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  1. Hello, new member here, hoping to find some wisdom and support in my post medicated life! My medication history in a nutshell: I have been on antidepressants around 15 years, most of them lived on a combination of progressive Citalopram doses (10-40 mg), Bupropion 150XR, and Lorazepam 0.5 mg for occasional anxiety management. Began taper 6-1-2020 of Citalopram, completed 8-15-2020. Went off Bupropion 10-1-2020, did not taper due to extended release and significantly lower doses not readily available. Lorazepam was not used frequently enough to require and sort of cessation plan. The Citalopram taper was rough, as usual, something I tried and failed many, many, years ago. However, I did not get brain zaps this time, I think it was due to the effect of the Bupropion, which is good as a support drug for tapering (i.e. it is used to help quit smoking). The only current medication I am taking is a 24 hour antihistamine, Zyrtec 10 mg one time a day, before bed. Why taper off, why now? I am currently unemployed, thanks to COVID, so have some time to ride this thing out and see if I can get healthy and free of the medications. I had been dealing with a lot of side effects of the drugs, kind of a laundry list of the normal side effects for these drugs, but here is a list of the primary ones I was dealing with. Kind of difficult to nail this all down, been on this stuff a LONG time. Agitation/Irritability Decrease in sexual desire or ability GI problems, constipation, semen leakage during bowel movements Dry mouth/increased thirst increase in the frequency of urination lack of emotion Tiredness/Drowsiness/lethargy/Yawning Restlessness, twitching. Weight gain Why am I here? I am off of the meds, but have dealt with a fair bit of discontinuation syndrome. Have any of you found anything that helps you get through the next few months/years after discontinuation? I am not super big on supplements, but open to logical ideas based in science or real life experience. I have a relative who takes a handful of expensive supplements daily, I am not going down that route as I don't believe in flushing expensive pee down the toilet. I currently take NOTHING other than the allergy pill. No vitamins, no caffeine, little to no alcohol, no nicotine, etc. My primary issues at present are that I am sleeping a lot, lack ambition and energy to do things even though I have the desire to work or take on projects. I do have some anxiety presently, very manageable at home but more difficult in a work environment--it is situational. Once I start on something, and I get engaged in it, I have no problem staying focused and completing it. The daily grind of just being alive and present is difficult, I have occasional, mild, suicidal thoughts such as questioning if it is all worth the effort. That said, I have never attempted suicide and would say I am at very low risk, but my mind can wander there or identify with musicians or artists who address the subject (i.e. 13 Reasons Why). What next? I have an appointment with my doctor in a few days, the first since I completed the taper, I talked it all through with her before the taper, but it went so well that I have not had intermediate appointments. Part of the reason for not having more appointments, during my taper, was the feeling that there really is nothing she can do to make it any better. The taper also went very well, in my opinion. I still feel that the doctors are limited in what support they can give you, other than going back on the meds, what are my options in seeing an MD? Some of my side effects are getting much better now, for example I noticed my dry mouth issues are gone and I have been more regular as far at GI issues!
  2. Hello, I've been very grateful for this site, comforting me in the knowledge that I'm not alone in my battle. 10% taper is working slowly but steadily, it'll be a while but I'm planning on finishing it this way. Withdrawal is not pleasant, but it doesn't suck as much as it did. Eating healthy (I got a really nice juicer) has been the biggest factor in helping manage my withdrawal symptoms, and mental wellbeing in general. Thanks for all of your stories, omnispan
  3. Hi, I have been taking bupropion 100 sr one tablet daily for the past two weeks. I have had some of the worst possible symptoms, including severe chest pain and tearing pain in my upper back that took me to my doctor who did not think is serious but I know in my body that the medicine is doing something to my heart and liver because I've never experienced this kind of pain before. Question: can I stop bupropion 100 sr cold turkey after being on it for two weeks or do I need to tamper the dosage? Thank you! Pyotr
  4. I want to thank everyone that is a part of Survivingantidepressants.org. Without you guys, I would have been lost or dead, by now. Every time I have had a problem, I would go to this website and read. The support here has kept me sane, especially since my husband has issues that he has to take care of and cannot relate to antidepressant withdrawal. I have no friends (do not want any friends right now) and I have no other family. Most of the time, this site and its people are all the support I get. For twenty years, I have been taking Bupropion. After 20 years of ingesting this poison, the time and situation were right for me to taper. In a year and a half, I went from 300 mg down to 100 mg: currently, I'm holding at 100-mg. It has been rough. From what I've read, Bupropion is one of the 'easier' antidepressants to get off. If so, the people who taper off of SSRIs have my total respect! I've noticed that after eating a meal, fatigue, which is almost debilitating, plagues me. After doing some research, I came across this article which I copied part of for your review, which might be the reason why I get fatigue after I eat: Your body is equipped with a natural stress-fighting mechanism called the NeuroEndoMetabolic (NEM) Stress Response system. It is an intricate network of various organs and six circuits, including the bioenergetics circuit, which functions in close coordination to help fight stress. A pair of walnut-shaped adrenal glands, located above the kidneys, are also part of the response system. During stressful situations, the NEM signals your adrenal glands to secrete the anti-stress hormone cortisol. However, when stress is constant, the adrenals can get overburdened and are no longer able to secrete adequate cortisol. This can affect the natural stress-fighting ability of your body, which can lead to adrenal fatigue. Frequently experiencing extreme fatigue along with symptoms such as low energy levels, difficulty in waking up, insomnia, brain fog, anxiety, stubborn weight gain, constipation, low concentration levels, and craving for salty and fatty food indicate signs of Adrenal Fatigue Syndrome (AFS). As the adrenals get more and more overworked with consistent stress, the result is a cortisol imbalance which can disturb the entire NEM stress response system. As the NEM connects various organs and circuits, the function of related organs is also affected. People in the advanced stages of AFS have a weak body. Everyday functions of the body and organs - including the liver, pancreas, and thyroid of the bioenergetics circuit - gradually begin to slow down. This can complicate the actions necessary for maintaining the health of the body, which in turn can trigger negative reactions such as experiencing fatigue after eating. The