Jump to content

Search the Community

Showing results for tags 'pristiq'.



More search options

  • Search By Tags

    Type tags separated by commas.
  • Search By Author

Content Type


Forums

  • Support
    • Read This First
    • Introductions and updates
    • Tapering
    • Symptoms and self-care
    • Finding meaning
    • Relationships and social life
  • Members only
  • Current events
    • Success stories: Recovery from withdrawal
    • Events, actions, controversies
    • In the media
    • From journals and scientific sources

Find results in...

Find results that contain...


Date Created

  • Start

    End


Last Updated

  • Start

    End


Filter by number of...

Found 100 results

  1. Hi anything would help. i was prescribed Zoloft, prestiuq,rexulti, lamotragene,Paxil during a 14 month period all at separate times and tapered off in 8 days. Also experiencing black mold toxicity. I’ve been off meds for almost 3 months. And out of the apartment for a month. Very desperate. I’m experiencing derealazation , massive depression and anxiety. I have no idea where to start to address these things. Psychiatrist wants to put me on Prozac and and taper in 3-4 months. Symptoms from both are conditions are similar and again don’t know where to start.
  2. Hi. I've been on Pristiq since 2014. I've taken varying dosages but have been taking 50mg for a long time now. I've been trying to wean off unsuccessfully since early 2019. The withdrawal symptoms are too serious and long-lasting. It makes it near impossible for me to continue working due to my need to be alert and aware enough to safely drive a vehicle regularly. My GP has just given me Loxalate 10mg. I'm to begin this over the weekend on the "off" day I've been trying to wean off my Pristiq and continue on Loxalate for a month everyday. I was wondering if anyone has any additional information they can tell me about Loxalate before I transition onto it and begin my journey of weaning off antidepressants all together please? Thank you in advance for your time.
  3. Thank you everyone in advance . I’m am new here and come for some help. I was switched from 5mg paroxetine to 100mg generic Pristiq 5 days ago. Was on the paroxetine for almost 3 years. I’m having a very rough time with increased anxiety, tingling , inner shaking and bad panic attacks. My shrink says I should not be having withdrawal symptoms as I replaced the paroxetine for something better. I am not sure if it is withdrawal or the new medicine or a mixture and don’t know what to do if stick to the new med or go back to Paroxetine , anyone in a similar situation? Today is my 5th day on the new AD. Thank you !!!
  4. Hi everyone I'm Dane, Please scroll down to "Long story short" for antidepressant story or continue for the full picture. 43 year old gay male, from Sydney who has had a couple of years of unstable mental health after being successfully medicated on Zoloft 100mg for around 7-8 years. The dates are foggy. I notice people leave there hx (history) of medications and experiences at the bottom of the posts, if someone could advise me on how to do that, id be very appreciative. Id like to play by the rules. My main issue has always been anxiety. In 1995 I had my first horrific panic attack. And nothing has been the same. My life isn't awful or terrible. I have a lot to be grateful and thankful for, however as time goes on, I'm finding things more difficult. Ive seen this website many times, but felt it was best to join and contribute/learn. I generally have been anxious rather than depressed, however the anxiety and feeling out of control led to me feeling quite down and dark. In my 20's i climbed out of it but when any stress or changes were added like a relationship, a job, a responsibility - I would become overwhelmed with that was being asked of me and get easily stressed and feel like I couldn't cope with life's demands. This has been a common reason for my anxiety. When I hit 30 in 2008 I was really beginning to suffer. I felt very alone, I was job swapping a lot, starting jobs and quitting, very unstable and sexual experiences ramped up. Seeking out novelty and sex and also what's known as "cruising". I then started to feel difficulties just going outside. I was super anxious about even going to the local shops, it got worse and worse and had to be brought back home to live with family. I felt completely failed as a person. I felt i was a burden and couldn't understand why and what was leading me to not be able to cope with life. I developed agoraphobia. I went on Zoloft and that worked for many years. I got two degrees during that time, I graduated, i was working, had friends but never feeling 100 percent. The agoraphobia never really left me at all. Sometimes I could travel long distances and other times I couldn't leave my suburb. Its fluctuates a lot. However I learned to drive a car, and can drive locally and have a job. My issues are finding the right medication or therapist combo. Long story short: 2018 I noticed Zoloft not working as well, I had some challenges with resurfacing anxiety. Went to 200mg, no result. Went onto Lexapro (escitalopram) 20mg, no change really, some side effects. Maybe 20% better. Side note: Ive done pharmacogenomics testing for metabolism of meds (Lexapro a no go anyway). I checked into clinic to wean off it April 2019 and started Effexor at 75mg. Over the course of a year that was increased to 225mg. It would seemingly work for a time at each dose increase and then take a tumble. The other theory I have is that I'm not that depressed really. In April of this year (2020) I went back to switch to Pristiq 100 and Valdoxan was added at 25mg an evening. Pristiq was shown to perhaps work due to metabolism. At the 12 week mark id had mayve 4 or 5 days feeling great. The other times I felt speedy, emotional, numb, sedated, as if the norepinephrine side was working full force, but no the serotonin. I had the energy extreme without the mood. Not fun. I am now down to 50mg Pristiq for two weeks 4-18th of August. I have been given Seroquel 50mg XR to help with the DROP to 0 - in Australia you cannot get 25mg doses. Now Seroquel has worked as PRN but will it work coming off the Pristiq? I'm feeling very poly medicated. And feel I need a HUGE scale back. Medication Journey: 5 medications August 2020 Zoloft 100mg 2012 - 2018 (stopped working) Increased to 200mg (no effect) Escitalopram 20mg Dec 2018 - no noticeable effect except side effects Venlafaxine started April 2019: 75mg (6 weeks) 112mg (6 weeks) 150 (3 months) 187.5 (3 months) 225 (7 weeks.) Each dose increase it just kept failing after an initial boost/response Pristiq 100mg & Valdoxan 25mg (May 2020) Pristiq 50mg & Valdoxan 25mg (August 2020 - due to side effects)
