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  1. Mod note Moved from http://survivingantidepressants.org/topic/5930-helpless-15-mg-mirtazapine/ Hi helpless. I also had worse experience with mirtazipine and wish I never took it. Been on countless meds over a 10 year period. Had bad experiences before and scary side effects but never lost who I was or my memories experiences etc. Mirtazipine did just that and I too have had overwhelmingly strong feeling of ending everything because I just don't feel myself anymore and not sure how long this is gona last. I don't take it anymore has been almost 2 months without it and still everything I have ever done or loved enjoyed experienced just feels like it was a blur and completely lost who I am and can't believe there is something so damaging out there that doctors gave me at first it was calming I slept well for first few days (before taking mirt I was on desvenlafaxine and felt too hyped up all the time like I was on speed) doctor suggested this and like I said at first it was fine then started to feel disconnected and disoriented, I didn't feel connected to my friends anymore had no interest in talking to anyone or doing anything at all then the tachycardia started, always as I was getting into deep sleep my heart would have scary bolts which caused my to jump out of bed and felt pain in my heart also, this went on for too long and started getting worse, doctor looked at me like a idiot and tried saying it couldn't do that, and then changed his mind said it can cause irregular heart rhythmia, but it got worse. I then reduced to 15mg and felt abit better at first but then started up again I was scared to go to sleep or even relax, I told doctor I refuse to go through this again as seroqual had given me similar symptons in the past and he suggested weening off the mirtazipine. Thats when I just lost everything I feel disconnected from life don't want to be around anymore I've never experienced this I don't have any sense of myself anymore my confidence is depleted I can barely walk into a shop anymore, I feel like its too late for me I cant even see anything changing yet I'm not on them anymore. I miss who I used to be. Would do anything to go back and never go down this path trusting my gp, he never even said a word about possible side effects. More I looked into mirtazipine found out they dont even know how it works but it is classed as atypical hallucegine ( why the f....ck would doctors give this to someone) I don't have any faith in professionals anymore they have ruined my life and my future. Found a better doctor that tried suggesting 25mg of seroqual and 50mg fluvoxatimine, I thought yes...I might actually be able to get past this, half hour after taking them I felt the heavy breathing and went into full on constant anxiety attack that lasted hours I thought it must just be a one off incident taking both at same time (as directed by stupid doctor) next day I tried taking fluvox first then seroqual it just got worst lasted longer and days I can't take antidepressants or antiphyscotics anymore I have a terrifying feeling from them now and I refuse to be on something so damaging. I'm left with constant anxiety and depression now which is unbareable, I feel like I'm gona stop breathing at times and sleeping has become fearful as I live on my own and worried I won't wake up. Only thing iv been able to do is take 5mg (half a tablet) of diazapam to calm me down a bit. Still everyday since mirtazipine wake up in tears and feel like I don't belong around anymore. What kind of sick people could create something like this and stupid doctors who say its safe how could this even still be aloud. Do not ever take mirtazipine it should be banned and removed the company who created it shoulld be held responsible.
  2. Ccnt80

    Kimberly''s Intro

    Dx: Bipolar, depression, anxiety, PTSD, treatment resistant insomnia, CFS, Fibro, chronic pain Current meds as of Dec. 2017: Lamictal 200mg bid Omeprazole 200 mg bid Motrin 800mg qam Iron 65mg qam Despiramine 125mg qhs Seroquel 300mg qhs Remeron 30 mg qhs Clonopin 0.5 mg up to 5 tabs a day as needed (can take up to 3 pills at one time) *** I very faithfully take my med as prescribed. Supplements when I remember to take them: magnesium, iodine, zinc, probiotic I attempted to drop Seroquel down to 250mg for a couple weeks and was VERY irritability and awful feeling, so I ended up moving it back to 300mg. I had also recently dropped the Clonopin down from 5 tablets to 4 tablets a day. I worry about being on Seroquel cause diabetes runs in my family. As of now, my HGa1C shows a decreased risk for diabetes. I am about 70 pounds over weight. I have lost 50 pounds since May 1. My main issue is massive insomnia. That is the main reason for the poly pharmacy. I've been dx bipolar since 2005 (I am 37), but on anti-depressants since 2002. Due to my lack of knowledge and horrid docs, was on up to 10 psych meds at a time prior to 2009. Two 3 year periods in my 20s only slept 10 hours a week, even tho I was medicated so heavily I could barely move. I was so exhausted and wrung out I wanted to die. I'm on the seroquel, remeron, and desipramine mainly for sleep but they also help mood. I average 4-6 hours sleep, but it takes me 12 hours to get it. I wake up every 45-60 minutes. So don't typically feel rested. If I nap during the day, my sleep at night is no worse. If I don't take clone pin during the day to nap, I get very irritable and overwhelmed filling. Sensory overload. I've been off work for 2.5 years this time around, for mood issues and pain issues.
