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  1. Hi I took effaxor for 5 months 75mg. I stopped 4.5 months ago and still stuck with PSSD. How hopeful should I be, do people here recover substantially from PSSD?
  2. im 47. Since 1992 I’ve been on all the so called anti depressants at some point . Amitriptline in 92 after a major car accident , for 4 years , then duloxetine for a couple of years , then citalopram switched to eicitalopram , then to fluoxetine , then to Effexor ( which actually was only one that helped apart from gave me non alcoholic fatty liver ) then switched to sertraline for 2 years , then next was venlafaxine 75 mg generic , then dr switched me about very quickly to roboxetine , which had me climbing the walls for 3 weeks , then at end of 2019 swapped me straight from robixetine to mirtazpine 30 mg along side venlafaxine 37.5mg . By. Early 2020, I felt like someone had put my brain to sleep . Did not have the get up and go mentally to do anything really . No interest in me life wife kids , just flat . Knew this had to be the mirtazpine . Dr said cut it in half , so 15mg for a week then stop . I said no , and dropped from 30 to 22.5mg . Felt very low for three months . But seemed to settle . But still felt mentally screwed . No Drive no excitement no anger no anything . I stayed put for rest of 2020.in 2021, I had to close my new business as I didn’t have it in me to run it . Bookkeeping . I then declared myself bankrupt . In June 2021,my mother passed away sadly . I had been caring for her when I could for 4 years . I hit a massive void . I have been out of work so I could be there to help her when needed . I was 3 weeks in to a too large reduction (33%) of my 37.5 venlalic when she passed away . I ended up in A and E convinced that I was dying . Drs increased venlafaxine to 75mg Effexor . I didn’t want it but I needed some immediate help . And it did. A bit . I began to taper slowly in august from mirt by 10% or less . I was on 22.5mg in august , I am now on 18.5mg . My last reduction of only .5mg ( 2.5%) two weeks ago. I have severe joint and muscle and tendon aches and cramps . I seem to have become intolerant to histamine ( if I eat a banana in am , 4 hours later I feel like I’m going to pass out ) but this only happens in morning . is this really all possible ? The pains in my joints are if I am100 years old . I’m 47 . And this has all come about since reducing mirtazpine ? Why is this at such small reductions ? How please can I get round this ?? I have crohnes disease and had a bowel resection 20 years ago . This has now flared up , no doubt due to the histamine and stress issues ? I can’t touch cod liver oil or vitamins as it makes me feel hot and anxious ?? What can I do ? No one is listening at the Drs or anywhere ? To add , since June ( at that point I was on 37.5mg venlalic and 22.5mg mirtazpine) I changed from tablet venlalic 37.5 to venlablue capsule in June with three tablets inside , and then tried to reduce this by 1 of the tablets , ( so, 33% for 3 weeks ) failed, so put back to tablet venlalic at 37.5mg. I was also diagnosed adhd 8 months ago . In July , they started me on various stimulants , elvanse 30mg for a week then 50mg for a week. I stopped as didn’t like how I felt . So they put me on dexamphetamin 5mg twice a day , and told me to start to also take the venlalic in eve with mirtazpine , so I switched the venlalic to eve straight away . Went through 2 weeks of feeling proper rough . Stopped the adhd meds as too anxious . Mid July So then I am back to the 37.5 Venlalic in a.m. 22.5mg mirt in eve . started to slowly reduce mirt 22.5 to 20mg. Got real bad due to grief and all, Drs upped venlafaxine to 75mg Effexor capsule in around September . since then done 2 more small mirt cuts so now on 18.5mirt and 75mg Effexor . im hurting . I’m aching everywhere . I can’t eat certain foods with histamine . have I gone wrong ?
  3. Hi my name is Alberto and I’ve tried a ton of ssris and antipsychotics over the past 7 years. Most recently I had a really bad experience with rexulti that gave me akithsia (which went away once I discontinued thank gawd) and my current ongoing bout with Effexor. I’m in a bit of weird situation in that I wasn’t in it for long and am looking for help as I’m at wit’s end and am seriously inching closer to suicide due to my symptoms. I started Effexor June 24 75mg. I immediately noticed really bad headaches and nausea but stayed he course as “that’s the side effects for 2 week”. By 5 days in the headaches had gotten really bad but I also had started getting burning sensations across my whole body and head. After dealing with this for a few days we reduced my dose to 37.5. The symptoms continued and got worse so we discontinued Effexor Monday 7/4. The first two days were a continued hell of body burning headaches nausea anxiety shortness of breath etc. The intense while body burning thankfully went away 2-4 days later tho lighter leg burning remained. The anxiety and shortness of breath have slowly gone away too but the headache and nausea feel worse/like they’ve stagnated. I’m two weeks post stopping this hell drug (for me) and almost a month since starting it but my nausea and headaches are just insane and making it impossible for me to live a good life and function well. It’s really impacting my work but most importantly my wife and kid. Has anyone every heard of or experienced anything like this? Did it go away, when? Did anything help you manage the symptoms til it did ? I have this fear that this is going to be a chronic thing I have to live with forever and tbh I won’t live long if that’s the case. The klonopin, zofran, and advil I take to manage do a meh job and I’m at wit’s end. Guess I’m looking for some success stories related to this and advice to help me get on the right track and ultimately save my life. Thank you and sorry for the really dramatic post, I’m just really hurting.
