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  1. Sex Med Rev. 2017 Oct;5(4):429-433. doi: 10.1016/j.sxmr.2017.05.002. Epub 2017 Jun 20. Sexual Consequences of Post-SSRI Syndrome. Reisman Y1. Abstract at https://www.ncbi.nlm.nih.gov/pubmed/28642048 INTRODUCTION: Sexual dysfunctions are well-known side effects of selective serotonin reuptake inhibitor (SSRI) use. Altered libido, erectile dysfunction, vaginal dryness, ejaculatory disorders, and orgasmic problems are frequently reported by patients treated with SSRIs. Moreover, these antidepressant-emergent sexual dysfunctions do not always resolve after discontinuation of the medication and can persist indefinitely. These complaints are termed post-SSRI sexual dysfunctions (PSSD). AIM: To examine the existence of this clinical entity, possible theoretical mechanisms, possible risk factors, and possible treatment modalities. METHODS: Through literature research and clinical experience, the available information about PSSD is reviewed. MAIN OUTCOME MEASURES: Summary of the current literature with insights into possible causes and management options. RESULTS: There are some indications that antidepressant-emergent sexual dysfunctions do not always resolve after discontinuation of the medication and can persist indefinitely in some individuals. Although some or all sexual side effects that start with the use of SSRIs might continue after stopping the medication, other sexual complaints can develop. Decreased capacity to experience sexual pleasure is the most frequent characteristic of this syndrome. CONCLUSION: The research and understanding of PSSD remain limited and not well understood; however, the data support the existence of PSSD, which can have a substantial effect on the quality of life of these patients. More research is warranted to show the cause and possible mechanisms of PSSD that could lead to the correct diagnosis and treatment. Reisman Y. Sexual Consequences of Post-SSRI Syndrome. Sex Med Rev 2017;5:429-433.
  2. Sex Med Rev. 2018 Jan;6(1):29-34. doi: 10.1016/j.sxmr.2017.07.002. Epub 2017 Aug 1. Post-SSRI Sexual Dysfunction: A Literature Review. Bala A1, Nguyen HMT1, Hellstrom WJG2. Abstract at https://www.ncbi.nlm.nih.gov/pubmed/28778697 INTRODUCTION: Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of drug. Post-SSRI sexual dysfunction (PSSD) is a condition in which patients continue to have sexual side effects after discontinuation of SSRI use. The prevalence of persistent sexual side effects after discontinuing SSRIs is unknown. The recognition and study of PSSD will increase our knowledge base of this underreported and distressing condition. AIM: To provide coverage of the current literature on PSSD, update information on the pathophysiology of PSSD, and discuss potential management options. METHODS: Comprehensive review of literature pertaining to PSSD. MAIN OUTCOME MEASURES: The symptoms, classification, pathophysiology, diagnostic considerations, and management of PSSD were reviewed. RESULTS: Common PSSD symptoms include genital anesthesia, pleasure-less or weak orgasm, decreased sex drive, erectile dysfunction, and premature ejaculation. Different theories have been proposed to explain the pathophysiology of PSSD: epigenetic gene expression theory, cytochrome actions, dopamine-serotonin interactions, proopiomelanocortin and melanocortin effects, serotonin neurotoxicity, downregulation of 5-hydroxytryptamine receptor 1A, and hormonal changes in the central and peripheral nervous systems. The diagnosis of PSSD is achieved by excluding all other etiologies of sexual dysfunction. Treating PSSD is challenging, and many strategies have been suggested and tried, including serotonergic antagonists and dopaminergic agonists. There is still no definitive treatment for PSSD. Low-power laser irradiation and phototherapy have shown some promising results. CONCLUSION: PSSD is a debilitating condition that adversely affects quality of life. Further studies are warranted to investigate the prevalence, pathophysiology, and treatment of PSSD. Bala A, Nguyen HMT, Hellstrom WJG. Post-SSRI Sexual Dysfunction: A Literature Review. Sex Med Rev 2018;6:29-34.
  3. Hello. Altostrata I saw your clip on the youtube where you talked about your experience with the medication. I took one week medication Paxil and It did completely destroyed me.. when I stopped taking this medication I felt so bad and did not know what was happening to me .. then I went to a lot of doctors first with a neurologist who prescribed it and Of course he did not know anything about why I felt so bad... I was doing a lot of analysis and review at doctor, and everything was fine ... even the magnetic resonance of the head, but still I felt so sick.... When I stopped the drug I had a bad concentration, bad memory, forgetfulness, bad sleep, poor libido, poor erection, muscles I do not feel always, Im tired, I can not get muscle inflammation after I exercise, I dont have passion for some things It simply destroyed myself - That drug. I spent so much time try to descover how to reverse this condition and every time i hit wall... the time can only help. I took it for one week, and now its past 5 yrs i feel the same ..im having same symptopms when I stopped that drug? Is it possible that im damaged for life? Please Altostrata, can you tell me this... After 9 yrs did you recover fully in sence that your memory, concentration, muscles and libido is as good as it was before you took that drug?
