Administrator Altostrata Posted October 22, 2015 Administrator Share Posted October 22, 2015 Full text PDF http://bmaopac.hosted.exlibrisgroup.com/exlibris/aleph/a21_1/apache_media/H6IB5G1BL8SX1KJ7VY4MCRCXVG6EV7.pdf As described by the Council for Evidence-based Psychiatry at http://cepuk.org/2015/10/13/cep-welcomes-report-bma-prescribed-drug-dependence/CEP welcomes report by the BMA on prescribed drug dependenceThe Council for Evidence-based Psychiatry welcomes the publication of the analysis report by the BMA’s Board of Science, titled ‘Prescribed drugs associated with dependence and withdrawal – building a consensus for action’, which can be viewed here. The report analyses evidence submissions from a variety of stakeholders, including CEP, patient groups and medical bodies such as the Royal College of General Practitioners and the Royal College of Psychiatrists. CEP agrees with opinion of the Board of Science that ‘too little is known about prescribing patterns, the levels of dependence and withdrawal, and the level of harm that is being caused. There is also too little research about the long-term effects of these drugs.’ CEP is pleased to note there is consensus among stakeholders regarding the inadequate current provision of specialised support services, as well the need for improved doctor training and more funding for non-pharmacological treatments. In addition, CEP agrees with the Royal College of Psychiatrists’ view (expressed in the report) that traditional addiction services are not appropriate for patients dependent on prescribed drugs, and supports its call for a review of the evidence and clinical guidelines in this area, including optimal methods of withdrawal. We hope that the BMA will use this consensus as the starting point for a series of initiatives to tackle this issue. As a priority, this must include the provision of appropriate support services for patients who have become dependent upon prescribed drugs, and we support the All Party Parliamentary Group for Prescribed Drug Dependence in their call for a national telephone helpline. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
nz11 Posted October 23, 2015 Share Posted October 23, 2015 Theme 7: Antidepressants Antidepressant prescribing Safety of antidepressants Approaches to antidepressant withdrawal Points relating to antidepressant prescribing, safety and withdrawal emerged as a distinct themeacross response submissions. There was a consistent view that antidepressant prescribing isincreasing, and some consistency that antidepressants can be prescribed without a clear clinicalneed. For example, the RCPsych noted that “...there is potentially overprescribing of thesemedications, particularly SSRIs, where there is no particularly strong clinical indication…”; and CEPnoted that “[a]ntidepressants are currently indicated in the BNF only for patients with moderate tosevere depression. Yet withdrawal charities report numerous examples of inappropriate prescribing ofantidepressants for mild depression.” The latter also highlighted research that in their view does notsupport the use of these drugs for moderate depression, and that the benefits are unclear even incases of severe depression. CITA reported that “[t]here is an increasing use of antidepressants fornon-depression diagnoses, the prescribing several antidepressants simultaneously within the samepatient for no apparent sensible reason other than to mask the side effects of each other.”There was disagreement between responses on the overall safety of antidepressants, particularly inregards to their abuse and dependence potential. Charity and support groups reported that the harmassociated with antidepressants – including severe mood disturbances, suicidal intention anddependence potential – is not generally recognised, or is underestimated, by GPs and psychiatrists. In contrast, the RCGP reported that there is “…evidence of the long term benefits of antidepressantsand the relative safety of their use. Most side-effects and problems occur earlier in treatment andthere is generally a delay in therapeutic response. Compared to the other medications considered[opioids and benzodiazepines] there appears to be a very low prevalence of misuse and addiction.” The RCPsych did note that antidepressants carry the risk of a discontinuation syndrome that can beunpleasant for the individual, but added that this is not prolonged. CEP highlighted their view that the increasing antidepressant prescribing rates reflected the fact that patients are unable todiscontinue their use due to the onset of withdrawal symptoms, going as far as saying that “…for aproportion of patients, BNF prescribing guidelines [of at least 6 months or more, and for at least twoyears for patients with a history of recurrent depression] are leading to involuntary dependence uponthese drugs. There is no safeguard here; it is a direct consequence of the manner in which these