  4. I am new to group this a.m. I am thankful to see the advice and help that is available. I was taking Effexor for 22 years. I was post pardom depression after my first baby. I tapered at 10% a month for a year or year and half(can't remember) my memory is shot. I am completely off Effexor for 15 months and thought life would be good and normal. I am depressed, anxiety ridden(never had anxiety issues before--figured it was menopause (I'm 55 y o). I feel isolated and withdrawn. Only recently after returning to FB group on tapering did I finally realize I was having withdrawal issues. I have no interest in doing anything I used to enjoy like reading or exercising. I just found this website as well. Im not very techie so hopefully I will navigate it correctly. Can someone tell me how long these feelings will go on. I don't know if I can take it for years! My marriage may not last it either. Are there any support groups in or around Atlanta Georgia for this? Any help or advice on what to do from here would be appreciated! My history: Effexor 300mg 10 yrs Effexor 150mg 11 yrs (cold turkey myself w/no adverse effects) Tapered 10% beads starting in January 2020 Completely off March 2021 8/5/2022--Feeling depressed, anxiety since off meds--thought it was menopause and life changes(kids growing up etc.) Starting fish oil and magnesium 8/5/2022
  5. Hi Everyone, I am just going to jump right into this. I developed anxiety 4 years ago after having several life crisis in a months time. My mom was diagnosed w Dementia. My little sister was diagnosed with stage 3 lung cancer. I was diagnosed with squamous cell carcinoma.A childhood friend died in his sleep from heart failure. I tipped over from the stress. I went to my GP and she started throwing AD's at me to help silence the anxiety. The AD's only made me worse. I went to the ER one night after experiencing my first panic attack The ER Dr gave me a script for Ativan. I took it for four weeks and then stopped because I was feeling much better. A few days later my world turned on it's axis. I didn't know what was happening. My anxiety was worse, I was pacing, heart racing, Panic attacks daily.... I went to my GP and she said I needed to see a Psychiatrist. To get in to see anyone was 3 months. I started to spiral. I had no idea I was in withdrawal! I ended up in the hospital to get help for my anxiety. I was put on Effexor (75mg)and Klonopin (.25mg). I stabilized and was sent home. I did really well on Effexor. After 4 months on Klonopin I started to slowly taper off. I tapered over 3 months. The taper went pretty well. I was cutting and weighing my pills. 8 months after that I felt good and talked to my Psychiatrist about tapering off of the Effexor. She strongly recommended to go slow and we did. I tapered for almost 7 months. To be honest, the Klonopin was easier to come off of than the Effexor. She put me on Prozac before my last cut of Effexor. Tapered off of the Prozac over 3/ months. I still had some anxiety but it was tolerable. It felt AMAZING to be free of AD'S and the Benzo....then COVID hit and my mom passed away. Anxiety came back w a vengeance. I ended up back in the hospital after a very bad reaction to Zoloft. My new psychiatrist kept telling me to "push through," the first 3 months. I was back on Klonopin but now it was.50mg twice a day.The hospital took me cold turkey off of Zoloft and started me on Remeron and Trazadone. The next day they added clonidine. The klonodine didn't agree w my system at all and I was taken off of that in two days. They released me from the hospital 5 days later. I lasted two weeks on Remeron. I was so disoriented, confused, high anxiety and felt like I could become violent on them so they weaned me off of that over 4 days and put me back on Prozac. Prozac didn't help my anxiety, I had constant headaches for months! I did get an MRI and it was normal. I started to feel more and more depressed on it. I was on Prozac for maybe two months when my psychiatrist took me off of that (tapered over 6 weeks) and put me on Lexapro. I had to have back surgery during this. I did NOT take a single pain med out of fear of making my WD worse. At first I thought the Lexapro was helping? I was still having breakthrough anxiety so he bumped it up. My Psychiatrist retired and a new woman came in to take his place until they could find a new one. She bumped my Lexapro up to 25mg when I told her I was having major anxiety rushes, my face would get bright red, I wasn't sleeping very well. That increased dosage was the worst! I was like a zombie but w heightened anxiety. I couldn't work, I would sit at my desk and space off for hours! I felt awful. So, she told me to start tapering off of the Lexapro (4 weeks total! I knew better...) and she wanted to cross taper me onto Effexor. I started that and boy....the depression was BRUTAL! I was not sleeping well, could hardly focus, anxiety was high, my legs felt like jelly, my head would burn, I felt my brain tingle all the time... I was nearing the end of my rope. I was desperate for a Psychiatrist that CARED. The interim Psych left and a new one came in. She wanted me off of the Effexor because she felt it was too hard to come off of and if it didn't work for me, I would be in for hell. I told her I was scared to switch AGAIN and she assured me that switching to Duoloxetine was it's "sister drug," and I shouldn't have an issue. I trusted her. The last 3 months have been.... (How do describe this hell?!) a daily battle to push through hell on earth. I am still working, I can still function, I take care of myself, my home, my dog. I am a divorced woman with a 22 year old son. I live by myself with my Rottweiler. Life is so friggin' hard when you are trying to get thorough this mess. I now have a WONDERFUL and caring Psychiatric nurse practitioner who truly cares. She is holding me on the last 10mg of Lexapro until the Effexor/Lexapro WD calms down...IF it calms down. I should tell you that I can't believe I have pushed through the last year. My symptoms have been Burning in my head, headaches, tingling in my head, mood fluctuations, burning on my skin, bloodshot eyes, pressure on my chest, sensitivity to heat, depression, sweat easily, joint pain, ringing in my ears, no motivation, grinding my teeth, feeling mentally off at times, at the beginning I couldn't sit still, short tempered, at times in the beginning of the Lexapro taper, I didn't want to talk at times...like I almost couldn't, buzzing in my body, feel like I'm going crazy sometimes, anxiety rushes...etc I am interested in this group for support and the combined knowledge from it's members. I know that NO ONE can tell me when this is going to end. What I am hoping is that someone can tell me what I am going through is normal for all of the med changes? I am honestly concerned if I am still having problems because of the Duoloxetine? My anxiety IS better since I have been on it. I get 8 hours of sleep. I don't drink. I don't use illegal drugs, don't smoke. I eat pretty healthy. I don't exercise. It's tough to get out for walks when you feel like hell and I guess I save my mental energy to work. I know I have rambled on. My mind feels like it's in a vice and also these drugs affect how well I put my thoughts into words. For the most part I am a happy and well adjusted person. I feel like the last few years have been stolen from me because I faithfully followed Dr's instructions and thought they knew best...I was so wrong. Thank you for your time. Blessings to all of you.
