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  1. Hi, this is my first post here, (your case is similar to mine - mod note: moved from Shaesurf's topic), my doctor recommended to me to stop cold turkey after six months and a half using Pristiq (before that I used Sertraline and I had a unbearable delayed withdrawal three months after I stop it cold turkey by medical recommendation, and the doctor didn't saw it as withdrawaw symptoms), and I on my own decided to cut the pills and I tapered for 8 weeks (54 days), that way: first week 3/4, second and third weeks 1/2, fourth week 3/8, fifth and sixth weeks 1/4, seventh week 1/8 and the eighth and last week 1/16. And then I started meditating (I went to a 10 day vipassana meditation retreat the day I stopped), and I had just a little bit of anxiety after the retreat and a hang-out like discomfort sometimes when I wake up but that's it. Tomorrow it will be one month since I stopped it and I'm doing fine so far. I take magnesium supplement, Lugol's iodine solution at 5%, and eat only raw vegan food.
  2. I want to know how to detox from all the psychiatric drugs that I took in order to make possible for my body not to need to take them anymore and to eliminate all the side effects that the psych drugs gave me. This is all the drugs that I took from psychiatrists: when I was 16 years old I took first paxil and rivotril (clonazepam) for a year and then only epival er (valproate semisodium) for a year and Then when I got 21 I took paxil and rivotril for 6 months. I changed to a 2nd psychiatrist he gave me symbyax (olanzapine and fluoxetine) I was with him for 4 months, then I went with a 3rd shrink that gave me lamictal and abilify for 6 months so then I changed with a 4th doctor which was a "neurologist" who gave me strattera for ADD and told me to go with his partner who is another psychiatrist (5th doctor) who added me sertraline, topamax (topiramate), olanzapine, lamictal, and because of the tachycardia that were produce by this drugs he added inderalici for my tachycardia. So after 7 months with this doctor I went with a 6th doctor that gave me paxil, rivotril, lithium and for my ADD he gave me methylphenidate (commercial name is tradea LP which is similar to Concerta). After 6 months with this doctor I changed to a 7th doctor that gave me sertraline in a very high dose and with this I decided to stop taking that pill a was taking but in a one day span it caused me to have a psychosis that made my father send male nurses to kidnapped and locked into a clinic (like hospitalization), in which the skrink that trated me was the one that treated me when I was 16 and he injected me haldol and gave pills more haldol, biperiden, triazolam and risperdal. I LIVED HELL WITH THESE DRUGS. Then the shrink after he saw that I recover reality, I was super depressed so he gave me citalpram but it didn't work so he gave me paxil and lithium. Then I started coming off meds and now I just take one quarter of a lithium pill every day in the morning. My actual side effects that I want to eliminate are: anxiety, very strong heart palpitaions or beats/beating that cause bad breathing and chest pain, difficulty to take decisions, nausea, extreme itching in my face, head, chest and back, buzz in the ears, difficulty to focus or concentrate, bad short-term memory, and wanting to pee all the time. Thank you very much.
  3. I've followed the Facebook page for this group for a bit now and thought I would add my own experience with antidepressants. So, I've been on antidepressants of and on (but mostly on) for about 21 years. The couple times over the years I got off of drugs like Paxil, Celexa, and Lexapro was by doing it the (wrong) way my doctor said to. The Ole' skip a day then every two days then voila! your done. I did that a couple times and I seemed to be good. But within 6 months, I was right back on something else. I mainly suffer from anxiety/panic and luckily don't suffer from depression; however, a year and a half ago I had my first case of depression which hit like a ton of bricks. Luckily for me, it was gone within a couple days. Phew! About 10 years ago, while on Paxil, I felt like a lot of anxiety was creeping in once again. I told my doctor at the time who was an internal medicine doctor this, and she said, "oh, you need to try this newer drug called Pristiq! It's an SNRI, not an SSRI." Without thinking anything of it, I was put on 50mgs of Pristiq-which was the lowest dose, at the time and off I went. I don't remember having any trouble what so ever making the switch. Fast forward to the summer of 2017-new doctor and I was feeling great - all things considered. I decided I wanted off. And I wanted off because I was starting to hear more and more people were being forced off their Pristiq and other antidepressants because the insurance company's didn't want to pay for them anymore AND I had watched people the prior Fall get hit by a hurricane in which many were forced into withdrawal because they couldn't get their refills because of damage to businesses/pharmacy's, etc. I didn't ever want to be "forced" off my medication for any reason and then have to endure possible side effects. So, in May of 2017, I began my journey that would (little did I know it) begin a two year struggle to get off antidepressants! I did the common thing at the beginning by telling my doctor that I was feeling good and was ready to jump off of my Pristiq. She agreed and said the usual...since I was on the lowest dose already, and the pills were extremely difficult to cut in half, skip a day for the next 2 weeks, then skip two days for the following 2 weeks, then stop. So the first two weeks were a bit unnerving and difficult but I powered through! Then came the second two weeks of skipping two days. After just the first try I was a mess! A complete mess! I had major anxiety, headaches, brain zaps, dizziness, the usual. I started pouring over the internet to find help because I knew there had to be another way! I started educating myself after finding a Facebook group that spoke of withdrawing off of Pristiq and learned a lot! I called my doctor's office and told them I needed to see her ASAP! because I was really struggling. Luckily, she got me in that same day. I told her how awful my experience was to get off this drug and she agreed that Pristiq is tricky to get off of. She said she doesn't really ever prescribe it but knows of docs that do, but mainly for menopausal symptoms! Since I came to her as a new patient back in 2011 and was already on the drug, she kept me in refills. So, at this point I told HER what I wanted to happen. Because I learned that there was now a 25mg pill which she had no idea of, I wanted her to prescribe this to me to help get me off. Then I told her that if that worked ok for me, I would then like to start compounding the drug down using a compounding pharmacy. I really had to educate her on the fact that this drug needed to be tapered off very slowly to have the best chance of getting off. She said she had never heard of that being done but was willing to work with me to get me off safely. And I had to commend her for that because I have since read and heard of many whose doctors refuse to help them in this manner get off their antidepressants. So I picked up my 25mg prescription from the pharmacy, headed home, and continued researching. I stayed on the 25's for 1 month which is when she wanted me to return to let her know how I was doing. I'll be honest here, it wasn't super easy. But, it was manageable. At my next appointment with my doctor, I came with compounding pharmacy info in hand and told her to call in a script for 15mg's to last a month with one refill in case I felt I needed to continue longer. My plan was to stay on that dose til ALL side effects were gone and to not jump down in dose until