bioenergetics circuit of the NEM system comprises of the liver, pancreas, and thyroid. Any imbalance in this circuit can lead to mitochondrial disorder, sugar cravings, reactive hypoglycemia, catabolism, dizziness, insulin resistance, and weight gain. The pancreas and liver play key roles in the digestion process. The pancreas secretes enzymes such as trypsin, chymotrypsin, amylase, and lipase which help digest proteins, breakdown carbohydrates, and convert fat to cholesterol and fatty acids. It also helps transport glucose to tissues through the blood and helps the liver absorb glucose. A significant detoxification center of your body, the liver performs multiple crucial functions. It secretes bile, which helps in detoxification and digestion. It also helps in the metabolism of fat, protein, and carbohydrates, and it maintains a healthy level of blood glucose and various other chemicals in the body. Dysfunction of the liver or pancreas has a direct impact on the digestion process, which can contribute to fatigue after eating. Reference: Why Do You Experience Fatigue After Eating? By: Michael Lam, MD, MPH https://www.drlamcoaching.com/diet/adrenal-fatigue-diet/fatigue-after-eating/ I don't eat processed foods but only eat fresh or frozen meats and vegetables and fruits and some nuts. I have also cut back on the sugar and sweets. I discovered that my body couldn't tolerate coffee or chocolate, so I have dropped them from my diet. To lessen my fatigue, I have taken to intermediate fasting. I eat one substantial meal each a day the then drink water (with lemon or lime) throughout the day. I stop drinking water at 6-pm. I reason that I spike my cortisol after I eat, so I get that out of the way early in the day. I've noticed that when I fast like this, I have more energy throughout the day, and at night I don't get up throughout the night to relieve myself. Have other people suffered fatigue after eating and how did you solve the problem? Let me know
  5. I am in my mid-thirties, and I've been on some form of antidepressant since adolescence. As a socially awkward, bullied young person in the throes of puberty, I hit a wall of apathy and sadness sometime in my sophomore year of high school. I no longer had the drive to make the Dean's List or pursue the activities I once enjoyed. This is when a pivotal conversation with my primary care provider occurred. He rolled toward me on a medical stool, pointing at printed charts illustrating neurotransmitters and a faulty brain chemistry. I think I was prescribed Zoloft, but I don't recall the details. I do remember that my parents remarked on the difference the medication made in my mood, and truth be told I was thankful at that time that I'd found the help I needed. Throughout college and into my twenties, my doctor adjusted my medication(s) several times. These adjustments usually corresponded with various hardships and bumps in the road inherent to living a human life. But I was fully bought into the idea that my brain was unbalanced, and feeling "okay" was just a matter of finding the right med or mix of meds to temper the discomfort. In my late twenties, I fought hard to get sober, recognizing that alcohol was causing far more harm than good in my life. Around the same time, I was prescribed Ambien for sleep (as needed). In the true fashion of an alcoholic, "as needed" soon became "every night." A couple years later, for reasons unknown to me or unremembered, my doctor prescribed Temazepam for my nightly sleep regimen to replace the Ambien. I had no understanding of benzodiazepines, their risks, or the withdrawals often associated with quitting them. I remained on a cocktail of Pristiq/Wellbutrin for depression paired with Temazepam to slow my brain at night for nearly five years. Honestly, I didn't think much of it. I trusted my doctor, and had no reason not to. I moved to a new city in 2016, started a new career, and felt in many ways that I was hitting my stride. In 2019, my then girlfriend suggested that I try and see what things might be like if I tapered off of the medication. Herself a trained therapist, she was particularly concerned that I relied on something to sleep every night. I agreed, and thought I'd like to see if these drugs were really necessary anymore. I was sober, I certainly wasn't depressed, and I had a good support system in place. In partnership with a new doctor and with my therapist on board, I made a plan to taper off of the medication. First the Wellbutrin, which we dropped over the course of a month or so. Then the Pristiq, which we tapered down over the course of a couple months. Then, snowed in on a November day and down to my last 30mg dose of Temazepam I thought, "I'll just stop taking this and be done with these meds completely." During the antidepressant tapering process, I was a bit more irritable and had some trouble focusing, but I was mostly functional. The symptoms were mild to moderate. Even in the immediate days and weeks after dropping the Temazepam, I felt okay. I slept fine, and I was mostly just excited to no longer be chained to a monthly sack of prescription refills to fix my "broken" brain. Fast forward to just after Christmas 2019. Some challenges in my relationship were giving me anxiety, but it was anxiety like I'd never felt before. And the strength of the anxiety was entirely disproportionate to the reality of the situation. It wan't long before I wasn't sleeping. Soon, I felt unsafe spending nights alone, fearing for my own safety. Thoughts of suicide cycled through my brain with regularity. A couple of weeks passed, and even basic tasks became insurmountable. I was in a near constant state of fight-or-flight. One Sunday evening I opened up my laptop to try and catch up on some things at work that I'd fallen behind on, and I couldn't focus my eyes to read an email. Panic began to set in, and I dialed my physician and then my therapist to try and make sense of what was happening. At the time, I placed much of the blame on my relationship, but I see now that I was in acute drug withdrawal. I fought my way through a haze of psychiatric evaluations, doctor's visits, emergency therapy appointments, the dissolution of my relationship, and a car accident (in which thankfully nobody was hurt). Eventually, at my own insistence, I found my way back to the original three medications I'd been taking, thinking that would be my best shot at finding some sense of stability. It's only been in the last month or so that I've felt some degree of what I would call stability, and I'm operating at about 75% of the mental capacity I once was, trying to pick up the pieces of my life and make sense of everything that happened. That search to make sense of everything is what led me here. I know that I do not want to be on a cocktail of medication for the rest of my life. I don't want to medicate my feelings or rely on a drug to fall asleep or live detached from my emotional experience. But I also know that right now, the right thing to do is to wait. I have to wait until my nervous system stabilizes and I can set up the proper plan and support system (the latter of which is made more complicated by the global pandemic we're all experiencing). If you have any advice for how I should go about tapering these medications based on my history, current dosage, and the experience described above, I am all ears. I look forward to actively participating in this withdrawal process alongside all of you, even if I need to wait a bit before I set out again. Much love.