  6. Conner

    Conner: Help

    #1 Help. I was on lexapro 8 years. Tapered off lexapro onto Effexor in sept 2021. Couldn’t handle it. Stopped taking after 5 days. Started Zoloft. Lasted 30 days. Side effects were bad. Tapered off to pristiq. Lasted 10 days and my psychiatrist said to just stop. I was trying to give my body a break so I could start a new med. 8 days later I went back to lexapro. Took it tonight. I’ve been having slight confusion lately, mental fog, poor concentration and not in touch with reality. I’ve always had panic attacks but what I experienced was not. My brain started to get warm and I almost wanted to pass out following extreme confusion with my heart/pulse racing incredibly fast. It’s like my brain was shutting down. I was so scared thinking i was having a brain aneurysm, stroke or seizure. I called 911. Went to hospital where I got a ct scan of my head. They ruled out a tumor, stroke or seizure: they didn’t check my blood sugar or run blood work. This happened at 10pm tonight. Got back home almost 2AM and went to bed extremely scared. I woke up an hour later in state of confusion to this happening again. The docs say it’s from the meds. I’m so scared I can’t sleep bc I don’t want it to happen again. I feel like it’s more than this and I’m actually going to die from whatever this is. It’s like my brain is broke. I was perfectly fine a few months ago. Idk why the docs couldn’t find an answer to what I was experiencing. I’m so scared this is something else. I’m 34, male, good health.. active
  7. InChristAlone

    InChristAlone

    I was in Lexapro 10 and 20mg (mostly 10) for 15 years. I was put on it when I was 19 after going through a breakup with my high school girlfriend. Also , I have dealt with minor anxiety issues most of my life and have a family history of anxiety and depression. Everything was going ok until I herniated a disc in Jan 2018. What felt like a nervous breakdown ensued. My GP stopped Lexapro cold turkey and started me on Luvox and this made things worse. I cold turkey quit everything for a couple months and things continued to get worse. My GP then put me on Effexor 150mg and Klonopin 1mg twice daily. Things improved for a while. After 6 months, I decided to taper Klonopin because I had found this site and benzobuddies. I am down to 0.25 mg of Klonopin daily and still on Effexor. I am living a life of waves and windows now. I am a middle school teacher and coach. Thankfully, God has strengthened me enough to continue to work through this WD process.
  8. I dont have anything to say about myself because I have nothing to reflect on unfortunately. So I am sorry but this is a pretty heavy post. I have severely kindled myself beyond repair. Is this possible? I dont have anything left. I forgot to mention in my history that after going off my antidepressant rapidly a second time that I took benzos twice weekly along with other gaba supplements and took other supplements that raised serotonin and dopamine. Kindling everytime withdrawing from gaba meds/supplements .And not consistently taking them. I believe messing with my gaba system is what did me in. I also came off progesterone very quickly late February and that's what ended my life. After that I used benzo again once to sleep because I had complete insomnia for 4 days. I probably withdrew just from one dose. Was getting horrible sensations in my gut like terror/tickling/stabbing. Took more supplements to try to help...made it worse. The last supplement I knew it was the end. Took NAC which I have before in the past. For 5 days and I became so agitated I was beyond suicidal. The problem is I was already mildly anhedonic on meds then coming off I had more anhedonia and dp/dr. So it was hard to know what I was feeling when doing all this damage. The more changes I made the worse it got. Now I hit the end. I'm completely lobotomized but can feel this severest internal anxiety. Complete apathy.I feel Like in dying 24/7 but it's not a panic attack. Everything looks and feels exactly the same and I mean that at the severest level. And everything I do keeps making it worse. Everyday I eat, sleep, do anything...the internal Agitation and anxiety and anhedonia/brain dead feeling gets worse. I never feel comfort and dont feel anything except pain. I dont have normal anxiety anymore with physical symptoms. I do not connect at all to anything at any level. I dont know what it means to do anything. I think I've lost many connections in my brain. I have nothing to do. I look at the tv and see nothing and I mean with my mind. I cant talk about anything. I have no soul left. No recognition of who I was. I no longer get comfort out of anything at all. I don't know what i look like. I dont recognize myself..cannot see myself in the mirror like a person with dementia. I am so bored because there is nothing I can do. I cannot engage in anything. But the severe internal restlessness is the worst. If I never went off my med the second time last summer I would be so okay. Everything I do makes it worse. Even positive thoughts. Any stimulation. MRI made me 10x worse. I'm stuck in some void with severe panic and no person inside to help save me or reflect on past memories or emotions. Cant feel time at all, dont register days/nights/months. Brain doesn't register going from one place to another. It's all the same. I never relax ever. Extreme restlessness beyond anything. This last time I messed up my brain knew it was the end and i completely lost all connections. Cant use any higher thinking to help. I didnt want my life to end at 33 with a 2 year old daughter. I wish I was never put on meds in the first place. I was a highly emotional person who was sensitive. Musically inclined. I loved nature and connected to nature and animals. All that completely taken away since ive done all this. But even on antidepressants I still had me, although I was becoming less emotional over time. But emotions were still there. There is no feeling more dead than this. Theres nothing left for me to do and my brain has seen everything that has happened and cant unsee. At least in February before the coming off progesterone and then messing with those last few supplements I had something still. I could still eat with only minor problems and was working a couple days a week and slightly enjoyed going to friends house and I connected at some level with my daughter and could feel empathy. Is there anyone who can tell me what may be going on with my CNS?
  9. DruggedSue

    DruggedSue: my intro

    Its been 10 days since I took my last antidepressant and I'm having a rough ride. I've been on one or another since 2010, however even before that I would be on and off one SSRI or another. About a year ago I saw my 7th psychiatrist in 5 years, they keep leaving, and he put me on mitazapine and venlaflaxine. I spent the last 6 months coming off mitazapine and then cut from 150mg venlaflaxine to 75mg then jumped off 10 days ago. I do have some experience of withdrawal from morphine and diazepam and I have always suffered bad side effects when starting a new antidepressant as well as withdrawals. My mental health nurse says I am very sensitive to drug changes. I actually think I'm not, I'm just quite self aware. Currently I'm struggling most with last of good sleep, I seem to be able to go to sleep but my fit bit is telling me I'm barely touching deep sleep, so exhausted all the time. I have terrible stomach issues anyway but the nausea is making eating impossible. I note my insatiable urge for chocolate and sweets is gone. Replaced with wanting a nice home cooked meal yet I haven't the energy to make a drink. I'm extremely emotional, crying at the drop of a hat. I feel pretty hopeless at the moment. I have a retreat booked for the end of August. They use psilocybin but also yoga, meditation, breathwork etc I am hoping I am at least feeling physically better by then as I have to get myself to Portugal. The brain zaps I was getting were unbelievable. I've had them before but nothing on this level. And they weren't just my brain, these were whole body zaps. Bought on by movement or sound. It felt like every nerve in my body was having a fit. Waking from a deep sleep. It was stopping me do everything but the first few days were the worst. Then I think they have become less severe and to a certain extent I've got used to it. Definitely still something going on. I live alone so can all be a bit lonely. No one to discuss things with and it would be nice to have someone to help with walking the dog, walking feels like I'm under water it's just so much effort.