then. So, I completed the next month with the 15's and at that following appointment told her I was still doing ok, and that I'd like a new script for 12 mgs compounded. She obliged. Another month with that dose and still hung in there. The next month I asked for a 9 mg dose to be compounded. Did that for about 1 week and BAM! The side effects were so bad, I just couldn't handle it. I went back into her office right away and told her that the jump from 12 to 9 was too difficult and that I was going to refill the 12's but now I needed to taper off 1 mg per month! The lower I got in dosage, the higher my anxiety was, however, I was determined to get off this stuff. At 3mgs, I jumped completely off. Unfortunately, at that point in my life, I had some major family stuff going on which only contributed to my anxiety! I was off completely for 16 days. During that time, and because of what was going on in my life, the anxiety and panic left me in a state of not wanting to leave my house. It was really hard. I made an appointment to see my doctor again as I was starting to feel desperate. I didn't want to feel this way anymore. NOTE During this time of tapering, I learned a lot about helpful supplements to aid me as I tapered - ones for brain health and helping the inflammation that occurs in our brains as a result of taking these meds. I also cut out most sugar/gluten in my diet as both cause inflammation and can contribute to anxiety/depression. I also sought out a Naturapathic doctor in my area who ran extensive blood work to look for any deficientcy's that could contribute to how I was feeling. That's another thread that I can speak about in the future!!! (Magnesium L-Threonate/Glycinate/Citrate is your friend!!! Along with a high EPA fish oil, and Turmeric/curcumin supplementation!) So while sitting in my doctor's office feeling major anxiety, I caved. I told her I didn't want to feel like this anymore and that I was willing to try a low dose SSRI to see if it would help. I tried Zoloft first but had an allergic reaction to it 13 days in (it didn't make me feel good anyway) so I stopped that and switched right over to 10mgs of Paxil. I have to be honest...it did help. Within 24 hours I could feel my anxiety lessening. However, now I felt like a failure. I failed at getting off of antidepressants. I ended up staying on Paxil for a year. Then, because of some side effects that I can only attribute to the Paxil, decided I needed to get off this and NOW. I broke the 10's in half and for two and a half weeks, I took 5mgs. I have now been antidepressant free for almost 2 weeks and I feel GREAT! The only thing I have experienced is a slight tingling around my mouth and ever so slight anxiety but it feels more like an adrenaline rush; like when someone scares you and you jump. Granted, I know it hasn't been that long, but what a difference I feel now from what I felt a year ago. I still have a little stress in my life - but who doesn't ?? I've continued with my supplements and eating the best that I can and I believe that it has completely helped me get through the hardest parts. Looking back, I don't know how anyone could ever get off these drugs without doing some kind of taper! And, over the last year and a half, I have tried to help hundreds get off Pristiq. I am a contributor/moderator/admin in a facebook group that does just that! We help others see that the safest way off this drug is a slow taper. Many people learn the hard way, like most of us. But then we see that success is "slow and steady wins the race!" There is hope on the other side! We need to educate people and the medical community that the drug manufacturer's way is not a good way! I mean, why would they want us off their drugs anyway? They would stand to lose billions of dollars. They are setting us up for failure so we need to stand up and prove them wrong. Thank you for allowing me to share my story...
  4. Hi, I'm new to the group and will start with a brief history of medications I started taking prozac at 17, didn't take it long. 2 years later, I overdosed on quite a bit of expired prozac. Yeah, not the ideal way to go out. I experienced seizures for 4 weeks after this. I was then put on several medications including: zyprexa, and later: abilify, wellbutrin, respiridol, tegeretal, and several others. I hated them so eventually stopped. Fast forward 13 years, I was recently prescribed pristiq. I was taking 50 mg for almost 2 months and realized it wasn't helping so I just stopped taking it cold turkey. I didn't think it would be a big deal since i wasn't taking it long. Well i was wrong. Its been horrible, its been a little over a week since stopping and ice experienced Weeping, crying spells for nothing. Screaming and yelling, extreme mood swings and extreme anger, and some others id rather not say now. On a positive note...today has been much much better... Anyway, sooooo that's where im at. I do firmly believe these medications have added to or posdibly even caused more problems
  5. I came across this forum in the recent New Yorker article and I’m excited to connect with others going through similar experiences. I’ve been dealing with this in isolation for far too long. JAN 2019 Over the years, I’ve been put on an increasingly complex regime - see signature. At the start of the year as I understand it, the mainstays were Wellbutrin + Pristiq, augmented by Latuda. Plus Adderall to combat daytime lethargy. I wasn’t satisfied: 1) I don’t like being on so many meds. I felt a personal stigma, plus I’m scientifically trained. Surely this was too many variables in terms of optimizing further. 2) I was still suffering from evening lethargy, basically crashing out around 8-9pm which was impacting my relationship and family. 5mg Adderall and a coffee at 7pm, and I could still pass out an hour later. WHERE I AM NOW: STREAMLINING MY REGIME This year, I’m working to simplify the regime with my psych. Immediate goals - taper Pristiq, stop Latuda. 2019 goal - reduce to two or three meds. To taper the Pristiq, we added 10mg Prozac. We also added Abilify to replace the Latuda, which I hope to discontinue soon. So I went from 4 meds to 6, hoping this makes sense. The Pristiq tapering has been a real journey - The hardest phase was when I was taking 50mg every 2 days, then every 3 days. - Thanks to this forum, I read that that was a bad idea (the rollercoaster certainly felt like one), and we switched to 25mg daily. Thats where I am now. - The switch from 50 mg every 3 days -> 25mg daily surprised me by being the hardest transition in terms of depressive symptoms. This was combined with a foot injury which meant I couldn’t exercise much. When it rains, it pours! Would love to hear your thoughts on any of the above. Stay strong.
  6. Hi, I am new to this group. I am trying for a baby in a few months and seeing my specialist today to come off my antidepressants, as they are unsafe for pregnancy. I am on 100mg Pristiq and assume he will taper me off. Has anyone had experiences with tapering off Pristiq and what to expect? Thanks for having me here 😊
  7. colinsma

    colinsma: Pristiq

    Omg, so much info on how to taper/discontinue Pristiq - been on this med for about a year... The posts seem to be old. Wondering if there's more updated trials on how to taper/discontinue this med. I have been taking antidepressants for years (my son died). I am just wanting not to be on this med. I think it's called a "washout" - at least for a while. As many know, one of the side effects is a bit of numbing; I cannot cry on this med - not that I want to cry - but if a med is that powerful, it makes me wonder what the hell else it's doing to my body. Thanks to for any help from a moderator or to anyone else who is going through this same experience. I just am wanting to do my "homework" before my doc appointment this July.