  4. Shar244

    Shar244

    I was taking 50mg Sertraline daily (prescribed for anxiety) for 2 months in 2016. I stopped taking them instantly due to various side effects; insomnia followed by extreme fatigue and when the sexual dysfunction kicked in that was the last straw for me. I suffered for roughly 3 months with vertigo and nausea. I believe I am left with PSSD and also cognitive issues. I have been anti-depressant free since December 2016 I have experienced two or three ‘windows’ I think they are called? The PSSD has probably improved overall 10% day to day in the last two years. Recovery stories give me hope
  5. Hey everyone. I was put on Zoloft and Concerta at the age of 11 for OCD and ADHD. I have been on 200mg of Zoloft for a long time. I CT'd the 36 mg of concerta in February 2017. I did not do my diligence. I made a change with my psychiatrist in 2017 for the zoloft. That change sent me to hell. She told me I could discontinue quickly while tapering onto another drug, which I thought I needed for my "sanity." I have since fired her and am off all medications after being diagnosed with "serotonin syndrome." Within a week of tapering from 200mg to 150mg and tapering on to another drug, I began experiencing strange symptoms, which, according to my "doctor" have nothing to do with the medication: complete emotional numbness (I struggle with this already due to depression but it is so so much worse now), a deep disconnection from my identity, ego, self, and external environment, random bouts of visual problems, severe memory loss, cognitive issues and fogginess--I feel like I am walking unconsciously, with the only thoughts I am having are intrusive, detached thoughts that don't make sense to me, along with bouts of suicidal ideation and severe and uncontrollable mood swings, an inability to think, reason, rationalize or plan ahead, a lack of spontaneous thoughts, soul crushing anhedonia, akathisia, tremors, numb crying spells with no feeling of sadness underneath, feeling like I am losing my mind, severe depersonalization and derealization, severe insomnia, muscle and joint pain, back pain, complete loss of sexual functioning, generally not feeling alive or like a human being, unable to connect to my environment, friends or family. I blame myself for not doing my research about coming off these medications and I blame myself for ever even going on them, though I don't remember if that was my decision or my parents. I had a pretty strong mind despite OCD and depression before coming off the drugs. I was incredibly smart and loved fishing and now I can barely work and my passion in life means nothing to me anymore. I have been in intensive CBT for the last few months, though it doesn't work because I literally cannot put thoughts together myself, my only thoughts are intrusive it seems. Doctors don't believe me and after doing the research I am not surprised. I understand it is too late for me to reinstate and that I am in for the battle of my life. I have been doing some things to help myself, though I have not seen improvement and don't expect to for years: meditation, engagement in life and things I used to enjoy, pursuing goals even though I don't care about them, eating nutrient dense foods, walking and light exercise, and hyperbaric oxygen therapy. Since I was on these drugs a long time and since I started as a kid I am feeling pretty hopeless that I can get better even though many people keep telling me I can. I expect to deal with OCD, depression, sexual issues the rest of my life but I don't expect to be an emotionless, anhedonic, depersonalized, cognitively impaired zombie who can barely function for the rest of my life. I am looking for hope mainly, a place to come to where people understand, and somewhere I can also offer hope to others who are going through the same. I don't think I can do this by myself anymore, and it is hard to go through all of this when my family and friends don't really understand. It is incredibly difficult to be around people who seemingly are enjoying life and taking for granted their humanity. It is incredibly isolating to be going through severe depression, depersonalization, and cognitive impairment that no one on my therapy team seems to understand. I cannot process my pain or emotions or my past trauma as I cannot access it on an emotional level. I want so badly to integrate my past pain into my life and recover from my life trauma but I cannot do it in this state. As I type this, I am so disconnected that I don't even feel the emotional pain of all of this. I wish you all healing and prosperity and hope that I will someday improve somewhat, at least to the point where I can enjoy fishing again. All I want to do right now is isolate and avoid people and everything that reminds me of what is missing in my life, but am fighting this urge and trying to stay engaged. I am hoping for some advice or hope from others who CT'd or rapid tapered at the advice of a doctor. I know I am afraid right now even though I cannot feel it in my body or mind. I am lost and am not getting the direction I need from therapy because they think I am just depressed, but this is not just depression. I don't expect to go through life without any suffering but this seems a bit too much to handle most days.
  6. theloneranger86

    Pudendal Nerve Entrapment PNE

    Hey Alto and other members on the forum Has anyone in withdrawal ever tested for PNE (Pudendal Nerve Entrapment) / other pelvic dysfunctions ? Could this be a complication from the trauma ? Didn't see a single thread about this on the forum so thought of bringing this up ?
  7. Dear all, This is my first post on this forum. I just wanted to share my experience with w/d of buspirone. I stopped 30mg/day about 23 days ago. I suffered 10 days, said enough, then went back to 10 mg/day. It didn't make much difference for another week. I gave up and upped to 20mg/day 7 days ago. While some bad stuff decreased, I am having very painfaul headaches since 2 days (tonight it woke me up). W/d symptoms: some that I know from SSRI/SNRI w/d, but some special for buspirone: "hangover" headache, "hangover" dry mouth, "normal" strong headaches, very angry (I have to punch some pillows or do pushups), flu-like chills and fever (for 3 days), strange pain in the neck. I want to emphasize that it seems as bad as paroxetine. For now I can even say it's worse cause when I came back to paroxetine, all symptoms went away. Now I'm stuck in the middle of nowhere (have many terrible symptoms, while still being on high dose). So, 1st I wanted to share, 2nd I'd welcome any ideas what to do (I already bought and am trying Omega-3)... I really don't want to go back to 30/day (for many reasons); besides I don't have guarantee that even that will bring me back to state before w/d. Did anyone was relieved after coming back to original dose after such long time (>3 weeks)? Did any particular supplement help?