drugshave been approved for use.” Charity and support groups also felt that antidepressants pose similar levels of harm asbenzodiazepines, in regards to the severity of side effects and withdrawal, whereas the RCGP and theRCPsych reported that antidepressants are safe relative to benzodiazepines and opioids. For example, CITA and Recovery Road noted that they have seen a rise in the number of individualscontacting them for support for antidepressant withdrawal, which, in their experience, can be assevere as benzodiazepine withdrawal. Recovery Road specifically highlighted that “…many doctorsrefuse to acknowledge it [antidepressant withdrawal] exists or even that there is a discontinuation syndrome. This results in patients taking antidepressants being left to self-diagnose and use theInternet for support.” In relation to this, the RCPsych submitted the 2004 CSM (Committee on Safety of Medicines) reviewon the safety of SSRI antidepressants submitted which provides an overview of research (up to 2004)on the relationship between SSRI antidepressants and dependence potential and withdrawalreactions. The report concluded that SSRI’s have low abuse liability but that they can causeunpleasant withdrawal reactions that should be managed through tapering over a period of severalweeks. A research recommendation to study the most effective methods for SSRI withdrawal wasalso documented in the report. The RCPsych commented that to their knowledge this research hasnot yet been conducted.Where there was agreement that antidepressants are associated with a withdrawal (ordiscontinuation) syndrome, it was also agreed that there is no recognised approach for managing thistype of withdrawal (discontinuation) syndrome. For example, CITA reported that their experienceaccrued over the years suggests “…that there is no consistent model being applied across and withinpractices…” with regard to antidepressant withdrawal management. CEP specifically noted that BNFand NICE guidance are in urgent need of revision as they have conflicting advice on antidepressantwithdrawal that may contribute towards this inconsistency, which is out of step with the charities’experience working with sufferers. The BNF advises that the dose should be reduced gradually overabout four weeks, or longer (up to 6 months) for patients on long-term maintenance treatment;while NICE advise that antidepressant use can be stopped over a four week period. CEP stated that “[t]he experience of the withdrawal charities suggests that antidepressants should be tapered very slowly at a rate of no more than 10% of the previous dose every four to six weeks, at a pace guided bythe patient. A four-week taper is therefore much too fast, and this guidance should be changed.” In consideration of the RCPsych’s comment on the CSM recommendation for research into SSRIwithdrawal methods, it may be the case that research clarifying what is the best practice to withdrawfrom antidepressants has not been conducted.Concluding remarks This report identifies various themes relevant to preventing and managing the potential harmsassociated with the prescribed use of benzodiazepines, Z-drugs, opioids and antidepressants. It doesnot provide a detailed examination of every issue highlighted to us, but aims to identify areas ofagreement and difference, with a view to supporting change. As the majority of submissions focusedextensively on benzodiazepines, our analysis has a particular emphasis on this drug group; however,many of the issues highlighted are relevant across the other drug types. For example, a commonthread among responses was the need for better training on the safe prescribing and withdrawal ofthese psychoactive medications (including the importance of adherence to prescribing guidelines;safe tapering protocols; the risks of long-term use; and providing appropriate support and advicebefore, during and after prescribed use). This is likely to be an important area for action.Looking to the future, this analysis identifies areas where there is some common ground amongstakeholders, such as the need for gradual tapering during withdrawal, the under-funding and pooravailability of non-pharmacological and psychological treatments, inadequate provision and fundingof specialised services, and the need for more research. In other areas, however, there are significantdifferences that need to be considered further. For example, a clear view emerged that some prescribing guidelines, as well as the views and understanding of medical professionals, do notcorrelate well with the lived experience of patients. This is typified with the differing views on typesand magnitude of harms associated with prescribed drug dependence and withdrawal, as well asattitudes towards the causes of dependence and withdrawal problems. While some of thesedifferences may be resolved or reduced through research, changing attitudes and mindsets willrequire a more collaborative