  10. Hi I am new to this forum and this is my first post . I am currently on 30mg mirtazapine and 200mg of pregablin , I have been on these mess for about 3 to 4 months . I have just cut my mirtazapine from 30mg to 15mg and in the space of 4 days I have have horrible side effects , anxiety through the roof , shaking , lack of appetite poor sleep crying spells and the general feeling of feeling crap . The reason I have started to withdraw from the mirtazapine is that after 3 months I feel no benefit only get awfull side effects . No help with my anxiety and depression if anything it's made me more depressed . I have gone through withdrawing from Effexor and that was really tough , however just the drop for a few days of the mirtazapine has left me crushed , my doctor told me that mirtazapine was a easy drug to withdraw from , but after 4 days it has left me house bound . Has anyone got any idea on how I get through this or any experience in mirtazapine withdrawals
  11. Hello! Well, this site is a breath of fresh air. Background: Have had chronic joint and muscle pain for many years, remembering it since childhood. Just moderate pain. Always ask about it--nobody has helped. Diagnosed with ADHD, taking Adderall. Kept asking for Cymbalta for pain based on their commercial, but shrink said no--too hard to withdraw from. Saw an MD for preventative stuff, she has been great, but was put on Effexor 75 mg for menopausal symptoms and pain. Positive effects: tinnitus went away, seemed to work for a while, slightly elevated mood, possible reduction in hot flashes but they may have just gone away. Side effects: made me sleepy, severe bloating, gas, constipation, a slightly dulled emotional feeling, lack of motivation, pain returning, moderately dulled sexual response, could not miss a dose without face tingling, severe sweating Tapered "a little bit less" by taking a little out of the capsule every day throughout July, 2022. Has been 3 or 4 weeks. Everything seemed fine, no symptoms. Discontinued 4 days ago, reinstated last "little bit" dose last night after a remarkably unpleasant time of it--extreme (to me) discontinuation symptoms that had me quite frightened and uncomfortable, and reading more on this site. Thanks for the information. Having slight tingly face today, but otherwise feeling so, so much better. Will be slightly increasing, and counting out balls tonight to make a plan, that's for sure.
  12. Hi all. I’m writing on behalf of my husband. Bit of background: 2003 was put on Prozac for 3 months- no adverse reaction and subsequently various doses of venlafaxine which he successfully came off of with no issues. 2013 was switched from Venlafaxine to sertraline. Had ‘activation syndrome’ (extreme anxiety) for 8 weeks (always thought it was him) but went away once body used to drug. August 2021 had been on 25mg for years and thought he would taper over 2 months, successfully came off no issues or problems. january 2022- I was having a C section and he was a bit worried, nothing extreme though, just normal worry and decided to reinstate the Sertraline. Within days, ‘activation syndrome’ was back. He stayed on for 5 weeks and then doctor said ‘come off as you weren’t anxious or depressed to start with’ symptoms of withdrawal started but manageable. He thought after 6 weeks that it wasn’t withdrawal as nhs website said it should have gone after 2 weeks! March 2022- started mirtazapine at 15mg going up to 30mg. Fine for 3 weeks, but then developed activation syndrome and quickly came off. GP advised to go back on to sertraline at a bigger dose- ended up in a and e, so agitated! 3 weeks later, he thought that the mirtazapine might be less activating at a smaller dose, so went back on at 15mg… alas, 3 weeks later, activation syndrome is back! june 5th came off and has been battling severe anxiety, but generally, every other day! I am aware of windows and waves but don’t understand this. One day he’s perfect and the next can’t leave the house! He also started propanalol in June which we feel makes it worse as apparently it blocks seritonin to a degree, but makes anxiety a lot worse if he reduces (or maybe he did too big a jump). NHS have left us to it, no help! Have a private appointment on Monday. Questions are: If he is getting windows this early on, is it a good sign?! The only symptom he has is extreme anxiety/agitation which seems more a reaction to lack of seritonin, thus firing out tons of cortisol? Could he go on a low dose of Prozac to see if that helps? Prozac is the only antidepressant he doesn’t think caused activation syndrome?! is there any experiences with propanalol making matters worse? I think there is a slight improvement in the anxiety but considering it’s only been out of his system for 6 weeks I expect takes a lot longer to build new pathways etc/level out. Thanks for reading. Just want my husband back, it’s destroying me and him!