  6. I had started this heavy headed ness in December 2018..The feeling was like someone tying strong knot around my head and its getting tighter...with NO relief in site....I ddint knw at that time , it was related to depression. So i kept hoping that it will ultimately subside after diet change, sleep patterns etc.. but nothing worked ....After 6 months of this unbearable pain.I visited psychiatrist.In our society and family , visiting psychitrist is taboo. He has Started off with amixide-h, flunil 20...it helped me ...I got recovered to some extent .But not completeely. then my doctor advised me to visit another doc at metropolitan area. so i did... he started with having galop 10 and betacap 20 ....and increased dsage gradually... I recovered but new monster arised infront of me 'ANHEDONIA/emotional blunting/numbness' ...It was making me disassociated from everyone i am closer and affecting every relations i have. Then i talked this to doctor, he changed tab to Dulexetin , buproprien and betacap for this emotional apathy .....This has really helped me in relieving some symptoms of depression ..Anhedonia but remained ... After 4-5 month of treatment , Now i am recovered to the extent but last problem for me remains. In between i tried supplements like MUCUNA pruriens for dopamine, its very effective for me with libido increase, sexual pleasure, but not helped much with anhedonia. Now i started on with AGOMELATINE for this anhedonia thing...so will update about its effectiveness after 1 -2 months. If anyone has gone through plaese reply and suggest any new thing for anhedonia...LETS beat this bastard...
  7. Good morning. I can't sleep right now, so I am posting here. Trying to learn as fast as possible, so bear with me if this information is in another thread. Partner has reduced from 200mg buproprion & 20 mg escitalopram to 150 and 15 respectively. I understand that it is only wise to do one drug at a time. We are on day 15 since reducing the dosage and started to notice prior symptoms reoccurring to a lesser extent around day 9. They are bearable. I don't want to cause damage one way or another by making adjustments too quickly. Have read and need to continue to read more about the 10% rule. I am going to ask the doctor for a liquid form to have a more gradual taper. I understand that we need to do our own research for understanding, and that sometimes doctors can only take us so far. Should she go back on her previous doses, stabilize for a month or two, then reintroduce a taper? Does going back on the previous dosage rock the boat too much or should we taper back up? Thank you so much for your insight. I appreciate everyone's posts here, and am looking forward to further educating myself in this newfound wealth of information.
  8. Zpssd

    Zpssd: Plz help

    I stopped fluvoxamine 2 months ago and started expiriencing sexual dysfunction so i went to my psychiatrist and he added bupropraon(wellbutrin).its been 4 days and i am not noticing any improvement.i need to know that my syptoms wont worsen as long as i am on ssri again
  9. I decided I didn't want to continue taking anti depressants anymore, I always intended to take them short term. I live in Alabama currently and the mental health programs out here are pretty terrible, I can't get an actual psychiatrist, I've had my doctor mess up my rx several times and I just want to be done with it. I have noticed that I have been dealing with the blurry vision up close issue for about two weeks now and it's a little worrisome. My dr after I asked to taper off suggested I cut the 150 mg XL in half and take half a day and then in two weeks to do every other day for a month. I tried that for a few days and felt REALLY irritable towards the end of the day. I was dragging and had low energy and fatigue. I did some research came across the forum and decided to take matters into my own hands. A while back when my dr messed up my rx I was prescribed bupropion 100 mg, I have about two months worth of that. I cut those in half and been doing the half of XL (75mg) and then the half of the regular bupropion (50mg) six hours later it helped for a couple days but now I find myself fatigued in the middle of the day and the blurry vision has returned. I don't normally eat a lot throughout the day due to a low appetite. I don't know if my issues is due to the lower dosage, which isn't a significant jump, 150mg to 125mg. Perhaps I need to increase back up? or will I adjust in a few days? Any advice is greatly appreciated.
  10. HI Gridley, I have had this anhedonia like condition , when i was on SSRI, then my doc changed it to SNRI and Bupropion , it reduced some of the anhedonia like condition....However not recoverred completely.I read on research paper that dopamine agonist receptor are required for it to treat...So my doctor started Promipex 0.25 .....It helped ....I am on tapering currently for Dulexetine and bupropion..How to do it? WHat more needed for this anhedonia to lapse as this is taking heavy toll on my learning , happiness, social sphere.
  11. Hi all. Gotta start out with a big thanks to all the contributors here for both the wealth of advice and for the validation. I was taking moclobemide (reversible MAOI) for approx 3yrs, 300mg/day. I found it to be very effective and honestly would have stayed on it quite happily for the rest of my days. However, I recently emigrated from my home country to the US, where moclobemide isn’t available, and it seems there’s nothing even in the same class (RIMA) on the market. I tried a rapid taper at one point, and all was good until about 2mths after complete discontinuation when mood nose-dived... so I re-instated. But obviously I ran out at some point and ended up doing a rapid switch from moclobemide to bupropion, with no taper. I wanted bupropion because I’m not willing to take SSRIs... been there briefly way back in my early twenties and it was not good. I also read that it’s easier to withdraw from than most other ADs. Unfortunately I’m at about the 3mth mark and things ain’t good. I don’t know if it’s that bupropion doesn’t work for me (just gone up to 300mg/day) or if it’s just that it’s not able to mask the withdrawal effects from moclobemide, since it is acting on far fewer neurotransmitters than my brain is used to. Things also aren’t awesome in my personal life. There don’t seem to be many experiences of moclobemide withdrawal on here so I’ve no idea what’s going on or what to expect. At this stage I metaphorically want to set my life on fire and I’m afraid my marriage isn’t going to survive this, but your stories give me hope.