  3. I have been off mirtazapine after a slow taper for five weeks. I am doing okay except I have a few days of bad symptoms. The past week I have been drinking a lot of milk, trying to increase my calcium. Yesterday I woke up and was having constant adrenalin all day. I only slept an hour last night. I was so frightened by the feeling of wanting to crawl out of my skin and burning up from heat that I broke down and took a piece of pill as tiny as the head of a pin. Finally I was able to calm down enough to sleep. The surges are still there but are much better today. My question is, could the extra calcium cause a surge in my withdrawal symptoms? I don't want to go back on this stuff again. It has given me fatty liver. I don't even drink. Just in case I have stopped with ththe extra calcium for now. Or is this just the way of the withdrawal?
  4. Peace and best wishes to all - I've been lurking on SA for about 10 weeks and have found the resources on SA to be a huge help. Thank you for this wonderful website! I'm finding Mirtazapine to be incredibly difficult to taper, much more difficult to taper than the benzo which I've been tapering. Because I've been taking mirtazapine for insomnia I therefore judge my success in a dosage decrease by how much sleep I get, and I'm not having any luck getting any sleep below 28.5 mg. Is this because mirtazapine has a short half-life? I've read to not decrease the dosage by more than 5% - 10% per month, and I've gradually been decreasing my dosage to these levels. I understand that this suggestion is a guideline, yet a good benchmark coming from others who have experienced AD tapers themselves. Any suggestions as to how I can successfully decrease the dosage past the 28.5 mg level? Thank you in advance for any and all suggestions.
  5. Trying to come off 15mg mirtazapine. Cannot get a liquid form, and the pill is so small, how do you cut it? Thanks. I have been on it about 7-8 months.
  6. I'm very angry and very scared about the withdrawal I am having from Remeron. I have been taking this drug for 18 years! When I started, I was told that when I was ready to come off of it all I needed to do was take one pill every other day for two weeks, and then stop. I have tried to discontinue this a handful of times without any success. This time I am determined to be done with this. It does not help me and I don't want to take prescription medication that is unnecessary. I feel that that is not in the best interest of my health. I began tapering in early August . I got down to 7.5 mg every other day for a month and then stopped. By day four, the nausea set in. By day eight I was absolutely miserably sick nonfunctional. It was horrific!I had nausea headache , Brain fog, trembling muscle pain from being so tense. It hurt just to have someone touch me. I took 7.5 mg that night. Nothing the next night. Then 3.25 mg the next night. Nothing the following night. I am still having withdrawal symptoms mostly flu like symptoms diarrhea and trembling. I have brain fog as well I feel like I am an idiot LOL. I was never told that this medication caused severe withdrawal. I'm scared and I'm angry and I want to be done with this. Has anyone come off of Remeron long term and had their withdrawal symptoms go away? And how long do I have to be sick as a dog?
  7. I've been taking Remeron PRN for the past 2 years to help me sleep, very small doses, half a 7.5mb pill. Just enough to help me sleep. Probably once a week at most, except when travelling. Well a couple weeks ago I took it 4 days in a row when travelling, and then over the past few weeks noticed restless legs. The research online seems to say it can 1) cause RLS, 2) withdrawal can cause RLS, 3) it can help RLS. But evidence for each of these scenarios in actual research tests have been very limited so they aren't sure. So just curious if anyone else had this happen? When I take it now, it seems to help RLS immediately that night, but then flare up the night after. Is it even possible to have withdrawal from such a small infrequent doses? I've heard Remeron withdrawal is crazy, even worse than benzos which I came off of 2 years ago and that was horrible, so really hesitant to normalize taking it, but can't deny it help my mood and sleep, though I've already noticed a slight tolerance, I don't get as much sleep as I used to when I just started it.
  8. Dianaberg

    Dianaberg

    Hi Hibari, it was suggested I join this group to chat with you regarding remeron and lamictal withdrawal! I went off of Remeron seven weeks ago and have been on it for six years. I've also been on the lamictal for six years. Because I'm in menopause and my mood is so bad, I was talked into putting on an estrogen patch. I believe now that it decreased my Lamictal by half. What I was thinking was Remeron withdrawal, is now I realize is Lamictal withdrawal. Very very disoriented, confused, could not put a sentence together, my eyes were not tracking, and going through serious crying issues, suicidal, and could not get out of bed because the fatigue was horrible. I also got a mini stroke from the estrogen patch so I've had it off for four weeks. So it's been four weeks where my brain is trying to figure out what is what. I've had serious brain issues in the past to do an illness so my brain is completely sensitive. I don't know if I'm on too much Lamictal now-bring that I dint gave mirtazapine to mask it-or too little- but I'm scared to ever go off or tamper with this drug again. The headaches and nausea and brain fog and disorientation and confusion and not being able to put a sentence together his mind blowing. Waking up with hot flashes and anxiety and feel hungover. Thought you'd be good to chat with!!! Thx!