  5. I am in my mid-thirties, and I've been on some form of antidepressant since adolescence. As a socially awkward, bullied young person in the throes of puberty, I hit a wall of apathy and sadness sometime in my sophomore year of high school. I no longer had the drive to make the Dean's List or pursue the activities I once enjoyed. This is when a pivotal conversation with my primary care provider occurred. He rolled toward me on a medical stool, pointing at printed charts illustrating neurotransmitters and a faulty brain chemistry. I think I was prescribed Zoloft, but I don't recall the details. I do remember that my parents remarked on the difference the medication made in my mood, and truth be told I was thankful at that time that I'd found the help I needed. Throughout college and into my twenties, my doctor adjusted my medication(s) several times. These adjustments usually corresponded with various hardships and bumps in the road inherent to living a human life. But I was fully bought into the idea that my brain was unbalanced, and feeling "okay" was just a matter of finding the right med or mix of meds to temper the discomfort. In my late twenties, I fought hard to get sober, recognizing that alcohol was causing far more harm than good in my life. Around the same time, I was prescribed Ambien for sleep (as needed). In the true fashion of an alcoholic, "as needed" soon became "every night." A couple years later, for reasons unknown to me or unremembered, my doctor prescribed Temazepam for my nightly sleep regimen to replace the Ambien. I had no understanding of benzodiazepines, their risks, or the withdrawals often associated with quitting them. I remained on a cocktail of Pristiq/Wellbutrin for depression paired with Temazepam to slow my brain at night for nearly five years. Honestly, I didn't think much of it. I trusted my doctor, and had no reason not to. I moved to a new city in 2016, started a new career, and felt in many ways that I was hitting my stride. In 2019, my then girlfriend suggested that I try and see what things might be like if I tapered off of the medication. Herself a trained therapist, she was particularly concerned that I relied on something to sleep every night. I agreed, and thought I'd like to see if these drugs were really necessary anymore. I was sober, I certainly wasn't depressed, and I had a good support system in place. In partnership with a new doctor and with my therapist on board, I made a plan to taper off of the medication. First the Wellbutrin, which we dropped over the course of a month or so. Then the Pristiq, which we tapered down over the course of a couple months. Then, snowed in on a November day and down to my last 30mg dose of Temazepam I thought, "I'll just stop taking this and be done with these meds completely." During the antidepressant tapering process, I was a bit more irritable and had some trouble focusing, but I was mostly functional. The symptoms were mild to moderate. Even in the immediate days and weeks after dropping the Temazepam, I felt okay. I slept fine, and I was mostly just excited to no longer be chained to a monthly sack of prescription refills to fix my "broken" brain. Fast forward to just after Christmas 2019. Some challenges in my relationship were giving me anxiety, but it was anxiety like I'd never felt before. And the strength of the anxiety was entirely disproportionate to the reality of the situation. It wan't long before I wasn't sleeping. Soon, I felt unsafe spending nights alone, fearing for my own safety. Thoughts of suicide cycled through my brain with regularity. A couple of weeks passed, and even basic tasks became insurmountable. I was in a near constant state of fight-or-flight. One Sunday evening I opened up my laptop to try and catch up on some things at work that I'd fallen behind on, and I couldn't focus my eyes to read an email. Panic began to set in, and I dialed my physician and then my therapist to try and make sense of what was happening. At the time, I placed much of the blame on my relationship, but I see now that I was in acute drug withdrawal. I fought my way through a haze of psychiatric evaluations, doctor's visits, emergency therapy appointments, the dissolution of my relationship, and a car accident (in which thankfully nobody was hurt). Eventually, at my own insistence, I found my way back to the original three medications I'd been taking, thinking that would be my best shot at finding some sense of stability. It's only been in the last month or so that I've felt some degree of what I would call stability, and I'm operating at about 75% of the mental capacity I once was, trying to pick up the pieces of my life and make sense of everything that happened. That search to make sense of everything is what led me here. I know that I do not want to be on a cocktail of medication for the rest of my life. I don't want to medicate my feelings or rely on a drug to fall asleep or live detached from my emotional experience. But I also know that right now, the right thing to do is to wait. I have to wait until my nervous system stabilizes and I can set up the proper plan and support system (the latter of which is made more complicated by the global pandemic we're all experiencing). If you have any advice for how I should go about tapering these medications based on my history, current dosage, and the experience described above, I am all ears. I look forward to actively participating in this withdrawal process alongside all of you, even if I need to wait a bit before I set out again. Much love.