approach.One example of the need for collaboration is illustrated by how medical organisations have called forbetter guidelines on tapering and withdrawal management for benzodiazepines, while charities andsupporting groups were broadly of the view that these exist and should already be in use. Thisdifference may be explained by the fact that the existing guidelines are expert-based rather thanhaving a strong scientific evidence base, and medical professionals may not therefore feel confidentin using them. Only by working together will such differences in opinion be resolved.A further consideration from this analysis is how responses from support groups, charities andindividuals included an element of 'blame' on doctors (eg for prescribing beyond guidelines or notproviding adequate information or support), while submissions from medical organisations reflectedelements of patients being at fault (eg for demanding a 'prescription'), or that some patients maybecome addicted because of particular personal and social factors. It is vital that these perspectivesdo not prevent positive action moving forward. .......................................//............................................. There is some excellent stuff here and what a wonderful voice is CEP. Cant speak more highly of them. But also what a lot of nonsense some people are talking . 'may become addicted because of personal and social factors '...what a joke to say that!! And who are these RCGP clowns clearly none there has ever taken these drugs. Later ...did a google ... "The RCGP is the professional membership body for family doctors in the UK and overseas. We are committed to improving patient care, clinical standards and GP training." Right so who is training the RCGP....pharma? Thought for the day: Lets stand up, and let’s speak out , together. G Olsen We have until the 14th. Feb 2018. URGENT REQUEST Please consider submitting for the petition on Prescribed Drug Dependence and Withdrawal currently awaiting its third consideration at the Scottish Parliament. You don't even have to be from Scotland. By clicking on the link below you can read some of the previous submissions but be warned many of them are quite harrowing. http://www.parliament.scot/GettingInvolved/Petitions/PE01651 Please tell them about your problems taking and withdrawing from antidepressants and/or benzos. Send by email to petitions@parliament.scot and quote PE01651 in the subject heading. Keep to a maximum of 3 sides of A4 and you can't name for legal reasons any doctor you have consulted. Tell them if you wish to remain anonymous. We need the numbers to help convince the committee members we are not isolated cases. You have until mid February. Thank you Recovering paxil addict None of the published articles shed light on what ssri's ... actually do or what their hazards might be. Healy 2013. This is so true, with anything you get on these drugs, dependance, tapering, withdrawal symptoms, side effects, just silent. And if there is something mentioned then their is a serious disconnect between what is said and reality! "Every time I read of a multi-person shooting, I always presume that person had just started a SSRI or had just stopped." Dr Mosher. Me too! Over two decades later, the number of antidepressant prescriptions a year is slightly more than the number of people in the Western world. Most (nine out of 10) prescriptions are for patients who faced difficulties on stopping, equating to about a tenth of the population. These patients are often advised to continue treatment because their difficulties indicate they need ongoing treatment, just as a person with diabetes needs insulin. Healy 2015 I believe the ssri era will soon stand as one of the most shameful in the history of medicine. Healy 2015 Let people help people ... in a natural, kind, non-addictive (and non-big pharma) way. J Broadley 2017 Link to comment Share on other sites More sharing options...
indigo Posted October 25, 2015 Share Posted October 25, 2015 Thanks for posting Altostrata. It's a beginning. On 20 mg of Prozac for about ten years. Sept 2012 started reducing 10% a drop using gram scale, with average of one month holds. When I'd reached the half way mark, taking 10 mg powder out of the 20 mg capsules, I switched over to 10 mg capsules and cutting down from those. Withdrawals got harder the lower I dropped. May 2013 changed to 5% drops, holding until all withdrawal symptoms gone. January 2015 changed to liquid prozac (concentration of 20MG per 5 mL) using a 1mL oral syringe. Current dose of fluoxetine solution equivalent 3.4 mg. Any effort to drop below this has been disastrous so for the time being I'm staying at this level. Adding 200 mg Tryptophan and 200 GABA a day has helped with anxiety. Also take 1,300mg Omega- 3, 875mg Magnesium, 1800mg Curcumin, 1000mg Vit C, 5000 Vit D. Link to comment Share on other sites More sharing options...
Recommended Posts