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  1. I'll try to keep this kind of short. I've finally decided to post an intro today after reading posts on this site for a few years now which has helped a lot with understanding what's going on since most doctors just told me my SSRI discontinuation/withdrawal symptoms-which were unlike anything I'd ever experienced before and physically and emotionally worse than I'd ever felt-were a return of my depression & anxiety or possibly a bipolar disorder according to one doctor. I knew for a fact that it was not my original anxiety & depression, but I had no idea what was happening in the beginning or how to explain it. I had social anxiety, depression, & general anxiety since age 12 and was not allowed to drive/take the bus/go out or do much by myself other than going to school (because everything was too dangerous) by controlling, religious parents with their own high anxiety and agoraphobia. I was never allowed to receive counseling for these issues & when I went off to college, it was an extremely difficult struggle going from not being allowed to do almost anything to suddenly being responsible for figuring everything out on my own. I was also not great with time management skills & knowing how to plan ahead. (I actually relate to a lot of symptoms of ADD & Asperger's, which both greatly affect social skills & ability to get through college and would explain a lot of problems I've had. I have learned more about them in the past year, but can't afford to get diagnosed right now so I've just been looking at support groups for days when my nausea is lessened.) I felt overwhelmed all the time and all my negative thoughts worsened severely. I didn't see the free counselor at college during this time either because I was embarrassed about everything and about asking for help. I finally decided I wanted to try to make a change and try counseling the summer after sophomore year of college at age 20 and was at rock bottom, desperate to not feel depressed. I knew someone who said their antidepressant helped them, so I asked a doctor for medicine and they prescribed sertraline. After taking the first pill, I had a surge of anxiety and racing thoughts that made it impossible to concentrate. Within the first couple days on 25 mg of sertraline, I was gagging and dry heaving over and over for at least 20 minutes as soon as I ate anything. I would also throw up multiple times in a short timespan after one snack or meal. I called my Dr & was told to skip a dose and then change the time I took the dose from morning to night. After a week of this (dry heaving & vomiting all meals) on 25 mg, and another call to the doctor, I was told that digestive issues are a possible starting symptom and to increase to 50 mg. As soon as I increased, the gagging & vomiting increased even more. After 6 days of this, I called the doctor again and was told I could stop taking it altogether since it had been such a short amount of time on it. And to come in for a different medicine Rx after the weekend. The very first day that I didn't take the sertraline, I felt the worst nausea I had ever felt in my entire life. I ended up asking a friend to drive me to the ER because I felt so sick. I told the Dr how I had just stopped sertraline. The doctor said that my pupils were dilated and my reflexes were overactive. Then, he listed off illegal drugs & asked if I had taken those. (No, I've never tried any drug before). He said "You need to tell me what else is going on because the antidepressant couldn't have caused this." And I said "I don't know" and started crying. I do know that people in my family are highly sensitive to medicines and have since found out I have a gene that causes me to metabolize slowly so things build up for longer in my system. Anyway, the Dr left the room and at one point I was given Ativan in an IV by the nurse which did ease the nausea. When the Dr came back, he told me I had SSRI discontinuation syndrome, (he didn't explain what that meant), that I could never try another SSRI, and gave me a Rx for a small bottle of Ativan. My mom said he mentioned something on the phone to her about serotonin syndrome which dilated pupils and overactive reflexes are symptoms of, but I don't remember him saying anything about it directly to me. He also mentioned reinstating a small amount might help but my mom didn't pass this on to me until much later because she didn't want me to take it. After that, I experienced: -more dry heaving which gradually lessened in frequency -random times of vomiting after eating and after exercising when I wasn't sick & the food wasn't bad (or sometimes