  12. Spring 2014: Effexor ? mg for 2 months then cold turkey (didnt know better at the time). Originally put on this for depression after a break up. Fall 2014: Dizziness, extreme memory issues, pins and needles in hands and feet. Occasional adderall use. Working 2 jobs to pay for engineering school. Health anxiety started when doctors couldn't find cause of symptoms. Tried samE, 5htp. Winter 2014-2015: tried molly with a friend. Ended up in the ER. Months that passed included many ER visits and eventually klonopin (? mg) Spring 2015: after researching benzo dangers wanted off. Tried to taper. Horrid withdrawal. Switched to diazepam 6mg. Dog/best friend died of cancer. Started celexa 10 mg. Rest of 2015: Moved back in with mom, slowly tapered diazepam, stopped daily on new years 2016. Winter-Spring 2016: back in school. Stopped celexa 10mg in January. Pins and needles and depression in February. Started on wellbutrin 150mg. Increased anxiety but allowed me to finish school. Graduated. Stopped wellbutrin after graduation. Summer 2016: quit job too much stress while going through what I now know to be withdrawal. Drove for ride share service when feeling well enough. Felt like living with chronic fatigue syndrome. No doctors could find cause. Fall 2016: started back on celexa 15mg after rock bottom depression. Eventually wellbutrin added back at 75mg. Moved to a new state. PM panic attacks started after going back on celexa. Started full time engineering job. Winter 2016 - Winter 2018: wellbutrin gradually increased to 300mg. Started celexa taper. 15 down to 10mg. Increase in depression but tolerable. Spring 2019: tapered celexa down to 5mg. Extremely depressed. Affected relationship. Found a psychiatrist who wanted to switch me to zoloft. Relationship break up the week of starting zoloft. Zoloft lifted depression at first. Summer 2019: got back together with boyfriend. zoloft increased to 50 then 75 then 100. Horrible reaction to 100mg. Worst anxiety of my life. Stopped cold turkey. Back on 2.5mg celexa. Dr Then tried liquid zoloft increase from 0 by 1mg every few days to cross taper with celexa. Able to stop wellbutrin easily. Also had tooth extraction during all of this (infected root canal). Fall 2019: up to 8mg zoloft 1mg celexa. Horrible anxiety. Stopped zoloft cold turkey after getting suicidal thoughts from severe anxiety. Current: trying to find a celexa dose to stabilize on. Trying 2.5 mg. Anxiety and fatigue battles daily. going to write more soon. Just wanted a quick recap to start.
  13. Today is my birthday and I feel like the best gift ever is finding this forum. I am tapering off of fifteen years of taking Symbyax and bupropion. My psychiatrist seems to have little knowledge about antidepressant withdrawal. I have been on half my usual dose for two months now and I seem to be getting more severe ups and downs. I am so grateful to find other people willing to share their experiences. It gives me strength. I will be monitoring this forum daily as I already feel better knowing you all are here. Thank you.
  14. I don't know how to put the medication history as a tag, so I guess I'll just put it at the end. Hi everyone! So, I started on 3/21/19 with the Bupropion and Risperidone after being hospitalized for suicidal ideation. I had been resigned for some time because of difficult changes that had been going on in my life socially for the past year, and I was responding angrily and with frustration (internally) until I was pushed to the limit. After hospitalization, I’ve had some transformative thinking around how I interact with people socially, which has led me to an ease with the situation that I hadn’t known before I was hospitalized. I still struggled with social interaction but I am much better and not feeling overwhelmed by my situation as I once was. Although the initial usage of Bupropion and Risperidone I had trouble sleeping the first week, everything seemed fine after that. I had some flare ups of anger, but I was working through it and seeing my psychologist twice a week. In May, my psychiatrist saw that Risperidone was elevating my hormone levels, and he wanted me off of it. I started taking Abilify as a substitute in July. Towards the end of July, the panic-like symptoms I would get from just sitting still was too much for me. I went off of it. He then put me on Latuda. I was on for two days and still had similar effects and I couldn’t sleep. I came off of it, all the while having a lot of withdrawal symptoms- profuse sweating, getting hot, panic. I still couldn’t sleep. I started supplementing with benadryl (at the suggestion of the nurse for withdrawal) then later melatonin. After talking to my psychologist, she suggested that I may have insomnia from the actual Bupropion. Because Risperidone makes some people groggy, what she thought was that the Risperidone masked the activating effect of Bupropion. After I stopped taking the Risperidone, the Bupropion was keeping me awake. She had several clients that had to switch to something else because of the Bupropion keeping them awake. So, I quit cold turkey on the Bupropion, and similarly all the other drugs. I guess my psychiatrist didn’t think I needed to taper from the Risperidone because I had only been on it for 3 months. I thought all was well, but I now have these rushes of anxiety that come over me for around 10-20 minutes at a time. It started after I dropped the Latuda, I believe I was having them even before the Bupropion was dropped but hadn’t noticed a pattern of getting them until the Bupropion was dropped. I get a few (5 or 6) rushes a day. When the rush is over, I'm still usually uneasy for a bit of time after that. I also have some light depression in the mornings, but that has dropped off. The possibility of the anxiety rushes usually stop after 6-7pm at night now (this is a newer development). I go to bed around 10-11pm, so now I can this period the “golden hours” where I feel completely myself and don’t feel like the onset of either a depression tinge or an anxiety rush will happen. So, it’s been technically a little over a month since I CT’d Bupropion and two months since I CT’d the Risperidone. I took both medications from 3/21-7/1 and only Bupropion (and Abilify) from 7/1-8/10. So total I was on medication for about 4 months. What do you think? Will the anxiety rushes fall away? When I am outside of them, I definitely think I can handle this, but when I am getting washes of them, I feel hopeless like it is not going to end. It is unlike anything I ever experienced before taking medication. I would get anxious from various scenarios in the past, but not this random, involuntary rush that occurs for no reason. I look to the writings on here about neuroplasticity (I am 44 years old) and how healing happens every day with building new neural pathways not that I’m off of everything, but I am scared that I am doing this for nothing. Also, I did everything CT, so how does that impact my withdrawal? Thanks for reading, Armorall 3/21/19 started Bupropion XL 150 mg 3/21/19 started Risperidone 2mg 7/7/19 start Abilify half dose 5 mg. discontinue Risperidone 7/9/19 full dose Abilify 10 mg 7/29/19 discontinued Abilify due to panicky side effects 8/2/19 Began Latuda 20 mg 8/5/19 discontinued Latuda due to similar side effects 8/10/19 discontinued Bupropion after realizing it was causing the insomnia From 8/10/19 no drugs whatsoever Withdrawal symptoms coming in and more acute in September
