Jump to content

StellaFree: What causes motility issues from Bupoprion?


StellaFree

Recommended Posts

Hello, 

I really am living in a medicated hell. I have been suffering from severe constipation that I believe has been caused by years of bupoprion use. I am trying to taper off this drug and it's been really hard. Does anyone know what can help my nervous system get back to normal. I am beyond needing the standard advice of fiber, water, exercise, magnesium, etc.. This is a nerve issue. I have had a lot of tests and seen functional medicine doctors, but nobody hooks it up back to my AD because I think doctors want to keep people on their drugs. Anyways, if anyone has any insight in Wellbutrin or bupoprion and how to recover from it, I would be so grateful. 

Edited by FireflyFyte
updated title

Bupoprion SR 150 mg

Bupoprion SR ( I think) 100 mg

Bupoprion IR 75 mg.

Medicated 25 years now trying to get off

Link to comment
  • Moderator

Hi StellaFree,

 

Welcome to SA. Please summarize your drug history in your signature by following the instructions at How to Summarize Your Drug History in Your Signature.

 

We have information on tapering Wellbutrin at Tips for tapering off bupropion (Wellbutrin, IR, SR, XR, XL, Zyban).

 

You can search the forums for topics related to people's journeys tapering from Wellbutrin.

 

Thanks,

 

Firefly

 

Pre- October 2022: Wellbutrin, Escitalopram, CitalopramSertraline, Adderall IR, Vyvanse, Propranolol, Buspar, Ativan, and Latuda

Oct 13, 2022 - Oct 24, 2022 and Oct 31, 2022 - Present: Zyprexa (2.5 mg). Jan 14, 2023 -> Began transition to liquid suspension. Jan 29, 2023 = 2.375mg -> Feb 12, 2023 = 2.25mg -> Feb 27, 2023 = 2.14mg -> Mar 12, 2023 = 2.025mg -> Mar 27, 2023 = 1.93mg -> Apr 10, 2023 = 1.82mg -> Apr 23, 2023 = 1.74mg -> May 7, 2023 = 1.64mg -> May 21, 2023 = 1.56mg -> June 4, 2023 = 1.48mg -> June 19, 2023 = 1.4mg -> July 2, 2023 = 1.33mg -> July 16, 2023 = 1.26mg -> July 31, 2023 = 1.2mg -> Aug 13, 2023 = 1.14mg -> Aug 27, 2023 = 1.08mg -> Sep 13, 2023 = 1.02mg -> Jan 22, 2024 = 0.97mg -> Feb 4, 2024 = 0.92mg -> Feb 19, 2024 = 0.87mg -> Mar 3, 2024 = 0.83mg -> Mar 17, 2024 = 0.78mg -> Mar 31, 2024 = 0.74mg -> Apr 14, 2024 = 0.7mg -> Apr 28, 2024 = 0.66mg -> May 12, 2024 = 0.63mg -> May 27, 2024 = 0.6mg -> June 9, 2024 = 0.57mg -> June 24, 2024 = 0.54mg -> July 6, 2024 = 0.51mg -> July 21, 2024 = 0.48mg -> Aug 6, 2024 = 0.455mg -> Aug 20, 2024 = 0.43mg -> Sep 3, 2024 = 0.41mg -> Sep 17, 2024 = 0.39mg -> Oct 1, 2024 = 0.37mg

Oct 14, 2022 - Present: Prozac (40mg) upped from 20mg on Nov 1, 2022.

Oct 31, 2022 - Present: Gabapentin (300mg 3x day) -> May 3, 2023 = 300mg 2x day -> Oct 1, 2023 = 570mg -> Oct 15, 2023 = 540mg -> Oct 29, 2023 = 510mg -> Nov 13, 2023 = 484mg -> Nov 27, 2023 = 460mg -> Dec 9, 2023 = 436mg -> Dec 24, 2023 = 414mg -> Jan 7, 2024 = 400mg

 

Link to comment
  • FireflyFyte changed the title to StellaFree: What causes motility issues from Bupoprion?
  • Mentor
13 hours ago, StellaFree said:

Hello, 

I really am living in a medicated hell. I have been suffering from severe constipation that I believe has been caused by years of bupoprion use. I am trying to taper off this drug and it's been really hard. Does anyone know what can help my nervous system get back to normal. I am beyond needing the standard advice of fiber, water, exercise, magnesium, etc.. This is a nerve issue. I have had a lot of tests and seen functional medicine doctors, but nobody hooks it up back to my AD because I think doctors want to keep people on their drugs. Anyways, if anyone has any insight in Wellbutrin or bupoprion and how to recover from it, I would be so grateful. 

Hi Stella! I'm truly sorry for what happened to you. Many of us faced poor understanding on psychiatric drugs effects from doctors, but we believe you. The taper needs to be very slow, and potentially getting slower and slower as the dose decrease. Sometimes you may also need to hold your current dose for some time to gain some stability. Good news is that, you can do this. You can successfully get off bupropion scot free and recover from any withdrawal symptoms. Sadly, there's no real cure for any of the issues caused by these meds. If test show no source of your struggles, then it's likely caused by instable CNS. This can very well result in all kinds of digestive system issues. You are giving yourself a chance to recover by slowly coming off bupropion. For now, you may want to explore drug-free coping techniques on this site and get to know the tapering guidelines. Wishing you luck!