  6. Well, i started to take antidepressants at 2017 for very strong anxiety, hard depression, panick attacks and insomnia. Im seventeen now. They tried some triciclics antidepressants first, and just as Fluoxetine they didnt seem to do anything, so the doctor prescribed me Desvenlafaxine (Pristiq) increasing the dose until 150mg at 2019 and asked me to quit school. At some point things started to fade away, and i coudnt even notice the changes, i was a zombie. So, i started feeling so numb and empty without even remember how does it felt to feel something, and i decided i had to quit those strong medicines... its important to notice that since 2017 i took more than 20 different types of sleeping medicines prescribed by the doctor at different periods and none of them seemed to work... and some other antidepressants in a very short trial, lets say a week or less... I decided to quit medications at December 2019, so i asked the doctor for help. He asked me for a 15 days tapering, and it was a disaester... he said he thought i couldnt live without medications, so i searched for another five doctors, with my family spending a lot of money... but all they did was trying to change the antidepressant or persist that 15 days of tapering was enough. At april of 2020 i was almost desperate... so, i thought my only option would be facing the cold turkey and i did a Prozac bridge trial for 2 days with 10mg hopíng it could make things less worst. Its been two months without any meds or specialist doctors help. Its been like hell... im having intense gastrointestinal reflux since, felling very weird in ways im not able to describe, having some crazy episodes of blood preassure fall and anxiety during the day, feeling very oscilating and numb... but still better than with the meds. Here in Brazil, doctors dont think antidepressants withdraw exists, family thinks my symptons are just another type of crisis and also dont know what to do. Im insecure to a point where i rather die than putting another of those pills in my mouth It feels like waking up from a coma... but also like hell. iv been reading a lot in this forum for help, but i feel so tired, and knowing that it can last several more months or even years at this mood, i dont know if i will have enough forces to keep enduring it... im tired, and things are tought, The antidepressants never solved any of my problems, but they destroyed my life. I want my life back, i really wanna have forces to endure it
  7. Hi group, may I introduce myself? I have had social anxiety and energy depression since childhood. I’ve been on Effexor since 1996 (24yrs!). This last month, I braved a medication review and the psych Nurse Practitioner added 2mg Abilify to boost my mood. The first pill took away all my body pains in an amazing wave... in a couple days I had more energy and less procrastination... but on day 11, I had shooting head and chest pains, scary blood pressure of 155/86 and heart rate of 100. My vision had zigzags in it. Of course I stopped taking it and called the Psych NP office. She told me that there was No Way a baby dose of 2mg could have caused the cardiac issue, and I should see primary care physician. I knew that Abilify has a long 4 day half-life (6day for some people) so I decided to wait and flush it out for 2 weeks. I drank hibiscus tea and went off caffeine and took some blood pressure meds as needed. The pains largely persisted. The psych NP then suggested I switch to Effexor’s potent daughter, desvenlafaxine (Pristiq). There would be a reduction in milligrams from 150 to 50mg but the overall effectiveness was supposed to be equivalent with less side effects (possibly not as likely to raise blood pressure). Since brand Effexor has become SO expensive and generic doesn’t work well for me - I agreed to try the des-venlafaxine. On the 3rd day I took a day nap and cried a little. On the 4th day I was wild with anxiety about my chest pains and sobbed when my physician let me come in for an EKG. The MD encouraged me to keep going on the Pristiq for 2 weeks, and keep working with the psych NP. The MD also made me feel more secure since the EKG and her other checks were OK. I was just freaking out, basically. So... The baby dose of Abilify caused a strong seratonin reaction in me, and dropping Effexor for its daughter caused a strong withdrawal reaction in me. I didn’t know what to think until I found this site, SA.org. What a giant help to get real information for once! Yes, SSRI and SSNRI’s have very, very strong effects on the body. I think I’m going to hold steady for a while, scared from these 2 bad experiences (btw I am being referred to a cardiologist). But I know now about NMT 10% dose tapering and that it is OK to remove the beads in Effexor, and OK to repackage in gelatin capsules...for when I am ready to try tapering. But is it worth trying Pristiq? Is it worth the hard shaky effort and strain to my relationship to go off Effexor??? My memory is shot and my blood pressure is high. But will they get better?
  8. angielynn78ii Over the last 10 years I’ve been on antidepressants. At different stages I was on Pristiq, Celexa, Cymbalta, Viibryd and Prozac. I was also on Lamictal and Klonopin. I am proud to say that I am currently free of all prescription medications. I took my last dose of Prozac 27 days ago. I’m surviving but I look forward to thriving. I could say so much and really want to share more but currently I just don’t have the energy or clarity. I will write again when able.
  9. Mikefeelworst Hi everyone, I am Mike. I just joined here. I am 18 years old. I got diagnosed depression and anxiety one year ago. And I spent one year on Pristiq. When I get better, my doctor decreased it to 25mg, I remember that I spent two months on it. Then I came off it. The nightmare is begin. At the first few days I started insomnia, don't want to eat, those symptoms are not terrible. After that I starting to become a zombie.Everyday is getting worse. Emotion numb, mind blank,. So I know that I have to take it again. So I starting again on last month 1st and added zoloft on 28th until now. Now, I am still emotion numb and my brain is very bad. Few days ago I just met my doctor, I told him I 'lost emotion experience' he don't believe me. He said those symptoms is impossible to happen on me. My family don't believe me too they think that I really want to sick wtf. They think I am just depression , anxiety and think too much. I think that I have got schizophrenia negative after withdrawal. I am so scare now. My mind is blank and I scare that I will develop Intellectual disability. And I am worry that I can't take care myself in the future. I don't know is that the side effect or something. Anyone experienced exactly the same thing like me? I don't want my life end in here.
  10. Luvtoride