  15. Hey all, 36 year old here – trying to sort out withdrawal effects, med side effects and potential underlying medical issues. Current meds: Bupropion (Wellbutrin) IR – 75mg w/breakfast, 37.5 w/ lunch, 37.5 with dinner (150 mg total) Amphetamine salts (Adderall) – 2.5 mg morning, 2.5 mg afternoon (5 mg total) Caffeine – 100 mg late morning Loratadine (Claritin) – 10 mg w/ breakfast Cefuroxime (antibiotic) – 250 mg morning, 250 mg evening Doxylamine Succinate (OTC sleep aid) – 17.5 mg before bed Current / past health issues: Depression – on and off since about 2000, started Bupropion in 2009 Anxiety – has always been low level, much worse since WD started IBS – dx around 2000 Chronic bladder inflammation (interstitial cystitis) – dx in 2010 Prostatitis – sort of chronic, reason for current antibiotics WD history, short version: Started Bupropion (SR) about 10 years ago. 2018 tapered 50 mg at a time from 300 down to 150. 2/2019 tried to taper from 150 to 100 and stopped due to withdrawal effects. Effects returned 4/2019 despite no dose change. Ended up switching from 150 SR to 150 IR on April 26th, and made large cut to my Adderall and Caffeine doses April 29th. Still recovering from symptoms and trying to stabilize fully. WD history, long version: In 2018, I started tapering the Bupropion down 50 mg at a time (at the advice of my doctor) starting at 300 mg. At the time I was taking the SR formulation. Sept/Oct 2018 - I taped from 200 mg to 150 mg around and got fairly sick for a week in October. Upset stomach, fever, flu-like symptoms. At the time I thought it was just a stomach bug, but after having similar symptoms during WD I’ve been wondering if it was WD. Feb 2019 - Tried to taper from 150 mg to 100 mg and experienced severe dizziness, nausea, fever/chills and sinus symptoms. I went back up to 150 mg after 5 days and felt better within a day or two . April 14th - Picked up my Rx refill, and on April 15th I started to feel lightheaded, dizzy and tired. I got worse over the next few days with headache, congestion, fever/chills, nausea and chest pain. I went to an emergency dentist on 4/21 thinking it might be an abscessed tooth (they said tooth looked fine) and went to urgent care due to pain while urinating. Urine culture was normal, and I tested negative for flu. I went to my PCP on 4/23 with very bad shakes in addition to the other symptoms. At this point, I started wondering if my new refill had somehow been a “bad batch” of the generic meds, so I got an Rx for the same meds from a different manufacturer. I tried that for two days with no improvement. 4/26, I switched from Bupropion SR (taken once a day at this point) to Bupropion IR (taken 3 times a day). The total dose didn’t change. Also had blood work done (CBC w/ diff, comp metabolic panel) – results normal. 4/29, following a morning with very rapid heartbeat, I cut my ADD meds (generic Adderall) from 15 mg to 5 mg. I also cut my daily caffeine from 200 mg to 100 mg. I’d reduced both the ADD meds and the caffeine in the past without any apparent ill effects, so I didn’t think it would have any effect this time around. 5/6 – 5/13 - Symptoms mainly resolved, except for some GI issues. 5/14 I had a rash, fever and shaking. Bad anxiety due to symptoms – went to Urgent Care b/c of rash. Over the next week I also started getting nauseous. 5/22 – Had blood work done again - (CBC w/ diff, comp metabolic panel plus ESR-Wes+CRP to check for inflammation). Also had Urine Analysis. All results normal. 5/29 – 6/6 again felt mostly better save for some lasting GI issues including mild belly pain. 6/6 had fever, chills, fatigue, added dizziness and shakiness over the next few days Most of June: occasional dizziness and stomach pains. 6/17 - Tried to taper from 150 to 131. Reinstated after a few days dizziness and nausea. Early July: Feverish, pains in stomach and chest. Occasional tightness in chest and heart palpitations. Lots of anxiety about symptoms. Started antibiotic July 17th. Current (past few days): some pain in stomach and chest, more frequent heart palpitations. Stomach a bit upset (probably due to antibiotics). I’m seeing a therapist every other week, mostly about anxiety. I’d been planning (hoping) to try tapering the Bupropion again this coming week because I have a few weeks off work, but I’ve having second thoughts since I just started the antibiotic. Also wondering if it would be better to taper the caffeine first, since I should be able to get off that more easily. Glad I found this site, very good to know I’m not the only one 😊
  16. All of my symptoms in bolded, for ease of quick scanning for relevance by anyone interested. I have ended up on this website after lots and lots of google research to pin down the cause of my incessant symptoms of a low-grade migraine headache and constant nausea that I have been experiencing for 10 days straight now. My Migraine History: I have been getting migraines fairly regularly (about 2 or 3 each month) since middle school. but they are pretty mild, as migraines go. About 25% of the time, one will be preceded by an aura that is a lightening-shaped blind spot or blurry vision and then the headache will be very severe. And occasionally, one will be accompanied by severe nausea. But normally, my migraines are just quite painful headaches accompanied by heightened sensitivity to light, sounds, and smells. With ibuprofen and extra sleep, they are usually completely gone within 30 hours. During puberty and especially pregnancy, my migraines were more severe in all aspects: nausea, sensory sensitivity, and pain. My Venlafaxine Withdrawal/Discontinuation Symptoms: I did not connect these symptoms to the cessation of Venlafaxine until recently because 1. I did not know that physical symptoms could be related to the cessation of antidepressants. 2. The onset of symptoms did not occur until 5 days after my last half dose of Venlafaxine. 3. I was only on Venlafaxine for 27 days (including a half-dose for the last 7 days). I only made this correlation after several days of googling possible causes, and after including symptoms that I had previously dismissed as insignificant and inconsequential in my internet searches I started experiencing a persistent nausea that did not seem like food poisoning or stomach flu (no stomach cramping, etc.) 14 days ago. There were/are waves when the nausea is worse throughout the day, and a constant malaise otherwise. Unlike the stomach "flu" or food poisoning, there is/was no stomach cramping or urge to vomit. On the 4th day of no relief, I realized that it was just like the nausea I get that sometimes accompanies my migraines. I hadn't equated it with a migraine previously, because there was no headache. I started taking ibuprofen periodically, treating it as if it were a migraine. On about the 5th day, I could feel a headache "trying to set in", which is my usual precursor to an impending migraine (although historically the nausea, if it develops, does not come on until after the headache presents). Since then, I have had no improvement in symptoms. On about day 6, I started googling possible migraine prescriptions and was considering seeing my M.D. the following day, if there was no improvement. I also started googling the combination of all my other mild/querky symptoms to see what else it could possibly be, if not a migraine. These other sporadic symptoms had each seemed inconsequential as they had come and gone here and there, and were easily