  8. SadDoll

    SadDoll

    Hiya, I'm Laur I dont know where to start. I'm new, kinda. I've been a lurker on this site on and off since 2015 but I've never joined until now. I'm a 24 year old woman from Ireland who was put on antidepressants when I was 18/19 for OCD, depression and suicidal tendancies. I was first given 20mg of lustral in late 2011 and it didnt affect my sex drive or emotions in any way. I didnt take them everyday though, I forgot a lot of the time. Then in late 2013 I was switched to 150mg of lustral. I dont think I took them every day either until I made an effort to take them regularly only to quit them one day out of the blue cold turkey sometime in early 2014. Stupid, I know. At the time I was constantly either stoned and/or drunk so I wasn't very responsible, to say the least. On top of this, I was binge drinking a lot, a few nights a week, and smoking weed nearly everyday from late 2012- 2016 as well as being constantly dependant on a dangerous recreational drug for about a year in 2013. Oh and I wasnt eating properly, so my nutrition was bad on top of this. Anyway, I haven't touched an antidepressant since Spring of 2014 but I have absolutely no libido to speak of, as well as no pleasure 'down there'. Sex for me feels like nothing at all every single time. No arousal. No sensation. I think maybe once or twice I had some slight sexual feeling with an ex boyfriend sometime last year. But it wasn't anywhere near my sexual function pre PSSD. On top of this, I worry so much that I wont be able to fall in love, that I'm incapable of romantic feeling. This bothers me the most because that has been my fear for about 5 years now. And I read online that antidepressants destroy your romantic feelings forever. I dont know how true that is, but it makes me want to die. Ironically, that is what my OCD focused on. The fear of never falling in love. So the doctors presribed me a higher dose of a new pill. I feel like I'm trapped in my own worst nightmare and I feel anhedonic and dead inside. I'm reluctant to post here as I dont want to make anyone feel hopeless from my story. And I'm afraid of other people's stories making me feel even more hopeless. I'm down in the depths of hell here. I feel empty and broken and incapable of love and feeling anything positive at all. Please, can someone offer me some hope? I feel like the fact that I was on a very high dosage (150mg), constantly high for the best part of 4 years, dependant on alcohol, plus a history of past substance abuse, PLUS the fact that I quit cold turkey means that I dont have any hope of recovering. I cant recall what it feels like to feel aroused and I cant imagine ever getting better. Please no negative comments as I'm very suicidal as it is
  9. Hello, After a couple of months of reading some of the posts on this forum, I have decided to join, because basically it seems that I have PSSD. As you will see from my signature strip, I have been on escitalopram at various doses for just over 7 years (finally came off in January of this year (2017)). My history on this drug probably looks a bit confusing. Basically I went on the drug late in 2009 for anxiety that I was suffering. I only intended to be on it for a short time – maybe 6 months – whilst I made some important decisions about my future. But my doctor at that time provided no guidance on coming off the drug. I came off very quickly and crashed. It basically took me about 3 attempts like this to finally realise I could not come off it quickly. In the end it has been a long and slow process with some bumps along the way, but finally I am off the drug – but it took 7 years. I am male and now in my mid-thirties. Anyway, whilst on the drug I suffered from sexual side effects, which from what I have read is very common. But it was in late 2013 that I found out just how much the drug was affecting me. I started a relationship with a girl who although I liked much, I could feel no deep emotion with. Basically I could not fall in love with her. At first I could not understand what was wrong with me, but one day shortly into our relationship I suspected the drug. After a simple ‘Google search’ I had the answer. This combined with the sexual side effects of the drug just made it impossible for me really and in early 2014 we split up. It was at this point that I realised no matter what, I had to get off the drug. It took 2 further attempts of slow tapering but finally I have managed it. I am now almost 5 months off the drug, but seems I have PSSD. At the end of December 2016 I reduced from 10mg every other day to just 5mg every third day. A few days after doing this I could feel something changing sexually – more normal feeling was coming back. And about a week later I had a couple of days of what I would say was completely normal function returning. However this only lasted a couple of days. Shortly after this I took the last tablet. I was now off the drug. About 2 weeks later I once again had a couple of days of everything returning to normal sexually. Again this only lasted temporarily. Then a period of 3 weeks of the numbness and erection difficulties. Then - 5 weeks after taking the last tablet - I again had a period of 2 days of normal functioning – this time I thought it was going to be for good, but unfortunately not. And that was the last time I experienced what I consider everything being normal. Since then I have returned to the numbness, lack of drive and erection difficulties that I had whilst on the drug. I have had the odd day or two in recent weeks where the numbness reduces a bit and there is a little bit of sensitivity, but only a very tiny improvement for a day or so. Then back to full numbness. Also I have developed a ache/pain in my testicles that radiates at times into the top of my legs and buttocks. I can’t remember exactly when this started but I think it was around 6 weeks after being off the drug. I also feel emotionally flat – I don’t think I could fall in love with somebody. I think that issue is still there. I can cry at times, but can’t feel any real happiness for anything. I guess like so many people here I feel the most desperate I have ever done in my life and just looking to talk with others in a similar situation. These past months have seemed like an eternity and every day is such a struggle. I am hoping somebody can give me some hope, because right now I can’t feel much of it. Also I do have a few questions which if anybody can give some sort of an answer to I would be so grateful. 1) Why did I have 3 separate periods of normal sexual function in the immediate period of coming off the drug (first 5 weeks) and then nothing further? 2) the ache/pain that I feel in the testicles – is this part of PSSD? 3) one of the things that really worries me is the fact that I noticed a change to my sexual function after taking just one tablet (God only knows why I did not stop taking them there and then) but as I only planned to be on the medication for a short time, it did not bother me too much. Does this immediate reaction to the drug combined with my long-term use of it mean it more likely my recovery will be a very long time, or worse still that I never recover? Thanks very much for reading.
