Aka Lustral, Serlift, Sertawin, Zosert, etc. Sertraline is an SSRI with a half-life of about 26 hours. It is metabolized mainly by the liver enzyme P450 CYP2B6, plus CYP 2D6 (substrate, inhibitor), CYP 3A4 (substrate, inhibitor), and CYP 2C9 (substrate). It has an active metabolite, norsertraline, with a half-life of 62 to 104 hours, which may extend its effects.   Dosage forms and strengths, from Pfizer: 25 mg tablets 50 mg tablets 100 mg tablets Oral sol