  9. Hey everyone, 46 year old single woman here with a history of anxiety and recently some intrusive thoughts & depression because of the anxiety/intrusive thougths. Have been on Remeron, Lexapro and Klonopin since 8/2015, my signature has the complete history and details. Anyway, I am currently trying to taper off 15mg of Remeron mainly due to weight gain and feeling better, but am having a pretty hard time. My psychiatrist originally told me to go down to 7.5 for 2 weeks, then 0 but I knew that would be too fast. I tried to drop by a quarter pill and was ok the first week just a little sadness. The 2nd week got headaches, trouble sleeping, worse mood, fatigue, achiness, a little nausea. At this point I started looking online for other peoples stories and found this site among others. I found information on one site on how to mix Mirt. into a liquid, and started dropping by 1mg a week, currently starting my 4th week and am at 12mg. But honestly I feel like crap. Depression is probably a 6-7 out of 10, having trouble sleeping and that really affects my mood, very low energy, hard to concentrate, some headaches and body aches, intense dreams/nightmares, feel very unmotivated and getting more intrusive thoughts (which I have dealt with for 2 years now). Ironically my anxiety is better! I thought I was going at a slow enough taper, maybe I'm wrong or maybe I wasn't ready. Not sure, just want to feel better though. I really want off the mirt because of weight gain (45 pounds!) and was feeling better, at least before I started taper. I see my psych next week and will talk to him. Just thought I would ask you guys for some advice since you've been there or are currently in the middle of a taper. Any thoughts about what could help me, should I go slower? I think sleep is the main thing that wrecks my mood and gives way to a lot of the other issues. Any tips or kind words would be greatly appreciated! Jade
  10. Mickeymouse

    Mickeymouse: Quick intro

    Hello all, Since ive been reading these forums ive come to the conclusion that my psychiatrists dont know jack about pills!! So a forum like this seems like my only option at the moment to really get reliable information, and im grateful that this platform exists. Ive been on mirtazapine 45mg for 1 year, and 15mg a year after that. And recently i wanted to quit, but that turned out to be freaking gnarly so i come here with questions that i will post in the tapering forum. Ive been reading up about psychiatric pills lately, and that combined with how my doc talks about tapering ( he recommended going from 15mg to 0mg in 2 weeks ) resulted in me just completely losing faith in pills and the so called professionals. ( 95% of them anyway ) Insomnia is the worst. The depressed feelings i feel i can handle a little bit, they are just really annoying but at the same time it makes me not care about anything when im depressed, including the fact that im actually depressed, if that makes sense. Ofcourse its crappy either way. Anyways, thats all for now, best of luck to all the fellow pill victims PS Ive read that the signature is important, do you put dates and stuff in there? Im not seeing any signatures from others?
  11. Hello fellow survivors, In 1998 I was in the throes of peri-menopause and some life stressors which caused me to experience severe anxiety. Went to my family doc who prescribed some Ativan, which caused me to feel really depressed. I was then prescribed Zoloft and slowly but surely I weaned myself off the Ativan. I have to be honest and say that the Zoloft did help with the anxiety and other peri-menopausal symptoms so I continued to take it. In 2010 my insurance changed and it no longer covered the brand name Zoloft I was using so went on the generic. I did not feel well after I began taking the generic so I went to my psych doc and she wanted to add a mood stabilizer to my regimen. I did not want to go that route so I decided that it was time to get off the medi-go-round. I continued taking the generic Zoloft, but also decided to give bio-identical hormones a try with the hope that I could eventually wean off what I believed was the worse of the two evils...Zoloft. Well, the estrogen patch only made matters worse for me and I went into a severe depression. I then went to see a homeopathic psych doc who increased my Zoloft from 100 mgs to 200 mgs., prescribed Klonopin, and Remeron. Boy was I over-medicated and a mess. Since then I have managed to wean myself from the K...the R and decrease the Z from 200 mgs back to 100 mgs. The more I lowered the meds, the better I felt. I am currently considering weaning completely off the Zoloft, but have so many concerns. It is my hope to continue to learn as much as I can about "surviving antidepressants" to be able to survive without them. Sunflower
  12. Last summer, i was sick of being so tired because of anti depressants. I decided to research how much I had to be on to prevent relapse. The year before, I was dismissed from a BSN program for academic reasons.Even though I was pretty sure that antidepressants were causing my problems with writing I thought I didn’t have a choice. As I researched antidepressants I began to realize that I did not want to be on them anymore. I started detoxing off of effexor and taking supplements.I am currently seeing a therapist and an integrative psychiatrist. The psychiatrist has me doing energy exercises and does EFT (emotional freedom technique) with me. I found this site while looking for information on the long-term effects of antidepressant use. For the most part friends and family are trying to be supportive but think I should be back on meds. If they have been really discouraged lately. I wonder if a lever and feel normal for very long or get my life back on track.