nothing was left to vomit & only a small amount would come up) -continuing debilitating nausea & dizziness -olfactory hallucination (putrid smell that wouldn't go away, would intensify around strong scents such as soap & car exhaust) -uncontrollable crying at every tiny thing (neuro-emotion, not regular sadness) -uncontrollable rage (neuro-emotion) -intrusive thoughts & floods of bad memories which I "word vomited" in texts to my sisters -didn't want to be around people who I associated with bad memories because it would greatly intensify neuro-anxiety. (I'd guess the feeling is similar to what people mean who talk about experiencing bad drug trips and how it's important to be with people you trust) -nightmares -paranoia/suspicion/distrust (felt like my mom & sister were not really my mom and sister even though logically, I knew it was them. Things feel creepy & sinister -almost like a horror movie sometimes. A post I read here compared the sinister feeling to a bad LSD trip. I have never tried LSD, but I understood what they meant & is the closest way I found to describe it. -cognitive fog (thinking, processing speed, & reaction time is noticeably slower) (I was a slow thinker/processor before, but it feels like I have brain damage now) -memory problems (I was somewhat forgetful before, but am even more so now) -depersonalization ("it feels like the medicine changed who I am & I don't have an identity/sense of self which I still hadn't fully formed before sertraline) -derealization (feel emotionally disconnected & distant from people/atmosphere. I know things are real, but they don't feel real. Sometimes it feels like consequences won't matter or there is no sense of helpful anxiety even in a potentially dangerous situation. Logically, I know they do matter and still want to do the right thing) -anhedonia/apathy/emotionally numb (don't care about things or have the same amount of passion for interests or feel empathy for other people's emotions or feel spiritual even though I had some spiritual beliefs before. Couldn't feel hopeful about anything/future or feel love towards or from anyone. These emotions have slowly returned to a certain degree since then & levels of ability to feel them have changed at different courses of time) -blurred/cloudy vision (when DR was at most intense, vision was different. Hard to explain) -eye floaters ( random black specks & lines) Didn't notice these until a year after DC-ing -constant yawning/air hunger -stomach/digestion issues -burning, tingling, itching, numbness, redness in feet -brain zaps/"crackles" (sometimes annoying, sometimes painful, but my most tolerable symptom) -head pressure/tightness, feels like head is being squeezed -headaches There was also a period of 6 months where I thought certain symptoms were over and after that period, the dizziness returned. Those are most of the symptoms I've experienced in the past approx 3.5 years. They're not in order. I'm 24 now. A few have gone away for the most part (vomiting, olfactory hallucination, yawning) and most are less intense. I have really improved a lot, I don't mean to sound overly negative. But, I still have the issues I went on the SSRI for & I have trouble accepting where I am & worrying about where to go from here & the uncertainty of how long this lasts because it has put lots of areas of my life on hold (I wasn't able to go back to college, I hope to someday) and ended up making things harder to deal with when I was told it would make them easier. (BTW, I am now seeing a counselor). I don't understand why people say SSRI's are not technically drugs when they have this much of an effect on your mind, mood, & perceptions. Sorry if I have over shared, I might need to post a shorter version of this at some point that's easier to read. And I'm still figuring out the layout of the website & where to post about certain questions & topics. I just know that sometimes other people's explanations made me feel better because I had some understanding of what was happening & words to describe feelings I'd never had before and didn't know how to explain. I've also had other stress & health issues and a few (physical health) medicines that have affected my withdrawal progress, but I guess that's a topic for a separate forum. Any advice, similar experiences, recommendations, tips for using the site, or insight into what happened to my brain is appreciated if anyone feels so inclined :)