  8. I started my tapering off yesterday. I've done tapering before but only to prepare for a newer prescription. This time I have decided to taper off of everything. I am feeling the withdrawal symptoms but am determined to muddle through them. I have an appointment with my psychiatrist tomorrow and will tell him what I am doing. It's very scary to me because I don't know what to expect because I've been on something or another for the past 27 years.
  9. I was on antidepressants for about 7 years, always trying to get off them. I have been on Celexa, Abilify, and Pristiq. I retired in December of 2014 so I no longer have job stress. I began tapering off Pristiq after I had only been on it about 2 months. I went down to 50 mg, the smallest tablet there is, then began cutting the tablets in half. When I wanted to reduce to 1/8th of a tablet, I crushed the tablets and used a razor blade to make a line on a mirror, and approximate 1/8th. All of my tapers lasted about 4 weeks until I got down to 1/16th. It was so small, and I had to travel for a funeral, so after two weeks of 1/16 I stopped. It has been 46 days and I feel myself slipping into depression and anxiety. But I am determined to stay off meds. I only take fish oil and Vitamin D. I just want to hear from other people that have survived Pristiq withdrawal. I want to hear success stories. Tell me I can do it! Tell my brain will heal. I run for about 30 minutes every other day and walk on the in between days. Pristiq 100mg/day two months 50mg/day x six weeks 25mg/day x six weeks 12.5 mg/day x six weeks 6.25mg/day x 2weeks Off Pristiq March 23rd, 2015
  10. Hello, Im a 28yo male, from Brazil, and Im desperate! - 2005 start taking Paroxetine 40mg, no big deal, worked quite nice. - 2006 stopped cold turkey, not more than a week with brain zaps and I was fine. - 2007 anxiety and depression came back, like when I wasnt on Paroxetine. - 2007 back to Paroxetine. I was "normal" again. - 2013 depression started again, transitioned to LexaPro 15 + Wellbutrin XL 300 with very few problems, 2 weeks and I was fine. - 2015 dropped Wellbutrin cold turkey without problems. - 04/2017 Transition to Pristiq 50, for five days I took half lexapro pill + half pristiq, the problems started, nausea, headaches, muscle stifness, neck pain, after these 5 days, things were the same... starting feeling miserable =(, I talked to my MD, she said to taper off Pristiq, 25mg for 5 days than 12,5 for five more than, stop taking. First drop and the brain zaps started, insomnia kicked in hard. - 05/12/2017 one week without Pristiq, I cant handle what Im feeling anymore, the zaps are driving me insane, I cant sleep properly, my body and head aches, my concentration is gone. Called my MD and she prescribed me lexotan to help ease the symptons. Still not taking it. I dont know if what Im experiencing is withdrawal from Lexapro or Pristiq, I DONT KNOW WHAT TO DO!!, should I go back to Lexapro and try tapering it slowly or should I keep going like I am? I just want to get rid of the freaking zaps! Im quite desperate, sorry for my bad english!
  11. I would firstly like to say a big thank you to Alto and the other members of this site for the invaluable information and support I have received over the past 18 months whilst withdrawing directly from pristiq. I have been on and off antidepressants for the best part of 16 years with little success with treating my "depression". About 4 years ago I was put on Pristiq after another failed attempt to be free of antidepressant medication. I had a very obvious pattern to my mental and physical health whilst being put on and pulled off sometimes cold turkey from various antidepressants but mostly within the SSRI or SNRI family of meds. But it was only since finding this site and relating to stories on here which then prompted me to get hold of my medical records, that the pattern become blatantly obvious to me. I only wish the doctors treating me could have seen the pattern which was staring them in the face.Time and time again i reported feeling worse on the medications, reporting anxiety, bouts of rage, flushing, shaking, insomnia, sugar cravings and a blood pressure that whilst on 50mg of pristiq required 3 different types of blood pressure medication at once to keep it under control. I am 40 years old, not particularly overweight so found this to be very alarming. I must also add here that I had a severe reaction to effexor several years ago which is why crossing over to effexor was not an option for me About 18 months ago after coming through a difficult relationship breakup for which my doctor wanted to increase my Pristiq to 100mg (which I refused) I decided that the antidepressants were not helping me and probably never did so i wanted off them. My Doctor reluctantly agreed to decrease the dose with a view to cessation at some stage. My doctor was a firm believer that I would need to be on antidepressants for the rest of my life but knew me to be a stubborn patient that would do it my way anyway so she agreed for me to try. I briefly tried my doctors way which we have all heard before of a ridiculously fast taper or one tablet every second day to only end up feeling out of control and miserable which is when I decided to "DR GOOGLE" which led me to this site. So after reading the info on here and with a bit of determination and a pill cutter, I began my Pristiq taper back in February 2013. The method I used this time around was to cut the tablets up. At first I took a half in the morning then a quarter late in the afternoon. I would often end up with a big half and a little half when cutting the pills up so I would take the big halves for a about 2 months then swap to the little halves therefore giving me a smallish dose reduction. I held on each reduction for about 6 to eight weeks and sometimes longer depending on how I was feeling. To try to simply summarise my dosing method which took about 14 months in total…... *Big half in morning quarter in early evening (around 4pm) *Small half in morning and quarter in evening *Small half in morning then 1/8 in evening *big half in morning and evening dose dropped *small half in morning *big quarter in morning *small quarter in morning *Big eighth in morning *small eighth in morning * a nibble of the already tiny tablet ) then i forgot to take a nibble for a few days as I got busy so decided to see how I would go. unfortunately I experienced mild but concerning withdrawal symptoms including "brain zaps" so with advice from Alto I reinstated a tiny nibble exactly one month and one day later.This seemed to do the trick for me and when I attempted to jump off again I was able to do so without any head shocks. I actually stopped the pristiq completely the day