    Luvtoride

    I've been antidepressants close to 30 years. I've tried prozac, paxil, zoloft, wellbutrin, most of the SSRI meds. I have no record of the dates and doses. I'm on Pristiq now and have been for over 5 years. I take 100mg/day. I really feel this is no longer helping me and want to discontinue the drug.
  11. Thankful to have come upon this forum and I’m thankful for all those contributing their time, experience, help, and care to so many. I just wish I would have found this a very long time ago. I consider myself an educated, intelligent woman. That I have been duped for so long could easily lead me to take it out on myself. I imagine it’s something I’ve known for a long time, but the “professionals” kept telling me that the recurrence of severe depression/anxiety after stopping the meds was just proof that I needed them, forever, and after so many failures, I believed them. I am about to turn 59 and have been on antidepressants for over 30 years. I will add a timeline to my signature very soon. My most-immediate issue involves the past 9 months and I was needing your help to try and decide what to do next. My next appointment with my psychiatrist is in mid-February. I’ve only seen him once before, but it was obvious he didn’t believe in slow tapers, although he did acknowledge withdrawals. In April, 2019, after being on Effexor for about 20 years, my then psychiatric nurse practitioner decided that I must be bipolar 2 since the medication was no longer working. She tried to convince me, even though I had never experienced hypomania. What transpired after that was a nightmare. I made a big mistake trusting her. Here’s the timeline of these past 9 or 10 months in a nutshell: April, 2019: Effexor 37.5 (had been on that dose for 2 years, but on Effexor for about 20) April 11, 2019 Latuda 20mg added to Effexor. April 22, 2019 Latuda increased to 40mg. Terrible panic (hadn’t had a panic attack in 20 years), terrible nausea, doom and gloom, facial ticks, etc. May 14, 2019: Latuda reduced back to 20mg. Still on Effexor 37.5. Panic and doom and gloom continue. May 27, 2019: Latuda reduced to 10 mg for 3 days then ct (per dr’s orders). Continue on Effexor 37.5. June 10, 2019: Rexulti added. Started w .5 mg a few days then increased to 1mg. June 5, 2019: Rexulti reduced to .5mg. July 1-24, 2019. Rexulti reduced to .25mg over couple of weeks then off. July 24, 2019: New psych had me CT off Effexor. When I brought up the idea of tapering it slower, she laughed, saying I was on almost 0 already. I should have trusted my gut, but didn’t. Within two weeks, I was in a crippling depression with lots of anxiety/panic and suicidal to an extreme. I can’t recall ever being this depressed, or that it was even possible to feel this bad. September 9, 2019, began Viibryd (low dose, not sure mg) via original psych NP. CT per dr’s orders on September 19 due to side effects. September 23, 2019, began Trintellix. Terrible nausea, pain. CT per dr’s orders on September 27. September 28, 2019, began 10mg Prozac. Helped calm the depression, but made me very anxious. Legs shaking up and down, inner agitation (not anger) October 24, 2019: Saw a new NP at the clinic of a new-to-me psychiatrist since I couldn’t get in with him until the end of December. She had me do a rapid taper of Prozac while starting on Pristiq 25mg for 10 days, then 50mg after that. Began having tinnitus, muscle pains, headache, neck pains, but depression and anxiety much better. December 26, 2019: Saw new psychiatrist. He wanted me to stop Pristiq (because of the side effects) by skipping it every other day for a week then switch to Cymbalta. I declined, knowing that my cns was already in an uproar. He then lowered my Pristiq down to 25mg. Without him knowing, I thought maybe cutting my pills to gradually lower to 25mg would be better. I took 25mg + 1/8th of a 50 (6.25) in the morning then another 6.25 12 hours later. I did this for 3 or 4 days but couldn’t take the side effects (stomach pain, tremors, flu, headache, etc). Decided cutting the tabs wasn’t going to work. Began just taking the 25mg tablet after those 3 or 4 days. Symptoms improved immediately. Have been on this dose since. So, here I am now. The Pristiq 25mg is feeling like it’s too much, but, then again, I don’t know if it’s the Pristiq or withdrawals from all the other junk my body has been fed the past 8-9 months. It’s really not too bad, though. I have tinnitus, muscle pains in my upper body and arms, some mild restlessness, itchy eyelids, and I feel kind of drugged. I really expected to feel worse. I’m a poor metabolizer of serotonin (SLC6A4), poor metabolizer at CYP2D6, plus I have slow motility of my intestines due to surgery for a small bowel obstruction 7 years ago (caused by adhesions). Small dosages go a long way in my body. The other huge factor is this medicine is causing high blood pressure (162+/82+) and I just had open-heart surgery 1.5 years ago to repair a rare congenital birth defect. I cannot afford to have anything messing with my heart. I’ve been off all heart medications since 3 months after surgery. The psych and NP new all of this information. I had even checked with my cardiologist to make sure Pristiq was ok (before taking the first dose). He said it should be, stating that only a small % had issues with it. I need to get off of Pristiq and AD’s in general. I just don’t know what to do. I want to have a plan thought out before my next appointment mid-February (or sooner, if you think it’s needed). After spending a lot of time reading this forum, I believe my three best options are: Stay on Pristiq and taper down using compounded dosages. The problem is that I live in the middle of nowhere, rural community, and have tried to find a compounding pharmacy in my state who will compound Pristiq. So far, I haven’t found one who would agree to do it. I’ve used the compounding pharmacy finder link here in SA. I have not heard back from everyone, though. My body does not tolerate the cut pills. The main drawback to this option is my blood pressure. I think the reason Effexor didn’t affect my BP much was because at the low dose, the norepinephrine didn’t kick in. But, with the Pristiq, it must kick in at the lower dosage. This is my theory, anyway. Switch to Effexor. I like this option solely because it would be easier to taper, in my opinion. It would also be better for my heart, unless I had a bad reaction switching back. That’s the main disadvantage of this option...not knowing if I’ll have a bad reaction getting back on the Effexor after being off 5+ months. My hope would be that the Pristiq is close enough to Effexor and my CNS wouldn’t be too angry. Do nothing and stay on the Pristiq 25mg for a few months, waiting for things to calm down. Again, the main disadvantage is the unknown. I’m not sure I can stand this dose for too much