22.10.2020 sertraline (50 upped to 100mg for two months) and pregabalin (150mg for half year)

2021 mirtazapine (30mg for some months), amitryptyline (cascading dose but doctor took me off it before reaching five tablets), olanzapine (5mg), lithium (this one I reacted to terribly as well, maybe due to my Hashimoto disease)

2022 duloxetine, reboxetine, venlafaxine (all unsuccessful attemps stopped after one day with no side effects following days, only reboxetine pushed through with one box)

2023 mainly bupropion (150mg stopped after few weeks, 300mg stopped after few another weeks, 150mg stopped after few months) until IAR, buspirone (5mg) tried for 3 days 

autumn 2023 - 150mg bupropion daily,

12.12.2023 - bupropion stopped,

16.12.2023 - 100mg sertraline,

18.12.2023 - 150mg bupropion,

19, 20 & 21.12.2023 - 150mg bupropion & 5mg buspirone,

Nothing ever since 21.12.2023, but 25mcg levothyroxine since around summer 2023 until 10.07.2024 for Hashimoto disease (non-psychiatric drug)

 

First wave: 18.07.2023; immediate adverse reaction to sertraline and first CNS crash: 16.12.2023: late onset protracted withdrawal from bupropion: 13.04.2024; third crash: 16.07.2024; currently still in acute phase of PAWS as of September 2024

Link to comment

Thank you for responding. What causes CNS crash? I do feel like I have respiratory, dizziness, blood pressure issues and often get a hunch that my gut motility problems are from circulation problems. I don't know. What thread should I look at for repairing CNS issues? 

Bupoprion SR 150 mg

Bupoprion SR ( I think) 100 mg

Bupoprion IR 75 mg.

Medicated 25 years now trying to get off

Link to comment
  • Mentor
1 hour ago, StellaFree said:

Thank you for responding. What causes CNS crash? I do feel like I have respiratory, dizziness, blood pressure issues and often get a hunch that my gut motility problems are from circulation problems. I don't know. What thread should I look at for repairing CNS issues? 

It's usually unfortunate drug interaction. Making too many changes, too often, stopping meds or lowering dose, sometimes taking the first dose. The whole withdrawal or adverse reaction experience is one big oversensitivity of nervous system. We don't have exact science, but years of observations here point out to users seeing slow improvement as they come off the meds. There are topics like "What's happening in my brain" here, but they explain how symptoms may be related to some understandable processes more than they serve as some guideline. Symptoms can change, their intensity also changes in unpredictable manner, but we don't have any solutions to them. CNS has to find its way to self-regulate. It overreacts, but it's not as simple as "calm it down" to make it work properly. Various users have tried mind altering substances, but they never worked as "fixes". We approach it like BIND (benzodiazepine induced neurological dysfunction) which, like any neurological injury heals via rehab. You provide your body safe enviroment, which in this case is a drug-free routine and let it adapt to it. It usually takes many months, sometimes even years, but most see full or near full recovery. The key is to see symptoms as a part of CNS trying to balance receptors sensitivity. They aren't dangerous, they won't take your sanity away and most importantly, they don't call for reaction. The signaling system sends false alarms, but as you can see, the test show nothing. These aren't issues of given body parts or systems, they have one source which is dysregulated CNS and if they're on 80% intensity, they'll be all like this, but when they drop to 0%, they'll also cease together. There are some ways to help you stay as little activated as possible like meditation, epsom salt baths, brain retraining programs, but there's no other cure than giving it time. The fact that we are experiencing these abnormalities is a sign that our brain is set for restoring its homeosthasis, however we never found a way to accelerate that process other than avoiding unneccessary upsets (basically common sense stress management). Whoever here suffers long-term symptoms caused by psychiatric drugs is facing this CNS instability, so you may look around to see how people are coping (cause they can't fix it) with them, potentially best by typing the given issue in search bar and visiting threads.

22.10.2020 sertraline (50 upped to 100mg for two months) and pregabalin (150mg for half year)

2021 mirtazapine (30mg for some months), amitryptyline (cascading dose but doctor took me off it before reaching five tablets), olanzapine (5mg), lithium (this one I reacted to terribly as well, maybe due to my Hashimoto disease)

2022 duloxetine, reboxetine, venlafaxine (all unsuccessful attemps stopped after one day with no side effects following days, only reboxetine pushed through with one box)

2023 mainly bupropion (150mg stopped after few weeks, 300mg stopped after few another weeks, 150mg stopped after few months) until IAR, buspirone (5mg) tried for 3 days 

autumn 2023 - 150mg bupropion daily,

12.12.2023 - bupropion stopped,

16.12.2023 - 100mg sertraline,

18.12.2023 - 150mg bupropion,

19, 20 & 21.12.2023 - 150mg bupropion & 5mg buspirone,

Nothing ever since 21.12.2023, but 25mcg levothyroxine since around summer 2023 until 10.07.2024 for Hashimoto disease (non-psychiatric drug)

 

First wave: 18.07.2023; immediate adverse reaction to sertraline and first CNS crash: 16.12.2023: late onset protracted withdrawal from bupropion: 13.04.2024; third crash: 16.07.2024; currently still in acute phase of PAWS as of September 2024

Link to comment

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
×
×
  • Create New...

Important Information

Terms of Use Privacy Policy