  10. Hello, Im a 28yo male, from Brazil, and Im desperate! - 2005 start taking Paroxetine 40mg, no big deal, worked quite nice. - 2006 stopped cold turkey, not more than a week with brain zaps and I was fine. - 2007 anxiety and depression came back, like when I wasnt on Paroxetine. - 2007 back to Paroxetine. I was "normal" again. - 2013 depression started again, transitioned to LexaPro 15 + Wellbutrin XL 300 with very few problems, 2 weeks and I was fine. - 2015 dropped Wellbutrin cold turkey without problems. - 04/2017 Transition to Pristiq 50, for five days I took half lexapro pill + half pristiq, the problems started, nausea, headaches, muscle stifness, neck pain, after these 5 days, things were the same... starting feeling miserable =(, I talked to my MD, she said to taper off Pristiq, 25mg for 5 days than 12,5 for five more than, stop taking. First drop and the brain zaps started, insomnia kicked in hard. - 05/12/2017 one week without Pristiq, I cant handle what Im feeling anymore, the zaps are driving me insane, I cant sleep properly, my body and head aches, my concentration is gone. Called my MD and she prescribed me lexotan to help ease the symptons. Still not taking it. I dont know if what Im experiencing is withdrawal from Lexapro or Pristiq, I DONT KNOW WHAT TO DO!!, should I go back to Lexapro and try tapering it slowly or should I keep going like I am? I just want to get rid of the freaking zaps! Im quite desperate, sorry for my bad english!
  11. I'm tappering off Cymbalta after starting it on december 2015. I didn't realize until it was too late, but while on cymbalta I lost the ability to feel, so i decided to quit I tought it coulnd't get worse, but now that I´m tappering I feeling even less, I guess that´s part of the withdrawal
  12. Hello everyone , At first i would like to introduce myself. I am a 24 year old boy from Italy and have been taking citalopram for several months. The exact time you can see in my signature. Already during the intake of citalopram I noticed a strongly sunken libido and I could not hold any strong erections anymore. As many of you were told me that these side effects disappear at the settle. Now I have stopped the drug since june and the sexual dysfunction have become worse. I still can get only a lacking erection. Genital numbness is present throughout and the libido is equally very low. So I unfortunately suffer as many others of PSSD and have already tried various supplements, but I could not see any improvement. My next try for a cure would be bupropion(150mg daily) and inositol (18mg daily). I have read that different people have noticed with these medications improvements. Now to my question: Can I take these 2 supplements (bupropion and inositol) together? My psychiatrist said it would not be a problem, but he can not imagine that inositol would change anything. I would take 150mg bupropion in the morning and in 18g inositol in the evening. So would you say that its Okay if i try a medication by connecting this 2 supplements together or would you rather to took first bupropion for 4 weeks and maybe after inositol if nothing changes. Im sorry for my bad english and i hope to get some advice! Greets, jescowhite
  13. A produced video explaining how child psychiatry has cured me, not:
  14. A year ago I came off effexor and Prozac. !! I developed insomnia, obsessive ruminations.. I felt very stressed!! All the time. Then one day I realized... I have no libido!! No sexual or emotional energy. I felt numb!! I tried suicide.. I somehow believed I was damaged. I went downhill fast. I quit my job, lost my fiance. I tried to end my life. I ended up in the psych ward. Long story short. I met a yogi. I was in a bad place in my head. Non stop ruminations. Chronic disabling insomnia. Complete numbness. I began to meditate and practice yoga. In other words, I gained awareness of my mind, and how it was making me sick. I abstained from masturbation for the past eight months. I've mastered my mind. I found God! Now,just in the past two months, my body has regained it's natural warmness. I feel once again , Pleasure! My body tingles with sensations in which I thought I've lost forever. I started feeling emotional last month . Someone in this movie was crying, and I felt his pain.. And I cried.. My stomach dropped and my breath left me. I let go. My depression is almost gone too!! I find myself laughing..! Even smiling!! Loving. . feeling peace, at last. I haven't felt this in years.. When I used to participate in negative conversations, I became consumed with hopelessness. I negative feedback loop if you will. I bought into the idea that I was damned for life. My mind wouldn't let go of this idea, until I gained awareness of my mind and it's conditioned cycles of repetitive negative thought. Feeding my depression. Now, I wake up, spend ten minutes watching what my mind comes up with, and I breath..gently.. And they come and go.. As I'm typing this, I have full bodily sensation. The nerves in my body feel alive. Much love to everyone!! Never give up!!