  13. Freedomiscoming

    Freedomiscoming: my nightmare

    I'm somewhat new here. Have checked out this site before. Looking for some insight and thoughts. I have been in misery for 6 months now. And long story short, I am now trying to taper Remeron slowly, but can't manage more than 1% at a time because of the excruciating results..... I think part of my misery is that my cortisol is 25, and many of my symptoms are related to that. It is a catch 22 because i need off of the drug to heal the adrenals, but I'm in misery trying to get off of it. And at this rate, it will take me 2 or so years to get off of it. I'm not sure how I can endure this type of misery for that long. I am wondering if I held and didn't taper, would the adrenals have any opportunity to heal enough to give me more strength for a taper. If I weren't so depressed, I think I could also muster the courage and the energy for this fight. Any insight would be helpful. Thanks...
  14. I've been slowly tapering down over a number of weeks on my Mirtazapine and now I'm at the state of being completely off the drug. Over the past week, I've been hit with (what sounds familiar based on other people's experiences) the feeling like I can't eat anything and severe nausea. The weird thing is that I am hungry here and there, but it feels like my stomach has either shrunk or that my digestive system has simply slowed down and isn't able to process large amounts of food without pain and severe bloating. I haven't been able to eat much other than small amounts of fruit for a week. I'm worried about the possibility of this lasting for several months like it has for some people. Does anyone have suggestions for what I should do in terms of diet? Should I just drink lots of protein drinks? I would ask my doctor but he always just tells me to ask my psychiatrist and my psychiatrist isn't available right now.
  15. Note by ChessieCat: heatherjc aka cakemaster - 3 topics have now been merged into one _________________________________________________________________________ ** merged from previously commenced topic ** Hi I have been lurking here for a while, been on Seroxat for almost 20 years, last few months been doing ok then tonight out of the blue Severe ANXIety/panic, just recently picked up my latest script, now I KNOW I CANNOT tolerate any generic as its taken me to hell in the past so my script is always BRAND NAME SEROXAT & thats what I have, but feeling exactly like when I have taken generic in the past, just checked & I am on day 4 of new script, the day when any changes are felt, so have studied the patient Info leaflet, its all exactly the same except its was updated August 2014, the precious pack I had was updated Sept 2013. I am convinced something is different, so just wanted to reach out in case anyone else UK based has noticed any difference??
  16. Hello everyone! I took finasteride to stop my hairloss for 6 years. After 6 years i lowered the dose of finasteride and became depressive few months later. I stoped taking finasteride but the depression was still there. 3 weeks later i went to a doctor who gave me mirtazapine. After 5 days of taking mirtazapine i had sexual problems, but i thougt that its the post finasteride syndrom. So i took a dose of 15mg mirtazapine for 2 weeks and lowered it. Then i took only 7.5 mg the next week. I noticed that my emotions were not so intensive. Then i lowered the dose and took only 3.5 mg mirtazapin the next week. And once in the morning i woke up and felt anything. My depression was gone but my emotions too. My glans was completely numb and i had no sexual interest. I was only a month on mirtazapine but took 6 years finasteride before. My testosteron levels were very low. Now, after 3 months, my testosteron levels increased. I can have erectons and orgasms and my libido is normal, as before. But i am suffering from genetal numbness, i have no feelings in my glans. Also the sexuall intensitives towards women are very low. And my emotions are gone. I can laugh but i don't feel joy... or i can look sad but i don't feel the sadness intensively. And now i don`t take any drugs. So my question now is: what can it be? Is it a permanent braindamage? Took someone finasteride or mirtazapine and has a simillar sitaution now? What can I do about this?
  17. Hi community! I am looking for support/recommendations and input regarding tapering of mirtazapine. I have been on mirtazapine15mg since November 2016 for anxiety. I have been doing cbt and lifestyle modifications so my doctor and I have agreed that I am ready to taper from the recommendation. She recommended a too fast taper - so I decided to taper over the next 6 weeks based on a pharmacist's input. Since the tablet comes scored, I can use a pill cutter to cut my doses. I am taking 3/4 tablet of a 15 mg dose so (11.25mg) which is a 25% dose cut. I am on day 2 of the taper and I intend to stay at each cut for at least 2 to 3 weeks before cutting the dose further. Liquid form of the medication isnt possible due to its expensive cost. I would really like some input regarding the 25% dose cuts and if someone has done this too?? Thanks so much! I appreciate it!
