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Rydgi121212: Effexor Withdrawal + Sertraline side effects


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As background, about 7 years ago I started Prozac and it worked wonderfully for me for 4 years until I had some trauma causing breakthrough panic attacks. I then went to 75mg and eventually 150mg of Effexor. This worked for me but I hated the side effects of weight gain and severe nausea and brain zaps when I didn’t take my medicine at the same time. I decided to taper off of it so did 75mg for 1 month, and then 37.5mg + 20mg of Prozac for 2 weeks. After 1 month, I felt okay, just more depressed than usual. But when I went down to 37.5mg I started having horrible dizziness, brain zaps, nausea, cramping, and the inability to get out of bed. After going to my psychiatrist, I was told to stop taking the Effexor and instead do 1 week just Prozac and then start 20mg sertraline. For that week, I had Xanax to help so I didn’t feel horrible. But now with no Xanax, my dizziness is at an all time high with horrible headaches, muscle spasms, and fatigue. I have been super nauseous with very negative thoughts and lots of crying. Just wondering if anyone had any advice on how to get past this/when this will end? Anything helps! 

2017 Prozac 20mg

2019 Prozac 40mg + Propanalol 10mg

2022 Effexor 75mg

2023 Effexor 150 mg 

April 2024 taper off Effexor, one month 75mg, propanalol 10mg as needed 

First two weeks of may- 2024 Effexor 37.5 plus Prozac 20mg

3rd week May 2024- Prozac 20mg and Xanax 0.5 as needed

4th week May 2024- Prozac 20mg, Sertraline 25mg, propanalol and xanax as needed 

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  • KenA changed the title to Rydgi121212: Effexor Withdrawal + Sertraline side effects
  • Moderator

Hello, and welcome to Surviving Antidepressants. We are a peer support forum to assist in tapering off psychiatric drugs safely, or recovering from psychiatric drug withdrawal.


We don't offer advice on which medication you might like to try next. What are you trying to achieve? Do you wish to be drug free? That is what we provide support for.

Active Monday-Friday UK time


Taper calculator spreadsheet



1) Sertraline:

50mg - Oct 2020, 100mg - Dec 2020, 50mg - April 2021, 75mg - May 2021, 50mg - Sep 2021, 55mg - 23 Feb 2024, 60mg - 20 March 2024, Start tapering - 24 April 2024

Current dose: 55.09mg  (1 July 2024)

2) Mirtazapine:

15mg - Nov 2020


Cod liver oil, Magnesium, Vitamin C

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