  2. Hi all, I am Katt, And I am weaning off of Effexor first and then will try to get off of Clonopin. I have suffered from depression and anxiety for as long as I can remember. I’m 59 and first started antidepressants when I was in my mid 20s. I’ve been on and off a large variety of medications, all of which either eventually stopped working or caused too many side effects. Wellbutrin caused terrible insomnia for way too long. I have tried Zoloft, Celexa, Prozac and a few others I can’t remember. I decided to wean off of Effexor after I completed the series of trans cranial magnetic stimulation which has seemed to help a lot. Now I want to get off of the anti-depressant and be sure That I am cured of my depression, or at least greatly improved. The Clonopin I take, 1 mg a day, is for help with sleep… It turns off that voice inside my head that wants to make a grocery list or remember to bring something with me when I go someplace. In other words, **** I don’t need to be thinking about at 3 AM! I haven’t figured out how to put in a signature line yet, but this is the latest information. I started Effexor in 2014 or 15. I was taking 300 mg, 150 twice a day. I am weaning down 37.5 mg every three weeks. At first I was on a two week schedule, but since my husband has metastatic cancer, my teenage daughter had a first psychotic episode, my youngest suffered recurrence of severe anxiety, depression and school refusal and I lost my job... so my psychiatrist decided a three week interval might be best. In reading through the possible side effects of Effexor, which I had read when I first began taking the medication, I now realize that it has probably been the cause of many adverse physical effects I have been blaming on other things! Below is a list, or at least a partial list, of side effects I believe are caused by the Effexor! Many things are new and, of conditions I had previous to Effexor, worsening of symptoms: Type two diabetes High cholesterol Elevated liver enzymes Elevated iron levels Gallstones Nonalcoholic fatty liver disease Level two or three scarring of my liver Excessive sweating Hot flashes Night sweats Nausea Weakness Severe fatigue Very tight muscles in my neck Muscle spasms of my back, neck and legs Abnormal healing creating abnormal scars Clumsiness or loss of balance? Memory loss, confusion, working and thinking slowly? Tinnitus Heart palpitations Tachycardia Persistent edema, especially of the hands Worsening of rosacea and acne Worsening of urticaria Itchy skin Easy bruising Stiff muscles, decreased flexibility and range of motion everywhere Excessive bleeding of cuts Anorgasmia, improved a little Tingling and numbness in my feet, not from the diabetes Extreme worsening of back hip and neck pain Worse arthritis Some Urinary incontinence or hesitation Hair loss Worsened asthma Sleep apnea And a whole bunch of other things I had never heard of or made the connection to Effexor since they may not have started or worsened for a few months or years after starting taking the drug. Glad to be here and compare notes with others. The main side effect of withdrawal I am experiencing now is nausea. Luckily the brain zaps have not started and I hope they do not. I’m starting physical therapy for pain, weakness and mobility issues soon. I have a TENS unit for my back and hip pain, I hope to get a Home traction unit for my spine and a new SI belt for hip pain. Katt
  3. In Feb of this year I decided that the cons of Adderall were no longer to my benefit and decided to quit cold turkey. I spent a month weak, tired, irritable and unable to cope with all the "noise" of everything that was happening around me. Driving, shopping, even conversations felt like too much to handle. They say that Adderall is not addicting but it is, maybe not in the physical sense for some but in the emotional sense I became heavily reliant on the pills just to be around people, to get out of bed; basically just to do the simple things that "regular" people get up and do day after day. When I was first prescribed Adderall about 7 years ago, every few months I'd purposely stop taking them for an entire wknd just to reassure myself that I could stop. To be continued.
  4. I have been on Wellbutrin for the last 10 years. I am currently on 300 mg of bupropion extended release. This will be my third attempt to taper off successfully. This time I have prepped my body and created a conducive environment to successfully taper off. I've followed the pre-taper protocol of a few holistic psychiatrists, mainly Dr. Kelly Brogan. Can anyone who has successfully tapered off Wellbutrin recommend a tapering schedule? Also, did you have the drug compounded into a liquid to taper or just taper down using the tablets? The compounding pharmacy said that they couldn't create a compounded version of the extended release of the Wellbutrin; it would just be immediate release. Is this true?