longer. It just feels like too much. My fear is that if I stay on this dose it will wreak more havoc on my system. Then again, maybe what I’m feeling is withdrawals. Also, if I stay at this dose, chances are that my BP will remain high. I can go on BP medicine, but that’s another can of worms. What would you recommend? I’ll admit that I’m very scared. I know that, all-in-all, I’ve been pretty lucky these past few months. I also know it could go south at any moment. Thank you for taking the time to read this and sharing your expertise. Note: I also take Ambien 10mg nightly, clonazepam .125mg nightly, omeprazol 20mg daily (but in process of reducing to Pepcid otc), Synthroid 125 mcg and Premarin .625 daily (long story). Also 1000 vitamin D3. After reading this forum, I know I need to address the ambien, clonazepam, and acid reducers, at some point. Was taking B complex, a multi-vitamin, and fish oil for years before these past 9 months. Can no longer take them due to side effects. Tried taking a very small amount of b12 and a very small amount of magnesium glycinate. Both gave me a bit of anxiety so stopped taking them.
  12. I'm a 25 year old female. I began taking Wellbutrin 75 mg in February 2019. I realized that my anxiety increased significantly, so my doctor suggested adding on another medication. I began Pristiq 25 mg at the end of November 2019. It made me calm down, but lowered sex drive. Could get turned on but not masturbate. In late December 2019 I developed Serotonin Syndrome, because I used St. Johns Wort along with these medications and accidentally took two Pristiq one day. I couldn't feel or think. I was almost catatonic. I was numb from my face to my feet. My ****** included and I didn't even find anyone attractive. No interest in sex. Emotionally, I couldn't feel much, but cry sometimes out of fear. I couldn't remember things or focus. I couldn't feel when I had to pee or poop. My doctor wanted me to wean off the Pristiq. She told me to take my pill every three days for two weeks. I began doing that Tuesday January 6th. I saw minor improvements throughout the week and the Sunday January 12th, it seemed as though it all lifted. I felt like me again. I could laugh and cry. I felt desire for love and a relationship again. I could masturbate and orgasm and they were intense. I was so relieved and happy that I only had one more week of taking Pristiq. I was happy that I felt like a person again. I took my Pristiq the next day, Monday, January 13th. I was weary about it, but figured I should wean myself off it one more week like the doctor instructed. I heard the withdrawals were brutal anyways. I felt great Monday. Tuesday and Wednesday it slowly went downhill. I could still masturbate and orgasm until Wednesday evening. My ****** became dry. I couldn't get turned on. My head felt heavy and my forehead became numb. I didn't feel like myself. Again. I can display very few emotions, except to cry sometimes. I don't care about anything and feel detached. Today, I could *****************, but I don't feel anything. I felt a little more like myself in the morning, was able to cry during a tv show and feel slight sensation when someone kissed. I But now going into the evening, I am losing these feelings again. I spoke with the doctor and she told me to stop taking the Pristiq. So the last one I took was on the 13th. Is this normal? The beginning of PSSD? (I know it's early, but this is odd) Anyone experience anything similar? Any support while I go through this would be wonderful. I will keep everyone updated on my progress if they are interested. I have a comprehensive list of my symptoms and medications I was taking up to this point included. Untitled 3.pdf
  13. Hey everyone, this is my story. About 13 or so years ago when I was 13-14 (I'm now 27) I had my very first panic attack which terrified me so bad that literally the next day I was at the doctors begging for meds, I did this because I didn't know any better and I wanted the anxiety GONE... I had health anxiety and every little pain, ache, sensation or feeling whatever it was, had me convinced I had a terminal illness and that I was dying which lead me to the panic attack after weeks of worrying about it, I should also mention I'm not sure where the worry came from because prior to that I was fine.. So I started on 50mg of Pristiq and back then I thought it would work like a benzo and relieve symptoms straight away but honestly it made my anxiety worse, I felt weird on it, for some reason death was on my mind more than ever like I would be down about the thought of me dying one day, my family dying,all these weird thoughts that I never had before and not what a typical13 -14 year old would have.. I stayed on it and for about 2 weeks I was absolutely bed ridden with intense anxiety, I could barely leave my room to pee, finally the tablet kicked in because I woke up 1 day nearly a few weeks in and my anxiety was almost completely gone, not to mention I felt a lot happier than before to, my life was back on track and I even got myself a part time job for after school at a fast food place, life was pretty great I mean I did notice I felt like I was in a dream kind of world but I didn't look to much into it, the anxiety was still there but not as intense, I found myself always getting reassurance which kind of worked but at the time I didn't realise that's such a bad thing to do and makes it worse, fast forward a few years later I was still on Pristiq 50mg, working and attending school, life felt like it use to, as I got older a pattern developed, out of know where an intrusive thought would come in my head which by the way happened a lot but normally I could disregard, however every so often the thought would be to complex and it would consume me, literally to the point where I would be bed ridden exactly like I was when it first started, this led to me having a dosage increased to 100 mg and being introduced to Zyprexa to help manage anxiety and sleep, at first I only stayed on the Zyprexa a couple weeks and never had it again as it made me to drowsy, fast forward to recently where I stopped Pristiq 100mg cold turkey purely because I couldn't afford it one week and my attitude was "I feel normal anyways I'm cured from anxiety" that lasted 6months lol, I should mention that withdrawal for the first few days was hard but I got through it but keep in mind, I was regularly attending the gym so that helped a lot and back then I never knew about withdrawal symptoms I thought it was like a week and then it's out your system, and honestly for a while in that 6 month period I actually did feel better off them because I appreciated life a lot more as I didn't feel as emotionally numb, a nice sunny day made me feel joy like never before it was so alien how magnified my feelings became, anyways after 6 months of