Jump to content

JaJo and the long journey to get off Venlafaxine


JaJo

Recommended Posts

Posted

Hello guys,

 

im glad to be here. Im a 36 year old Male from Germany. So please excuse any language induced mistakes. 

 

I got started on Venlafaxine around 2012 after a panic attack. 10 minutes with a psychiatrist...he asked me if i would take med...i often wished i could go back to this point. I did not know better and agreed...tried Sertraline, reacted bad to it and got on 75mg of Venlafaxine for 2 Weeks then 150.

It did indeed help with the panic or the panic was just gone. I still had major health anxiety. After a heart attack in 2015 (luckily no damage taken, everything went pretty quick) i was increased to 225 and later 300 due to the Heart Anxiety.

I got more and more depressed what i have never been before.

Around 2017 i wanted to get off. Psych reduced me in 75mg per Week steps...hell broke loose...Anxiety, OCD, Panic...you name it. It was followed by half a year of trials of different meds. Nothing helped and i was finally started back on Venlafaxine slowly increasing to 150mg.

In 2019 i started to taper again. Homeoffice due to covid made me think i can take the last step of 37,5 mg in one hit and suffer through it...yeah...no. I really tried hard but gave in after 3 Month...slowly raising back to 150mg where it once again stabilized. Things got better...not great...but okish.

It always made me tired and not care about anything. I still wanted to get off. So i started to research and found sites like this talking about tapering really slowly. 

So once again in 2021 i started the journey im on till today. My capsules contain 12,5mg tablets. So i took this for the steps. The whole time i have cbt supporting the taper. I got down to 75mg last summer...still felt tired and sad all the time. I reduced to 62,5 in January and stabilized. I still had symptoms of restlessness or sadness but not enough to disrupt my life. 

It was ok for the first time in a while. So i went down to 50mg already fearing the 12,5mg could start being to large of a step. Some work changes and medical issues came up and my anxiety skyrocketed. I tried to push through it but gave in after 4 weeks and went back to 62,5. Sadly i did not seem to be able to stabilize. The whole time i had unbearable restlessness and out of the sudden got panic attacks which i rarely had up to this point. Sleep issues came up and it started interfering with work. So i went up to 75mg after 6 Weeks of waiting where i am now for 3 Weeks. For the first 2 Weeks symptoms started to improve, better sleeps, less panic and restlessness. But last sunday after some good days the restlessness came back in full force...arguably harder then before the step up. Its a pretty disgusting feeling in the stomach and extremities...can't relax or focus very well.  If i cant detach my thought from it it can quickly spiral in to panic. It often gets better towards the evening but can be a real torture when in full strength. When it's less i feel quite ok. 

 

So here i am now....searching for advise on how to proceed with the taper. Should i stay with 75mg for a while? Should i go back to 62,5? Should i take other meds to help with the symptoms? I have a wide aray available here but i am always to afraid to take something ... maybe half an Atarax with sleep issues. But thats it ... and thats been twice since stepping back to 62,5.

I also look for tips how to deal with the restlessness and encouragement to get through it.

 

I hope that explains everything. Thanks for reading through it.

 

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • 2 weeks later...
  • Administrator
Posted

Welcome, @JaJo

 

What date did you start taking 75mg venlafaxine again? How has your symptom pattern changed since that date?

 

Please put ALL your drugs in this Interactions Checker and post the report or a link to it in this topic.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

  • Mentor
Posted

Hi @JaJo!  I'm trying to get off Venlafaxine too.  I'm glad you're here for guidance and advice; you came to the right place!  

 

We can all encourage each other during this journey.

 

Warmly,

Catina ❤️

Disclaimer:  This is not professional medical advice but is based on personal experience only.

1994 - 2017:  Prozac, Cymbalta, Celexa, Paxil, Wellbutrin, Zoloft, Seroquel, Buspar, Lorazepam, Xanax, Ambien

2005-present:  Trazodone 50 mg 

2017:  Effexor XR 37.5 >> 75 mg 

2020 (March):  Began 10% monthly taper of Effexor XR (got down to 12 mg)

2021 (September):  Completely crashed with horrific symptoms.  Went back up to 37.5 mg but kindled myself

2024 (Avg. bead count per capsule is 111):  1/1:  -6  |  2/1:  -11  |  3/1:  -16  |   4/1:  -18  |   5/1:  -21   |   6/1  -25 |   7/1  HOLD |   8/1  -29  |   9/7  -33 |   10/7  HOLD |   Nov. HOLD. |   Dec. -34

Reasons for starting psych meds:  PMDD/Depression, Generalized Anxiety Disorder

Other medications:  Levothyroxine 50 mcg (as of Nov. 2024)

Supplements:  Dr. Berg's Electrolyte Powder on occasion   

 

Never give up  Holding On with Patience & Endurance

Posted

Hey guys, thanks for having me.