  18. Hantise

    Hantise: Hello

    Hi, I have a similar question as BAT in another introduction thread, but i'd like to give an introduction so i'll go with it. It's just related to whether it's possible to tell if i'm suffering from a recurrence of anxiety - which i've always had but felt more in control of when on antidepressants - or from withdrawal symptoms. I've been on Mirtazapine for 18 years; many of those years at 30mg, and maybe 6 years at 15mg. I started to withdraw down to 7.5mg back in December 2016: first came down to approx. 11.25mg until February 2017, and then started on 7.5mg. In the last few weeks i've had spike in my anxiety, and the main outcome of that for me is lack of sleep - so naturally i'm wondering what's going on. It was interesting to read on BAT's thread that someone said that withdrawal symptoms - other than in the weeks that immediately follow a reduction in dose - can start to occur 2-3 months after reduction. Is that really true? That's kind of incredible isn't it? There are a lot of replies in BAT's thread so perhaps it's not necessary to repeat yourself here, but I wanted to post an introduction.
  19. Hi, my name is Trevor, I'm 28 years old and I have been recovering from Remeron withdrawal for a while now. I took 15mg Remeron for 7 years and every time I tried to stop taking it I experienced debilitating insomnia that would last for weeks til I just couldn't take it any more and went back on the medication. Finally I decided it was time to kick this drug for good and started out by reducing my dose to 7.5 mg for a few months, then I started the long process of slow reduction using the liquid titration method. I spent 5 months reducing from 7.5 mg to 0 and by the time I got down to 2 mg I was already experiencing insomnia along with other side effects like depression, anxiety, crying spells, body itching, heart palpitations, and chronic diarrhea. It's been three months now sense my last dose and I still can't manage to get consistent sleep. On good nights I might sleep 5-6 hours but most nights I only get 2-4. Even when I do fall asleep my dreams can get pretty disturbing and I wake up every 30 minutes to an hour. When I lay down to sleep my heart beats very heavy, not fast or sporadic like with anxiety, but slow and forceful. Even if I can get my mind to shut off and be completely relaxed my body will not relax. Any time I get my blood pressure checked it's completely normal but I have noticed my resting heart rate is kind of slow. The other day it was as low as 48bpm. I still get diarrhea some days, and it doesn't make a difference what I eat. It always happens first thing in the morning when I end up running to the bathroom every 15 minutes about 3-5 times. A few months back I went to an alternative health clinic and they started me on a bunch of supplements in an attempt to re balance my hormones and get me sleeping again. Some of the stuff I was taking was Chinese herbs so I don't even know what was in it. I got tired of spending 100's of dollars on supplements every month I didn't even know where helping or not so recently I began to cut back on the supplements. I even went to see a hypnotherapist last week and am going back later this week. The other problem is that I picked a very stressful time in my life to get off the meds. I had just quit my job and sold my house to go back to school plus my girl friend had just broke things off with me. Sense then I tried to date another girl who rejected me after a couple dates. My alcoholic father moved back to Missouri after living in Colorado for 14 years and just recently he got diagnosed with ALS and only has a few months to live. His ex wife came and got him and moved him to Michigan where she plans on taking care of him. I'm just glad I don't have to watch him die a slow death. School is going well but I'm taking easy classes right now, I'm afraid that if I don't start sleeping well by the time I get accepted into my program of study I might fail the program. It's so difficult for me to concentrate on my studies when I'm only getting 2 hours of sleep some nights. I used to be very healthy and full of energy, I was big into fitness like running, biking, and yoga. Now days I barley have enough energy to go for a walk. What advice would anyone have for someone who has already been off a drug for a while but is still experiencing side effects? I keep telling myself this can't go on forever and I will eventually start sleeping normal again but progress is so slow it gets very discouraging. This Friday I will be going to get my yearly check up with the VA. I haven't been to the VA clinic for any of this because I was afraid they would just try to put me on another medication. But now I'm beginning to realize there may be other things they can do for me like sleep studies or talk to a therapist. Any suggestions on how to approach my doctor about this? In my experience military and VA doctors are terrible when it comes to health problems like this, I want to make sure he gets me the help I need without me being disrespectful or acting like a know it all. Are there any treatments I should ask for directly?