course the health anxiety was back as well as weird physical symptoms I never had before, tingling and tightness in my head like a rubber band being squeezed, bowel and tummy issues, intense intrusive thoughts ect... Anyways I ended up back on pristiq but it wasn't like being on them before it felt different, I hated it and got hit with intense suicidal thoughts which lead me back on Zyprexa as well as pristiq, that lasted about a year until I cold turkeyed both the Zyprexa was first to go which was so hard to do omg man 😕 a few months later I cold turkeyed pristiq, if anyone out there is considering for the love of god don't cold turkey!!!! it's been a year to this day since I had a pristiq and a few months longer since Zyprexa, in the last year I've felt: depersonalisation/derealisation, intense head pressures and pains, vision problems, bowel problems to the point I had a colonoscopy to make sure I didn't have bowel cancer, I had a CTscan on my head to make sure it's not a tumour putting me through this hell, extreme anger and depression, extreme sleep problems, sex drives gone downhill a bit, I'm paranoid like it honestly feels like I'm in fight or flight 24/7.. The worse anxiety I've ever felt, the hardest symptoms I've had to deal with and this is what has lead me to join this group, I don't know if I'm hallucinating, but it feels like I can see my own thoughts in my head clearer than the real world in front of me.. I know it sounds strange, I feel trapped in my own mind I can easily ruminate over my intrusive thoughts and visualise them more than I can pay attention to the real world and I hate it will this nightmare ever end?Have I done PERMANENT damage? Sometimes the head pain hurts a lot I feel like I'm seconds from dying from the pain, like it's getting worse I constantly ask myself if I should go back on the meds and taper off but it's been so long plus I hate the meds I want nothing to do with them, any advice would be great I'm sorry for the novel
  14. i’ve been on antidepressants for approximately 10 years doctor put me on different kinds. Just want to be off of them. Recently I was put on mirtazapine to help get off of Pristiq and now I am experiencing with drawl symptoms from tapering down on the mirtazapine. I am withdrawing from mirtazapine at present I would like to be part of a support group to help me get through And to learn if there’s anything I can change i.e. diet to help lessen the symptoms of withdrawal.
  15. I've followed the Facebook page for this group for a bit now and thought I would add my own experience with antidepressants. So, I've been on antidepressants of and on (but mostly on) for about 21 years. The couple times over the years I got off of drugs like Paxil, Celexa, and Lexapro was by doing it the (wrong) way my doctor said to. The Ole' skip a day then every two days then voila! your done. I did that a couple times and I seemed to be good. But within 6 months, I was right back on something else. I mainly suffer from anxiety/panic and luckily don't suffer from depression; however, a year and a half ago I had my first case of depression which hit like a ton of bricks. Luckily for me, it was gone within a couple days. Phew! About 10 years ago, while on Paxil, I felt like a lot of anxiety was creeping in once again. I told my doctor at the time who was an internal medicine doctor this, and she said, "oh, you need to try this newer drug called Pristiq! It's an SNRI, not an SSRI." Without thinking anything of it, I was put on 50mgs of Pristiq-which was the lowest dose, at the time and off I went. I don't remember having any trouble what so ever making the switch. Fast forward to the summer of 2017-new doctor and I was feeling great - all things considered. I decided I wanted off. And I wanted off because I was starting to hear more and more people were being forced off their Pristiq and other antidepressants because the insurance company's didn't want to pay for them anymore AND I had watched people the prior Fall get hit by a hurricane in which many were forced into withdrawal because they couldn't get their refills because of damage to businesses/pharmacy's, etc. I didn't ever want to be "forced" off my medication for any reason and then have to endure possible side effects. So, in May of 2017, I began my journey that would (little did I know it) begin a two year struggle to get off antidepressants! I did the common thing at the beginning by telling my doctor that I was feeling good and was ready to jump off of my Pristiq. She agreed and said the usual...since I was on the lowest dose already, and the pills were extremely difficult to cut in half, skip a day for the next 2 weeks, then skip two days for the following 2 weeks, then stop. So the first two weeks were a bit unnerving and difficult but I powered through! Then came the second two weeks of skipping two days. After just the first try I was a mess! A complete mess! I had major anxiety, headaches, brain zaps, dizziness, the usual. I started pouring over the internet to find help because I knew there had to be another way! I started educating myself after finding a Facebook group that spoke of withdrawing off of Pristiq and learned a lot! I called my doctor's office and told them I needed to see her ASAP! because I was really struggling. Luckily, she got me in that same day. I told her how awful my experience was to get off this drug and she agreed that Pristiq is tricky to get off of. She said she doesn't really ever prescribe it but knows of docs that do, but mainly for menopausal symptoms! Since I came to her as a new patient back in 2011 and was already on the drug, she kept me in refills. So, at this point I told HER what I wanted to happen. Because I learned that there was now a 25mg pill which she had no idea of, I wanted her to prescribe this to me to help get me off. Then I told her that if that worked ok for me, I would then like to start compounding the drug down using a compounding pharmacy. I really had to educate her on the fact that this drug needed to be tapered off very slowly to have the best chance of getting off. She said she had never heard of that being done but was willing to work with me to get me off safely. And I had to commend her for that because I have since read and heard of many whose doctors refuse to help them in this manner get off their antidepressants. So I picked up my 25mg prescription from the pharmacy, headed home, and continued researching. I stayed on the 25's for 1 month which is when she wanted me to return to let her know how I was doing. I'll be honest here, it wasn't super easy. But, it was manageable. At my next appointment with my doctor, I came with compounding pharmacy info in hand and told her to call in a script for 15mg's to last a month with one refill in case I felt I needed to continue longer. My plan was to stay on that