 

the last 2 Weeks since i signed up here were pretty rough 😞

I raised to 75 on the 23.06.2023. Followed by 2 weeks of improvement in Symptoms and a crash thereafter. All the restlessness, anxiety and panic returned.

This led to me being signed off from work for a week and my Psych. raising me back to 112mg on the 18th of July. Which i agreed to due to the severe symptoms. 

So i guess this is now my baseline. I still have not stabilized thought. Anxiety and panic got a bit better. The restlessness is still there quite often. 

 

He also gave me Mirtazapine which i took twice aprox 2mg on sunday and yesterday and will never take again as i still feel drownsy depressed and dissociated from it today. At least i hope its from M. and not V. and will get away once its out.

 

My plan was to stabilize on 112mg now before going back down. I feel ashamed i gave in but i felt such an urge to do something about the symptoms. 

 

I have so much fear that i will never be better again and that my ZNS is completely messed up by now. 

 

 

Here is the interaction check...i have been taking them all for years without issues together. 

Moderate

aspirin  venlafaxine

Applies to: Aspirin Low Strength (aspirin), venlafaxineModerate

aspirin  venlafaxine

Applies to: Aspirin Low Strength (aspirin), venlafaxine

Using venlafaxine together with aspirin may increase the risk of bleeding. The interaction may be more likely if you are elderly or have kidney or liver disease. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

aspirin  valsartan

Applies to: Aspirin Low Strength (aspirin), valsartan

Talk to your doctor before using valsartan together with aspirin. Combining these medications may reduce the effects of valsartan in lowering blood pressure. In addition, these medications may affect your kidney function, especially when they are used together frequently or chronically. You are more likely to develop impaired kidney function during treatment with these medications if you are also using a diuretic ("water pill") or if you are elderly or have preexisting kidney disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience signs and symptoms that may suggest kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

Posted

Welcome JaJo,

Sorry you are going through this nightmare too.

I've recently tried to stabilise on 75mg after reducing from an initial 225mg too quickly.

I have been unable to stabilise on it and, like you, have continued to experience agitation, panic, poor sleep, low mood over a month since reinstating.

I've found it necessary to go to 150mg for now, as getting initial stability seems the most vital thing to achieve.

Are you still having CBT? Do you have other support around you?

F

Primary and secondary school- struggled socially. I am neurodiverse. Anxiety and OCD. Bullied. Insomnia.

1989 First struggled with severe anxiety and panic aged 16. No meds that I can remember.

1993, At Uni. Eating disorder and low mood/anxiety. Prescribed Sertraline 50mg, took for some months.

1994-97 On and off (mainly on) Fluoxetine 20mg.

1998 First seen by specialist mental health team and prescribed Venlafaxine/Effexor. Soon increased to 150mg, then 225mg.

Have made serious attempts to come off Effexor, too many to remember.

2022 March began reducing from 225mg- went to 150mg and kept at this for 6 months.

Sept 22 reduced to 112.5mg. March 2023 reduced to 75mg. Felt fine right up until this point.

March 2023- current time- I have rushed a further reduction until I was on 25mg.

Went into full panic and withdrawal syndrome on June 18th 2023.

June 20th Reinstated 75mg Effexor. June 27th increased to 150mg. July 9th- have reduced to Effexor 75mg for 6 months

Also going through menopause symptoms- no meds for this.

Posted
11 minutes ago, felinegaze said:

Welcome JaJo,

Sorry you are going through this nightmare too.

I've recently tried to stabilise on 75mg after reducing from an initial 225mg too quickly.

I have been unable to stabilise on it and, like you, have continued to experience agitation, panic, poor sleep, low mood over a month since reinstating.

I've found it necessary to go to 150mg for now, as getting initial stability seems the most vital thing to achieve.

Are you still having CBT? Do you have other support around you?

F

Thank you 🙂

I feel you with those symptoms. It's so debilitating but you are right. I had to swallow my pride and go up. There is no point in reducing until im stable again.

Once ill get to 75 again ill switch to a capsule with the tiny balls so i don't have to go in 12,5 steps anymore. 

Yeah im still doing the cbt...hes no fan of medication so there is no pressure to up something. He tries to teach me acceptance and other techniques which help to some point. 

I'm trying to stay working most of the time as the routine helps. My family is really supportive in this but they obviously can't do much besides being there which is also hard for them. 

Did you manage to stabilise on 150?