  20. Hi there, I was put on Mirtazapine last year during a disastrously fast Diazepam taper that literally almost killed me. My WD symptoms were misdiagnosed as conventional anxiety and depression. They kept pushing the Mirt dose up until it reached 45mg, as of last April. In August I stopped tapering the Diazepam at 3mg (I had come from 35mg), and stopped having any benzo WD symptoms and I haven't had any since. I know far, far too much about benzo WD and 'tolerance withdrawal' etc and I am SURE that what I am currently going through is NOT benzo related. Until my shrink put me on a Mirt taper at the beginning of Feb I was rock solid. No WD of any sort. This is NOT benzo WD, just making that clear so we don't go down that rabbit hole I wanted off the Mirt so he put me on a reduction schedule which was to alternate from 45 to 30 daily first week, then 45 one day, 30 two days second week. I made it half way through the second weetk when I started to get side effects: adrenal surges, dizziness, anxiety. I reinstated to 45 by the weekend so the taper only last about 11 days. Since then I have continued to have symptoms, most days, coming in waves. They're two fold: anxiety / dread feeling in the pit of my stomach, depersonalisation. And flu like symptoms: pounding head and feeling feverish, face gets very hot and visibly blotchy. I get some periods of relief like last night was pretty much symptom free...but back again today. This has come at a disastrous time for me, I have several meetings set up I must go to, as I have a chance of getting my beloved job back which I lost during the benzo hell. I desperately need to get back to where I was before the Mirt taper, when I was FINE. No symptoms at all. I know the taper was far too aggressive, I just couldn't believe I'd get unlucky with 2 different drugs. So I won't make that mistake again. I just need to get back to the point I was at before the taper. I was rock solid and had been for months and the only thing to change was the Mirt so I KNOW it's not anything else...I'm trying to avoid stress and not panic but that's easier said than done sometimes...I really don't need to hear any horror stories, I'm quite vulnerable and impressionable at the moment. Other forums have assured me I WILL stabilise and get back to where I was, if I just hold it at 45. I am praying that is the case. If I can't get stable again, I'm going to lose everything. Any chance of resuming my career, possibly home and marriage. Thank you all for your time, I'd really appreciate your support and expertise.
  21. I did read the "read this first" post about the distinction between relapse and withdrawal, but I've read conflicting ideas about time frames, distinguishing symptoms, etc., so I welcome any insights. I tapered off Cipralex (Escitalopram) after taking it for two years, in January of this year. That seemed to go smoothly with little withdrawal to speak of. I tapered off Remeron (Mirtazapine), which I took at 15 mg for two years. I tapered first to 7.5 mg for a month, then 3.75 mg for a month and then discontinued entirely on April 3. I had more symptoms, primarily headaches, loss of appetite, upset stomach, and anxiety/nervousness, to varying degrees over the tapering and discontinuation period. These have continued, and at each point I've worried I might be relapsing, because stomach issues were a bit symptom for me, as well as anxiety and loss of appetite, prior to starting medication. These symptoms often last a day or two and then I feel better. In fact, at times I feel better than I did while on these meds. I have more energy and motivation. But I am no 7 weeks out and thought that dicontinuation symptoms would likely be done. But the last few days (Monday, Tuesday, Wednesday, and now today, Thursday) have been bad and the symptoms only seem to be getting worse. My head is fuzzy, I feel sick to my stomach, anxious, with mood swings, and familiar "depressed" feelings, as well as self-criticism, negative thoughts, and racing thoughts. I did drink too much Sunday night (it was a long weekend) and have been getting back into the habit of overindulging with beer on weekends. I guess what I'm asking is at what point I should consider re-starting one of my medications, or trying something new? I know most (or all) of you are not medical doctors and in no position to offer medical advice. I would just welcome your thoughts, based on your own experiences. This is my first time taking antidepressant medication and my first time coming off it. Thanks!
  22. Have been on this stuff for only six months... 60mg Mirtazipene (in doses raised from 15mg. In 15 mg. increments) and 50 mg Serequol. I want off, but am aware that this stuff mucks up your brain. Temporararily or permanently? I am 81...what hope have I at this stage of life? I could cheerfully murder the psych who put me on these and now that I'm so much more informed re both depression and the meds... Help!
