Onepillbuproprion: Immediate ADR one pill Bupropion SR 150mg

[Onepillbupropion]

Hello,

 

I stumbled on this website like most probably, seeking answers.  As the title indicates, I literally took one pill.  Within an hour I started to feel every single positive feeling I was supposed to feel, but also unfortunately negative as well.  Numb from the neck down physically.  I got through the day not thinking much of it, and actually enjoying the positives.  Pure calm, I could focus.  I could read endlessly.  I could concentrate.  I was incredibly relaxed in my stomach if that makes sense.  I hoped the negatives would fade.  I soon learned they wouldn’t.  

 

My background:

 

regular life until 2011.  I was working 15-16 hours and started the energy drinks.  They worked.  They really really worked.  Then I stopped, thinking nothing of it.  Nobody, including doctors, wanted to believe it was energy drinks.  It was something else, the stress of life and responsibilities.  No.  It wasn’t, and it was actually confirmed with this adverse reaction 12 years later.  I went through major withdrawal, much like what happens here.  I had a headache for a year, with a tight band around my head.  I couldn’t concentrate.  I had no memory.  I was searching for words.  That lasted about a year.  I found some balance, but the fatigue mentally and physically remained.  I experimented with every kind of supplement, but no antidepressants, as I feared the side effects.  The only one that made a monumental difference was B12, and by monumental it literally was a light switch to my brain.  I have taken a B complex everyday since, and when feeling fatigue, a bit more of B12 on top.  I got better and got through, but never the energy as before, but highly functional.

 

After some life circumstances the last 3 years which culminated in December, I went back to my counselor.  It always helped.  I received a text from her office promoting TMS brain therapy.  I talked to my counselor about it and it was worth investigating.  At that point, I was fine, ok, alright.  I just thought if I really have depression and lacking chemicals it could give me a “shot in the arm”.  When discussing, they (insurance) wouldn’t approve unless I first tried medication, which I’ve always been hesitant.  I picked up the prescription, and literally stared at it every day for a week in the cabinet while taking my supplements (one a day, B complex, as well as Prevacid and allergy meds).  

 

I finally decided, despite knowing and reading all the potential side effects, to give it a shot.  I’m 51, and if it helped me get the boost of energy I kept hearing about, it would be worth it with whatever time I have left in life to enjoy.  One pill, and that was it.  After the initial jolt, everything went south.  Insomnia, no appetite, physically and emotionally numb, no tears or laughter, libido and ed issues, all of it.  I wanted to have a panic attack but couldn’t.  It’s as if it caused it, but also stopped it at the same time.  I knew I was in trouble when I accidentally knocked over a cup of coffee and just stared at it thinking, “hmmm.” Instead of being frustrated about spilling a cup of coffee all over my carpet and IPad.  I didn’t even flinch.  Add in the constant fear this would be permanent and I was a mess, and still recovering.  I could exercise endlessly, but that made me nervous, because that’s just not me.  A mild walk? Sure.  Feeling like I could run a marathon?  Problem. So while I could write every single note down (I’ve taken daily notes, hourly and minute by minute at times), I’ll simply say that 50 days after I am healing and it’s moving in a positive direction.  I feel my brain power mostly back.  Memory is coming back.  I can laugh and cry again, but the range is not as wide as before the pill.  I don’t feel depersonalized anymore, but that was there.  What’s left is my concern of loose skin and remaining return of libido and ED, which seems to be improving.  A part of me feels like I’ll be changed forever, much like I never was the same after energy drinks, but if I can get full use of things back that would be great. Emotionally, I was pretty sensitive before, so I’m ok actually not getting that part back, but I’d like to laugh again, have firm skin again like I have my whole life, and just move on from this crazy episode.  

 

supplements tried:

 

Magnesium (don’t really feel it helped)

Zinc ( I truly believed this helped but after a week might have been too activiating)

Vitamin E ( can’t tell, but no harm)

Fish oil (took first one today so no idea)

 

Overall, I’m monumentally better than a month ago, in every possible way, but it has left its mark, and hopefully the rest heals in time.

 

I’m incredibly fortunate to have found this site, as I would struggle to believe it myself if it didn’t happen to me, but one pill literally did this.  I know my body incredibly well as a result of having tried so many things from the saga of the energy drinks.  I was simply looking to get over the loss of a family member and relationship, and was on my way, doing ok, simply looking for a boost in energy, and this happened.