before i went in for spinal surgery so I had a rough few weeks with pain and feeling teary all the time but this time around I didn't have the head shocks so persisted with discontinuation. I also wasn't sure if the emotional issues were due to the anaesthetic, pain medications and having way too much time on my hands as i was off work to recuperate. I must also mention that I took fish oil and magnesium and had regular saunas to aid the process but was taking these before tapering anyway so they were not new to my system. I can say now that I am the happiest I have been in a very very long time. I am just over 2 months into a loving and healthy relationship with a man who knows what I have been through and although he doesn't really "understand" as such, he has been very supportive of me and he is a funny bugger so we laugh and laugh when we are together which has been wonderful medicine. I must also add a side effect I have noticed since being pristiq free and that is a , small but noticeable weight loss (probably about 4kg in the first month). I have not been eating differently in fact have been a little naughtier than usual with going out for dinner a little too often and my boyfriend does love his chocolate which it would be unsociable to let him eat it on his own but I no longer crave sugary and fatty foods at night like I used to for years and years whilst on various antidepressants. I am now 3 months and 2 weeks Pristiq free and although I have had an episode a few weeks ago ( the magic 3 month mark!!) of feeling teary and itchy ( my scalp would get very itchy during certain stages of my taper.) I have come through all that and am feeling certain that I have beaten this horrible drug once and for all. So again I will say F@#K YOU PRISTIQ. I WIN ))
  12. Hi Alto & fellow Survivors, Thought I would update you on my progress. So in July of 2011 I had reduced my Pristiq down to the minimum (50mg). Pristiq, just like it's predecessor Effexor has a very short half life and therefore more intense withdrawal symptoms than the old fashioned Prozac. So I switched to Prozac - the first day I think it was 80mg, then 60mg for a day or so, then 40mg for a few weeks, then down to 20mg. It was at this point I wrote my original post and took Alto's advice to let myself stabilise on the 20mg. This was a very difficult time but I just persisted with it. I was able to get the Prozac in a tablet form under the brand name Lovan which allowed me to slowly reduce down to 5mg over the next 5 months or so. During this time I experienced many days where I was nauseated, would sometimes vomit or feel as if I was about to at any moment, had brain fog, felt anxious, felt depressed, but these symptoms fluctuated and sometimes were way better than others. I began to feel my emotions coming back slowly, which I had not felt in a long time. When I was on Pristiq I was just numb, no good emotions, no extreme emotions, just nothing. I also became a little more outgoing and made friends at school more easily. I was able to keep all my appointments & turn up to class everyday and get assignments done (sometimes i needed extra time and this was granted) despite feeling crappy. However, when I went down to the last 5 mg, my anxiety took a turn for the worse. I started to have increasing intrusive thoughts that were extremely distressing and this made me feel suicidal. I began to exhibit symptoms of OCD, developing obsessions and compulsions (both mental & physical). My therapist did not diagnose me with OCD but she TREATED me for OCD for the next 12 months to help me learn how to manage the distress and anxiety and that is something that has really helped me get by. At one point in around November/December 2011 my Doctor commnced me on Abilify 10mg as he thought was concerned about these thoughts in the contxt of his bipolar diagnosis. He chnaged my diagnosis to Bipolar 1 and interpreted these symptoms as 'verging on psychosis'. My therpaist and myself both disagreed with this as at no point did I ever lose touvh with reality, have thought insertion, broadcasting, thought disorder, ideas of reference, halucinations etc. However the Abilify did lift my mood, decrease my anxiety (not initially but within a few weeks)and help me feel less suicidal, and i was able to finish the schhol semester. But of course I then had to taper off the Abilify (I stopped the Prozac 5 mg as soon as I started the Abilify). I tapered off the Abilify 1/4 of a tablet every week until I was off it by the end of January this year. I was on break from school at the time, and put a lot of effort into looking after myself physically from that point on, more vegetables, more good fats, more fruit, more meat, more exercise, more social contact, and more SLEEP! Since then I have continued to focus on physical health to relieve mood & anxiety symptoms. The big thing that helps me is a walk every day. If I don't do that, I start to get flat. I also put into use every day the skills I learned in therapy to deal with anxiety. I was able to finish my degree in July and have since started working full time in my new profession, so i am off disability, I'm contributing in my own way and feel the rewards of that, and I've been slowly integrating healthy lifestyle choices and making a routine around work. I have to be very careful to stay in a routine as best I can, fit a walk into my day on MOST days, eat fruit and vegies and see my friends every second week or so and get enough sleep. My life to others probably appears very boring at the moment, but I am quite content. I keep up with my chores, am organised, and I have less episodes of feeling depressed, & my anxiety is more managable. I haven't felt those old suicidal feelings for several months now although i still have periods of feeling down, but these are less intense and go away quicker. And I haven't had any symptoms of mania whatsoever. Eventually I hope to be able to start some hobbies (or at least one)and start doing a few extra outings like the movies and theatre etc, but now I feel I just need to focus on the basics of staying well. My friends are amazed that I am my old self again if not better! So that is a success story of sorts. So if you are struggling - persevere. Get the support you need from friends, family, therapists etc to see you through this difficult time. part of coming off meds is learning adaptive techniques of coping with symptoms other than taking medicatiosn, and this isn't easy to do on your own. Take care of your physical health, and be compassionate with yourself. Your brain is amazing and is not doomed to always feeling these effects of psychotropics, It will heal and adpat in time. Mine is still adapting, but I'm a lot better than where I was.