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Administrator
Posted

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Posted
2 hours ago, Altostrata said:

My usual way would be to go in 12.5 bobble steps as I had not problems doing so last time. But this would be a bit more then 10 for the last step. I need to switch to a different capsule to get the tiny balls which I planed to do at 75 mg originally. But I could obviously do so at 112.5 as well. Maybe that be better. Last time It went pretty well down to 62.5 .

 

Feeling pretty depressed the last days. Everything seems to overload the brain. I still hope it's from the Mirtazapine due to its long half-life. Hope it's not the venlafaxine. That be kinda annoying. Not sure what to do if the increase made the panic better butore depressed. But I guess it would be to early to tell anyways after 8 days.

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

Posted
4 hours ago, JaJo said:

My usual way would be to go in 12.5 bobble steps as I had not problems doing so last time. But this would be a bit more then 10 for the last step. I need to switch to a different capsule to get the tiny balls which I planed to do at 75 mg originally. But I could obviously do so at 112.5 as well. Maybe that be better. Last time It went pretty well down to 62.5 .

 

Feeling pretty depressed the last days. Everything seems to overload the brain. I still hope it's from the Mirtazapine due to its long half-life. Hope it's not the venlafaxine. That be kinda annoying. Not sure what to do if the increase made the panic better butore depressed. But I guess it would be to early to tell anyways after 8 days.

Are you going to give yourself a chance to stabilise on 112.5mg for at least 6 months?

My reducing was similar, going in the 12.5mg steps. Ultimately it was much too fast.

I hope to stabilise on 150mg but it's far too early to tell, I've only been back on the dose for 3 days. It's possible I might need the 225mg.

Functioning well and not having suicidal thoughts is my immediate aim. Tapering again can be for the future. It's tough to accept this but necessary. We are dealing with very powerful substances here and need to respect that. I've realised that this is not about whether we are 'strong' or not.

Are you still absent from work? What job do you do? 

Oddly I can mostly manage work, although I'm not exactly full of joy. I do have a supportive group of colleagues around me though. How about you?

I'm glad you are still seeing your CBT person.

F

Primary and secondary school- struggled socially. I am neurodiverse. Anxiety and OCD. Bullied. Insomnia.

1989 First struggled with severe anxiety and panic aged 16. No meds that I can remember.

1993, At Uni. Eating disorder and low mood/anxiety. Prescribed Sertraline 50mg, took for some months.

1994-97 On and off (mainly on) Fluoxetine 20mg.

1998 First seen by specialist mental health team and prescribed Venlafaxine/Effexor. Soon increased to 150mg, then 225mg.

Have made serious attempts to come off Effexor, too many to remember.

2022 March began reducing from 225mg- went to 150mg and kept at this for 6 months.

Sept 22 reduced to 112.5mg. March 2023 reduced to 75mg. Felt fine right up until this point.

March 2023- current time- I have rushed a further reduction until I was on 25mg.

Went into full panic and withdrawal syndrome on June 18th 2023.

June 20th Reinstated 75mg Effexor. June 27th increased to 150mg. July 9th- have reduced to Effexor 75mg for 6 months

Also going through menopause symptoms- no meds for this.

Posted
3 hours ago, felinegaze said:

Are you going to give yourself a chance to stabilise on 112.5mg for at least 6 months?

My reducing was similar, going in the 12.5mg steps. Ultimately it was much too fast.

I hope to stabilise on 150mg but it's far too early to tell, I've only been back on the dose for 3 days. It's possible I might need the 225mg.

Functioning well and not having suicidal thoughts is my immediate aim. Tapering again can be for the future. It's tough to accept this but necessary. We are dealing with very powerful substances here and need to respect that. I've realised that this is not about whether we are 'strong' or not.

Are you still absent from work? What job do you do? 

Oddly I can mostly manage work, although I'm not exactly full of joy. I do have a supportive group of colleagues around me though. How about you?

I'm glad you are still seeing your CBT person.

F

Yes i definitely need to stabilize before tapering again. The last days the anxiety and restlessness were better...the depression worse thought. So i'm kinda worried Venlafaxine is making it worse and i have to go down again or sth. similar. Or that the restlessness was only better from the 2 times i took mirtazapine.

Its really hard to stay positive atm. Ruminating the whole day and really hard to break the cycle. I hope that's just from increasing the Venlafaxine and not the end result. 

I have been working again this week. Half from home and half office. Typical office IT job. The distraction often helps and my team is really nice but most of them don't know i struggle. The office days are harder because of all the traffic stressors and stuff. 

2 Weeks holiday incoming soon. So i hope i can stabilise a bit during that phase. 

Overall the symptoms seem to jump around quite heavily atm....depressed, feeling better, panic/anxiety, intrusive thoughts switching within minutes it feels. 