  5. So here we go... About 6 months ago I was diagnosed with depression and ADHD. Initially my doctor prescribed me Lexapro for my depression and I stopped taking it after around 5 days because it made me feel terrible. He decided to put me on Wellbutrin 150mg because of my depression and lack of motivation. The 150mg didn't really do anything for me so he bumped me up to 300mg. When he wrote me the script for the 300mg, he also wrote the vyvanse script for my ADHD (Initially 30mg now at 50mg). So i started taking the vyvanse and Wellbutrin at the same time. They worked very well at first and I started doing better at work, school and i started going out more with my friends. But after a couple months, the side effects really hit me. I would take my meds around 6:30am and I would start to crash around 10am. This was not ideal because I still have classes all the way up until 2pm. When I crash, I have a very cloudy, foggy feeling in my head and I can't think straight. It gets worst and worst everyday and I don't know what to do. I am a chronic marijuana user (multiple times a day). My doctor is aware i smoke and he told me that my chronic use of the drug contributed to my depression. I started smoking only a few times a week. My new meds started to work and I wasn't smoking weed anymore... Until the crash began to be too much on my head. Marijuana has helped me sleep, eat, interact with others, be happy etc... So here are my questions... 1. Are there any other good substitutions for Wellbutrin that isn't an SSRI? 2. Should I continue to smoke marijuana? If not, why? 3. Is there anything that will help my energy levels besides caffeine, medication and better health choices (I've tried a lot of them) Any other recommendations will help P.S. It will take a lot to convince me to stop smoking
  6. This is an extremely troubling article from the New York Times from October 9, 2012. If you think the picture of the boy is disturbing, the dead look in his eyes are only the beginning of yet another life destroyed by psychiatric drugs instead of fixing our failing schools. Attention Disorder or Not, Pills to Help in School CANTON, Ga. — When Dr. Michael Anderson hears about his low-income patients struggling in elementary school, he usually gives them a taste of some powerful medicine: Adderall. The pills boost focus and impulse control in children with attention deficit hyperactivity disorder. Although A.D.H.D is the diagnosis Dr. Anderson makes, he calls the disorder “made up” and “an excuse” to prescribe the pills to treat what he considers the children’s true ill — poor academic performance in inadequate schools. “I don’t have a whole lot of choice,” said Dr. Anderson, a pediatrician for many poor families in Cherokee County, north of Atlanta. “We’ve decided as a society that it’s too expensive to modify the kid’s environment. So we have to modify the kid.” As the article goes on, we meet several children, including Quintn who suffered from symptoms (adverse reactions) so severe that at only 10 years old, he's locked up and then placed (i.e. forced) onto an antipsychotic. When puberty’s chemical maelstrom began at about 10, though, Quintn got into fights at school because, he said, other children were insulting his mother. The problem was, they were not; Quintn was seeing people and hearing voices that were not there, a rare but recognized side effect of Adderall. After Quintn admitted to being suicidal, Dr. Anderson prescribed a week in a local psychiatric hospital, and a switch to Risperdal. Even after this experience, the crime continues: Despite Quintn’s experience with Adderall, the Rocaforts decided to use it with their 12-year-old daughter, Alexis, and 9-year-old son, Ethan. These children don’t have A.D.H.D., their parents said. The Adderall is merely to help their grades, and because Alexis was, in her father’s words, “a little blah.” This is telling because it's putting the narrative into the parents' hands - "the Rocaforst decided to use it" with their other children. Decided to use it? Really?! I would think the doctor made that decision and scripted the drugs. And what do the doctors conclude? “This is my whole angst about the thing,” Dr. Anderson said. “We put a label on something that isn’t binary — you have it or you don’t. We won’t just say that there is a student who has problems in school, problems at home, and probably, according to the doctor with agreement of the parents, will try medical treatment.” He added, “We might not know the long-term effects, but we do know the short-term costs of school failure, which are real. I am looking to the individual person and where they are right now. I am the doctor for the patient, not for society.” This is such a cop out because we DO know the long-term effects. This is an indication that every pediatrician should be required to read Robert Whitaker's Anatomy of an Epidemic, as well as his website, including this article by Bruce Levine: Is Society or Psychiatry to Blame for the “Seriously Mentally Ill” Dying 25 Years Prematurely? It's both ironic and tragic that as the schools deteriorate, pediatricians take it into their hands to "fix" the situation by destroying the very children they say they are there to help. No, Dr. Anderson, you are not the doctor for society. But you certainly aren't the doctor for the patient, either.