  13. University of British Columbia Pharmaceutical Sciences Student Journal, Volume 3, Issue 1, March 21 2016, pages 31-33. Preparation of Lower Dosages of SNRI Antidepressants to Ameliorate Discontinuation Symptoms: Two Case Studies. Benton Attfield, B.Sc. (Biology), B.Sc. (Pharm) Lori Bonertz, B.Sc. (Pharm) Cory Hermans, B.Sc. (Pharm) Valerie Kantz, Senior Pharmacy Technician. Full text pssj-v03-i01_attfield.pdf Abstract There is a large body of evidence showing that adverse effects experienced with antidepressant treatment ameliorate over time and that disease-state symptoms improve for many patients. However, there is a paucity of information relating to how to stop these medications when a patient’s depression has remitted. Presented here are two cases that demonstrate the role pharmacists play in helping patients discontinue SNRI medications through the preparation of lower strength dosage forms. From the paper:
  14. Frankle WG, et al. Synapse. 2018 An open-label positron emission tomography study to evaluate serotonin transporter occupancy following escalating dosing regimens of (R)-(-)-O-desmethylvenlafaxine and racemic O-desmethylvenlafaxine. Authors Frankle WG1, Robertson B2, Maier G3, Paris J4, Asmonga D4, May M4, Himes ML4, Mason NS5, Mathis CA5, Narendran R4,5. Author information 1 Department of Psychiatry, NYU Langone Medical Center, New York, New York. 2 Shire Pharmaceuticals Inc., Lexington, Massachusetts. 3 MaierMetrics and Associates, LLC, Boston, Massachusetts. 4 Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. 5 Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania. Citation Synapse. 2018 Mar;72(3). doi: 10.1002/syn.22021. Epub 2017 Dec 13. Links https://www.ncbi.nlm.nih.gov/pubmed/29216407. Full text available here (requires membership) https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.22021 Abstract SEP-227162 [R(-)-O-desmethylvenlafaxine] is an enantiomer of the venlafaxine metabolite O-desmethylvenlafaxine (ODV, Pristiq™, Wyeth). This study compared the serotonin transporter (SERT) occupancy achieved by SEP-227162 and ODV, at daily doses of 25, 50, 100, and 150 mg using [11 C]DASB positron emission tomography (PET). Sixteen healthy male subjects participated in one of four dose groups (N = 4 per group) during which they were administered two doses of the study drug (SEP-227162 or ODV). For each study drug, total daily doses of 25, 50, 100, and150 mg were studied. Subjects underwent three PET scans with [11 C]DASB. A baseline, off-medication, scan was performed prior to dosing and a [11 C]DASB PET scan was performed after 72 hr at each dose level. [11 C]DASB binding potential (BPND ) was calculated using the simplified reference tissue method. SERT occupancy was calculated as the change in BPND (ΔBPND ) from baseline scan to the on-medication scan relative to the baseline BPND value. SEP-227162 and ODV significantly reduced regional distribution volumes and region BPND values in a dose-dependent manner. Across all doses ODV produced significantly greater SERT occupancy than SEP-227162 (ANOVA F = 21.8, df = 1,23, p < .001). The total daily dose required to provide 50% SERT occupancy was 24.8 mg for SEP-227162 and 14.4 mg for ODV. In vitro data suggests a ratio of 3.3:1 for binding at human SERT for SEP-227162 relative to ODV. Our study suggests a ratio of 1.7:1, highlighting the value of in vivo imaging in the drug development process. PMID 29216407 [Indexed for MEDLINE].
  15. I’ve been on antidepressants since I was 13 diagnosed when I was 13 with depression and anxiety disorder. When I was 18 I was diagnosed with major depression after suicide attempt. At 27 years of age now my new doctor of just one month diagnosed me with bipolar 2, I believe solely on the fact that my mother is bipolar one and she believes I’m “genetically prone” to this disorder My medication history. First it was lexapto, then Prozac then Wellbutrin, then cymbalta and Xanax now tapering off pristiq which I personally find the worse. And now I’m put on lamictal. My doctor seems to think I can withdrawl from my pristiq (100 mg) which I’ve been on throughout a year time span, in “two weeks” and being put on 200 mgs of lamictal it should “ counteract the withdrawal “ . I’ve been out of work for a year (previously a full time teacher”. I feel like I’m losing my mind for lack of better words. I’m so desperate and truly believe big pharmaceutical agencies just want to make money off of me (us) . I’m lost and isolating myself, my life is falling apart, and I’ve never been in a worse mental state than I am now. I’m here for help and reassurance I suppose. Don’t know how much longer I can do this. -Amy
  16. I've been taking Pristiq 100mg (plus 5mg Somit to sleep and 100mg Activigil to wake up) for the past 3 years more or less. I've been trying to quit Pristiq for many months due to HORRIBLE withdrawals whenever I forgot even one pill. I got to down the dose to Pristiq 50mg after enduring two weeks of those horrible withrawals and then they were gone, luckily. Now I'm trying to figure out my next step. There's no Pristiq 25mg where I am from. My psych told me to switch to venlafaxine 75mg three days ago, not the XR, the regular. It has such a short half life that I'm having horrible symptoms as well, even though I'm taking 37,5mg in the morning and 37,5mg in the afternoon. I'm trying to figure out if this is the best way to quit Pristiq. She says I should stay with venlafaxine and taper down from it. I'm worried about feeling awful. I can't function. Should I stay with the venlafaxine or switch back to Pristiq 50mg and figure out something else? Should I bridge with Prozac form Pristiq? Should I stay with venlafaxine and THEN bridge with Prozac? Should I just taper down from venlafaxine? By the way, thank you all for describing so accurately all the discontinuations sympotms of the Pristq- the brain zaps, the headaches, the dizziness, the confusion. What has this done to us? I want out.
  17. ADMIN NOTE 10 09 17 Lilu wants everyone to know: "Please disregard my initial posts, since my knowledge about the subject of withdrawal was very limited and often wrong. Please follow the administrators' knowledge and advice to properly taper your medication." I would like to know if anyone else has experienced while on Pristiq: I take 50 mg of Pristiq every morning at around 8 am. But despite sleeping for 8 or 9 hours a night, I wake up feeling tired and sleepy with a heavy brain fog that pretty much lasts all day. It does seem to lift at around 3 pm when I find myself suddenly feeling more clear and awake. Sometimes though the sleepiness (somnolence) last all day and I feel like I just can't think clearly. It's as if I'm always slightly buzzed or sedated. Recently I found out that Pristiq reaches it's peak concentration level after 7.5 hours. So I will try to take it at night, and see if I will feel more awake and fog-free in the morning. Also, I guess I should mention that when I forget to take a dose of Pristiq, I start to feel extremely drowsy, just as if I have taken a sedative.
  18. I started taking pristiq some time in June. I started feeling like I wanted to avoid my family and just go out by myself. I never want to cuddle or be intimate with my husband anymore and I all of a sudden want attention from other people. This is extremely out of character for me. I dont know if its the medication or what but its really scaring me. I feel like i could just run away from my life and not look back but I know this isnt me. Has any been in a similat situation??? I'm feeling so helpless.