I hope you had a good day at work. It's nice to have some support there and to keep working as a distraction. 

 

JJ

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Administrator
Posted

We advise 10% reductions for a good reason. If you've already had withdrawal symptoms, you might not tolerate the reductions you made before.

 

Have you reviewed adverse effects for each of the drugs you're taking?

 

Please put ALL your drugs in this Interactions Checker and post the report or a link to it in this topic.

 

 

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Posted
44 minutes ago, Altostrata said:

We advise 10% reductions for a good reason. If you've already had withdrawal symptoms, you might not tolerate the reductions you made before.

 

Have you reviewed adverse effects for each of the drugs you're taking?

 

Please put ALL your drugs in this Interactions Checker and post the report or a link to it in this topic.

 

 

Yeah the interaction report was in the post from yesterday. Nothing major in there. Been taking them forever. 

It might indeed be better to switch to the balls capsule once stable and then reduce in smaller steps. Want to be stable before switching...had issues with different genericas before. 

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Administrator
Posted

What have you found out about adverse effects of rosuvastatin and valsartan?

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Posted
8 hours ago, Altostrata said:

What have you found out about adverse effects of rosuvastatin and valsartan?

The above is all it gave me for all my medication. There are non between rosu and valsartan...just double ckecked.

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Administrator
Posted

Please check the adverse effects of each drug, not the interactions. Thank you.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Posted
33 minutes ago, Altostrata said:

Please check the adverse effects of each drug, not the interactions. Thank you.

my bad that one got lost in my language skills 😉
 

They both have psychiatric side effects indeed. The rosuvastatin is actually pretty new for me (around may)...i was on another statin before that.Had to switch one because it wasnt doing enough, and could not tolerate another one due to sleep disturbance. I'm already tracking it in my journal not taking it on some days to see if there is a difference but have not found one yet.

The thing is due to my coronary disease i need a statin.

Can't really relate to the valsartan causing anxiety but i could ask my cardiologist to switch me to something different i guess. Usually it just makes anxiety worse if i forget to take it due to the palpitations. 

Im on a really low dose thought...20mg only. I also could not find any evidence to support this. Studies seemed to show it helps with anxiety and depression actually. 

 

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Administrator
Posted

The depression element of your daily symptom pattern may be from rosuvastatin. You may not be able to to avoid it as you taper venlafaxine.

 

25 minutes ago, JaJo said:

Usually it just makes anxiety worse if i forget to take it due to the palpitations. 

 

Taking doses of any of your drugs irregularly might cause symptoms such as "depressed, feeling better, panic/anxiety, intrusive thoughts". Please be careful to take your drugs on a regular daily schedule.

 

It's going to be very difficult to sort out potential adverse effects of valsartan and rosuvastatin from withdrawal symptoms that might arise from tapering venlafaxine. It could be your difficulty in "stabilizing" is actually adverse effects from these drugs.

 

Please keep daily notes of times o’clock you take your drugs, their dosages, and your symptoms throughout the day. We need to know how you feel before and after taking each drug, and any significant symptoms in between. Post 24 hours of notes at a time in this topic, in a simple list format with time o’clock on the left and notation (symptom or drug and dosage) on the right. This can help identify symptoms that are adverse effects from one or more of your drugs.

 

 

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Posted

Hey JJ,

How are you feeling today?

I was wondering if you have anything planned in for your two week holiday? I know that for me it is better to have a structure when I'm struggling, and to have others around, even if they don't necessarily know that you're having a hard time.

I have to say that your language skills are superb. I'm a typical Brit in that I haven't successfully learned any other language, despite French at school and several attempts to master Spanish! I'm always so impressed to see people managing to describe their experiences here when English is not the first language.

Are you managing to sleep and eat well at the moment?

Are you exercising?

Hope today is manageable,

F

x

Primary and secondary school- struggled socially. I am neurodiverse. Anxiety and OCD. Bullied. Insomnia.

1989 First struggled with severe anxiety and panic aged 16. No meds that I can remember.

1993, At Uni. Eating disorder and low mood/anxiety. Prescribed Sertraline 50mg, took for some months.

1994-97 On and off (mainly on) Fluoxetine 20mg.

1998 First seen by specialist mental health team and prescribed Venlafaxine/Effexor. Soon increased to 150mg, then 225mg.

Have made serious attempts to come off Effexor, too many to remember.

2022 March began reducing from 225mg- went to 150mg and kept at this for 6 months.

Sept 22 reduced to 112.5mg. March 2023 reduced to 75mg. Felt fine right up until this point.

March 2023- current time- I have rushed a further reduction until I was on 25mg.

Went into full panic and withdrawal syndrome on June 18th 2023.