dismissed. But I was starting to realize they might be related. Muscle Weakness in my biceps that I had noticed when using a steering wheel or when filing through clothing racks while shopping. Crying and/or the feeling that I needed a good cry, without provocation, that felt very similar to PMS (although this was about 10 days after my last menses). Brain Fog in the middle of conversation. I will have to concentrate really hard to remember what the conversation is about, and what I was going to say next. I will forget what my husband told me just minutes ago. Word Recall Difficulty both while texting/typing (spelling) and in conversation (vocabulary). High Pulse Rate of 88pm, which was noted at the medical appointment that I had on the fourth day after my last dose of Venlafaxine, when I felt great. Chills Hot Flashes/Feeling Flushed Sinus Congestion which was present before, but is now much worse, especially at night. Nausea that feels like "Morning" Sickness when there is 0% that I am pregnant. Yes, 0%. At times, I can tell that I will feel better if I eat, and at other times I can tell that eating will make me feel worse. My best time of day is the first 3-4 hours after waking up. Shivers not related to body temperature this one I just experienced last night, and suspect (hope!) is more likely related to my inadverdently taking 2 different antihistamines (diphenhydramine and cetrizine) at the same time! Very pronounced and fast onset of "prune skin" on the soles of my feet, followed by Extreme itchiness on the soles of my feet Another really bizarre symptom that I think might have another cause. ??? I had sprayed the soles of my feet at bedtime with magnesium oil two nights in a row, as I have done in the past when experiencing a severe migraine. I did not bathe or shower until a third night. 5 minutes into my bath, my feet (and only my feet) were EXTREMELY pruny, as if I had been soaking for more than an hour! I have found nothing online indicating that this wierd fluke may be related to the magnesium oil, nor to antidepressant withdrawal/discontinuation. After the bath, my feet were excruciatingly itchy (just the skin, not the nerves) for at least 30 minutes! After much reading on this and other similar forums, I contacted my P.A. that has been assisting in my medication management for the last 3 months. I am going to reintroduce 5 beads of Venlfaxine tonight and see if it makes a difference by the time my afternoon appointment rolls around tomorrow. She is doubtful that any of these symptoms are related to the antidepressant, so I hope this works. I really hope that my experience, along with the litany of literature I will be leaving with her tomorrow, convinces her of this very real and very under-reported issue!
  17. Hi Everyone, I found this forum through the recent New Yorker article and have already found it very helpful. Here's a brief version of my story... I was put on Effexor XR at the age of 15 to treat severe anxiety (I was given a diagnosis of Generalized Anxiety Disorder). At the time I was dealing with teenage hormones and a suicide in the immediate family and having regular panic attacks. As I got closer to 30 I decided I wanted to know what life was like without them, and wondered if being put on them at such a young age had impacted my emotional development. I felt like I had reached a point of relative stability in my life (stopped drinking, good support system). Going off Effexor ended up being a disaster - in hindsight it seems like it was a very fast taper and I reached the point of not being able to get out of bed in the morning due to anxiety. I found a new psychiatrist who put me on Lexapro and Xanax (not every day, to take as needed). I felt very good on Lexapro but I gained about 50 lbs in one year. She then added Wellbutrin into the mix, which didn't make me feel as good. I felt very agitated and had a hard time concentrating. At this time my psychiatrist was fixated on my weight and wanted to increase my Wellbutrin while going down on the Lexapro. We'd have arguments about it where I tried to explain how bad the Wellbutrin made me feel, despite the weight loss benefit. Eventually we parted ways and I am now trying to taper off everything for the first time in my adult life with another psychiatrist. I'm currently 4 weeks off Lexapro and on 100 mg of Wellbutrin. I am in therapy weekly in addition to seeing my psychiatrist monthly. I started taking fish oil after reading this site and am trying to integrate some dietary changes in addition to my regular yoga/meditation practice. I struggle with feeling a lack of agency over my own life and feeling helpless. The constant focus on and discussion of my weight over the past few years has also not been great. On my bad days I have feelings of hopelessness and despair and occasional depersonalization. I don't have an expectation that I will feel great all of the time, I just want to feel some level of control over my mental and emotional state. Reading this site helps me because I feel like I am not alone. You guys have already helped me so I want to say thank you and I hope I can learn more - the concept of windows and waves is really useful. Today is a window which is why I'm able to write this - I've had two good days and that feels really encouraging. In the meantime if there are any suggestions for additional supplements or lifestyle changes I'm all ears!
  18. rhanch

    finding my way

    I've been taking antidepressants, nearly as long as they've been around. Following a psychotic break - clinical depression, which might have been predicted, given the circumstances and looking back at it. I was first prescribed Sinequan by my family GP - a tricyclic drug considered at the time the latest medical miracle. It seemed to work and brought me back to earth, though it may have been just as much a result of a change in circumstances. The thing is, the fact that it seemed to work against the closest thing to absolute hell I could have possibly imagined created the fear that going off it would return me to the same state. So I continued taking it, in larger or much lesser amounts but continuously, through the coming decades. The ssri's came on the market and books were written declaring the latest and most important, culturally transforming chemotherapeutic drugs. I threw my hat in the ring and decided to try Prozac. Was quickly thrown into some sort of dissociative/ serotonin syndrome state and quickly retrieved the hat. My GP eventually retired and had to shift to a psychiatrist to ensure my supply of antidepressants. He more or less turned me into his psychiatric guinea pig. "I believe it may be prudent to throw Abilify into the mix at this point." "Well, you're the expert." Or so he figured. The upshot: I'm currently taking 150 mg Buproprion,150 mg Venlafaxine 50 mg Trazadone & 5-10 mg of Diazepam. Though I haven't taken any Venlafaxine for a few days because I believe it has left me with ED. I have a lot of opinions and insights into what led me to where I am today, but leave that for later. Thank-you for your attention and/or feedback.
  19. Topic title: Welbutrin use for 10 years have done with tapering but awful things happening almost 2 months still My daughter has been in and out of er spent a week in the mental ward. Since getting off these meds we are at a dead end she is a awful mess. She was put on buspar 2 weeks ago to help cope , any insight any help would be so welcome at this point.