  19. 41 years old. Never before suffered anxiety and depression until I crashed into menopause overnight my world was turned upside down. Tested for every disease imaginable I was bedridden for months before the diagnosis months later of premature menopause. I was put on mirtazapine 30mg for about 8 months. It did nothing for my anxiety or depression. I reached crisis point and was switched to pristiq 50mg in February of this year. I was meant to have two weeks cross over but had such a bad reaction I stopped the mirtazapine after five days. I was seriously ill for two weeks later who knows if that was withdrawal or the pristiq. So I also started on hormone replacement same time as pristiq and was doing so well they told me to wean off the pristiq after being on it for just six weeks. I did two weeks at 50mg two weeks at 25mg and two weeks at 12.5 before stopping for ten days altogether before having to start again due to severe withdrawal. Pdoc says to get a week of 12.5 and a week of 6.25 and go off after two weeks! I saw you posted details of a podcast in Aussie rob purssey I contacted him and I'm 41 years old. Never before suffered anxiety and depression until I crashed into menopause overnight my world was turned upside down. Tested for every disease imaginable I was bedridden for months before the diagnosis months later of premature menopause. I was put on mirtazapine 30mg for about 8 months. It did nothing for my anxiety or depression. I reached crisis point and was switched to pristiq 50mg. I was meant to have two weeks cross over but had such a bad reaction I stopped the mirtazapine after five days. I was seriously ill for two weeks later who knows if that was withdrawal or the pristiq. So I also started on hormone replacement and was doing so well they told me to wean off the pristiq. I did two weeks at 25mg and two weeks at 12.5 before stopping for ten days altogether before having to start again due to severe withdrawal. Pdoc says to get a week of 12.5 and a week of 6.25 and go off after two weeks! I saw you posted details of a pdoc in Aussie rob purssey I contacted him and I'm yet to see him but he suggested not cutting pills and going back to 50mg pristiq and said next step will be 75mg of Effexor. So withdrawals I had both weaning and off were insomnia, sweating all day, nausea, diarrhoea, confusion, no short term memory, suicidal thoughts, periods of great sadness, urge to cry and just generally feeling agitated beyond belief as though my limbs were all filled with concrete. I'm shocked that I've only been on it three months and it's this bad. So is moving to Effexor a better way to wean off in every bodies experience. Thank you
  20. Hi to all, Posted in the "Marriages Destroyed by SSRI SNRI" thread in more detail... Basically I stumbled across this forum after 18 months of increasing changes in our relationship dynamic, culminating in my wife wanting to separate/divorce me over the last few months. We have been married 12 years and have 2 energetic boys aged 3 1/2 and 2. I have reluctantly moved out of our family home due to her demands, and hate every minute of it. Since she went on Pristiq (50 mg) around 6 months ago, the following has happened: - I don't love you anymore / I've not loved you for years / I've never loved you - We're more like flatmates / brother and sister than lovers and partners - I need space to find myself and be free - We don't have anything in common - I want to separate / divorce - She 'developed a crush' / or actually cheated on me with a male friend she was helping train as a personal trainer (evidence suggests it may have been more than just a crush) - Osscilations between wanting to separate and not for utilitarian reasons (not feelings) - Seeing me completely break down in front of her and our children, and literally feeling nothing, nor react at all - She has gone from wearing her heart on her sleeve to being absolutely flat and uncaring towards me, often times being really derisive and rude/argumentative, which is extremely out of character Even prior to that, there was definitely emotional blunting taking place on the Eleva (100 mg) she was taking for the year before the Pristiq. I have somehow convinced her that she should consider the medication as being a factor, and she mentioned wanting to come off them anyway. She has started tapering her dose in order to be completely off them over the next few months. Yeah, so that's why I am here, and am hoping to learn from you all and your experiences. Some of you guys seem really knowledgeable. I wish you all the very best! Dawood
  21. Hi guys, Currently finished my tapering and now into the Withdrawl of pristiq. After spending so much time googling all the symptoms and anecdotes of others I wanted to add to it, in hopes of helping anyone else who'd be in my situation in the future! I think too much time spent reading some of the horror stories (and I feel terrible for those poor souls), really made me so much more anxious than I needed to be. Some background: I was on pristiq 50mg for 5 months, no history of antidepressants or mental illness, until I had a breakdown of sorts due to family tragedy/work stress/love life difficulties and basically just everything at once. I was diagnosed with GAD, put on pristiq (because at the time I could barely leave the house without having a panic attack), and sent to a psychologist for CBT. 5 months later my doc suggested coming off as id done well etc am ready. He gave me a tapering program for 3 weeks - 1st week every second day, 2nd week every third day, 4th week on the fourth day then stop. Tapering: this was for me not as horrible as I made myself believe it would be. I had probably two evenings where I'd feel the brain zaps (it felt more like popping candy sensation than a bolt of electricty, that idea scared the hell out of me lol) and was pretty tolerable. Before I finished completely, I researched all the natural remedies that might help ease any discomfort. And found a million different opinions.. I settled for fish oil tablets and vitamin B. Kept some ginger tablets and paracetamol on hand in case. Also, the app Headspace I can't recommend enough! Guided meditation has been an absolute life saver for me, and after trying a few different apps out I found this the best for me DAY ONE: Felt normal. I figured because of the tapering, and feeling normal on the first days off during it, today would be no different. Towards the end of the day I started having that throat tickle you get before you get a cold.. and thought great timing to get a cold DAY TWO: Woke up feeling like I had a cold, I had read flu like symptoms to be common in tapering, but I had assumed it would be the more brain fog rather than sneezing and coughing. Anxiety was a bit higher than normal, but I reminded myself to stop looking for symptoms and get on with my day. DAY THREE: Bit of brain fog in the morning, more a nuscance than anything.. managed to get rear ended while driving which really wasn't ideal lol. Was feeling pretty emotional after that but, as anyone would be. Rest of the day was fine, bit sleepy here and there and brain zaps before bed (now I know how they feel, it's easier to ignore them) DAY FOUR: I had read day 4 can be a common time for people to feel the grunt of side effects.. and I was on the war path for most of the day. Not usually an angry person but, Jesus, I was banging pots and pans and swearing. It took me a while to step back and realise I needed to calm down. Meditated, and felt a bit frazzled and went for a walk.. it seemed to help a whole lot DAY FIVE: I'm at the end of day five now, this is the first day without a headache, and first day without any painkillers (yay) brain zaps are still around, and find myself getting a bit teary to songs on the radio but I feel like I might be on the way down the mountain I'll keep updated on my days, I know everyone is different and I feel so so lucky to have gotten off easy so far with side effects. I just want to share a success to try and help balance out the horror
  22. Hi everyone, I am new here, have been on Pristiq for 10 day 50 mgs, feeling spacey and confused...This is my 3rd anxiety episode...had one 5 years ago, when I was able to come off Pristiq during 3 weeks of alternating days gradually. ..but my sleep was OK then...want to reduce Pristiq , but unfortunately I still take 1 tablet Immovane at night, also for 10 days...not sure what to do next, so I could keep my sleep and take less Pristiq...GPsaid to cut in half, but the tablet split in 4 irregular bits....25 mgs not available in Australia...
