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Gerpenn: Long time Pristiq user


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Hello, this is my introduction.

I am a long time Effexor user, age 38 male. It never was completely effective and I struggled with side effects, so I ended up cycling off and on periodically for the last 10 or so years.

For the last two years, I have been using Pristiq instead, and don't feel I need it, but I have not been able to stay off. Even after tapering to where I am off it with no short term withrdawal, I will get bad symptoms of withdrawal (characteristic headache and dizziness) returning about 6 weeks after.


I just restarted 25mg Pristiq and am hoping to successfully get off.

I have a lot of questions, including whether I should switch back to Effexor just for the ability to count the time release balls and taper that way.

I would like to post in the tapering forum.

Thanks you.


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  • ChessieCat changed the title to Gerpenn: Long time Pristiq user
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Welcome to SA. We are a volunteer ran site with member such as yourself tapering off or have tapered off similar medications as you.


This is your introduction page where you will receive information, ask questions and meet other members such as yourself. We ask that each member only have one introduction page so we can keep all your information in one place.


First, can you please create a signature. Thank you.


Instructions:  Withdrawal History Signature


You say you just reinstated Pristiq at 25 mg, when was that? And how do you feel now? I would not suggest going back on Effexor at this time because Pristiq was the last antidepressant you tapered off of.



Tips for tapering off desvenlafaxine (Pristiq)

Why taper by 10% of my dosage?


About reinstating and stabilizing to reduce withdrawal symptoms


What is withdrawal syndrome?

Dr. Joseph Glenmullen's withdrawal symptom checklist


We don't suggest a lot of supplements on here except 2. If you would like to try one, try a small amount and wait a few days before introducing the other.



Omega-3 Fish Oil


After you have read the links provided, please reach out to us with any questions you may have.



PREVIOUS medications and discontinuations: Have been on medications since 1996. 

 Valium, Gabapentin, Lamictal, Prilosec and Zantac from 2000 to 2015 with a fast taper by a psychiatrist.

 Liquid Lexapro Nov, 2016 to 31-March, 2019 Lexapro free!!! (total Lexapro taper was 4 years-started with pill form)

---CURRENT MEDICATIONS:Supplements:Milk Thistle, Metamucil, Magnesium Citrate, Vitamin D3, Levothyroxine 25mcg, Vitamin C, Krill oil.

Xanax 1mg 3x day June, 2000 to 19-September, 2020 Went from .150 grams (average weight of 1 Xanax) 3x day to .003 grams 3x day. April 1, 2021 went back on 1mg a day. Started tapering May 19, 2023. July 28, 2023-approximately .87mg. Dr. fast tapered me at the end and realized he messed up. Prescribe it again and I am doing "slower than a turtle" taper.

19-September, 2020 Xanax free!!! (total Xanax taper was 15-1/2 months-1-June, 2019-19-September, 2020)

I am not a medical professional.

The suggestions I make are based on personal experience.

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