  15. Hi all, Long story short. Was anorexic last year until Christmas, starting recovering from that/weight restoring in January 2016. One of the ED therapists I worked with told me anxiety peaks once weight it restored, which happened (although didn't learn this until recently) - end of April 2016 I went into psychiatric hold because the anxiety was making me suicidal. Big mistake. Doc there put me on 20mg of Citalopram. For the next month I did therapy which along with an occasional Benzo resolved the anxiety. By May the Citalopram kicked in, with all its side effects. Extreme nausea, dry heaving, insomnia, weight gain, hunger cues messed up (already were from anorexia, but worsened), acne, gynecomastia, swollen fingers, fatigue - so bad (daily nausea was excrutiating) I nearly killed myself at the end of June. But I finally found a good doc, who through the next month of tests, determined it was the meds. Began tapering first day in August, 20 mg to 15 mg. Took a supp called Serosyn with 5HTP, L-theanine, and B vitamins. Withdrawal consisted of chapped lips in in the first week, increased hunger (I could be full but my brain still screamed to eat), fatigue (different form than when on 20 mg), wired feeling and weight gain. Leveled off a bit after 3 weeks, although I should have stayed there longer (but I didn't because the effects of 20 mg have been so bad that I've been trying to get off asap). 2 and a half weeks ago went down to 10 mg. Like before, chapped lips in the first week, wired feeling persisting, continued weight gain, and insatiable hunger. As before the lips are healing, but the hunger is still messed up (early fullness, insatiable hunger). Tired still, waking up hungry even after eating a lot at night. Haven't exercised in 8 months - first b/c of anorexia recovery, by now b/c exercise messes up my hunger cues/I cannot seem to physically eat enough. Worried I've been too aggressive with the taper, and that I'm doing irreparable damage to my nervous system. I wonder if I should reinstate 15 mg (scared it won't help/cause more complications) and start a slower taper? Seriously scared reinstating will mess things up even more, but equally scared that I've dropped too fast and have messed up my nervous system irreparably (and that my hunger cues/weight, which have been messed since starting anorexia recovery, are doomed for life). tl;dr: 20 mg citalopram was full of terrible side effects, dropped to 15 and then to 10 pretty quickly, and paying the price; wondering if I should wait it out for another week to see if anything improves like the 20-15 drop, or reinstate 15 and go slower from there (also scared I'm ruined for the rest of my life, I've had to quit a lot of things because of this damn med). On the bright side, gynecomastia, acne, and such are improving as expected. But this messed up hunger is getting at me (as is the weight gain and general crap feeling that I've had ever since starting this med).
  16. The cause of antidepressant-induced sexual dysfunction is multfactorial, as many hormonal systems are disrupted. J Clin Psychopharmacol. 2009 Apr;29(2):157-64. doi: 10.1097/JCP.0b013e31819c76e9. Sexual dysfunction, depression, and the impact of antidepressants. Kennedy SH1, Rizvi S. Abstract from http://www.ncbi.nlm.nih.gov/pubmed/19512977Full text http://www.mediafire.com/download/t92z22kzoxrh3z7/09_Kennedy_Sexual_Dysfunction%2C_Depression%2C_and_Antidepressants.pdf Sexual dysfunction is a common symptom of depression. Although decreased libido is most often reported, difficulties with arousal, resulting in vaginal dryness in women and erectile dysfunction in men, and absent or delayed orgasm are also prevalent. Sexual dysfunction is also a frequent adverse effect of treatment with most antidepressants and is one of the predominant reasons for premature drug discontinuation. Selective serotonin reuptake inhibitors are the most widely prescribed antidepressants and have significant effects on arousal and orgasm compared with antidepressants that target norepinephrine, dopamine, and melatonin systems. The availability of an antidepressant that does not cause or exacerbate sexual dysfunction represents an advance in pharmacotherapy for mood disorders and should reduce treatment noncompliance and decrease the need for switching antidepressants or adding antidotes. The purpose of this review was to provide an update on the prevalence, psychobiology, and relative adverse effect burden of sexual dysfunction associated with different antidepressants.
  17. Hi all...... I am new here. Searched google 'how to recover from risperidone' and found this site. I don't know how things work here, but I am sharing my experience. I was misdiagnosed with Bipolar disorder and took the medicine for 3 months. The details of the drugs are in my signature. Its been almost two months since I quit the medicines cold turkey. I am now suffering from withdrawal symptoms. Sexual dysfunction, ie.. no sex drive which is driving me crazy. I watch porn, but not able to get excited now. I am deeply depressed. Suicidal thoughts are coming to me thinking about my life. I have just completed graduation in B.tech in engineering. I was not able to write the final exams well because of memory problems, no interest to study, which was during my medication period. Now i am thinking what I will become in life, I can't function properly as a human being. In the morning I feel like sleeping more. I feel tiredness while trying to become active after waking up. So after breakfast I lay in bed again. In the evenings I will become more active till I sleep. Is this normal? Will I be able to lead my normal life back? If so how much time will it take to recover? Reply please........ I am in need of help.