 

Thanks for reading.  Good luck and God bless.

 

 

Edited June 29, 2023 by manymoretodays
name to topic title

[Altostrata]

Welcome, @Onepillbupropion

 

As you've probably seen, we have a small group among our members who never did get along very well with the antidepressant. Many have had severe adverse drug reactions (ADR) within a few doses.

 

These people, who are tagged "immediate ADR", have symptoms that are like protracted withdrawal syndrome but they don't have withdrawal syndrome, they have similar symptoms because their nervous systems were upset by taking the drug. Their recovery is slow, with frustrating waves and windows, like people with withdrawal syndrome, but it seems their recovery isn't as long. Since they had a serious ADR to an antidepressant, they probably should not consider reinstatement. 

 

Please read Immediate adverse reactions to an antidepressant or within a few doses? How long for recovery?

 

On 6/28/2023 at 5:11 PM, Onepillbupropion said:

Overall, I’m monumentally better than a month ago, in every possible way, but it has left its mark, and hopefully the rest heals in time.

 

This is a good sign, and relatively fast progress, too. Please be patient while you very gradually recover. 

 

Be sure to report this adverse reaction to your doctor and FDA.

 

Many people find these to be helpful:

Magnesium, nature's calcium channel blocker 

Omega-3 fatty acids (fish oil) 

 

You might try a low dose of one at a time to see what it does for you.

 

Please let us know how you're doing.

[Onepillbupropion]

Thank you. I really appreciate. I’ve learned so much already here and the success stories are wonderful to read. I will update, hopefully with continuing good news. 

[Onepillbupropion]

Random 211th day update:

 

 I’m better. Not all the way there but better, and different. If I were to simply put numbers to it, 0 being all negative emotions and 10 being all positive, this is what it would look like:

 

 before energy drinks:

0-10 regular life

 

 after energy drinks before this ADR

-4 to +6

 

I rarely reached top happy and couldn’t break through that wall, but could definitely feel lower/more sad/sensitive/quick to anger than ever before. Didn’t like it. 
 

After one pill and calming down somewhat from the mania:

 

+4 to +12

 

I’ve noticed since emotions have slowly started returning that I can’t really get sad/down/angry. I’ve been to funerals where I know I would otherwise be sad and crying, but nothing. I also know things that used to make me upset/anxious just don’t. They are also the funny stuff that isn’t that funny but I’m too giddy. 
 

little by little things are indeed balancing. I’m feeling regular body aches and pains again, which I actually welcome. I felt nothing initially. Nothing. 
 

The male parts are slowly returning from dead, so I would rate that as about a 6 now. Not totally dead, but not totally back. 
 

I’m stable, and sleeping through the night again, but still have moments of frustrations about all of this. Thank God for this site to teach me about the concept of windows and waves as around 3 months I thought all of this was completely past me but then hit with a month long wave, but not starting from zero. It’s been more windows and waves in every area since, but shorter intervals. I can cry again, at appropriate times, just not as much as once before. Emotional range continues to expand. I’m just trying to be patient and hope for continued recovery. 
 

I tried fish oil but didn’t agree with it. Magnesium seemed to help so I’m still taking that. I was already taking b complex so just continued that. I tried vitamin E, zinc in the beginning but just felt odd, and the more I’ve read, the more that time seems to be the best medicine, so the only added thing I still take is magnesium. 
 

Just going to continue to be hopeful and read all the success stories. 
 

And like others have said, I just stopped telling people, my doctor especially. Unless you lived it, nobody gets it. 
 

Grateful for this site. 

[Onepillbupropion]

One year exactly update for anyone who this might help:

 

 I’m…better. Pretty good. Around the 10 month mark is where I truly started to BELIEVE I would be ok. The previous months were just hope and prayer. 
 

The last two months have skyrocketed my confidence in healing. So where am I at after taking a pill that potentially changed things forever? I would say it’s exactly like everyone else who has healed has described, windows and waves, with each progressive window stronger, and each wave less bad. 
 

I listed all my symptoms above so I’ll simply add a bullet point list to where I’m at. The only three things in still concerned about:

 

1. PSSD. Remarkable strides have been made, the likes of which I never imagined, but still don’t have full confidence. Windows stronger. Waves not as bad. I don’t want to be too descriptive and follow all rules, but every aspect of it is better, I just hope and pray for the consistency factor. 
 