  7. Used Remeron for a couple of months, and was weirdly content at all times, but also zombie/lethargic/sedated, and it increases my adhd symptoms/stops mt adhd meds from working. Meh, ill write more later. Been lurking on this forum after my first taper attemt was to impatiemt, and backfired after 2-3 weeks. Got a sore throat todat, and feeling a bit sick, not sure if it is from tapering or if I'm actually getting a cold. Feel sick from time to time, that is probably due to cutting Remeron from 7,5 mg to half of that. Was on 7,5 (from 15) for 3 or 4 weeks, and it was fine, except that I was still umable to get anything done. A lot of my meds history indicates that I'm a poor metaboliser, and when I read that the antihistamine effect was full even on small doses og Remeron, I dropped to the last dose of 3.75. A little trouble with sleeping, but melatonin helps. Eating got better after adhd meds was increased, cuz now head works better. Im not spaced out. Basically a nuber of symptoms coyld either ve tapering symptoms, or; because reducing remeron might give more room for adhd meds to work, side effects of Vyvanse. After dropping remeron I have washed clothes for the first time in 1 or 2 months. Yay! Meh. Need to have patience. When Remeron tapering is done I need to look on my adhd dose. Writing symptoms & diary is a good idea. Lasted for 2 weeks, perhaps itnwent south when I started with Remeron. Didn't know it blocked histamine receptors, know from experience that antihistamines and ritalin made me so "woosy" I could not walk straight. Yeha, Remeron, and also tapering, messes up my adhd. Big time.just look at this post. Took it to reduce ptsd symptoms, sleep more and eat more. Not having so many triggers now (change of situation), so going to try to use adhd meds alone. Being so sensitive to meds it's not tempting to spend several months trying out something that is likely to give too troublesome side effects. As in not functioning. Want to cook, take out trash and get stuff done, not play app games all day and too litle energy to shower or change a light bulb. I'll sort out my introduction later.
  8. I am making a final decision about getting off antidepressants/stimulants for good. Please help me decide. I am in great need of encouragement and wisdom. It has been about 2 years since I started my journey. But some history: In college (2005) I was started on 20mg Adderall XR to help with ADHD which was said to be causing a lot of anxiety and perhaps depression. Adderall induced depression in me after my dose would wear off, so the doctor prescribed Lexapro 20mg. I felt probably the best I've ever felt in my life. However, I still wanted see who I was without the meds. I wanted to re-connect with parts of me that felt lost. I also never wanted to take brain medications for life. So from 2005 to 2014, I took the drugs and tried maybe 3 different times to get off; never really tapering much like I should have. It never worked and I always ended up back on them, happy, and enthusiastic about life again. I decided to make my final, serious effort to get off the meds in 2014. Happily married, with a good career and social support at this point (and still). I tapered off Adderall XR over the course of at least 4 or 5 months. The primary care doc warned me to get totally off the Adderall first, then deal with the Lexapro. Big mistake. After I was done with the Adderall and just on Lexapro, I was depressed, lethargic, weepy. This went on and got worse, so the Lexapro was replaced with wellbutrin, and I felt better. Over the next year though, I started getting bad anxiety, and had trouble sleeping. 25mg of Zoloft was added in Nov or Dec of 2015, and I got a lot better. Then I began my taper... but not very responsibly, again. Will I ever learn?! Split the Zoloft in half for a few weeks, then stopped it. Waited awhile and the anxiety returned, as well as the sleep problems. Psychiatrist and I agreed that the Wellbutrin must've been exacerbating my anxiety, so suggested I stop it cold turkey. I resisted a little bit, but not enough; I stopped pretty much cold turkey. That was 3 months ago, and here I am, very shaken and having had major issues with anxiety, insomnia, fear, worry, and other issues including the 2nd panic attack I've had in my life. I've worked hard on mindfulness practices over this time. However, my wife and I have agreed that it's time for me to get help again. I