  18. Someone from the PSSD yahoo group wants to start a class action lawsuit because of PSSD. Here's the link https://groups.yahoo.com/neo/groups/SSRIsex/conversations/messages/27313 So if you want to answer Craig's post, here's the link https://groups.yahoo.com/neo/groups/SSRIsex/conversations/messages/27313
  19. ☼-branyan-from-pp-genital-anesthesia-and-pssd Hey guys! Branyan here from the old PP forums. I haven't written in any SSRI or related forum in almost 2 years now. The reason being? Things for the most part have been pretty damn great. My actual life is great. I have a great career started. I am finally independent and financially stable. I've had a couple of short relationships in between now and when Paxil Progress ended. During that sexual relationship I almost NEVER had one problem. Not only that, things were pretty freaking great in that department. I never had any problems getting it up, and sex was frequent and very good. Now there is still some of the genital numbness, and spotty libido, but was scarcely a worry. So. fast forward. We broke up. Not the right time in our lives, etc etc blah blah. Now the libido and functioning goes right back down to nothing good. This has been the pattern in the post SSRI/PSSD world for almost 5-6 years now. In the relationship things work great. Outside of that relationship, even when by myself things just dont feel very good. I realize how lucky I am. I'm grateful to have what I have. I'm so lucky. I'm not even really complaining. I just kind of needed to vent because its kind of scary. And in the past the one habit I've made is obsessively trying to hook up with girls or look at porn to keep testing if things are working. And I want to be a lone for a while and do some more soul searching. The last girl i was with I was very upfront about the PSSD stuff, and we took our time to get to sex and that made all the difference. I cannot discount the emotional and psychological part of it. It's almost as if the PSSD has made those components so strong that I am now 'demi-sexual". If you look that up it basically means you can't be aroused without an emotional connection.. I've got a lot of work to do in therapy to deal with this. I need to listen to my rational mind and not the fearful part. I can do this. I'm of course open to any and all questions as I know that my story has been used as a success story for many people fearful of PSSD around the internet.
  20. I'm working on a book on antidepressants and intimacy - Regaining The Edge. We all know that antidepressants can blunt emotions and cause physical side effects, many of which interfere with intimate relationships directly (sexual side effects) and indirectly (e.g.., weight gain, nausea, diarrhoea, etc...). I want to fill the book with people's stories, the wisdom of experience. I am interested in strategies that worked to manage these side effects (and why and how they worked), as well as highlighting the daily struggle that many of us being treated for depression and other mental ills face, both with our mental health, but also the consequences of our treatment. There is a questionnaire on my site at RegainingTheEdge.com, as well as a contact form. I am also interviewing people one-on-one, either face-to-face if you live on the east coast of Australia, or via Skype or email if you live elsewhere. You can follow me on Facebook at https://www.facebook.com/regaintheedge. Please take the time to share your story with me - this is an important issue, one that has received scant regard to date. Michael
  21. More documentation of Post-SSRI Sexual Dysfunction (PSSD), lasting long after discontinuation of the drugs. J Clin Psychopharmacol. 2015 Jun;35(3):273-8. doi: 10.1097/JCP.0000000000000300. Post-SSRI Sexual Dysfunction: Clinical Characterization and Preliminary Assessment of Contributory Factors and Dose-Response Relationship. Ben-Sheetrit J, Aizenberg D, Csoka AB, Weizman A, Hermesh H. Abstract at http://www.ncbi.nlm.nih.gov/pubmed/25815755 Emerging evidence suggests that sexual dysfunction emerging during treatment with selective serotonin reuptake inhibitors (SSRIs) and/or serotonin-norepinephrine reuptake inhibitors (SNRIs) persists in some patients beyond drug discontinuation (post-SSRI sexual dysfunction [PSSD]). We sought to identify and characterize a series of such cases and explore possible explanatory factors and exposure-response relationship. Subjects who responded to an invitation in a forum dedicated to PSSD filled out a survey via online software. Case probability was defined according to the following 3 categories of increasing presumed likelihood of PSSD. Noncases did not meet the criteria for possible cases. Possible cases were subjects with normal pretreatment sexual function who first experienced sexual disturbances while using a single SSRI/SNRI, which did not resolve upon drug discontinuation for 1 month or longer as indicated by Arizona Sexual Experience Scale scores. High-probability cases were also younger than 50-year-olds; did not have confounding medical conditions, medications, or drug use; and had normal scores on the Hospital Anxiety and Depression Scale. Five hundred thirty-two (532) subjects completed the survey, among which 183 possible cases were identified, including 23 high-probability cases. Female sex, genital anesthesia, and depression predicted current sexual dysfunction severity, but dose/defined daily dose ratio and anxiety did not. Genital anesthesia did not correlate with depression or anxiety, but pleasureless orgasm was an independent predictor of both depression and case probability. Limitations of the study include retrospective design and selection and report biases that do not allow generalization or estimation of incidence. However, our findings add to previous reports and support the existence of PSSD, which may not be fully explained by alternative nonpharmacological factors related to sexual dysfunction, including depression and anxiety.