June 20th Reinstated 75mg Effexor. June 27th increased to 150mg. July 9th- have reduced to Effexor 75mg for 6 months

Also going through menopause symptoms- no meds for this.

Posted
2 hours ago, felinegaze said:

Hey JJ,

How are you feeling today?

I was wondering if you have anything planned in for your two week holiday? I know that for me it is better to have a structure when I'm struggling, and to have others around, even if they don't necessarily know that you're having a hard time.

I have to say that your language skills are superb. I'm a typical Brit in that I haven't successfully learned any other language, despite French at school and several attempts to master Spanish! I'm always so impressed to see people managing to describe their experiences here when English is not the first language.

Are you managing to sleep and eat well at the moment?

Are you exercising?

Hope today is manageable,

F

x

I was working from home today. Lots of restlessness and anxiety. The depressive symptoms were better today thought. 

suicidal OCD flared up recently as well which usually tends to happen in bad phases. 

We missed on our usual holiday location this year so we will go with daytrips and go there in autumn holidays this time. 

So yeah lots of family trips coming these days. This usually helps with restlessness at least.

Sleep seems to go well atm...aside from the early awakening...i tend to wake up at 5am kinda restless and its hard to fall back asleep then.

Eating normal...i never eat breakfast besides weekends (never have). When the agitation/restlessness is there i tend to only eat a small lunch. 

Usually it gets better in the evening. So i tend to get a warm meal there. 

I usually do 2 dog walks and a bit of bicycle each day so i tent to get a bit of fresh air and movement if i want or not 😉

 

 

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

Posted
22 hours ago, Altostrata said:

What have you found out about adverse effects of rosuvastatin and valsartan?

It hadn't occurred to me that a statin or a hypertensive med might have an influence... I too will have to check mine out. 

Good luck JJ.  

Various ADs from 1991, always for depression with anxiety and agitation... sertraline, paroxetine, citalopram (with 2.5mg olanzapine briefly), coming off each for increasingly shorter times until 2000 when I went on meds full time with Clomipramine 200mg. Then Venlafaxine (XR) since 2008, initially 225mg, then 300mg, plus tried on venlafaxine with mirtazapine (California Rocket) for only a week in 2017(?) as absolutely intolerable. 

July '23 Venlafaxine XL 300 to 275mg.  Aug '23 275 to 250mg. Sept/Oct '23 250 to 230 to 225mg.  Nov '23 205mg. Dec '23 185mg.  28 Dec '23 reinstated 225mg after crashing. 

 

Supplements: Vitamin D and fish oil. 

 

"L'exposition du merde est temporaries".

 

Although I have a background in health, I am here to learn from others, encourage others and share my experiences, not to give professional guidance. 

Posted
1 hour ago, BigCat said:

It hadn't occurred to me that a statin or a hypertensive med might have an influence... I too will have to check mine out. 

Good luck JJ.  

yeah you find those entries pretty often actually. You can only try it with a different med for a while to see if something changes. Both...sartans and statins also have a lot of studies showing the complete opposite with them helping with depression and anxiety...so i guess you never know which end you get if one at all.

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

Posted
On 7/28/2023 at 8:30 AM, Altostrata said:

The depression element of your daily symptom pattern may be from rosuvastatin. You may not be able to to avoid it as you taper venlafaxine.

 

 

Taking doses of any of your drugs irregularly might cause symptoms such as "depressed, feeling better, panic/anxiety, intrusive thoughts". Please be careful to take your drugs on a regular daily schedule.

 

It's going to be very difficult to sort out potential adverse effects of valsartan and rosuvastatin from withdrawal symptoms that might arise from tapering venlafaxine. It could be your difficulty in "stabilizing" is actually adverse effects from these drugs.

 

Please keep daily notes of times o’clock you take your drugs, their dosages, and your symptoms throughout the day. We need to know how you feel before and after taking each drug, and any significant symptoms in between. Post 24 hours of notes at a time in this topic, in a simple list format with time o’clock on the left and notation (symptom or drug and dosage) on the right. This can help identify symptoms that are adverse effects from one or more of your drugs.