  23. Moderator note: Link to Shrike's benzo thread - Shrike: Switching from Clonazepam to Diazepam? Hey Everyone. 3 months ago I finished my taper off of SSRIs. The agony I have gone through is well appreciated by this group. That’s why I’m here. There are still days I wonder if I can make it BUT I am also getting to the point though where it is hard to imagine “going back” (on SSRIs). I am getting some “glimmers” of hope. I have good days or even multiple days. I smelled a candle last night and couldn’t believe how rich it smelled. A song with sounds you can “feel”. Beautiful. All my senses were dulled on antidepressants. I didn’t even realize it and had just gotten so used to it. Now I feel things again. Sure sometimes that feels like way too much BUT I’m starting to think it’s worth those bad “waves” to get my brain and emotions back. Having a good day today. Hope you all are too. I’m taking some time off work to get my head back and heal through some of this build up. I’m overwhelmed by my life but am happy to be “back in it”! Any encouragement or wisdom is welcome. One of the lingering symptoms for me is sleep. I am getting better but still waking up too early and restless and racing.
  24. emergingfromhell

    emergingfromhell: Tips

    Hi. I'm HOPEFULLY coming out of what could be called a 7 month mental breakdown induced by antidepressant roulette ....I've read so many of your stories over the last few months (which have been the worst) and they have helped me...so I feel like I should share my experience in case anything in it can help someone else. First is a short version of what happened to me. Below that is a list of specific things that helped me. And below that, I've shared a longer version in case you'd like more details. I'm truly in awe of how behind psychiatry is. No one should have to suffer like this. WHAT HAPPENED TO ME - I was on Wellbutrin and Prozac for a few years - couldn't quite get the balance right (turns out SR and XL were getting messed up so that didn't help). I was always a little too anxious or a little too depressed. It wasn't bad, but could have been better so I thought I'd try something new. First, I got off Wellbutrin CT. Prozac alone was hell - probably bc of Wellbutrin withdrawal. Then I cross tapered Prozac with Pristiq. Pristiq worked for a month then stopped- I was in hell again - probably delayed Prozac withdrawal. Then I added Ability to the Pristiq - horrible side effects. Then I stopped those CT and I took Viibryd. Pristiq/ Ability withdrawal + Viibryd side effects, and after all I'd already been through, worse than hell. I took Klonopin and 10mg Prozac to wean off of that. I started to feel slightly human again. I got back on Wellbutrin and Prozac and felt more human. Then had to wean off the Klonopin - worse than what's worse than hell. Now I'm just on the Wellbutrin and Prozac like I was originally and I finally feel like a person again. What a nightmare - 5 withdrawals in 7 months. Anyway...I've learned some things.... THINGS I'VE LEARNED - Medicine tips: 1. Try to stay consistent with a pharmacy/manufacturer if you're taking generic bc that can make you respond differently to the medicine (I think that was a problem with my wellbutrin originally - also XL is smoother than SR and it's important to stay consistent with that as well) 2. Adding Prozac while weaning off an anti-d can really help with withdrawal 3. Wellbutrin can increase the concentration of Prozac in the body if taken together which is important to know when tweaking the dosage 4. Don't CT anything even if you're on something else or getting on something else. 5. Changing is a REAL b**** so only do it if you have to. 6. If you have to take a benzo to help with withdrawal, don't take it everyday or for too long bc you'll have another withdrawal and nothing to help with that one. Anxiety: 1. When panicking, holding ice, getting in a really hot bath, running or doing push ups can be good bc your heart is racing due to a threat it doesn't understand...when you give it a real reason to race and then take it away...your heart feels the threat is removed and will slow down a bit. Plus your mind will focus on that pain instead of on the more painful racing negative thoughts. In some messed up way, it's like a less harmful version of cutting. 2. Lavender oil is very calming, and smell is the only sense with a direct pathway to the amygdala which is the part of your brain associated with mood and emotions. Smells that remind you of happy times work as well. 3. Warm baths helped me more than anything. Increasing body temperature can help regulate mood. Sometimes, putting cold water on for a little helps as well bc that can help circulation and increase oxygen. Switching back and forth can help with the chills/hot flashes that come with withdrawal. 4. After bath, I put towel down on floor and did some stretches to open chest and hips bc that's where we carry a lot of grief. I recommend making it part of a morning routine. 5. Writing affirmations on paper with a pencil or pen can be therapeutic. Find words that resonate with you - simple sentences. It sounds silly, but it actually helped. 6. If people are pissing you off, but you know you shouldn't be confrontational in this state, write them letters that you don't send. 7. Fresh air really helps, even if you just open a window. 8. The mornings are the worst bc of Cortisol. 9. Google Alternate Nostril Breathing and do that for longer than feels comfortable. Also, when taking deep breaths, the exhale should be longer than the inhale and is more important, but if you do it for a really long time, make them equal so you don't get light-headed. 10. There's a good mediation app called "Insight Timer" and another called "Calm". 11. I read a book called "Love Warrior" that was a good distraction and very relatable. If you have stress relating to a toxic relationship, "Women Who Love Too Much" is also a great book. 12. Binge on a Netflix series to distract your mind. The Moth app is good for that also if watching is too hard. 13. Hugging or cuddling releases oxytocin and can really calm stress. Massages obviously help a ton as well. 14. Imagine a happy place in detail - the smells, sounds, textures etc...for a proper amount of time. Get lost there. 15. Talk to yourself and tell yourself the things you wish someone would say to you to calm you down. You'll feel crazy at first, but it helps. 16. People who've had easy experiences don't write on message boards, but there are plenty. So don't get discouraged only reading horror stories on here. They're the worst cases. 17. Focus on today. Making big changes to address the underlying issues that caused the original anxiety and depression are things to consider once you're stable. And whatever in your life is getting messed up bc of the state you're in, focus on fixing those later when you're better as well. Be honest with work, family, friends etc and hope for compassion. In the meantime, think of the next right thing to do and the next breath. One thing at a time, one moment at a time. Everything else will be much less daunting and easier to fix when your biochemistry isn't going haywire...so cut yourself some slack. Nausea: 1. Pepto can help. 2. Chocolate Boost Plus is good for when you're too nauseous to eat but need to keep weight up. Banana and peanut butter smoothies with chocolate protein powder helped me. Whole foods has a bunch of shots, smoothies etc if you can't make them. 3. Pedialite can help with dehydration. 4. Three fingers from your wrist is the pressure point for nausea. 