  23. Hello All, I am glad I found this site because I have been at wits end trying to find someone who has information/experience about withdrawing from the drug abilify I was put on it after a brief hospitalizatioon in May 2013 for a suicide attempt/depression side of bipolar. I also take Trileptal 900mgam/pm. On Abilify I have experienced anticholinergic effects, orthostatic hypotension, and a sedated kind of doped out feeling and thoughts are not always clear. It is my desire to get off Abilify because of its dangers of more intense SE's as time goes on and the desire to prepare my body for pregnancy. My husband and I are currently trying now. I am 43 and believe my childbearing years are waning. I recently discussed my situation with my doctor in letting him know about my feelings, etc. At that point we made the agreement not to get off just yet because I had been studying for an RN refresher course and had a huge exam in which I took two days ago. I had been searching all over the internet and making calls to detox centers and no one has heard of abilify detox. I regret going on the abilify and think a lot of these drs are very quick to prescribe anything for any little thing. My doctor likes to tell me "You are doing better than you think you are" and I have to disagree. I canceled my appt which was a day before my exam with him specifically bc I did not want to get into a stressful conversation with him before my nursing exam which was a wise choice on my part. My next appt with him is Oct. 2. I am tired of being convinced that I need to be on it and leaving his office with yet another prescription for 15mg of Abilify. And when I discuss all the dangerous SE"s with him that e could possibly happen he just says Oh that's a small percentage and the drug company has to put that on the list because there's a 0.1% chance of that happening. This really bothers me.....And I am not sure how any Dr. can consciously and ethically prescribe this drug knowing all the possible things that could happen. (See Drugs.detox.com) I just want to get off of it safely and I honestly don't think most Dr's know how to do this or even want to. The last time I expressed getting off a regime before he wanted me to sign a liability waiver. I am not sure how to approach this subject again with him and I am tired of being "compliant" He has made so much money off of me visiting him every two weeks. And to complicate matters since I was hospitalized the state board of nursing put me on a 5 year probationary status where I am tied into seeing this Dr. and they are looking for compliance. But does compliance mean doing everything the doc says? My doctor believes that the only possible reason to give the board as to tapering down is a possible pregnancy since he has to report to them every 90 days. (He seems to dismiss any of the SE's I am experiencing as a reason to discontinue) And I'm afraid if I get pregnant then he's going to want to take me down fast. So I need to know how to propose to him taking me down BEFORE I get pregnant. I feel like a gullible fool for him making me believe I need this and me knowing all the dangers associated with it but I know there is a physical dependence going on here. And I'd l to like to know how others have done this and approached their Dr's on this issue (of getting off) I'd like to know the best way to self advocate....and how I can guide my doctor into the best way of tapering down and what is that? I have heard the 10% rule but a lot of these docs want to go down 30 to 50% within a week to four weeks and because I have an upcoming hospital clinical in the next two months I don't want to attempt a drastic change.but the need for me to get off this is very strong......Any suggestions of how to handle this next appointment? My nephrologist says that I should be political, about it but I am not sure exactly what that means or how to go about it. (Help!!)
  24. In-depth article about how genetics informs how you process drugs, and also how it affects drug interactions, and the genetic tests used to determine if you will likely react badly to a drug or not. It's written by a forensic medical examiner. I've only skimmed it but seems well worth a read through. https://www.madinamerica.com/2017/01/cyp-testing-prevent-dangerous-adverse-drug-reactions/ CYP Testing to Help Prevent Dangerous Adverse Drug Reactions By Selma Eikelenboom-Schieveld, MD January 24, 2017 Readers of this website might be aware that antidepressants can cause suicide, other violent behavior and even homicide. These can be side effects or adverse drug reactions from the medication taken. Not only can antidepressants cause these side effects, but basically every psychoactive medication can put patients at risk. Few people may know that there are DNA tests that can identify individuals who might be prone to these adverse drug reactions.1 To understand what kind of information such a test would provide, it might be helpful to explain the science behind these DNA tests. In general, human cells contain 23 pairs of chromosomes. The father donates half of the chromosomes; the other half comes from the mother. Every chromosome contains many genes. A gene is the part of the DNA that codes for proteins, and proteins cause hereditary characteristics to be expressed. A gene can have two forms, called alleles. If someone inherits the same allele from the father and the mother, the person is called homozygous for that trait; if they are different, the person is heterozygous. Medication needs to be metabolized to be expelled from the body. This is done by certain proteins called enzymes. Most medications that interact with brain chemistry are metabolized by an enzyme system called Cytochrome P450 (also known as CYP450 or P450). There are many different P450 enzymes, and they are divided into families and subfamilies. Cytochrome P450 family names are denoted by an Arabic number (e.g., CYP2), the subfamily by a Roman uppercase letter (e.g., CYP2D), and the individual enzymes by another Arabic number (e.g., CYP2D6). The alleles are indicated with an asterisk and a number, separated by a forward slash. More at above link...