 

 

28th July
0630 - waking up mentally restless and anxious about the day
0640 - start working from home
0650 - taking Aspirin , Valsartan and Rosuvastatin
0900 - varying degrees of anxiety and restlessness sice the last entry //overall less depressed than yesterday but more restless..
1030 - a bit more relaxed
1100 - Anxiety attack, intrusive thoughts
1130 - Anxiety better, restlessness worse 
1230 - lunch
1300 - Dog walk, worse restless feeling and palpitations,
1400 - a bit better
1445 - finished working from home
1500 - bit of Cycling...lots of intrusive thoughts
1545 - Venlafaxine 75mg
1630 - bit of Gaming...more relaxed
1800 - Dinner
1830 - Bike tour and Geocaching with Family - mostly relaxed
1930 - Dog Round - mostly relaxed
2000 - Venlafaxine 35mg
2030 - bring child to bed - mostly relaxed, tired
2100 - watching a show on TV - mostly relaxed, tired
2300 - to bed, quickly asleep

 

29th July
0530 - woke up with slight restlessness
0900 - slept on and off slight restlessness
0915 - taking Aspirin , Valsartan and Rosuvastatin
0930 - small Breakfast

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Mentor
Posted

I see you are taking Venlafaxine in unequal doses at two different times of the day (1545 and 2000). Since Venlafaxine has such a short half-life, this could be causing you problems. Is there a reason you are taking it like this?

1988-1996  Various AD’s, all classifications.  1996-2019  Effexor XR 37.5mg to 150mg. Jan 2017 onward, 37.5 mg.

2019  Apr 11 - July 24: Trials of Latuda then Rexulti. CT'd off per dr.  Jul 24: CT Effexor (per dr)  Sep 9-19: Viibryd, CT (per dr).  Sep 23-27: Trintellix. CT (per dr).  Sep 28 - Oct 24:  Prozac 10mg.  Oct 24:  Stop Prozac, began Pristiq 25mg->50->25mg.

2020  Feb 1: CT Pristiq. Feb 1: Reinstated Effexor XR (10 large beads) gradually increasing to 22 beads (15L+7M) or 9.072mgai on Mar, 2020.

2021  Started Jan w 21 beads (13L+8M) or 8.47mgai ended Dec: 17 beads (7L+9M+1S) or 6.19mgai. Severe COVID + TIA.

2022  Ended yr w 14 beads (3L+5M+5S+1XS) or 4.5mgai. Major jaw injury during year + family tragedy.

2023  Jan: 13 beads (2L+5M+5S+1XS) or 4.2mgai; Feb: 12 beads (2L+4M+5S+1XS) or 3.9mgai; Mar: 11 beads (2L+4M+4S+1XS) or 3.6mgai, Apr: 10 beads (2L+3M+4S+1XS) or 3.3mgai; Jun: 9 beads (2L+3M+3S+1XS) or 3mgai,

 

Current: July, 2023: Effexor XR -  9 beads (2L+3M+3S+1XS) or 2.7 mgai

Other current meds: Ambien 10mg 3.935mg , clonazepam .125mg .107mg, omeprazoleSynthroid, Premarin.  Supplements: D3, C, probiotic, K2-MK7, Mg Glycinate

Posted
17 minutes ago, FindRest said:

I see you are taking Venlafaxine in unequal doses at two different times of the day (1545 and 2000). Since Venlafaxine has such a short half-life, this could be causing you problems. Is there a reason you are taking it like this?

Its XR so i only have to take it once a day but above 75mg i always spread it in to 2 doses to spread it out a bit. Before i increased to 112,5 11 days ago i was only taking 75mg in the afternoon. Over the years even in higher doses i never found it to be activating so i don't take it in the morning. 

Should i take it all together?

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Mentor
Posted (edited)

Most people take XR all together, one time a day. If you split the dose and take it twice a day, it is best to split them into equal doses and take them 12 hours apart. You could very well be inadvertently increasing your symptoms with your current dosing routine.

Edited by FindRest

1988-1996  Various AD’s, all classifications.  1996-2019  Effexor XR 37.5mg to 150mg. Jan 2017 onward, 37.5 mg.

2019  Apr 11 - July 24: Trials of Latuda then Rexulti. CT'd off per dr.  Jul 24: CT Effexor (per dr)  Sep 9-19: Viibryd, CT (per dr).  Sep 23-27: Trintellix. CT (per dr).  Sep 28 - Oct 24:  Prozac 10mg.  Oct 24:  Stop Prozac, began Pristiq 25mg->50->25mg.

2020  Feb 1: CT Pristiq. Feb 1: Reinstated Effexor XR (10 large beads) gradually increasing to 22 beads (15L+7M) or 9.072mgai on Mar, 2020.