  20. Want2Want2

    Want2Want2: hello

    Hi yall, So much to say, but little time now. Will be back w/more info soon. Glad to be here. Currently struggling with ongoing apathy, indifference, just-not-caring, from initial (and fairly immediate) introduction of Zoloft in 2013. It has persisted since then whether on or off medication, although it IS dose dependent w/Prozac. Reading this forum has been instrumental in my previous tapering but only now have I created an account. So thanks to all, especially Altostrata. I know there are much more difficult symptoms, as I've had many of them in the past, but this indifference seems to have completely (permanently?) changed my personality. Preparing to discontinue current doses of 10mg Prozac and 150mg Wellbutrin, beginning in April.
  21. Hello, and many thanks to this website for being so informative! I only wish that I had known about this site a few years ago (or even a few months ago). Here is why - My 19 year old daughter is, I believe, now going through Bupropion withdrawal. It's hard to know for sure because a virus *could* be partly to blame. Either way, she is too out of it to be her own advocate right now so I am trying to learn as much s possible so that I can best help her. My daughter began taking Bupropion (150mg) in the summer of 2016 for pretty severe depression. In the winter of 2017, Fluvoxamine 100mg was added for OCD. Gabapentin (900mg per day) was added about 9 months ago for nervousness. During this time we moved and had to switch doctors. The new doctor changed her Bupropion to the 150mg XL (extended release) formula about 6 months ago. She was previously taking the 75mg SR version twice per day. It was soon after our move, which corresponded to the new doctor and new Bupropion formula, that my daughter's mental health seemed to take a downturn. In the past 4-5 months in particular she has stayed in bed most days with a low mood. She also started having a tremor in her hands and feelings of nausea off and on. I contacted her PCP in August this year to share my concern and was told it was probably a virus and that she would feel better soon...but she only got worse. A month later the nausea got so bad that she began vomiting all the time. After 5 days of this severe vomiting with no other viral symptoms, the doctors agreed to run tests. We found her ALT to be elevated, and this was concerning in regards to the Bupropion so it was agreed that she would stop taking the Bupropion. Her PCP recommended that she titer by half every 3 days. I thought that I was being cautious by making this a week instead of 3 days. Now, after a month, she is on 18.75mg every other day of the Bupropion SR. Her psychiatrist says she should be off it by now, but I have added this every other day titration at this point and I'm not sure where to go from here. The psychiatrist wants her off the Bupropion so that Lamictal can be started. I'm still not sure about starting another drug at this point! Anyway... To make things even more complicated, we tested her blood for the Epstein Barr Virus (EBV) and her result was borderline (technically they call it "equivocal"). She had mono (which is caused by the EBV) two years ago and got very, very sick then. The fatigue she is experiencing could be related...or not. It's hard to tell. Her PCP feels her fatigue is depression related. The psychiatrist thinks it could have something to do with the EBV. She will be re-tested for EBV next week. And to make things even MORE complicated, her psychiatrist said we should take her off the Gabapentin by reducing one 300mg pill per week. I hired another psychiatrist to oversee psychiatrist number 1 and he said that we could reduce the Gabapentin every 2 weeks but that he did not want to wait longer than that because he wants her to start the Lamictal. We took away one pill almost two weeks ago. Right now my daughter's main symptom is fatigue. She is in bed 90% of the time. She had to drop out of college this semester. She is also super depressed. She was having intense nightmares and sleepless nights these past few months, waking up each morning screaming, but that seems to have gotten a bit better (no waking up screaming the past few weeks). The good news is that her tremor is gone! She does get a little more agitated than normal as well. My daughter is currently taking fish oil (900mg/per meal) and vitamin D3 (5000IU/day) as supplements, and last night she took her first dose of Melatonin 0.3mg. She also takes birth control pills for PCOS. I believe that these pills might be behind her depression but at this point I don't want to jar her system further by removing/changing them. As soon as we can we will address this. My quandaries now are: - How to proceed with Bupropion (currently on 18.75mg every other day - doctor does not want her to reduce more because he wants her to start on Lamictal). - How to proceed with the Gabapentin (doctor says 1 pill per 2 week titer and I worry about this) - Do we give Lamictal a chance? Once she is stabilized, she will begin tapering the Fluvoxamine. We don't think it's really helping her. I now know that this needs to be done at 10% increments each month for years. We will think more about this when the time comes. For now I want to make sure that she is able to get through this Bupropion and Gabapentin withdrawal. If anyone here has any insight or knowledge to share then I would really appreciate it. Thank you, Snek (I chose this name because my daughter loves snakes and this is a cute word she uses for them - she does still smile when I show her pictures of cute snakes so I now love snakes too)
  22. Hi, Since June 2016, I've taken bupropion XL. 150mg a day for first month, 300 for second month, and then on, 450mg a day until May 2018. As far as I could notice, it did not effect my sexuality either negatively or positively. Around, I believe, the middle-to-end of May this year, I stopped the bupropion pretty much cold turkey because I thought it was just elevating my anxiety and not really helping depression. I did not, at the time, believe I had any negative withdrawal symptoms. It seemed pretty painless. At the beginning of this August, I started taking 150mg of bupropion a day again because I thought - why not - see one more time if a lower dose can help while not increasing your anxiety. Now, though, I'm considering if my noticeable sexual dissatisfaction/lowered libido for the past little while may be connected to my cold turkey discontinuation of bupropion back in May. I'm not 100% sure - I couldn't say exactly how much my current sexual dissatisfaction aligns with the discontinuation, since I hadn't thought to watch for that (I thought bupropion couldn't cause negative sexual side effects.) But based on what I do remember, it seems like a very real possibility, which makes me scared of PSSD (so to speak, since bupropion is not an SSRI.) As I said, I reinstated the bupropion at the beginning of August at 150mg XL a day. In terms of effects, I wonder if for this past week it might be elevating my anxieties again, though It could just be my natural anxiety going into overdrive in reaction to the possibility of PSSD. I don't think there's been a positive effect on my sexuality over the month - though it's seemed a bit more okay these past two days, but that could very well be due to hormones from my period that just arrived, or from abstaining a few days from sexual activity before hand. I don't think it's had a negative effect either - my sexuality has been noticeably not good over the course of this month, but my best guess is that this predates the reinstatement. (But