  22. 2014 the beginning of November I went to a psychiatrist and got misdiagnosed with psychosis and depression and was prescribed Rispolept (Risperidone) 3 mg and Cipralex (Escitalopram) 10 mg. I took these drugs at home, then in the psychiatric hospital until around the end of December, so for about 1.5 month, until I was discharged, then cold turkeyed. Antipsychotic - 3 mg/day, SSRI - 10 mg/day. I felt very bad, suicidal that whole time, at first not even realizing it was the drugs affecting me and in fact almost committed suicide. While on medication I experienced akathisia, severe fatigue, anhedonia, weak emotions, almost non existent libido that gradually got worse, slowed reaction time, thinking, talking, moving, poor memory, what I'd call derealization, zombie like state, frequent urination, dizziness , headaches, one side of brain, frontal lobes especially, abnormal gait, strange feeling in frontal lobes, increased appetite, too high body temperature, especially after running, nerve pain in left leg, arm, numbness in left arm, leg and left side of face I think. After quitting the drugs I thought everything would go back to normal, but it didn't. After about a month drug free I had: severe sexual dysfunction (post antipsychotic sexual dysfunction-PAPSD), my left hand was somewhat numb, and to a lesser extent, my left leg. I also started noticing dystonia in my left cheek and eyelid. Slight tremor in left arm fingers. Dizziness when turning head. I also noticed I had developed slight gynecomastia. After two months the painful tingling in my left arm was very severe some days lasting the whole day. Very bad pain. Dizziness disappears. Month 3: painful dystonia in middle of back, left side of spine appears, more pronounced in the evening. Weak morning erections appear. Month 4: (2015-04-09) tingling in left arm subsided, but it's still numb. I think the tingling is the nerves recovering. Hoping for recovery. Will update. I'm optimistic about the dystonias, paresthesia (but probably won't recover sensation fully), sexual dysfunction, as far as I know my new man boobs should also reduce in size with time. But I heard that the neuroleptic induced parkinsonian tremor does not always disappear, and I'm not seeing a reduction in the tremor, so I'm worried about that. Also, obviously worried about the sexual dysfunction. I used to be very sexually active, but now have very infrequent orgasm, because they're so very difficult to achieve and not so rewarding. My pre-neuroleptic emotionality has fully returned after stopping the drugs, I think. I also heard Risperidone can permanently reduce testosterone, but I haven't seen a reduction in facial hair growth. Been drug free for 4 month now. Never took any psych drugs before in my life. Now only taking fish oil, multivatamin and mineral tablets, sometimes magnesium 300 mg. I tried Vitamin B Complex but I think I'm allergic to it. Psychiatrists truly are ignorant.
  23. Hello everyone, 36 year old male, suffering from depression since 2010 brought on by a death in the family-someone I was terribly attached to. Since then, lost a lot of interest in the things in life that used to make me happy. Contracted severe OCD as well; would make the sign of the cross and touch table surfaces upto 8 times anytime an intrusive thought came into my head, and would hum prayers under my breath which became (at times) embarassingly noticeable to those around me. In 2012 things got better; I left a depressing, dead-end job and decided to take time off work to do my MBA in Spain (I live in Dubai btw). Didn't have much time to be depressed doing my MBA since it took so much of my time and I felt I was doing something worthwhile, but I had a massive hit in self-esteem when I lived there. I felt pretty alienated and lost in a foreign land with a foreign language and developed social phobia as a result. My sex drive also suffered as a result. At the end of 2013 I moved back to Dubai to find a job. It wasn't until April 2014 that I finally got a job offer, but with a company and a prospective manager I had serious doubts about. As a result, I visited a pyschiatrist and mentioned that I need a coping mechanism for the next one year (the period I assumed I would have my hands cuffed to this job after 2 years of wonderful independence). I was prescribed citalopram (Celexa) for mood stabilisation, and clonazepam for social anxiety. Citalopram worked fairly well for me; I noticed I was a lot calmer, less prone to mood swings, less prone to depressive thoughts and behaviour. However in September 2014, I got this wonderful brainwave to go off Citalopram cold turkey. Yes, I know It was almost close to what I would expect a heroin withdrawal to be like, with the emphasis on mental vs. physical symptoms. For 2 weeks I suffered, and my actions during those weeks came back to bite me 2 months later. In the meantime, the doctor prescribed me to go back on Citalopram. It helped immensely; I was back under my normal, subdued, antidepressant greyish cloud. In November 2014, I visited him again and told him the sexual side effects (yes, we're finally getting to why I am on this board ) were not great. Even to the extent that Cialis couldn't counter it! I had read a lot about Bupropion (Wellbutrin) being able to counter the sexual side effects of anti-depressants, so I asked him to prescribe it for me. He did, but I have only recently started taking them (4 days ago as a matter of fact). Later that same month (November 2014), I was called into a meeting with my bosses, and told that they had decided to terminate my contract. As I suspected back when i first took this job, my direct line manager turned be a boorish, arrogant, bossy tw*t, and our showdowns which intensified during my unfortunate cold turkey phase had led to him plotting to remove me from my position, because he couldn't try and forcefeed me the daily bullsh*t he was giving. I, unfortunately, played into their hands. Nevertheless, not working for that company has been brilliant. However, it's now February 2014 and I am still unemployed. I feel like the situation and the antidepressants have completely robbed me of my sexuality. I have developed OCD in terms of unwanted sexual thoughts. My loving and understanding girlfriend and I haven't made love since November last year. I've started tapering off the Citalopram since December, and have recently added Bupropion to the equation, hoping that I can get my sex drive back, heck even get a solid and firm erection and have a reasonable fantasy about a woman and masturbate. Incidentally, during my cold turkey phase, I did get some of my sex drive back. By the end of this month, I plan to get completely off Citalopram and give Bupropion a real go. But I'm really, really worried about PSSD.....not least because my sex drive was anyway suffering for the past few years, and I have history of using 'disco' stimulants in the past.