  25. I'm having a bad problem right now involving Remeron, Ambien, Xanax, Benadryl, Anxiety, Insomnia, GI problems, and fibromyalgia. I have a history of ambien use. 2 years ago I used 5-10MG of Ambien every night for 9 months. I started gradually having mild anxiety and depression throughout the 9 months so I decided to quit and then I did a 3 months taper. It was probably too fast because I had terrible anxiety throughout the process and it never stopped after I jumped. I was clean for 4 months. Then 5 months ago I had an incident which has since plunged my life down the toilet bowl and I have been terribly ill ever since, lost 30 pounds, and my anxiety and panic disorder has transformed into full blown agoraphobia. It started when I took an antibiotic for an ear infection. I had an allergic reaction and I had to start taking 50-75 mg of Benadryl every night. The next day I started a 5 day course of a different antibioitic, took corticosteroids, and took 0.25mg xanax to get to sleep. All was fine until 3 days later when I suddenly got chest/back pain, gastric burning, and a panic attack. This started a 5 month cascade of gradually elevating anxiety and gastric symtoms which was misdiagnosed as GERD. I went on many medications including prilosec, zantac, benadryl, antacids, tylenol, an experiment with librax (about 8 pills), and a few doses of muscle relaxer. I was on a cycle of using Xanax every 3 days and Benadryl every night. Every 3 days I would have a panic attack and take 0.25mg of Xanax, which has an interaction with Prilosec so it was probably actually more like 0.5mg. The gastric symptoms would strangely improve whenever I took the Xanax and then deteriorate over the next 3 days until it was time for the next Xanax. My nightly dose of 25mg-75mg Beandryl also helped and I would typically be better in the beginning of the day and then deteriorate throughout the night until it was time for the next Benadryl. At the time I thought Benadryl was just an antihistamine and did not know that it was also an anticholinergic and a mild SSRI. 3 months ago the gastric symptoms went into a constant steady state with no remissions and I started having wierd muscle twitching and electric sensations. So I went on a witchhunt to remove all of my medications in suspicion that one of them was causing my GI symptoms, which had eluded my GI doctor and all of his tests. First I got rid of the prilosec, zantac, antiacids. This didnt help. Then I tried to get off the Benadryl and that's when the **** hit the fan. Muscle stiffness and Insomnia from trying to quit Benadryl drew me back to Ambien. It started with 1mg doses and then quickly went to 2 and then 5 in a matter of days. The first day off Benadryl I had terrible anxiety and I was immediately in a state of having extreme insomnia and after a couple nights of taking Ambien or missing sleep I also had fibromyalgia, which further prevented me from sleeping as I could not find a comfortable position to sleep in. I've never had fibromyalgia in my life. For the next 2 weeks I would flop between different combinations of Benadryl and Ambien as my condition continued to deteriorate. I was averaging 2 or 3 hours of sleep per night. 2 weeks ago I saw a psychiatrist sleep doctor who Prescribed Remeron 7.5mg. I started by cutting it to 3.75mg which worked wonderfully for the first 5 days. I didnt need any Ambien and was getting 9 hours of sleep. However, I had side effects like dry mouth, dehydration, weakness, exercise intolernce, anxiety, suicidal ideation, memory issues, binge eating on junk, and daytime tiredness. Then on the 6th day I was having muscle stiffness, muscle spasms/twitches, and insomnia. I could not sleep on 3.75mg. After a drink (i dont normally drink), a hit of weed (i dont normally smoke), and then another 3.75mg to bring it up to 7.5mg, I STILL could not sleep. I could not sleep until I added 2.5mg of Ambien, and then I slept for 3 hours. This situation might have been amplified by having a steroid trigger point shot and a sedated procedure 2 days prior. Nevertheless, it scared me away from Remeron. I was scared of the side effects, the dose escalation, and possibly Neuroleptic Malignant Syndrome. I also quit Claratin 10mg, which I'd be taking for years while going on an antihistamine witchhunt and suspected I had 'Histaminosis'. For the next 4 days I would use Ambien 2mg and then 5mg and then two nights at 10mg, and I was still only getting 3-5 hours of sleep. I was hoping my GI symptoms would go away, if I was on just Ambien for a while. They didnt. Soem of the twitching was still there too. My psychiatrist told me to go up to 12.5mg of Ambien CR. Hell no. I was already possibly getting addicted to Ambien and didnt want to cement that with a long course of high doses and cement this addiction after everything I went through over the past 2 years. Over the last 2 nights I did an experiment where I 'reinstated' Remeron at 1mg and used 1mg of Ambien. One to initiate sleep and one to maintain sleep, instead of using an unnecessarily large dose of a long acting drug to initiate sleep or an unneccessarily large dose of a short acting drug to maintain sleep. Miraculously it worked. On only 1mg of remeron and 1mg of Ambien I have gotten 9 and 10 hours of sleep during the previous 2 nights. However, today I am again having some issues with minor twitching and electric sensations throughout my body, which I woke up with, and after thinking of it too long I am having bad anxiety. I don't know whether I am having a withdrawal from Ambien, a withdrawal from Remeron, side effects of Remeron, a withdrawal from one of the previous drugs (I havent had Xanax in 2 weeks), etc. After having only about 10 or 15 doses of Ambien at an average of 3-4mg per night, am I already addicted? Am I KINDLED? Do I need to taper Ambien in order to avoid seizures or brain damage, regardless of Remeron? For how long - a week, a month, months? Am I having some rare side effect syndrome of Remeron and need to go back on just ambien? Do I need to taper the tiny dose of remeron I took for a week? Do I need to go back on Benadryl or Xanax? Did I get addicted to the Xanax every 3 days? I feel like I urgently need a professional to work all of this out and tell me which doses of what I need to take over what time frame in order to avoid harm or seizures and assure me that I'm not having Neuroleptic Malignant Syndrome or something like that. I want my life back. I know these all look like tiny doses and time frames to you guys but I feel like I'm going insane, or I'm going to die. What do you guys think?
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