2.  Metabolism/weight loss. 
 

This continues to worry me. I feel as if I drink water I’ll gain weight. My body composition has gone to mush, and I was very in shape for a 51 year old. It sucks. Loose skin. Love handles that only seem to expand, and a constant thought of I’ll ever get my body back. 
 

3. Full emotional range. I’m significantly better, and appropriately can get a bit sad as the situation will call for, but still very muted emotionally. Better, but not all the way there. Maybe I don’t want all those emotions back is what I think sometimes. 
 

Overall, it was the belief that I’ll be ok that helped turned the corner. 
 

Trusting everyone hear who has healed, I’ve simply relied on time. I tried supplements in the beginning, then just “trusted the system” and stopped everything except my allergy and reflux meds, which also worry me after taking about histamine and reflux medication. I’ve tried to taper them. I just can’t. I also still take a probiotic, which times out with my belief that I’ll be ok. Coincidence or helpful I don’t know, but I’m not going to stop. 
 

The big time hyper is gone. At first, I could walk 8 miles and not blink, and I’ve never done that in my life. Now I’m back to regular walking and even the “I just fine feel like it” mentality, which is much more myself. 
 

Sleep is back to regular, and I’m an odd way, some anxious/nervous feelings are returning, which I’ll gladly accept. 
 

Oh, and tinnitus is something I welcome. I was so clogged up for lack of a better term, I couldn’t even feel/hear it. To me, that actually means healing. I have itches at times, and goosebumps. It’s weird to never feel the need to itch. 
 

So after a year, I’m much better, but still look forward to more healing. I have confidence again, something I feared was gone forever. 
 

I hope this helps at least one person, and I continue to pray I get to write a success story soon. 

[Onepillbupropion]

Day 406 update:

 

i chose this because yesterday I had a 3 hour window where I was completely myself for the first time in 405 days. A ceiling was broken so to speak. 
 

Of all the things I’ve read here, someone wrote, “you’re not special. You will heal”. And that struck me hard, in a positive way. 
 

I continue to heal in windows and waves, with windows lasting longer and waves shorter. 
 

1. Emotional range is expanding. Snails pace, but it’s better

 

 2. Body composition/weight gain. Better. Cravings gone. Appetite control better, losing weight slowly. 
 

3. PSSD. Better, with windows and waves, but not all the way there yet. 

 

I continue to pray that I’m not special, and will heal. 

[buproprionanxiety]

Your post and updates have brought me hope.  I took bupropion XL 150 for four days in July.  I immediately started feeling anxious and paranoid, got hypertension and tachycardia, memory loss, and couldn't stop catastrophizing.   Today is day 26 off the medication.  The first two weeks were absolutely miserable - the insomnia, racing thoughts, etc.  I finally started having better sleep in week three with the help of supplements (magnesium, melatonin, ashwagandha, NCA, l-theanine).  After 26 days, I think I'm 85-90% back to normal.  The waves aren't as intense, and the windows are getting longer.  Interestingly enough, I still struggle with gaps in my long-term memory.  I couldn't recall the name of my mom (passed away in 2006).  I hope that will fix itself in the future.

 

I work in healthcare, so I had the advantage to share my experience and seek guidance from a lot of doctors.  None of them have ever heard of a reaction like this, and that made me feel like I was making this all up in my head.  Your post (and this website) have been a lifesaver for me.  It's absolutely amazing that taking a pill for four days can have such a crippling and lasting effect.

[Onepillbupropion]

1 hour ago, buproprionanxiety said:

Your post and updates have brought me hope.  I took bupropion XL 150 for four days in July.  I immediately started feeling anxious and paranoid, got hypertension and tachycardia, memory loss, and couldn't stop catastrophizing.   Today is day 26 off the medication.  The first two weeks were absolutely miserable - the insomnia, racing thoughts, etc.  I finally started having better sleep in week three with the help of supplements (magnesium, melatonin, ashwagandha, NCA, l-theanine).  After 26 days, I think I'm 85-90% back to normal.  The waves aren't as intense, and the windows are getting longer.  Interestingly enough, I still struggle with gaps in my long-term memory.  I couldn't recall the name of my mom (passed away in 2006).  I hope that will fix itself in the future.