  13. Hi all, Thank you for letting me join this wonderful fountain of knowledge. I have been on Effexor since late 2008, when I was 20 years old. My first long term relationship had just ended and I was understandably an emotional mess. I was also alcoholic at the time and using a lot of recreational drugs, which didn't stop the doctor from providing me 75mg of Effexor XR. I loved it at first because I literally felt high. I had tried other antidepressants in the past but none had worked, whereas with Effexor I just seemed to have so much energy. Fast forward to 2011, I am in residential rehab for my alcohol and drug addiction problem. The counsellors there suggest it might be a good time to try coming off my meds- 300mg Effexor and I also taking 25mg Seroquel at this point, as I was unable to sleep on the Effexor. I am referred to a completely incompetent psychiatrist who gives me a taper programme which takes me from 300mg to nothing in a month. Not knowing any better, I complied with his insane schedule. Within a few weeks I was kicked out of rehab for out of character, rageful behaviour. Back home, I slowly lost my mind. Couldn't leave the house without feeling like I had a target sign painted on me- I felt everyone was looking at me and talking about me. I lost my temper at the drop of a hat over minuscule things. No one around me realised what was happening. My memory of this time is hazy, but I do remember being home alone one night and suddenly becoming obsessed that there was a government conspiracy to give people heart attacks by putting too much salt in food. I was walking around the kitchen in circles screaming, unable to stop. I considered the possibility of hanging myself to make it stop. Luckily I called my boyfriend instead and found another website which is no longer active, who advised me to go straight to a doctor and resume the Effexor at a maintenance dose. I did this and was put back on 75mg. The damage was already done and I fell into clinical depression. A month later I decided I couldn't be more miserable that I was and relapsed on alcohol. Luckily I got straight back into a 12 step programme and have been sober since that relapse. But I struggled with the after effects of that withdrawal for many months. i have been absolutely petrified to try coming off Effexor again since, despite many side effects including palpitations, mental confusion, dry mouth, bad breath, constant clenched jaw and every type of stomach complaint. I fell pregnant in 2014 and came down to a quarter of a 37.5mg tablet during pregnancy. I wanted to come off it entirely, but my relationship was very unstable and I was being constantly triggered (we have now split up). I was devastated to not be able to breastfeed my daughter, but I felt the Effexor presented too much of a risk to do so. I went back up to 37.5mg shortly after her birth. She is fine and healthy today, but the responsibilities of single motherhood have left me terrified to attempt withdrawal again. However, since giving birth I have found that the Effexor now has a sedative effect on me. I now have to take it at night time, or I am almost passing out during the day. Sometimes I forget (I'm insanely forgetful now, which fairly sure is a side effect of long term antidepressant use) and then I have a choice of spending the whole day "shocking" or being a half passed out zombie fighting to keep my eyes open. I realised I can't carry on my life like this, I want and need my energy back. I've become completely reliant on coffee to have any kind of energy, so I'm always up or crashing back down. My daughter needs me to be fully present in her life, which I don't feel like I am a lot of the time due to this horrid side effect. I found this website and have been reading up on safe tapering, and on June 14th began the 10% reduction method. At the moment it looks like it's going to take about 3 years in total. I'm in no rush after my last withdrawal experience, I can't risk ending up in such a bad way as I'm all my little girl has. I have been dissolving the 37.5mg tablet in 75ml water, making sure it's all evenly dispersed, then removing 7.5ml (equal to 3.75mg) with an oral syringe. In the UK they no longer prescribe the slow release Effexor so as I can't do the bead method, this is the only accurate way I can really do it. Yesterday I had tingling in both hands all day then at night I had some brain zaps when I was trying to sleep which went all down my left side, which has made me wonder if I should maybe hold this dose for longer that a month. If anyone could advise me on this, I would appreciate it. I find my daily meditation practice my most valuable asset in keeping me sane so I'm hoping it will aid me in my withdrawal. If you have made it this far in my mammoth post, you are truly amazing! Love and healing light to you all x L
  14. JJCC

    JJCC

    hi i really want to type a good intro except tbh i've reached my lifetime limit of psychiatric and therapy intake sessions and i'm struggling to see this intro post as something different... communication in general is extremely exhausting for me and i really just want to ask a question about electrolyte balance... so i'll just vomit a list of random stuff into this text box: i am in my 40s, male, diagnosed conditions are tourette's (vocal mild, motor severe), add-i (extremely severe), chronic major depression, kinesthetic synesthesia -- all conditions have been present since early childhood and have remained mostly unchanged. i am also prone to migraines and seasonal vertigo (the latter gets milder with age), and debilitatingly ticklish (which might be relevant because i think it's linked to why i experience certain drug side effects). i'm in relatively good physical health otherwise. i take 30mg adderall xr daily + 5mg adderal ir 7 hours later (50mg mydayis is ideal but insurance does not cover) and am satisfied with that as it greatly improves my quality of life. the 30+5 schedule was the result of a lot of careful tuning. i am stopping 225 mg effexor xr. i have poor cyp2d6 function but did not receive that test until well after starting effexor. the only other medication i take is pepcid for reflux. i smoke approx. 