5. Ginger helps more than you'd think. Ginger candies to suck on are good. Despite what people say, I found Ginger Ale made me more nauseous. Loved Ones: 1. It's helpful if other people can make many of the daily small decisions for you bc thinking at all can be really overwhelming. 2. Complicated conversations about politics, business etc should happen in another room. It's important to focus on simple and positive things to help your brain heal 2. Google SSRI withdrawal symptoms and show them to your loved ones so they know what to expect and so they know your behavior is the result of a chemical clusterfuck and is not reflective of a new or old you. 3. Explain to loved ones that if you sense their anxiety about your anxiety or their fear or impatience, you will feel it magnified and it will slow your recovery massively. You need to be around supportive people who will tell you you're going to be ok and keep you calm. That's crucial. From Me to You: This is only temporary. You will get through this and be yourself again, no matter how impossible that seems while you're in it. I know my story isn't very encouraging, but I really believed the new me was going to have to live like that forever, and I really didn't think I'd survive if that was the case. But I did survive and I'm here now - feeling like the old me with a new appreciation for everything, and the hope that what I went through will somehow help someone else. Here's the more detailed version if you think it might provide some useful information - about what NOT to do For a few years, I was on 300 wellbutrin and 40 prozac... I couldn't quite get the balance right for anxiety/depression, and I thought maybe being on just one drug would be a better idea. My doctor suggested I CT the wellbutrin and up my prozac from 40 to 60. I stayed on just Prozac for the month but crashed - fatigue, anxiety, depression - and A LOT of it. I still don't know if that was wellbutrin withdrawal but, in hindsight, I suspect it may have been. I went to a new doctor who suggested I try Pristiq bc my mom does well on Effexor (strong proof that members of the same family tend to do well on the same drugs) and it was the improved version. Also bc I had done well on Cymbalta years earlier, except for the intense fatigue, she thought another SNRI might be good for me. I weaned off Prozac in a couple of weeks while taking the Pristiq. It worked really well for about a month on it's own and then I crashed again - fatigue, anxiety, depression - and A LOT of it. Again, in hindsight, I wonder if the prozac had a delayed withdrawal bc that can happen even though doctors don't acknowledge it much. I raised the Pristiq by 25 for a couple weeks and it didn't help. Studies have shown that increased levels of Pristiq doesn't increase efficacy of the drug...it's just more to get off of later. So I went back down to 50 and my doctor then added 5mg of Ability. I had awful side effects - restlessness, jumping out of my skin, major depersonalization, etc. She suggested Rexulti which has less side effects but isn't covered by insurance and would have been 1k a month so I tried Geodon instead for three days - same class of med, same problems. So I gave up on Pristiq. Stopped CT and started 10mg of Viibryd. That's when things started to get really really bad. I basically compounded Pristiq withdrawal with Viibryd side effects. I eased up over a month to 40mg - the therapeutic dose. I woke up in a panic attack every morning, I couldn't function at all, I could barely talk or eat. I felt terrified and almost catatonic. I took 20mg at 11am and 20mg at 3/4pm, and you have to take it with food which is hell when you're that nauseous. It got a little better after 5/6 pm everyday which was strange. It also got a little better at 40mg in that my good windows would last a little longer but my bad ones were still awful and still lasted for the majority of my day. I added Valium in the morning but didn't want to get addicted so I'd go three days or so then experience increased depression when I stopped. My doctor kept telling me to be patient, that things would turn around, but after two months of feeling like I was dying everyday, unable to function and having suicidal thoughts, I lost any bit of patience I had left. He had also told me that he thought a lot of this was psychological not chemical and that I should spend more time talking to my therapist. Anyone who has been through awful side effects and/or awful withdrawal very much knows the difference between issues that can be resolved by a therapist and issues that need a good psychiatrist. The only thing I needed to talk to a therapist about at the time was the physical pain I was in due to the medicine. I saw another doctor who told me to wean off the Viibryd - that I should be feeling better by that point. I honestly thought I wouldn't make it through another withdrawal period, but the Viibryd was so bad for me that the withdrawal was actually less miserable than the side effects had been. She also told me to take Klonopin .5mg in the morning and at night. My anxiety was way worse in the morning so I took it then, but fortunately, didn't get addicted to the full 1mg a day bc I didn't take it at night. She also added Prozac - 10 up to 20 while I weaned down on Viibryd. After being off of the Viibryd for a little over a week, I needed to figure out what anti-depressant was next. I honestly felt too scared to try anything else so I added 300xl of Wellbutrin to the 20 Prozac - a little less than I was on originally - before I started all the changes. Still not finished - then I had to withdraw from the .5 Klonopin I'd been taking for a month. I cut in half for a week then half of that for 3 days. I suffered terribly that whole time and then for a few days after my last dose. I am writing you from the other side. So...I basically went through all of the hell to circle back to where I started, and I definitely didn't have it in me to get off altogether bc I know adjusting to life without meds after 16 years on them is going to be a bigger task than I have the energy for right now...but I did learn some things....
  25. Howdy, I've just now been looking at online resources on quitting this drug, and since I've been informed I have to wait three more weeks until an appointment with a psychiatrist to ask a simple question, I'd like to ask y'all about it since y'all seem more knowledgeable about this drug than I ever could be. This seems quite dangerous, because it is and co-pays are hell, but I've been off this drug cold turkey from 100 mg for a week due to circumstances out of my control (a credit card to pay a co-pay was rejected, and the pharmacy made the sound decision of refusing to notify me until i was expecting my shipment, leaving me about 2 weeks without the drug), and I was wondering if anything's known about how long I could expect to stop suffering the majority of withdrawal symptoms, thus far I've stopped involuntarily white knuckling random things and involuntarily twitching(more like jumping!) and I've stopped cold sweating in bed already. Honestly the most annoying thing for me is the fact that my damn digestive system can't seem to expel any solids for love or money, which in and of itself is an annoyance at worst. I still do have an additional week wherein I'm forced to not take anything, and if I can turn this horrid situation entirely out of my control into a great situation where I can stop taking this damn drug it would be great to know that. Thank y'all in advance!
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