 

I work in healthcare, so I had the advantage to share my experience and seek guidance from a lot of doctors.  None of them have ever heard of a reaction like this, and that made me feel like I was making this all up in my head.  Your post (and this website) have been a lifesaver for me.  It's absolutely amazing that taking a pill for four days can have such a crippling and lasting effect.

I’m so glad I’m helping at least one person as others here have helped me so much. 
 

I’m continuing to heal. Windows stronger ave waves weaker, but in a way it makes waves more frustrating because I’m SO close. 
 

I have itching again. It was weird to not have any itching for a year. My emotionally range gently continues to expand. I felt a little empathy last week. It was awesome. 
 

I’m still not crying too much at appropriate times but laughter is good. Anger/fear/anxious all returning but not totally. I actually have a headache today, and it’s…. AWESOME. I actually feel it. I would never know in the last 465 days if I had one because I was so numb. I have increased feeling in my skin when I pinch, and I’m continuing to get my old body composition back, but so slowly. 
 

I would say I’m 60-70% almost all the time, with brief moments to 90% and a few moments to 50%, but the best part OSs the lows never really get below 50% anymore. It doesn’t consume my thoughts every waking moment like it did for the first 10 months. 
 

I just continue to trust everyone else’s system and rely on time. It’s worked the best for me. 
 

I’m glad my posting helps. I’ll continue to do so. I’m not there yet, but I feel stable, and continuing to heal. 
 

All the best to you. 

[Onepillbupropion]

I’m so glad you know I’m helping at least a couple people. That said, some cool progress to share day 474:

 

 in the last 24 hours, I got emotional and teared up a bit watching a TV show, has MAJOR back pain getting out of bed, and got a little emotional and teared up a little bit at a funeral today. 
 

Those Tim’ just didn’t happen early on. I am embarrassed to say my first funeral after the pill I had to stop myself from giggling. Totally not myself. 
 

last 24 hours pretty cool. I’m keeping the faith that healing will continue. 

[Onepillbupropion]

Day 500 update:

 

500 days. I’m some ways I didn’t think I could last. In others, I didn’t feel anything so didn’t know the difference.  (The fact I can chuckle at this is huge in my opinion)
 

Here’s where I’m at today:

 

 Mentally, the sky is opening faster, and lots of times where I’m just myself, doing myself things, without even thinking about it, but emotions still never too high or low. While numbness is wearing off, it’s slow, both physically and mentally, but definitely improving. 
 

Physically I’m in a tough spot. I’m in a rough wave of the PSSD, and then just feel like my bloat will never go away, no matter how much I watch calories. I’ve lost weight ever so slowly, but the bloat feeling remains, and I’m just not sure things are “moving along” correctly. I feel like have negative metabolism. My loose skin continues to bother me, and my body composition is just…saggy, for lack of a better description. 
 

This is probably the biggest variance I’ve felt since this all began. I feel really good mentally, but the physical issues remain, and I’m still a bit spooked by it. 
 

i had a great window for a month or two of not thinking about things or reading too much, but that has returned as my physical stuff really bothers me, and again, I’m done sharing with the outside world. 
 

So good progress overall, but in a bit of a wave physically. 

[BaccatePlayer]

Thanks for the update! Glad you're seeing some improvement. The fact that you only took one dose and know such a variety of suffering it can bring for so long is truly upsetting, but at least you have our empathy. Things are on the right path. Sending support!

[Onepillbupropion]

51 minutes ago, BaccatePlayer said:

Thanks for the update! Glad you're seeing some improvement. The fact that you only took one dose and know such a variety of suffering it can bring for so long is truly upsetting, but at least you have our empathy. Things are on the right path. Sending support!

Thank you so kindly. It’s a weird spot to be in because mentally things truly are progressing. The physical is taking its time. I’m at the point where I continue to post because I know it’s helped at least a couple people. And I only survived that first year because I’d this site and the success stories. 
 

Thank you. Hopefully healing continues. 

[Farm24]

On 9/9/2024 at 10:51 AM, Onepillbupropion said:

Thank you so kindly. It’s a weird spot to be in because mentally things truly are progressing. The physical is taking its time. I’m at the point where I continue to post because I know it’s helped at least a couple people. And I only survived that first year because I’d this site and the success stories. 
 

