) that is quite a lot of liquid for you to consume, unless you are happy to drink that amount every day. If you are able to get a prescription for smaller sized tablets you could combine a tablet and make up the dose with liquid. You could use up your current 200mg tablets to make the liquid which generally can be kept covering in the refrigerator for 3-4 days. According to the tips for tapering Seroquel/quetiapine: On 9/28/2012 at 11:19 AM, Altostrata said: Dosage Forms and Strengths 25 mg tablets 50 mg tablets 100 mg tablets 150 mg tablets 200 mg tablets 300 mg tablets 400 mg tablets I will provide some other strengths and I have added the calculation under the formula so you can use these examples if you use different tablets strengths. My suggestion would be not to use any less than a 1:2 ratio (1mL = 2 mg dose) because of the solubility of quetiapine is "Solubility in water: 3.29 mg/mL" (don't worry about these numbers, I have included the information my own and the use of others if needed): Tablet Water Each mL contains mg dose 200mg 200mL 1 1 divide both sides by 200 200mg 100mL 1 2 divide both sides by 100 If you can get 100mg tablets: 100mg 100mL 1 1 100mg 50mL 1 2 1 hour ago, Reign said: And also if you don't mind explaining how the calculation would be then as I struggle a bit with numbers. @brassmonkey Would you please assist this member with their taper question? Thank you. Please see this post for what they are thinking of doing. 1 * NO LONGER ACTIVE on SA * MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment
Reign Posted May 18, 2022 Author Share Posted May 18, 2022 (edited) Thanks so much. Regarding: "My suggestion would be not to use any less than a 1:2 ratio (1mL = 2 mg dose) because of the solubility of quetiapine is "Solubility in water: 3.29 mg/mL" (don't worry about these number" So is it ok to use a 1:1 ratio? Or rather not? It's the easiest for me to calculate as I'm not so good with numbers, although I can learn of course. If I should rather use a 1:2 ratio would you mind giving me a few calculation examples. thanks Edited May 18, 2022 by ChessieCat removed black background from some text 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Moderator Emeritus ChessieCat Posted May 18, 2022 Moderator Emeritus Share Posted May 18, 2022 Yes it's okay to use 1:1 and 1:2 ratio. From the ones I provided above Italics are 1:1 ratios, the bolded ones are the 1:2 ratios. Tablet Water Each mL contains mg dose 200mg 200mL 1 1 divide both sides by 200 200mg 100mL 1 2 divide both sides by 100 If you can get 100mg tablets: 100mg 100mL 1 1 100mg 50mL 1 2 * NO LONGER ACTIVE on SA * MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment
Reign Posted May 18, 2022 Author Share Posted May 18, 2022 Also wanting to ask if I can use tap water for the solution? Thanks 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
Moderator Emeritus Shep Posted May 18, 2022 Moderator Emeritus Share Posted May 18, 2022 3 hours ago, Reign said: Also wanting to ask if I can use tap water for the solution? Thanks Most people live in areas where the tap water is not safe to drink due to possible contaminants. If it's like that where you live, you should use filtered water. There's no special type of water required, as long as it's clean. Link to comment
Moderator brassmonkey Posted May 18, 2022 Moderator Share Posted May 18, 2022 I would use a 1:2 pill to water ratio just because of the volume of water involved. This would mean that every 1/2mL of liquid would have 1mgai (milligram active ingredient). So the calculations should be pretty easy. It is best to do a cross taper to go from solid to liquid: Cross Over: Changing form (eg tablet to liquid) of drug OR changing brand of same drug - Tapering - Surviving Antidepressants The baseline Brassmonkey Slide is pretty gentle, most members are reporting very mild symptoms. You can vary the percentage of each reduction as long as you don't do more that 2.5% a week. We have many members using smaller percentages. A smaller percentage would work better than taking two weeks between reductions. 20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013. Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks. The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better. Final Dose 0.016mg. Current dose 0.000mg 04-15-2017 "It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general." Stephen Hawking Link to comment
Reign Posted May 18, 2022 Author Share Posted May 18, 2022 Dear @brassmonkey Thanks so much for your advice. Just to make sure would you mind confirming below calculationis correct: 1:2 pill 1/2 ml represents 1 mg So if I want to take away 5 mg I divide this by 1/2. So 5mg is 2.5 ml Right? And when transitioning from solid to liquid. I have a 200m pill. Could I for instance half the pill and then take half as a liquid and half as solid, and do this for a few days before taking the full tablet as liquid? Thank you very much for your time! 2013 Medication induced psychosis - Quetiapine 600 mg 2015 Quick taper below 200, hospital Nov 2016 - Jan 2017 taper 600 to 300 mg March 2019- Jan 2021 taper 300-200 mg hosp Jan 2021 from Quetiapine to Olanzapine back to Quetiapine 300 mg May 2021 - Nov 2021 micronutrients + Quetiapine taper 300 mg - 87,5 mg hosp Nov 2021 Risperidone 4mg-1mg January 2022 - 200 mg Quetiapine, 0.5 mg Clonazepam for tardive dyskinesia Link to comment
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