started Buspar 2 weeks ago and don't like the side effects. I was given 5mg Adderall XR to try and help as needed. I am planning to get back on meds now... but I don't know which ones because I don't know if I should resign to taking them for the rest of my life or try to taper again. Tapering on Adderall XR and Lexapro will be harder than Wellbutrin and Zoloft was. So I've got a couple options as I see it: 1. Bite the bullet, swallow my pride, and take Adderall and an SSRI for life. Live long and enjoy life; it's too short to keep causing myself this much pain. I truly enjoyed how I felt on Adderall and Lexapro, despite my adamant desire to stay off of them. 2. Own my setbacks and move forward. Take the Wellbutrin and Zoloft again and after 6 months to a year, conduct a true, gradual 10% taper off of each one. If it takes years to be med-free, so be it. Either way, I NEED to get better ASAP; my job feels like it's falling apart, and my wife and son need a capable man in their lives to hold onto. I need myself back. So either way, I plan on getting back on medication(s) (unless you guys can somehow convince me that staying off and risking my work and family life is better). What do you guys think? I've frequently written in my journals that all I want in the whole world is to just be free of these medications. But I could also see myself being happy and feeling great the rest of my life if I just give in and take the combination I used to THRIVE on; Adderall and Lexapro (or another SSRI). And what about the tapering? If I get back on the Wellbutrin (150mg XL) and Zoloft (25mg), wait until I've had some time to recover and enjoy my life and family again (at least 6 months), and then begin with a true, gradual, 10% taper off both medications, do you think I'll still have to deal with crippling anxiety, fear, dread, and insomnia that has plagued my family and I over the past few months? Or do you think that a 10% taper over a series of years will allow me to reach my goal and be medication free, while still being able to enjoy my family and be a good father... I mean, would the taper make my problems significantly easier to cope with? And once I'm fully off the medications, would I still have to deal with the crippling protracted withdrawal? I keep thinking I might still be dealing with increased anxiety from such a long time taking Lexapro. I was never in my life this anxious or stressed by such little things (big things, yes, but not these kinds of things). I ruminate and obsess so much, it kills me. The Adderall helps, but I can't keep taking that if my plan is to get off meds. Any advice would be deeply appreciated. I am open to staying on medication for life if need ends up being. But I'm not in the best state of mind and I've constantly gone back and forth between the two options. Advice will be so much appreciated, encouragement as well. Thank you guys so much for the excellent website you've created.
  9. Hi all, I have been taking Effexor Xr 75mg for about 8 years now. During that time, the cause of my anxiety became known (ADHD-PI) and while Effexor was excellent at controlling my anxiety, I no longer feel I need it now that my ADHD is under control via other medication. Plus the sweat. God the sweat. I sweat if I tie my shoes, I sweat reaching up to brush off the sweat that came from tying my shoes. I am not unfit. I just sweat. All. the. time. It is ruining my life (and my sheets) I cant remember when the sweat started, but my mother is on it, same sweating issue. My aunt recently started it. Never had a sweat problem, now its uncontrollable. I am pretty sure its the Effexor. The problem is, I cant get off it. The manufacturers recommendation to doctors is, 75mg, 37.5mg, 75mg, 37.5mg etc etc for two weeks. Then two weeks of 37.5mg, then 37.5mg, nothing, 37.5mg, nothing etc for two weeks until off. This does not work. The brain zaps and vertigo make life impossible. I took a long break from work to do this and ended up having to go back to the full dose because I wouldnt have been able to go back to work at the end of my leave if I didnt. So. I had an idea to reduce the dose via removing beads, searched how many beads in a capsule and found this site. Hi. What I would love to know first off is... Did anyone else have this sweating problem? Did ending Effexor work to stop it? Has anyone else successfully stopped effexor after being on it as long as I have? Thanks all.