2 packs every 3 days. i do not do any other drugs. i do not smoke marijuana, i have never used cocaine, and i rarely drink these days. the only other drugs i have ever done were psychedelics, and it has been a few decades. i do not like antidepressants but every few years i'll go on a run for a few years, always as a last resort. i used to prefer zoloft but about 4 years ago i tried effexor instead because zoloft caused too much general apathy. i chose effexor because my mother takes it and i figured if it works for her (although now i'm not sure if it does) then might as well. i have tried other antidepressants; but side effects were always unmanageable: i tend to get hit with all of the rare sexual side effects for any given drug, and every single motor control side effect imaginable, for some reason, and they never go away until stopping the drug. for effexor, though, the only real physical side-effect that never went away was excessive sweating. generally speaking it takes me about 72 hours to stabilize after an effexor dose increase. also, on missed dose, i will start to feel it within about 12 hours (just a feeling of strangeness + vivid dreams), and after almost precisely 36 hours i'll suddenly get hit hard with balance issues, slurred speech, brain zaps, and become prone to cataplexy attacks (the cataplexy triggers are repeatable, consistent, and hilariously specific - let's just say that if you tell me a good joke or give me great news then touch my feet i'll just completely deactivate like a scruffed cat, haha - very weird experience). incidentally, depakote virtually eliminates a lot of the motor control withdrawal side effects (quickly, too, within an hour or two). however i do not take this and will not start. i discovered this after i experienced my first missed dose cataplexy attack but we didn't know what it was at the time and my psychiatrist, fearing a TIA, put me on depakote as anti-seizure protection for a few days until i could get to a neurologist to identify what happened. i won't get into why i want to stop effexor except to say that i think it's causing more problems than it's solving, my career in particular is at high risk right now, and also this 4-5 year run is my longest on antidepressants and i'm not comfortable with that. also i'm starting to realize that it seems to be doing something weird to my emotions (hard to explain so i wont unless asked)... and i've noticed a huge increase in my tendency to dissociatively respond to stress. because of enzyme function test results, a few months ago i considered getting desvenlafaxine level lab tests then switching to a roughly equivalent dose of pristiq. but i just decided to stop entirely instead. i stopped kind of cold turkey about 2 weeks ago. the timing was because my psychiatrist is on maternity leave, i was running low on effexor (150 + 75 = 225), and tbh i just didn't really feel like calling the substitute psychiatrist. so i dropped the 75's and took 150mg for a few days until i ran out of those two, then i just stopped. that was about... a week-ish ago. it's been hell since, but... i seem to be slowly but surely crawling back into reality. my gut feeling is that i'll get through the withdrawal ok eventually, but my fingers are solidly crossed. i'm not concerned about long term withdrawal syndrome at this time but get back to me in a couple weeks on that. i've been emotionally and physically all over the place since stopping but i just assume it's par for the course. but i'm also experiencing a lot of overwhelming anxiety that i think might be 4 years of effexor-suppressed stress all coming out at once, if that makes sense (like, real life things that i should've been concerned with but wasn't, and now suddenly they're all hitting me). i seem to at least have gotten through the suicidal depression part of the withdrawal. there were about 3 mercilessly bleak days that basically consisted of me determining that the only logical solutions to the remaining mysteries of quantum mechanics were solidly in the realm of profound nihilism and that i was an illusion. the only thing that got me through it was the fact that my cat loves the absolute crap out of me; so making her purr was my sole reason for existing last week, haha (which really, isn't much of a change from normal now that i think about it). sooo... that's my intro but like i said i really just want to ask about maintaining electrolyte balance because effexor withdrawal, dehydration, and *over*-hydration all have exactly the same set of symptoms and since stopping every single fluid in my body is taking every opportunity to come out of every possible hole it has access to, plus some. also i have questions about venlafaxine vs desvenlafaxine pharmacokinetics, mostly out of curiosity. i've had no luck with my own research because "venlafaxine" and "desvenlafaxine" are used interchangeably in a lot of lower quality information sources but there is enough of those that it just completely pollutes search results. i'm not actually sure how to ask a question cause all the "new post" buttons are disabled except for in this forum. so i'm just assuming i have to type this intro to get that privilege. in any case thanks for making this site and i really do hope that everybody here is able to get through whatever they're going through right now because this stuff sucks no matter how mild or severe it is. j ps generally poor sense of time + overall lack of structured life + confusion of the last few days + logistically complicated real life events = don't trust the precision of "2 or 3 days" above, i'm actually not entirely sure when my last dose of effexor was i'd have to work backwards to figure it out. but i'm pretty sure this has all happened in the last 2 weeks. overall though my state has been best described as "utter confusion".
  15. Hi, I have been struggling with hearing sensitivity and eye issues ever since I made the mistake of listening to my neurologist and trying Effexor, and then upon recommendation of a psychiatrist, Prozac. Both were for short time periods. I am a little more than 4 months out of my last prozac dose. Ears/Hearing: hypersensitive to certain sounds - sudden sounds, sharp impact sounds, crinkling plastic wrappers etc. High pitched tinnitus that is generally not too instrusive and can be better or worse but always there. No hearing loss as of post-Effexor, pre-prozac. Eyes: “tight” feeling that is somewhat better than a few months ago but still not normal. I probably have some visual snow, and my night vision is worse because it’s like my eyes are amplifying light that’s not even there. Constantly bloodshot and dry eyes - taking restasis but opthamologist didn’t see any other eye issues. Balance: generally ok but occasional unsteadiness. Other: Mild constipation: gastroenterologist didn’t see anything wrong. Some TMJ pain and minor random muscle twitches. Occasional facial tremors that are better than a few months ago but not gone. Frequent trouble sleeping- falling asleep, getting enough sleep or deep sleep. Basically I believe that these drugs hypersensitized me. I sincerely hope that this hypersensitivity will decrease over time. I have seen some improvement vs say 2 months ago, but I have a long way to go. I have read on this site that it can take a long time for the nervous system to calm down. I believe that I am generally improved on magnitude of sensitivity vs say 2 months ago, but I am clearly not on a “some people take as much as a month to recover” timeframe.
  16. Started withdrawal from venlafaxine a month ago (cold turkey) after 1 year on it at 37.5 mg. Everything was normal and mild (dizziness, vertigo, and insomnia). In the fourth week, I started experimenting burning thighs, pretty unpleasant. I had to reinstate venlafaxine at 37.5, within one week most symptoms are gone (occasionally I get the burning, but once I take the dose it slowly goes away). I will start a tapering plan with my psychiatrist because I no longer need these meds. Is anyone suffering from the same symptoms? The burning sensation can be incapacitating...