  24. I was given 20 mg of Prozac back in 1997 for depression. I was still technically a minor back then. I had an initial "high" from the Prozac which was mistaken for me not being depressed anymore. A few months later, Prozac stopped working and I had completely lost my sexual functioning. I told my doctor about this, so I was switched to Effexor. I kept on being switched from medication to medication in an attempt to achieve the initial "high" of the Prozac and to reverse the sexual functioning but things just got worse. One day I was put on a medication called Wellbutrin and that caused a manic episode from the first dose which caused me to have to be put into an inpatient facility. I was now switched from just being depressed to having bipolar disorder. I was put on Depakote which stopped the manic episode. Depakote caused me a lot of suffering, so I decided to cold turkey the medication about 6 months later. This led to another inpatient hospitalization and now I was polydrugged with Depakote and Zyprexa. This was the first polydrug combination I was on. This combination of medications was even worse because I was sleeping at least 16 hours a day. After another 6 months or so, I cold turkeyed both of these medications and that led to another inpatient hospitalization. I was fortunate in some ways to have the Zyprexa removed and be able to function somewhat ok on just Depakote and now Klonopin. I stayed on Depakote for years but my sexual issues were never solved and I had a lot of other side effects from Depakote such as multiple sclerosis and Parkinson's disease like symptoms. In around 2005, I discovered the first person who had described the same sexual issues I experienced. It was called Post SSRI Sexual Dysfunction. I discovered forums similar to this one, and consumed books by people like Dr. Breggin. In 2007, I was able to successfully withdraw safely from all medications by switching over to lithium and valium and using a compound pharmacy to taper down. I felt a lot better and recovered from some of the damages caused by the medications. I began social drinking in 2008 because I felt like I missed out on such a big part of my life. About 6 months later, I completely lost my ability to sleep probably due to the alcohol damaging what the benzos had already damaged. I was forced into a state psych ward and given a diagnosis of bipolar NOS, psychosis, anxiety etc. After 3 or 4 months in the state psych ward, I left on a combination of Depakote ER and Ativan. I had to eventually updose the Depakote ER and switch to Klonopin again. So for the last 3 years or so, I've been on 1250 mg of Depakote ER and 3 mg of Klonopin. While I am not suffering nearly as much as I did when I was bombarded with antipsychotics like Haldol and Geodon, life isn't nearly as good as I know it could be. That's why I want to get help in coming off of the Depakote ER and Klonopin safely. My confidence level is a bit low because I feel like I may be damaged beyond repair due to being on dozens of psychiatric medications and due to the past experience with insomnia I freak out when I cannot sleep and that is what is happening now. I started to taper off of Depakote ER on 11/24/2014 and I'm on 750 mg Depakote ER now and 3 mg of Klonopin. That's my intro but I'm not sure what to do next...
  25. Pharmacol Biochem Behav. 2014 Jun;121:138-45. doi: 10.1016/j.pbb.2013.12.003. Epub 2013 Dec 11. Antidepressant-related sexual dysfunction - Perspectives from neuroimaging. Graf H1, Walter M2, Metzger CD3, Abler B4. Abstract at http://www.ncbi.nlm.nih.gov/pubmed/24333547 Full PDF text here https://xa.yimg.com/kq/groups/14420181/1954044300/name/SSRI+and+FSD+-+MRI+2014.pdf Abstract: Sexual dysfunction is not only a common symptom in major depression but also a frequent side-effect of antidepressant medication, mainly of the selective serotonin reuptake-inhibitors (SSRI) that are often prescribed as a first line treatment option. Despite of the increasing incidence and prescription rates, neuronal mechanisms underlying SSRI-related sexual dysfunction are poorly understood and investigations on this topic are scarce. Neuroimaging techniques, mainly functional magnetic resonance imaging (fMRI), provide a feasible approach to investigate these mechanisms since SSRI-related sexual dysfunction is most likely related to central nervous processes. This review summarizes the recent literature regarding the basic clinical findings and imaging correlates of antidepressant-related sexual dysfunction linking brain regions and networks potentially involved two phases and subcomponents of sexual processing and antidepressant action. In particular, fMRI studies on SSRI antidepressants including paroxetine and SNRIs including bupropion are highlighted. .... Conclusion: Recent investigations focusing on antidepressant-related sexual dysfunction could demonstrate that neural networks and subcomponents of sexual processing are affected specifically according to the drugs' impact on neurotransmission. Whereas serotonergic drugs like SSRIs led to decreased activation in reward and emotional networks, dopaminergic medications led to enhanced activations within these brain regions, thus, providing evidence and neural correlates for the clinical observation of SSRI-related sexual dysfunction that is absent under dopaminergic drugs. Although further research is necessary, neuroimaging studies thus could link clinically observed antidepressant-related sexual dysfunction to a plausible explanatory neurobiological model. Moreover, it seems reasonable that these approaches may not only be helpful for the selection of specific drugs according to their receptor profiles but also for developing new medications.[/size] Direct Download: https://xa.yimg.com/kq/groups/14420181/1954044300/name/SSRI+and+FSD+-+MRI+2014.pdf SSRI+and+FSD+-+MRI+2014.compressed.pdf
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