  10. Hi I'm Lauren, I'm 24, and have been on and off meds since I was 18. I was put on 5mg of lexapro at 18, with strattera 70mg for ADD. I was on both for about 2 years, strattera did nothing for me. And I tapered off lexapro slowly after two years with no problems except brain zaps for a few weeks. Depression never came back. I had a baby when I was 21, and came down with post partum depression and was put on Wellbutrin for 2 months. It made me feel crazy, very up and down and much more depressed so I tapered off quite fast, and was fine afterwards. Suffered no real withdrawal. I was then put on adderall xr 10mg twice a day for ADD the end of 2012, it helped my anxiety and my focus immensely, but I then became allergic and stopped December 2013; I was then started on concerta 30mg for about a week, but it made me feel like a zombie, and also became allergic..so my doctor switched me to Vyvanse 30mg, and after 2 months, I am now on vyvanse 50mg and lexapro 10mg. In January this year, I was put back on escitalopram (lexapro) , due to depression and anxiety returning from home issues. I was then upped to 10mg lexapro (actually escitalopram) and began feeling better... Than I felt nothing after about 2 months, and two weeks ago decided I didnt want to be on antidepressants anymore, and started (by myself) alternating my dosages. Huge mistake. I did 5 mg one day, 10mg the next, then 5mg... For only about 5 days. I began to feel VERY depressed and teary and spoke to a friend who uses this site and she told me alternating was very wrong. So deep in depression last week (Wednesday) I drank beer and liquor. Ended up getting too drunk and blacking out very quickly. Quicker than usual. I became erratic, and bumped my head a few times and woke up with a bruise on my head.... Since then, Ive been back on 10mg every day. But have been having headaches since Wednesday, dizziness, listless, depressed, No energy or motivation, and not feeling like myself... Not wanting to converse, I feel out of it, unable to smile.. But this alternates. Two days ago I felt like myself again, and then this comes back. I feel as if Ive been hungover for a week. I am also still on vyvanse, and some days since then, my add meds work and sometimes dont. Today I took my meds like normal, and my vyvanse felt stronger than usual... I just want to feel like myself again. I dont know if this is from drinking with my meds, bumping my head or alternating my dosages for 5 days. Please help. I was fine when it was just me and the vyvanse.
  11. I have recently found out that Sudafed (Psuedoephedrine) increases Norepinephrine in the brain. I looked this up because I noticed that when I take Sudafed, I become more energetic, more alert, more awake...at least for a while. The effect lasts for about 5 hours. http://www.drugbank.ca/drugs/DB00852 An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem] Perhaps for those of you, who like me, experience extreme drowsiness during withdrawal, maybe Sudafed can help? Especially when bridging with an SSRI from an SNRI like Pristiq or Effexor? I found this blog, which mentions the same Sudafed effect that I have noticed, as well as the ADD medication Straterra, have any of you tried it or a similar medication to help with drowsiness type of withdrawal? http://accidentalscientist.com/2005/08/the-sudafed-test-for-adhd.html Also: http://www.fpnotebook.com/ent/pharm/Dcngstnt.htm A phenethylamine and a diastereomer of ephedrine with sympathomimetic property. Pseudoephedrine displaces norepinephrine from storage vesicles in presynaptic neurones, thereby releasing norepinephrine into the neuronal synapses where it stimulates primarily alpha-adrenergic receptors. It also has weak direct agonist activity at alpha- and beta- adrenergic receptors. Receptor stimulation results in vasoconstriction and decreases nasal and sinus congestion.
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