2021  Started Jan w 21 beads (13L+8M) or 8.47mgai ended Dec: 17 beads (7L+9M+1S) or 6.19mgai. Severe COVID + TIA.

2022  Ended yr w 14 beads (3L+5M+5S+1XS) or 4.5mgai. Major jaw injury during year + family tragedy.

2023  Jan: 13 beads (2L+5M+5S+1XS) or 4.2mgai; Feb: 12 beads (2L+4M+5S+1XS) or 3.9mgai; Mar: 11 beads (2L+4M+4S+1XS) or 3.6mgai, Apr: 10 beads (2L+3M+4S+1XS) or 3.3mgai; Jun: 9 beads (2L+3M+3S+1XS) or 3mgai,

 

Current: July, 2023: Effexor XR -  9 beads (2L+3M+3S+1XS) or 2.7 mgai

Other current meds: Ambien 10mg 3.935mg , clonazepam .125mg .107mg, omeprazoleSynthroid, Premarin.  Supplements: D3, C, probiotic, K2-MK7, Mg Glycinate

Posted
21 hours ago, JaJo said:

yeah you find those entries pretty often actually. You can only try it with a different med for a while to see if something changes. Both...sartans and statins also have a lot of studies showing the complete opposite with them helping with depression and anxiety...so i guess you never know which end you get if one at all.

Just checked my blood pressure meds, and although neither interact with venlafaxine, lisinopril which I take,  is an ACE inhibitor and common side effects include depression, sleep disturbance and tinnitus, all of which I have experienced pre tapering...

I have tried various statins and always end up with muscle and tendon discomfort.  

JaJo, did you find any reduction/improvement of your BP when you reduced the venlafaxine?  

Various ADs from 1991, always for depression with anxiety and agitation... sertraline, paroxetine, citalopram (with 2.5mg olanzapine briefly), coming off each for increasingly shorter times until 2000 when I went on meds full time with Clomipramine 200mg. Then Venlafaxine (XR) since 2008, initially 225mg, then 300mg, plus tried on venlafaxine with mirtazapine (California Rocket) for only a week in 2017(?) as absolutely intolerable. 

July '23 Venlafaxine XL 300 to 275mg.  Aug '23 275 to 250mg. Sept/Oct '23 250 to 230 to 225mg.  Nov '23 205mg. Dec '23 185mg.  28 Dec '23 reinstated 225mg after crashing. 

 

Supplements: Vitamin D and fish oil. 

 

"L'exposition du merde est temporaries".

 

Although I have a background in health, I am here to learn from others, encourage others and share my experiences, not to give professional guidance. 

  • Administrator
Posted
12 hours ago, JaJo said:

0650 - taking Aspirin , Valsartan and Rosuvastatin

 

Given that you seem to have a peak of symptoms after you take this batch of drugs and *before* you take Effexor, it seems likely that at least one is causing the uncomfortable symptoms you experience starting at around 11 a.m.

 

To test this, please post more daily note to see if this is a pattern that recurs from day to day. Do you also have coffee in the morning? Please include timing and amount in your daily notes.

 

(To find out which drug is the culprit, you'd take them some hours apart.)

 

Are you taking venlafaxine IR or XR? Please indicate in your daily notes.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Posted
2 hours ago, BigCat said:

JaJo, did you find any reduction/improvement of your BP when you reduced the venlafaxine?  

No, it never really affected my BP in any direction. With the small sartan dose im basically always normotensive.

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Administrator
Posted
11 hours ago, JaJo said:

Its XR so i only have to take it once a day but above 75mg i always spread it in to 2 doses to spread it out a bit. Before i increased to 112,5 11 days ago i was only taking 75mg in the afternoon. Over the years even in higher doses i never found it to be activating so i don't take it in the morning. 

 

Please give more detail about why you split the dose of venlafaxine XR.

 

12 hours ago, JaJo said:

2000 - Venlafaxine 35mg

 

How are you measuring 35mg?

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Posted
1 minute ago, Altostrata said:

 

Please give more detail about why you split the dose of venlafaxine XR.

When i first started V. i was told to take 75mg XR twice daily. I always felt it made me tired in the morning so i went for midday and evening.

So i did this for most of those 10+ years. There were times i took it single dose, there were times where i tried morning and midday or evening only.

I never noticed a huge difference tbh. which kinda makes sense due to the xr and the stable blood level after 4 days. 

I kept taking 2 doses as it never worried me and i thought if one dose gets effected by a stomach flue, diarrhea or whatever its at least only a part of the daily dose missing. 

The psych said its completely irrelevant how i do it. 
I can try taking them together and watch for a difference. I can also spread out the other meds...they are not timebound either. 

Will include coffee and xr in the daily report. Coffee is usually 3 large cups before midday and sometimes one after midday. But i'm currently trying to skip the 4th as it tends to effects my sleep if i get it to late.

The coffee consume is basically the same for about 10+ years as well.

