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  1. Hello everyone. I'm CF. Been of psychiatric medication for 4 years, when I was a teen - due to depression and eating disorders. After switching many drugs, by August 2019 (discharged from last hospitalization) I was taking: 100*2mg Lamotrigine, 20*2mg Clotiapine, 25mg Promethazine, 400mg Seroquel XR, 60mg Mirtazapine. In the past: Lustal, Lorivan, Clonazepam & more I don't have documentation of. As of today, I take 100*2mg Lamictal, 400mg Seroquel XR and 45mg Mirtazapine. I am interested in lowering all of those, currently very interested in lowering Seroquel... I was never psychotic or manic. I was given Seroquel, Clotiapine and Promethazine because I was agitated and would self harm constantly. These medications did not change my situation; ECT improved my situation for a month, than went away. Therapy in last year helped a lot. -- My withdrawal history: - Prozac: 20mg (1y) -> 30mg (short) -> 60mg (1y) -> 30mg (1d) -> 0. Side effects: Unknown. Withdrawal: I had no adverse reaction at all, the day I lowered to 30mg I was given Remeron and started having tics. - Clotiapine: 10*3mg (?m) -> 20*3 (4d) -> 20*2 (6m) -> 20mg (2w) -> 0. Side effects: sleepiness (on 20*3). Withdrawal: No symptoms, more energy. - Promethazine: 25mg (6m) -> 0. Side effects: helped with allergies. Withdrawal: no symptoms, allergies still way better than before Promethazine😉 - Lamotrigine: 100mg (?) -> 100*2mg (3m) -> tampering to 0 in 2-3 weeks -> 100*mg (1.6y) Side effects: dry mouth. Withdrawal: Can not recall due to ECT treatment. I believe there were none but not 100% sure. - Mirtazapine: 45mg (1d) -> 60mg (10m) -> 45 (1m). Side effects: 60mg: tics (2h after administration, went away by next morning), sleepiness. The first day I was given Remeron I had tics and couldn't sleep, until I was given a sedative. Became better in the next week. 45mg: sleepiness. Withdrawal: Went from 60mg to 45mg in 1 day. Immediately stopped getting tics, sleep about 1.5h less than on 60mg (7.5h/night now). - Seroquel/Seroquel XR: 20mg (?) - 200mgXR + 20mg (?) -> 300mgXR (2y) -> 400mgXR (2y). Side effects: major weight gain, sleepiness. Withdrawal: not exactly withdrawal, but when I skip a night I have insomnia (2-3h sleep max), and when I skipped two doses - next day was almost normal (5-6h) with no side effects. Slightly sensitive/agitated on day 1 (lack of sleep?). I stopped taking Promethazine and Clotiapine in October-December 2019, Mirtazapine 60->45mg - since March 2020. These are the ones I can remember. I was given other medication before but I can not recall anything. -- My current situation is, my Psychiatrist refuses to let me try and reduce Seroquel XR because of COVID situation. I take XR is cutting it myself is not an option. Don't know what to do, I want to stop taking it, more time = worse withdrawal. I stopped taking 60mg Prozac with no issues (SERT, NET inhibition), Entumine (can not find mechanism of action), Promethazine (D2 and H1). I never had any issues with using brand VS generic. -- I interchangeably use: Lamictal & Lamotrigine; Clotiapine & Entumin/Etumin; Mirtazapine & Remeron.
  2. Hi everyone. I was diagnosed with major depression and an anxiety disorder in my early twenties, although I had my first mental breakdown/became seriously ill at seventeen. I managed to make it through university but had a second breakdown just as it was ending and have never fully recovered. I was first prescribed antidepressants (Effexor to start) at the time of my diagnosis and had a terrible reaction in the form of a mixed manic state, where I was both depressed and manic. However, I knew side-effects could happen and continued on through it as I was desperate for something to work. It did pass, but the nightsweats that kept me up all night eventually became too much and I had to go off of it. Over nearly the past decade I have dutifully tried antidepressants from every class, many different combos, as well as antipsychotics although I have never been psychotic, mood stabilizers, and benzos. Several years ago, I told my psychiatrist a long-standing fear of mine; that I thought I was treatment-resistant. I have one antidepressant that I feel may have worked moderately, and one that worked actually quite well for about a week - more about that later - but many of the others made me significantly worse and all had unbearable side-effects. My psychiatrist disagreed with me and tried me on more meds, but after my worst reaction ever last winter (Duloxetine) he finally agreed that I was, in fact, treatment-resistant. Duloxetine was the one med I thought really worked for me, but after only a short period of time on it I had a severe physical reaction with GI symptoms/vomiting that went on for over a month. All other causes for this but the med were ruled out through tests, and I became very ill/lost a lot of weight, and had to withdraw from it abruptly. The abrupt withdrawal was the worst I'd ever experienced, and caused a severe upswing in suicidal thoughts, and some sort of rage syndrome, which was completely uncharacteristic for me and the most terrifying thing I've ever gone through mentally. Anyway, after that, I wanted to try going off of antidepressants altogether and I had the support of my psychiatrist, who I had freaked out with my Duloxetine reaction and who at this point had put me on a useless antidepressant from the 50's, I guess as a last-ditch effort in his panic over my condition. He wanted to withdraw me from it too quickly, but I took a longer withdrawal period, and was able to do it! I'm currently off of antidepressants for the first time in many years. So I am no longer having the horrible mental or physical side-effects to the many meds I took, but am still suffering from the suicidal ideation that never left and am now at a loss as to what to try next. Not knowing what else to do, I asked my psychiatrist for a referral to ECT and was sent to an psychiatrist specializing in ECT, who approved me for it, but suggested I try a mood stabilizer first, as he said he'd seen many people who had treatment-resistant depression who actually had an atypical form of bipolar where they just hadn't presented with their first manic episode yet. This seemed sketchy to me, but again, I was really desperate. I was put on Lamotrigine, and have been having excessive crying spells, but it's impossible to tell whether that's from going off of antidepressants or the Lamotrigine itself. In any case, it's either causing crying spells or doing nothing, so I am currently tapering from it, and don't seem to be having the problems tapering I've had with antidepressants, at least. I have to be tapered from it fully to try ECT, as Lamotrigine is an anticonvulsant that would cause the ECT to be unsuccessful. I am also still taking Ativan, sometimes for anxiety but more often than not for when the suicidal thoughts get too much. I've gone off of Ativan before during times when I've been in a bit better place, so I'm capable of it, but I have to get the suicidal thoughts under control first. If anyone has any first-hand thoughts on or experiences with ECT I would appreciate it so much. I've been overprescribed by psychiatrists and traumatized by therapists over the years, I've only met the psychiatrist specializing in ECT once, and I just don't have much trust there or with anyone I've encountered in the mental health profession, unfortunately. I have done research and know the possible scary side-effects of ECT, but also that it has a much better success rate than antidepressants, something that I am pretty annoyed I had to discover on my own. But, yeah, I am still very unsure of it. I hope this is halfway articulate. Thank-you so much for listening.
  3. Trigger warning. She got StevensJohnson syndrome and was misdiagnosed with flu. Sensitive people please avoid watching. http://www.myfoxla.com/story/28552915/georgia-grad-student-has-rare-terrifying-reaction-to-common-medication
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