Thank you. Hopefully healing continues. 

As my muscles become less numb they have dystonic type issues. Have you gone through any of that? My skin does go through times where it gets better but then it gets worse again. It's weird. 

[Onepillbupropion]

49 minutes ago, Farm24 said:

As my muscles become less numb they have dystonic type issues. Have you gone through any of that? My skin does go through times where it gets better but then it gets worse again. It's weird. 

In all honesty I had to look up dystonic. I have had a small but if that, but nothing worthy of note. My skin looks aged, to me, but others wouldn’t notice. Biggest improvement is veins are starting to show and flow again. I’m otherwise still in a rut physically. Weight stall and body composition are frozen, no matter what I do with diet and exercise. Internal bloat remains. But again, mentally, I’m definitely on the right path. I’m just in a wave, after a great window of healing in July and August. Hopefully October turns things around. 

[Farm24]

10 minutes ago, Onepillbupropion said:

In all honesty I had to look up dystonic. I have had a small but if that, but nothing worthy of note. My skin looks aged, to me, but others wouldn’t notice. Biggest improvement is veins are starting to show and flow again. I’m otherwise still in a rut physically. Weight stall and body composition are frozen, no matter what I do with diet and exercise. Internal bloat remains. But again, mentally, I’m definitely on the right path. I’m just in a wave, after a great window of healing in July and August. Hopefully October turns things around. 

I'm hoping so too.  Sounds like you are going in the right direction. 

[Onepillbupropion]

Day 566:

 

I’ve been wanting to update recently.  The urge hits often, but then I don’t want to bombard, but then I know it helps others.  This indecision right here, in a weird way, is my old indecisive self, so healing is happening. So, to where I’m at for any who may be reading, in short version:

 

TL;DR.  I’m good, acceptable, getting better but not there, hoping to be great.

 

Mentally:

 

 Every time I think I’ve reached my peak, it just keeps getting better.  Today hit a bit hard though.  I don’t drink or smoke so I don’t know if I’d feel effects from it like others who say they don’t.  I did get a slurpee, and drank it too fast, BUT DIDN’T GET A BRAIN FREEZE.  That spooks me to be honest.  I did feel it physically, but no brain freeze.

 

I’m otherwise continuing to get back to my old self mentally.  Emotional range does increase, ever so slowly, but still not there.  If this is the range I have for life though, I’m ok with it.

 

The best part is awareness.  I look back now and can actually see the growth from when my brain completely shut down from this, and was totally numb.  I didn’t experience panic or anxiety, just pure numb.  Numb, numb, numb, with endless hyper energy, minimal sleep, and total brain and body numb.

 

Physically:  

 

I feel like I have a bloat suit around me that is totally numb, and skinny me is inside.  I’ve been fat.  I’ve been ripped.  I was ripped before I took this pill, but never numb, or bloated.  I still feel both, but now bloated more than numb, and weight loss just isn’t happening.  PSSD still very present.  There are days I’m filled with hope, only to return to feeling that sunk feeling in my stomach, which then gives me hope, because I could feel it, but that doesn’t help, because it doesn’t change things.  My body is still pretty bloated and numb.

 

Overall, I believe in data.  I can crack my knuckles, and knees.  I feel pain.  I have headaches from time to time.  I genuinely laugh, and yesterday laughed until some tears came out.  I can get a tad sad.  I can feel tremendous anger about this, and also lately defeated, but I look at that actually as a positive.  Feeling defeated means I actually feel something.

 

So I’m somewhere in the healing process, not totally numb/hyper, but not totally healed.  I do believe it’s all in the gut, and if my gut regulates and flows smoothly again, the rest will as well.  Until that thaws, my love handles and stomach feel like a brick wall that just won’t soften, like everything is just stuck.

 

the best part again, is I just quit and give up, and give in, and am living the best I can, hoping the finishing touches arrive physically and mentally.  Nobody would ever know a thing if you just met me and we had a conversation.  Further, again, nobody would ever believe one pill could do this, so thank you all for believing.  I know exactly who i was and how I felt and looked physically before this, and how things were in the bedroom, and I know exactly how I look and feel after, as well as the bedroom.  It was the pill.

 

So maybe a little longer update than I intended, so I’ll scroll back up and do a TL;DR update, but I’m good, hopefully on the way to great.