  17. Hi there, I'm a new one here. Luckily, I've found this website because we don't have any single website which helps people who want to stop taking antidepressants in my country. My name is Anastasia, I'm 32. I work as a teacher at school. I'm married and have a lovely cat. I take antidepressants for 11 years. I've always been a shy person with lack of confidence. Since my childhood I've suffered from intrusive thoughts just about any imaginable staff. The first time I went to the psychiatrist was because of intrusive thoughts about my relationship. And my horror story began. I had various reasons for my constant painful thoughts. I had permament nausea, irritable bowel, which didn't let me leave my house, a sense of guilt, depressive thoughts, anxiety. constant tears and just liying at home and staring at one point - not all at once, of course. These were the reasons for many many visits to the doctor. Each time antidepressants helped a lot and I was back to life again. Can't say I was always in a good mood, but, nevertheless, I could live. I really don't remember the years and dosage of medicines, but in different periods I took amitriptilin, venlafaxine, zoloft, duloxetine, fluoxetine, phenazipame, atarax. One day pills stopped helping me. I changed three doctors hoping someone'll help me. The first one finally said that my brain had become tolerant to drugs and I had to quit. I tried so many times and always my thoughts came back and tortured me. The second doc said I had endogenous depression and it's ok to take antidepresants just for the whole life. She also said that if one medicine didn't help, so let's try another. And we tried and changed. My thoughts and depression didn't go away, but I felt not well, not bad. The third doc finally said that my diagnose was anxiery disorder and eating disorder. Insisted on treating my depression to the end and then quit. My latest medicine was venlafaxine 75 mg. But I decided to come to my first doctor and tried to withdraw like 37, 5 - one week, 18,75 - two weeks. Now it's three weeks I'm off. And it's just a hell. My thoughts (now about my weight and shape) have become more painful than they were on medicines. I find it hard to go outside because I feel really uncomfortable in all my clothes. It seems they are too tight. I'm depressed, angry and nervous. I can't do anything and distract myself. Even in my pyjamas I feel fat and uncomfortable. The story of my eating disorder: when I got married, my husband and I gained some weight. Then we started keeping to a diet. We lost weight and I felt just great for some time. Then it wasn't enough and I started to eat 1000 calories a day. But still I had a fat belly and wasn't satisfied with my weight and the way I looked. I gave up dieting and gained half the weight I had lost previously. Now I'm obsessed with my weight and it's just a nightmare. I think about it 24/7 but can't stop eating. Food is the only thing that gives me pleasure. I tried Gestalt therapy and CBT a bit, but I'm convinced that these sessions just do nothing. I understand everything, nod to the psychologist but don't believe it can help. I'm really confused now if I have to be on medicines or not and don't know what to do... Living like this is not a real life. The only wish I have now is to stop this suffering, by means of drugs or not, I don't know. I 'm studying this website and try to understand all the mechanisms. I'm not sure I'll manage to tolerate this for many years, it's been only three weeks but I'm completely exhausted. The reason why I wanted to quit was to have a baby, but it's practically impossible to think about pregnancy and birth now because of my condition. Seeking for help and support. Thank you in advance. PS: I was really frightened to start my topic here because of the country where I live, because of my nationality. But I want you to know that I just can't stand all the hell that is going on right now in the world. Of course, it adds a lot to my anxiety and depression.
  18. Long story short, I have anxiety and panic disorder. My doctor stopped my Prozac CT in April 2022 after 14 years stable on antidepressants. Said would be no issue due to the long half-life. Started getting physical symptoms and severe depression 6 weeks later, so he started Effexor 75mg cause it worked in the past. Since the have had days I feel okayish but the past week has been hospital visits due to SI and severe panic. They just keep giving me benzos but it’s making me worse. I had clonaz once and fainted and still don’t feel right. They want me to wean my Effexor onto Zoloft. What do I do? I can’t go on much longer like this…
  19. I would really appreciate your comments concerning my situation. I have always stopped AD (Escitalopram) too quickly simply because of lacking knowledge in the previous years. Now I may be a bit smarter. Doctors always say it's the underlying disease coming back. It seems that I don't benefit from SSRI/SNRI anymore, at least I'm not willing to try anything anymore, I just want to get out of the current poison (Venlafaxine) in a reasonable time. Mainly SSRI was described to anxiety in a difficult life situation. Symptoms: Main concern is a pressure type of feeling in my head (starts in the morning) which started after stopping Escitalopram abruptly in 2021 after feeling really sick on the medication for 4 weeks. I have also some inner restlesness but not akathisia and occasional anxiety. The symptoms have got a bit better but some drugs (Seronil) seemed to make them worse and was discontinued. I may be on a protracted withdrawal from Escitalopram but I'm not sure. At the moment I don't actually know what Venlafaxine is doing, in a way it might have lowered the symptoms but days vary - not feeling stable. I think my central nervous system is a bit shaky at the moment and I really would like to have some suggestions/comments that am I going to the right direction if I try to stabilize on a small amount of Venlafaxine (12.5-37.5 mg) for some months before WD? I didn't want to start this drug but it just happened and that's done, can't go back. Sleeping aids: Melatonin, Magnesium and L-Teanin for the last 3 months (sleeping 3-6 h/night) Used to take sleeping pills (Triptyl, Surmontil, Mirtazapine and Benzos) occasionally but built tolerance and stopped them. I have never been addicted to above meds.
  20. Hi, I have been doing research on here to be able to wean off effexor. I know it can be a nasty drug to come off of. I have read the tips but have some questions. In the thread on weaning off effexor it says you can make a liquid from the extended release venlafexine. I have tried emptying my 37.5mg capsule into 5 ml of water and let it sit over night while stirring occasionally. It doesn't appear the beads are dissolving. Am I doing something wrong? I have also tried using a jewelry scale to do my reduction. Typically the beads weigh 0.11g but I am finding some variation from capsule to capsule which I understand is an issue particularly with the generic. Am I better off switching to regular venlafexine and making a liquid to do my reduction? Regarding switching to regular from extended release, I want to makes sure I understand correctly. Since I am on 37.5 mg of extended release, I would reduce my dose to 33.75 and then divide it into two doses of 16.88mg twice a day....is that correct? I sincerely appreciate all the work that has been put into this forum.
  21. i swore i would never take an snri again after what i went through on effexor, but he suggested i try cymbalta for the chronic pain and told me that generally there are less side effects/zaps than with effexor, so i said i would give it a try. my psychologist and his super decided that i have bipolar 2 not mdd, but the pdoc waved this away and didn’t even consider mood stabilizers. when my pdoc raised my dose of cymbalta after i expressed a wish to discontinue, and wrote in my record that i display “abnormal illness behaviors” (which just means i disagree with him?), i have decided to get off the ADs once and for all.
