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  1. Hello. I have been reading threads through this forum and finally I have the courage to ask for help. I saw the wonderful work that you all do here, so first of all, I would like to congratulate all of you involved in helping people. Since 2002 I use antidepressants intermittently. In 2016, due to an undiagnosed withdrawal syndrome, I was gradually subjected to a multidrug regimen. So, since April 2014, I'm on these drugs: Paxil - 20mg initially - Depakote SR 1000mg Modafinil 200mg 450mg lithium Aripiprazole 1mg In February 2020, I
  2. After 25 years on more than 20 different drugs to treat major depressive disorder, I have decided enough is enough. I've had 15 rounds of ECT, with no improvement. As a 'last resort' , my psychiatrist put me on Riluzole, which is used mainly to treat ALS. A side effect is lessening of depression. Apparently it works on the glutamate system in the brain, and not the typical neurotransmitters. I feel I have had some success with this medication. I no longer live in a deep, dark pit of despair. I do need to mention that over the last year (while being on Riluzole), I have expanded my spiritu
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