dose til ALL side effects were gone and to not jump down in dose until then. So, I completed the next month with the 15's and at that following appointment told her I was still doing ok, and that I'd like a new script for 12 mgs compounded. She obliged. Another month with that dose and still hung in there. The next month I asked for a 9 mg dose to be compounded. Did that for about 1 week and BAM! The side effects were so bad, I just couldn't handle it. I went back into her office right away and told her that the jump from 12 to 9 was too difficult and that I was going to refill the 12's but now I needed to taper off 1 mg per month! The lower I got in dosage, the higher my anxiety was, however, I was determined to get off this stuff. At 3mgs, I jumped completely off. Unfortunately, at that point in my life, I had some major family stuff going on which only contributed to my anxiety! I was off completely for 16 days. During that time, and because of what was going on in my life, the anxiety and panic left me in a state of not wanting to leave my house. It was really hard. I made an appointment to see my doctor again as I was starting to feel desperate. I didn't want to feel this way anymore. NOTE During this time of tapering, I learned a lot about helpful supplements to aid me as I tapered - ones for brain health and helping the inflammation that occurs in our brains as a result of taking these meds. I also cut out most sugar/gluten in my diet as both cause inflammation and can contribute to anxiety/depression. I also sought out a Naturapathic doctor in my area who ran extensive blood work to look for any deficientcy's that could contribute to how I was feeling. That's another thread that I can speak about in the future!!! (Magnesium L-Threonate/Glycinate/Citrate is your friend!!! Along with a high EPA fish oil, and Turmeric/curcumin supplementation!) So while sitting in my doctor's office feeling major anxiety, I caved. I told her I didn't want to feel like this anymore and that I was willing to try a low dose SSRI to see if it would help. I tried Zoloft first but had an allergic reaction to it 13 days in (it didn't make me feel good anyway) so I stopped that and switched right over to 10mgs of Paxil. I have to be honest...it did help. Within 24 hours I could feel my anxiety lessening. However, now I felt like a failure. I failed at getting off of antidepressants. I ended up staying on Paxil for a year. Then, because of some side effects that I can only attribute to the Paxil, decided I needed to get off this and NOW. I broke the 10's in half and for two and a half weeks, I took 5mgs. I have now been antidepressant free for almost 2 weeks and I feel GREAT! The only thing I have experienced is a slight tingling around my mouth and ever so slight anxiety but it feels more like an adrenaline rush; like when someone scares you and you jump. Granted, I know it hasn't been that long, but what a difference I feel now from what I felt a year ago. I still have a little stress in my life - but who doesn't ?? I've continued with my supplements and eating the best that I can and I believe that it has completely helped me get through the hardest parts. Looking back, I don't know how anyone could ever get off these drugs without doing some kind of taper! And, over the last year and a half, I have tried to help hundreds get off Pristiq. I am a contributor/moderator/admin in a facebook group that does just that! We help others see that the safest way off this drug is a slow taper. Many people learn the hard way, like most of us. But then we see that success is "slow and steady wins the race!" There is hope on the other side! We need to educate people and the medical community that the drug manufacturer's way is not a good way! I mean, why would they want us off their drugs anyway? They would stand to lose billions of dollars. They are setting us up for failure so we need to stand up and prove them wrong. Thank you for allowing me to share my story...
  16. Hi, I'm new to the group and will start with a brief history of medications I started taking prozac at 17, didn't take it long. 2 years later, I overdosed on quite a bit of expired prozac. Yeah, not the ideal way to go out. I experienced seizures for 4 weeks after this. I was then put on several medications including: zyprexa, and later: abilify, wellbutrin, respiridol, tegeretal, and several others. I hated them so eventually stopped. Fast forward 13 years, I was recently prescribed pristiq. I was taking 50 mg for almost 2 months and realized it wasn't helping so I just stopped taking it cold turkey. I didn't think it would be a big deal since i wasn't taking it long. Well i was wrong. Its been horrible, its been a little over a week since stopping and ice experienced Weeping, crying spells for nothing. Screaming and yelling, extreme mood swings and extreme anger, and some others id rather not say now. On a positive note...today has been much much better... Anyway, sooooo that's where im at. I do firmly believe these medications have added to or posdibly even caused more problems
  17. I came across this forum in the recent New Yorker article and I’m excited to connect with others going through similar experiences. I’ve been dealing with this in isolation for far too long. JAN 2019 Over the years, I’ve been put on an increasingly complex regime - see signature. At the start of the year as I understand it, the mainstays were Wellbutrin + Pristiq, augmented by Latuda. Plus Adderall to combat daytime lethargy. I wasn’t satisfied: 1) I don’t like being on so many meds. I felt a personal stigma, plus I’m scientifically trained. Surely this was too many variables in terms of optimizing further. 2) I was still suffering from evening lethargy, basically crashing out around 8-9pm which was impacting my relationship and family. 5mg Adderall and a coffee at 7pm, and I could still pass out an hour later. WHERE I AM NOW: STREAMLINING MY REGIME This year, I’m working to simplify the regime with my psych. Immediate goals - taper Pristiq, stop Latuda. 2019 goal - reduce to two or three meds. To taper the Pristiq, we added 10mg Prozac. We also added Abilify to replace the Latuda, which I hope to discontinue soon. So I went from 4 meds to 6, hoping this makes sense. The Pristiq tapering has been a real journey - The hardest phase was when I was taking 50mg every 2 days, then every 3 days. - Thanks to this forum, I read that that was a bad idea (the rollercoaster certainly felt like one), and we switched to 25mg daily. Thats where I am now. - The switch from 50 mg every 3 days -> 25mg daily surprised me by being the hardest transition in terms of depressive symptoms. This was combined with a foot injury which meant I couldn’t exercise much. When it rains, it pours! Would love to hear your thoughts on any of the above. Stay strong.
  18. colinsma