I will admit that I am working off of imperfect memory and not careful tracking.) If it is indeed a symptom of the withdrawal/discontinuation, I am wondering if I should be tapering off (safety and slowly, this time,) or if I should basically continue with the reinstatement in some manner. This site says that reinstatement for withdrawal symptoms is most likely to work within a month and gets more unpredictable the later you go on. It's been 3 to 3.5 months since my discontinuation of 450mg bupropion, and about 1 month now since my 150mg reinstatement. I am worried that, if this was induced by the discontinuation, staying on the medication that caused the problem will potentially cause more long-term damage. But I am also worried that this might be my best opportunity left for reinstatement to work, if it will work, since it's been sub-4 months since the cold turkey discontinuation. What should I do? What is the safest bet here to preserve and heal sexual functioning? Taper off, stay on 150mg longer (and for how much longer?), or increase dosage (and if so, increase it to what, for how long)? Is a reinstatement of this nature likely to work on PSSD symptoms? Is it worth the risk? I do still have some sexual functioning/libido, which I value and can enjoy, even if it's noticeably not what it used to be in the earlier months of this year. I really don't want things to get worse. But of course, I'll be unhappy if they don't ever get better again, either. Is there a wrong choice, here? In honesty: a very large part of me feels sick and anxious at the idea of staying on any longer than necessary, in fear that staying on will potentially cause more long term damage. I *want* to start tapering off safely as soon as possible. And I don't want the possible further elevated anxiety of increasing doses. But I worry I won't heal this possible PSSD naturally, either, and that I'm missing my best chance here by not reinstating further. And not knowing how to proceed - fear of making the wrong choice - is distressing me. Other questions: - Before this, I have never considered myself even remotely sensitive to withdrawal symptoms. I'd cold turkey'd off of, or tapered down fast from, a variety of drugs without any apparent consequence. Even with this most recent CT off the bupropion, the sexual dissatisfaction is the only thing I can think to possibly associate with the discontinuation. How should this information effect my decision, if at all, and does my historical insensitivity to withdrawal symptoms possibly make it more likely that this particular symptom - if it is a withdrawal symptom - will heal naturally? - If this is PSSD, then it's noticeable and I want it fixed, but it's not as severe as I know other people's symptoms are. I do still have some sexual functioning which I can enjoy to a certain extent. Could this also make the chance of natural recovery more likely? - I have not had the chance to discuss the situation fully with my GP yet and tell him my concerns over possible sexual dysfunction caused by discontinuation. I don't know how that information might effect his advice. But, my pharmacist called him and absent these full details, my GP recommends as a process for weaning off bupropion - should I choose to do so - to updose for 2 weeks to 200mg SR (as opposed to 150mg XR I'm on now) and then taper off, I think, by 100mg every two weeks. I already know that's way faster than what this site recommends, but what about the initial up dose to 200mg? Is that a bad/good idea? What is the value in it? I will be seeing my GP to discuss this with him in a week. Thanks.
  23. I weened off my Welbutrin and almost done weening off my Lexapro. It took almost a year now but with a lot of time staying at the same dose (could've taken a lot shorter amount of time but procrastinated initiating dosage drop). Just wanted to let everyone know that I used 5 htp to help with withdrawal symptoms (mainly light headedness/ brain flashes). and it really helped. I basically stopped the Welbutrin cold turkey with taking about 200 - 300 mg of 5 htp for about a week then lowering the 5 htp dramatically and that really helped. The lexapro is harder but the 5 htp really helps. I don't come on this website often so I you guys are always already talking about 5 htp sorry for the redundancy. I just felt the responsibility to come on here and let everyone know. I was on Lexapro 20 mg and Welbutrin 300 mg and now I'm off. and my sex drive is back and I feel emotionally fine because they were probably a placebo in the first place. good luck
  24. Hi everyone, I am new and super happy to be here. I have been on Prozac 20mg and Wellbutrin XL 300 for twenty five years. I have tried to get off a few times but was not successful. I started to taper in Jan and was down to half doses on May first. The withdraw, specifically anger and self hate became too intense and I went back to old doses two weeks ago. Now I feel like crap. Side effects are harsh and benefit little. I feel like I have let an angry tiger out of the cage and can't get it back in. I am thinking of going back to the half doses and just dealing with the emotional stuff by working out. I started yoga in Jan but maybe harder cardio is the way to get the anger out. Problem is that I am also very tired. I work and come home and go to bed. I journal, go to AA meetings been sober over 15 years. I feel like I am a mess. I am wondering about some of the natural antidepressants like SamE or 5HTP? I just feel like my brain is raw and hurts. Any ideas on how to supplement and sooth my brain? thanks, and I also will stop the taper and work with my doctor but can't see him for another month so that is why I am thinking of going back to the Prozac 10 and Wellbutrin 150 that I have been taking for the past couple of months.
  25. In brief: in 2017 took bupropion 150mg 5 days, 300mg 8 days and very abruptly experienced pain in testicles, loss of libido, 80% ED, genital and other skin numbness. Stopped due to this ct and ran into a terrible state including total anhedonia, deep amotivation, loss of appetite, loss of tiredness and panic-like anxiety for multiple weeks. 11 months later no real improvements beside less anxiety, using remeron 15mg and getting some sleep. All in all very wide and disastrous symptoms. So bad, had to leave job and basically have been in bed ever since. Nothing feels and motivates. Lately also quite severe anxiety attacks for hours. Scared and worried about ever recovering. Pssd alone is a tragedy, but having lost all emotions and motivation and will to live is even more devastating. Really sad about the small number of found recovery stories in contrast to number of sufferers. Bupropion is no safer than 'ssri' s. Forget about the categories, they are all poisons. I deeply regret ever taking one, which I did after weeks of thinking. Was so anxious that I fell for the 'marketed safe' one. It turned out to be a disaster and made the original state even worse (depression and anxiety into panic). I am really angry for these poisons and their prescribers being legal. Ready to join into any group/class suite etc. It is unbelievable how the pdocs cover themselves and each other all over the world using same phrases and not even 'believing' the victim. Many say they are clueless, I say they are collegially lying. To them it is nothing if 1 or even 5 in 100 get the devastating lasting symptoms. It is still low enough to claim that everything is due to depression etc. Glad to hear any encouraging recovery stories or talk PM with similar cases.
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