FerricIon Posted February 10, 2023 Posted February 10, 2023 Hello, I'm FerricIon My story could be triggering as hell for some people, only read if you know you can handle cruelty. Previous History I was diagnosed with depression and given various antidepressants like fluoxetine, citalopram, venlafaxine, bupropion, but each one was discontinued after one month of starting treatment due to side-effects being too much for me. The last medication that I got prescribed was desvenlafaxine, and since it didn't destroy me with side-effects, it was the medication I kept taking. First 2 months was 50mg desvenlafaxine, then 3 months of 100mg desvenlafaxine. After taking desvenlafaxine for those 5 months, I gradually changed into something I'd now describe as a raging sociopath. I was previously a very socially anxious person, couldn't talk in front of an audience if you paid me a million dollars, felt bad if I noticed I accidentally stepped on an ant (too much empathy, borderline pathological). In those 5 months I gradually lost any kind of social inhibition, and felt no emotion from anything (be it enjoyment from hobbies, or boredom/frustration from repetitive tasks), nor any kind of empathy. The positive side of that was that being an university student, I could study for endless hours without feeling bored, and I could present stuff in class without a problem. The negative aspects were much worse than expected, I started getting something I can only call "emotional cravings" that would only be satisfied by torturing and eventually killing animals. The only times I felt anything at all were in those moments, and it created a sort of addictive feedback loop that could even make me wake up at 3 AM shaking with the cravings. At the time, I didn't realize that was aberrant behavior, it seemed normal due to my lack of empathy and emotion. How I got out of that spiral of craziness is that my girlfriend at the time (now wife) noticed my pets going missing, and also noticed I kept buying new ones for them to also go missing shortly after. She then talked to me and made me realize that something was very wrong, thanks to that conversation I was able to notice that I literally had changed completely, and went cold turkey off 100mg of desvenlafaxine the same day. (I stopped taking it not due to feeling like I did anything wrong, like I mentioned, no empathy; but because I didn't like the thought of a drug changing my personality) It caused no noticeable withdrawal effects, and after 6 months I was back to my normal self only with the added guilt of all I did during that time. For months afterwards I dealt with enormous amounts of guilt daily that I now only feel a few days a month. The guilt stems from reliving those memories but from my usual empathetic point of view. Current Problem Years later, I had a complete lack of energy, could barely move out of bed (these were the symptoms that got me my first depression diagnosis, there was never an emotional component) and foolishly decided to go to another psychiatrist. I told them my history, and after looking at me like I was absolutely crazy (I assume they didn't believe my story) decided to prescribe desvenlafaxine to me again, 100 mg. Foolishly again, I accepted, believing that they knew what they were doing after listening to my story. This time after one year of taking desvenlafaxine it did absolutely nothing, no effect, positive or negative. I later decided to lower the dose to 50 mg and wait some more time, another year went by without any change. Now, due to having some gastric problems, I decided to stop taking desvenlafaxine altogether, and it's when hell began. I tried to stop taking the pill like before, but this time I got awful withdrawal effects after 3 days, brain zaps, dizziness, borderline panic attacks. This is when I found out about this site and discovered that the concept of tapering was even a thing. Disclaimer about my reaction to the drug. I don't get withdrawals until at least 48 hours later, where I start getting a sort of brain fog as the first side effect; if I don't take a dose that day, the symptoms get exponentially worse with each passing day. Battle Plan There is no 25mg dose of desvenlafaxine in my country. Due to that I'm currently investigating whether to split, crush and weigh the 50mg desvenlafaxine pill, or switch to venlafaxine (specifically Effexor XR) and weigh the beads instead. This has been difficult to decide due to how terrible venlafaxine was when I took it in the past. Thank you for reading.