  22. Hi, this is my first post - I'm 6 weeks off Efexor and the withdrawal is brutal. I was prescribed 75mg of Efexor in July 2020 by an endocrinologist who suspected depression, and I began to experience what I now know to be tolerance withdrawal in October/November 2020, and it was incredibly severe. I experienced the following symptoms: severe headaches (myriad and varied types) every day brain fog fatigue light and sound sensitivity eye pain when looking at light muscle weakness heart palpitations joint pain itching tinnitus insomnia jaw pain poor memory hallucinations These symptoms plagued me and escalated over 16-ish months. No migraine medications worked and every test and scan under the sun came back with no leads. I had to stop work due to the pain and brain fog. I came off the drug myself after a bout of corticosteroids (prednisone) was miraculously effective, and pointed towards neurogenic inflammation as the cause of my issues. I became suspicious that this was Efexor's doing. In desperation I "tapered" way too fast and went down from 75 to 37.5 for one week, before coming off it entirely. The acute withdrawal in the first two weeks was awful. I was suicidal, had excruciating headaches, brain zaps, immense fatigue and insomnia, colossal mood swings including a hypomanic episode, anger, irritability, fear, severe nausea and severe full-body itching that made sleeping almost impossible. However, a huge majority of the tolerance withdrawal symptoms of the prior 16 months stopped as soon as I came off the drug. The muscle weakness, tinnitus, jaw pain, photophobia, heart palpitations, sensitivity to sound, and hallucinations all stopped immediately. After the first two weeks, things got a lot better, and I could go outside and walk again for the first time in a long time, and though I still battled the headaches, nausea, itching, brain fog, and fatigue, it was more manageable than it had ever been. I got a vaccination 4 weeks ago and for whatever reason, I think it interacted badly with my withdrawal. My symptoms immediately got much worse and are yet to improve - I haven't had that kind of 'window' since. The fatigue and brain fog are the worst of them, those are the symptoms that keep me debilitated, but the mood issues are making it difficult to cope. One of the hardest parts of this is that Efexor worked perfectly for what it was intended to regulate. I felt the happiest and most stable I have in my life, with my depression (potential cyclothymia) completely stabilised and my mood incredibly under control. However, the cost of being utterly debilitated and in pain all the time was obviously too high - I have lost my mid-20s to this. I haven't been tempted to get back on Efexor, for obvious reasons. I don't really have any idea of when this is meant to get better. I really didn't want to be unmedicated for my mood issues and they are just as difficult to deal with during all of this pain and debilitation as I expected they would be. In fact, some of them feel new and withdrawal-caused, and I'm hoping this crucible of an experience hasn't made the underlying condition worse. I've had many a psychologist for anxiety and depression over my life, and I practice CBT and mindfulness every day, as well as living as healthy a lifestyle as I can while being largely unable to do much. I see a physio, I do the exercises, I eat all the food groups and plenty of vegetables, I walk outside at least once a day, I have a psychiatrist and psychologist lined up, as well as specialists to check whether this has done any further damage to me. It just feels incredibly brutal when none of this stuff actually seems to help. I live a healthier life now in this 'wave' than I did when I was experiencing the 'window', and yet it doesn't seem to make the wave shorter or the window come sooner. It doesn't even lessen the symptoms. This website has been very helpful to me, as has Recovery and Renewal by Baylissa Frederick (I know others on the site have found her writing helpful), and so I thought I would post in case others have been through similar - I'd really appreciate hearing about it if you have. Thanks, Alice
  23. I had been on Effexor 37.5 was varying doses for approximately 7 years. As of the beginning of 2022 I started having really strange symptoms such as hot flashes sweating insomnia racing heart and general feeling of being unwell. June fourth I had only slept about 4 hours for a few days each and decided to go to the ER to rule out anything physical. When I told them if I don't sleep I want to drive my car off a cliff they kept me. So I stayed 3 days with no medication. Initially I started to feel well. Clear minded and actually could feel Joy. No it's July 4th and it's getting worse if that's even possible. My symptoms are becoming intolerable so I decided to take 5 mg of Fluoxetine. This was about an hour ago. I feel like I'm in a dream I have no energy it's hard to even walk and my heart is racing I can literally hear it pounding in my ears and all I want to do is cry and go to the hospital. But I don't know if they treat this there discontinuation syndrome. I don't know what to do please help
  24. Hi, ive recently been taken off Effexor which I was on for 2 months, I was then on pristiq for 25 days. 3 months in total. I have had a really tough year trialling meds that didn’t help but made everything worse. My psyc told me to stop pristiq cold turkey due to my rapid decline in mental state. the first 6 days where hell with zaps and vertigo and migraines. I still feel dizzy at times and my cognitive function feels like it’s lagging. Now day 10 I have woken with what I thought was a UTI. I went to the doctor and I don’t have a UTI. Upon research based on symptoms I’m concerned it’s Cystitis as my bladder feels like it’s on fire and or possible PGAD. are there any success stories where this naturally corrects itself and this is another withdrawal symptom. Naturally the body and nerves will take time to heal? advise and help needed- I mentally feel so good putting all meds in the bin but feeling very overwhelmed physically thank you in advance x
  25. cocacolaeyes Hi all, I found this forum from someone who mentioned it on reddit and thought I would come to share my story and learn from others. I had a really bad episode of dissociation and depersonalization in August of 2019 due to weed. I have a history of panic disorder and GAD so this was a very scary experience. By October, I decided I couldn't handle it on my own anymore and was put on Cipralex (lexapro for my American friends). I started on 5mg for 1 week and eventually got up to 15 mg. Unfortunately, I found the drug to be very numbing and left me feeling like a zombie. I was immediately switched with no taper to Effexor XR in February of 2020. The medication worked wonders however, I started having a rare side effect of orthostatic hypotension. I felt constantly dizzy, my blood pressure was dropping lower each day. My doctor decided he would rather I just get off medication entirely as I clearly am too sensitive to the effects of them. We decided on a plan to work with my therapist and lifestyle changes to manage my anxiety going forward. Now for the scary part... Today was my first day off the medication entirely. The taper plan recommended by my doctor was to go down to 37.5mg for two weeks and then today I could stop taking it. We tried this a month ago but I had really horrible withdrawal. The brain zaps were constant, I felt ill, I was panicking. This time, he has recommended a slower taper of taking 1 pill of 37.5mg every other day for a week, then 1 pill every 2 days for a week and so on... I know a lot of people do not recommend this style of taper, and prefer the bead counting. I asked my doctor about that method and he said it would be difficult and time consuming and would rather I stick to this method. I trust my doctor a lot and he has been immensely helpful in the past and has never misguided me. I am currently waiting for the horrible brain zaps and panic to set in again. I am very afraid of how I will get through this taper. I want off the medication so badly but the last time I tried to get off it was so scary. I also keep scaring myself by reading horror stories of people who have had lasting side effects from the withdrawal for years and am terrified that will be me as well. If anyone has any kind words or stories of hope they can share or even some advice it would be much appreciated. Thanks for reading!
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