 

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

Posted

29th July
0530 - woke up with slight restlessness
0900 - slept on and off slight reslessness
0915 - taking Aspirin , Valsartan and Rosuvastatin
0930 - small Breakfast
1030 - dog round,bit of restlessness
1130 - axiety flare up, 
1000-1200 3 Large Cup of Coffee 
1200 - doing crosseries, feeling pretty good
1315 - back home,artificial feeling of sadness or sth.
1330 - restlessness/Anxiety
1345 - lunch
1415 - Anxiety better, still restlessness
15-17 - Venlafaxine 75mg XR; family trip to train museum, pretty relaxed, some artificial sadness feeling
1800 - resteless feeling
1830 - Dinner
1900 - 2020 Dog walk at the lake...physicall restless feeling but relaxed
2000 - Venlafaxine 35 mg XR, gaming relaxed
2100 - TV show mentally relaxed but some tearing/restlessness in legs 
2300 - off to Bed

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Administrator
Posted
2 minutes ago, JaJo said:

15-17 - Venlafaxine 75mg XR; family trip to train museum, pretty relaxed, some artificial sadness feeling
1800 - resteless feeling

 

2 minutes ago, JaJo said:

2000 - Venlafaxine 35 mg XR, gaming relaxed
2100 - TV show mentally relaxed but some tearing/restlessness in legs 

 

Do you feel better or worse after taking each dose of venlafaxine? Is the restless feeling at 1800 the same as or different from the restless feeling at 1330?

 

Please explain "tearing/restlessness in legs" at 2100. Is it like how you feel at 1800?

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Posted

Yes 1330 and 1800 were kinda similar. My restlessness feeling is usually a really hard to explain disgusting feeling in stomach and proximal extremeties combined with varying degree of mental terror/anxiety. It varies in degree. Maybe I should differ the intensity better. The whole thing is pretty hard to explain and describe for me.

The 2100 feeling was basically like only the physical component in the legs.

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Administrator
Posted
1 hour ago, JaJo said:

1000-1200 3 Large Cup of Coffee 

 

This is a lot of caffeine. This can make you nervous.

 

Please continue to post daily notes.

 

Many people find fish oil and magnesium supplements helpful, see

 

https://survivingantidepressants.org/index.php?/topic/36-king-of-supplements-omega-3-fatty-acids-fish-oil/

 

https://survivingantidepressants.org/topic/15483-magnesium-natures-calcium-channel-blocker/

 

Magnesium in the evening may calm your legs. You might try a little bit of one at a time to see how it affects you. Please let us know how you’re doing.

 

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Posted
On 7/30/2023 at 12:11 AM, Altostrata said:

 

 

Please continue to post daily notes.

 

Many people find fish oil and magnesium supplements helpful, see

 

 

 

I think i still have Magnesium and Omega 3 here...gonna give it a go

 

30th July
0600 - woke up with slight restlessness
0900 - slept on and off inner vibrations
0900 - Aspirin and Valsartan
0910 - Breakfast inner vibrations, mentally pretty calm
0920 - first coffee
1010 - inner Vibrations, bit of Anxiety
1020 - Dog walk, increasing restlessness feeling
1045 - 2nd coffee, bit better feeling, gaming
1120 - rosuvastatin, resttless + physicall tearing in extremeties. 3rd coffee
1330 - still anxieous, mostly about the restelessness getting stronger, mucles in arm leg and face tensed
1505 - Venlafaxine XR 75 mg
1615 - Home from family tour...the whole time restlessness and muscle tearing in legs and arms. 
1700 - Gaming...symtoms varyingin strenght 
1830 - feeling a bit better after Dinner
1847 - Venlafaxine XR 37,5mg 
1930 - dog round, mentally better, physical restless/tearing  
2000 - gaming mentally better, physical tearing in legs
2130 - TV show mentally relaxed but tearing/restlessness in legs 
2330 - after Gamin, to bed

 

31th July

0530 - woke up ,strong reslessness
0940 - slept on and off ,strong restlessness
0945 - Aspirin, Valsartan, 1. Coffee

Med History:

-2012 to 2017 up to 300mg Venlafaxine

-2017 quick taper and crash. Back to 150mg

-2019 slower taper but last step to quick...crash and back to 150mg

-2021 starting taper in 12,5mg steps. 

-2022 Summer 75mg

-2023 January 62,5mg doing pretty well

-2023 April 50mg, strong anxiety, back to 62,5 after 4 weeks.

-2023 End of June. Not being able to stabilize 75mg

-18.07.2023 raised to 112,5 by psych as I can't stabilize.

-20.08.2023 back to 150mg...waiting to stabilize since

Other Meds: Heart Aspirin, Rosuvastatin and Valsartan

  • Administrator
Posted

Suggest you taper off caffeine by gradually replacing your coffee with decaf. The caffeine effect may be causing some of your problems.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
×
×
  • Create New...

Important Information

Terms of Use Privacy Policy