    colinsma: Pristiq

    Omg, so much info on how to taper/discontinue Pristiq - been on this med for about a year... The posts seem to be old. Wondering if there's more updated trials on how to taper/discontinue this med. I have been taking antidepressants for years (my son died). I am just wanting not to be on this med. I think it's called a "washout" - at least for a while. As many know, one of the side effects is a bit of numbing; I cannot cry on this med - not that I want to cry - but if a med is that powerful, it makes me wonder what the hell else it's doing to my body. Thanks to for any help from a moderator or to anyone else who is going through this same experience. I just am wanting to do my "homework" before my doc appointment this July.
  19. Hi, I am new to this group. I am trying for a baby in a few months and seeing my specialist today to come off my antidepressants, as they are unsafe for pregnancy. I am on 100mg Pristiq and assume he will taper me off. Has anyone had experiences with tapering off Pristiq and what to expect? Thanks for having me here 😊
  20. I started my tapering off yesterday. I've done tapering before but only to prepare for a newer prescription. This time I have decided to taper off of everything. I am feeling the withdrawal symptoms but am determined to muddle through them. I have an appointment with my psychiatrist tomorrow and will tell him what I am doing. It's very scary to me because I don't know what to expect because I've been on something or another for the past 27 years.
  21. Frankle WG, et al. Synapse. 2018 An open-label positron emission tomography study to evaluate serotonin transporter occupancy following escalating dosing regimens of (R)-(-)-O-desmethylvenlafaxine and racemic O-desmethylvenlafaxine. Authors Frankle WG1, Robertson B2, Maier G3, Paris J4, Asmonga D4, May M4, Himes ML4, Mason NS5, Mathis CA5, Narendran R4,5. Author information 1 Department of Psychiatry, NYU Langone Medical Center, New York, New York. 2 Shire Pharmaceuticals Inc., Lexington, Massachusetts. 3 MaierMetrics and Associates, LLC, Boston, Massachusetts. 4 Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. 5 Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania. Citation Synapse. 2018 Mar;72(3). doi: 10.1002/syn.22021. Epub 2017 Dec 13. Links https://www.ncbi.nlm.nih.gov/pubmed/29216407. Full text available here (requires membership) https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.22021 Abstract SEP-227162 [R(-)-O-desmethylvenlafaxine] is an enantiomer of the venlafaxine metabolite O-desmethylvenlafaxine (ODV, Pristiq™, Wyeth). This study compared the serotonin transporter (SERT) occupancy achieved by SEP-227162 and ODV, at daily doses of 25, 50, 100, and 150 mg using [11 C]DASB positron emission tomography (PET). Sixteen healthy male subjects participated in one of four dose groups (N = 4 per group) during which they were administered two doses of the study drug (SEP-227162 or ODV). For each study drug, total daily doses of 25, 50, 100, and150 mg were studied. Subjects underwent three PET scans with [11 C]DASB. A baseline, off-medication, scan was performed prior to dosing and a [11 C]DASB PET scan was performed after 72 hr at each dose level. [11 C]DASB binding potential (BPND ) was calculated using the simplified reference tissue method. SERT occupancy was calculated as the change in BPND (ΔBPND ) from baseline scan to the on-medication scan relative to the baseline BPND value. SEP-227162 and ODV significantly reduced regional distribution volumes and region BPND values in a dose-dependent manner. Across all doses ODV produced significantly greater SERT occupancy than SEP-227162 (ANOVA F = 21.8, df = 1,23, p < .001). The total daily dose required to provide 50% SERT occupancy was 24.8 mg for SEP-227162 and 14.4 mg for ODV. In vitro data suggests a ratio of 3.3:1 for binding at human SERT for SEP-227162 relative to ODV. Our study suggests a ratio of 1.7:1, highlighting the value of in vivo imaging in the drug development process. PMID 29216407 [Indexed for MEDLINE].
  22. University of British Columbia Pharmaceutical Sciences Student Journal, Volume 3, Issue 1, March 21 2016, pages 31-33. Preparation of Lower Dosages of SNRI Antidepressants to Ameliorate Discontinuation Symptoms: Two Case Studies. Benton Attfield, B.Sc. (Biology), B.Sc. (Pharm) Lori Bonertz, B.Sc. (Pharm) Cory Hermans, B.Sc. (Pharm) Valerie Kantz, Senior Pharmacy Technician. Full text pssj-v03-i01_attfield.pdf Abstract There is a large body of evidence showing that adverse effects experienced with antidepressant treatment ameliorate over time and that disease-state symptoms improve for many patients. However, there is a paucity of information relating to how to stop these medications when a patient’s depression has remitted. Presented here are two cases that demonstrate the role pharmacists play in helping patients discontinue SNRI medications through the preparation of lower strength dosage forms. From the paper:
  23. I’ve been on antidepressants since I was 13 diagnosed when I was 13 with depression and anxiety disorder. When I was 18 I was diagnosed with major depression after suicide attempt. At 27 years of age now my new doctor of just one month diagnosed me with bipolar 2, I believe solely on the fact that my mother is bipolar one and she believes I’m “genetically prone” to this disorder My medication history. First it was lexapto, then Prozac then Wellbutrin, then cymbalta and Xanax now tapering off pristiq which I personally find the worse. And now I’m put on lamictal. My doctor seems to think I can withdrawl from my pristiq (100 mg) which I’ve been on throughout a year time span, in “two weeks” and being put on 200 mgs of lamictal it should “ counteract the withdrawal “ . I’ve been out of work for a year (previously a full time teacher”. I feel like I’m losing my mind for lack of better words. I’m so desperate and truly believe big pharmaceutical agencies just want to make money off of me (us) . I’m lost and isolating myself, my life is falling apart, and I’ve never been in a worse mental state than I am now. I’m here for help and reassurance I suppose. Don’t know how much longer I can do this. -Amy
  24. I've been taking Pristiq 100mg (plus 5mg Somit to sleep and 100mg Activigil to wake up) for the past 3 years more or less. I've been trying to quit Pristiq for many months due to HORRIBLE withdrawals whenever I forgot even one pill. I got to down the dose to Pristiq 50mg after enduring two weeks of those horrible withrawals and then they were gone, luckily. Now I'm trying to figure out my next step. There's no Pristiq 25mg where I am from. My psych told me to switch to venlafaxine 75mg three days ago, not the XR, the regular. It has such a short half life that I'm having horrible symptoms as well, even though I'm taking 37,5mg in the morning and 37,5mg in the afternoon. I'm trying to figure out if this is the best way to quit Pristiq. She says I should stay with venlafaxine and taper down from it. I'm worried about feeling awful. I can't function. Should I stay with the venlafaxine or switch back to Pristiq 50mg and figure out something else? Should I bridge with Prozac form Pristiq? Should I stay with venlafaxine and THEN bridge with Prozac? Should I just taper down from venlafaxine? By the way, thank you all for describing so accurately all the discontinuations sympotms of the Pristq- the brain zaps, the headaches, the dizziness, the confusion. What has this done to us? I want out.
  25. I started taking pristiq some time in June. I started feeling like I wanted to avoid my family and just go out by myself. I never want to cuddle or be intimate with my husband anymore and I all of a sudden want attention from other people. This is extremely out of character for me. I dont know if its the medication or what but its really scaring me. I feel like i could just run away from my life and not look back but I know this isnt me. Has any been in a similat situation??? I'm feeling so helpless.
×
×
  • Create New...

Important Information

Terms of Use Privacy Policy