Administrator Altostrata Posted February 11, 2023 Administrator Posted February 11, 2023 Welcome, @FerricIon On 2/10/2023 at 2:34 PM, FerricIon said: First 2 months was 50mg desvenlafaxine, then 3 months of 100mg desvenlafaxine. It sounds like these dosages of the drug were stimulating, maybe causing hypomania or mania. These are known adverse drug effects. On 2/10/2023 at 2:34 PM, FerricIon said: I don't get withdrawals until at least 48 hours later, where I start getting a sort of brain fog as the first side effect; if I don't take a dose that day, the symptoms get exponentially worse with each passing day. That is a normal pattern of withdrawal from desvenlafaxine. Here are our Tips for tapering off desvenlafaxine (Pristiq) To help us out, follow these instructions Please summarize your drug and withdrawal history in your signature You may need to use a computer to do this. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted.
FerricIon Posted February 12, 2023 Author Posted February 12, 2023 Yeah, thank you. I've honestly read the content in that link a few dozen times by now, but I'm still undecided on the method I'll use. I'll keep updating here once I start taking proper steps. I still can't believe this crap is legal. It may be the case that my reaction to the drug was rather rare, but no one told me it was even a possibility to begin with. At least the second time I started taking it, I made sure to have someone monitor my behavior like a damn hawk. Thankfully it didn't matter because for one reason or another, desvenlafaxine has no effect anymore, which I find rather fascinatingly puzzling just from a biochemical point of view. Anyway, curse this pill and whoever said it was fine to sell it without even thinking about giving patients a decent vehicle to stop taking it. I'll make sure to edit the signature later! 1
Mentor littlebird Posted February 13, 2023 Mentor Posted February 13, 2023 Just popping in to say hello and welcome! Solidarity in the struggle against Pristiq, it's a helluva drug. There are success stories on here, so it's possible to get off. Pronouns: they/them/theirs Started on Prozac in early 2000s to treat cPTSD, been on various cocktails ever since. 2002-2004, 2017-2022: Buspar, tapered down to 0 2016-present: 100mg Seroquel for sleep -> May 2023: 90mg -> June 2023: 81mg -> September 2023: 72mg -> switched to brand name, much too strong, down to 60mg -> October 2023: 54mg -> November 2023: 50mg -> January 2024: 45mg -> April 2024: 40.5mg -> May 2024: 41mg -> June 2024: 35mg -> July 2024: 31mg -> August 2024: 28mg -> September 2024: 25mg 2016-Present: 100mg Wellbutrin SR -> January 2023: 75mg IR (37.5mg 2x a day, a mistake, don't replicate) -> February 2023 (33.75mg 2x a day) -> July 2023 (30.37mg 2x a day) -> August 2023: 25mg 2x a day -> October 2024: 22mg 2x a day 2018-present: 25mg Pristiq 2015-present: 600mg Gabapentin (200mg 3x a day) -> December 2022: 300mg Gabapentin (100mg 3x a day) per GP's recommendation after side effects -> March 2023: 90mg 3x a day (switched to liquid suspension) -> April 2023: 81mg 3x a day -> September 2023: bad generic, switched back to homemade liquid; too strong after bad generic, down to 70mg 3x a day, still bad. Adjusted slowly till at 60mg 3x a day, much better. Long hold till -> December 2023: 54mg, still feels too high after November Seroquel switch from brand name to generic, doc recommended 50mg which feels better -> January 2024: When Wellbutrin went down, Gabapentin started putting me to sleep, went down to 45mg, then 41mg to stay awake, so far so good -> February 2024: 36mg, still too high, 34mg -> March 2024: 31mg, STILL too high, 30mg down to 25mg Supplements: Multivitamin w/magnesium, probiotics, digestive enzymes, anti-viral nitric oxide nose spray as needed
FerricIon Posted February 13, 2023 Author Posted February 13, 2023 28 minutes ago, littlebird said: Just popping in to say hello and welcome! Solidarity in the struggle against Pristiq, it's a helluva drug. There are success stories on here, so it's possible to get off. Thank you! I don't think people in general doubt the possibility of getting off the train, but how bad it feels when you do. Hopefully by logging my experience with it, someone might get something out of it.
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