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  1. Grayskies

    Feels like waking up

    I have just read almost all of “Prozac backlash” and It kind of blew my mind. I am sure this is old news for most of you on this site, I just had no idea. I also had tried to go off Effexor pretty much cold turkey and basically was a ball of nerves, sobbing uncontrollably the whole time. I thought at the time, “my anxiety must really be this bad, i guess i really cannot function without my AD.” OMG. I had no idea this was such a universal experience for people to go through such difficulty when trying to get off them. And to try to do this without any coping skills too? That was entering a losing battle. I am now seeing a therapist and I feel empowered to do this for the first time in my life. Having this community is really great too, to know it’s hard to do for all of us. For the first time in my life I suddenly see that this has been a lie I have told myself for years, that I need these to function. I always assumed “some people need meds for mental health and some don’t.” Reading this book demonstrating the actual figures for people who manage their depression/anxiety without meds is truly uplifting for me. I have had a rough month trying to start the taper. Someone tried to attack me at my job (this has never happpened to me before) and I was quite affected by it, starting to feel my anxiety sky rocket even on my full dose. This event set off some really tough emotions for me as I already have a stressful job and have been working on ways to move to something less stressful for me. For financial reasons, I need to stick with it for another 1.5 years. I feel pretty angry and anxious the first few days after a taper, I have noticed and the lightening strike emotions are there. I think mindfulness and encouraging self-talk in preparation for this possibility is key for me. Like positive visulations, even practice (role play) like what will i say if XYZ happens. I am on 121.5 mg of my effexor right now which is the second taper I have done. Much of my focus has been on the bad sides of my withdrawal. I go to Zumba pretty religiously and yesterday in my class I felt something I haven’t felt for a very long time—- it was joy. I felt joyful as I moved, and used my body, and felt alive. I felt free. I realized that this feeling has been covered up for some time in addition to my demons I am now facing. I was sitting in the sunshine with my dog and drinking coffee, listening to the birds sing, and I thought.. this is truly a perfect moment. It has been so difficult for me to feel moved in any way for the last 7 years. And in the back of my head I can feel my anxiety telling me “this won’t last, you could still be in trouble, you could still be unsafe...” And I am letting myself just for now to feel alive, like I am waking up.
  2. Hi all I'm on day 3 of tapering off venlafaxine XL 37.5, only 2 beads out at a time,I will get a scales soon because It will only get harder the more I have to count out the beads .I am going to take it extremely slowly this time.I did a taper in march 2016 and it lasted till the june and i didn't go beyond 5 beads out each day before going back to 37,5. Its been a very tough time , I have extreme anxiety,extreme iratibillaty ,intrusive thoughts,. to name a few. What I have learned since that time is to have compassion for ones self and b very patient when doing the taper . My advice to everyone is don't ever believe u cant get through it .our nervous system and soul take time to heal Over the last 3 years I have learned and practice mindfulness ,it is amazing. It has helped me to calm down during a couple of flights to the UK when starting to panic. Today I had a bad anxiety attack but I was able to snap out of the attack fairly quickly because I have been practicing it and I recommend always getting out for a walk in the sun if u can and clear your mind. Please always keep your mind open to new ways to heal.We all now its hard but don't ever let anyone break your spirit. Total respect to everyone .
  3. mmcdonald21

    mmcdonald21: intro

    Hey, I've been trying to get off medications for a while now, to no avail. I'm currently on 30mg Remeron, 300mg Effexor, and 10mg Abilify. I also take a lot of vitamins and fish oil with a high concentration of EPA. I don't feel very good right now, and I've had periods where I've felt good, but I'm pretty sure they were just times that were flukes. I think the things that really help me are exercise, meditation, and to some degree, my vitamins and fish oil, but I really do want to get off of the medications. For over four years I've been reliant on these medications, and still I haven't felt very good at all during the time. I started getting off of my medications by taking 75mg less of the Effexor XR (I was on 375mg). I will report back how that goes. Any tips or advice would be much appreciated.
  4. Caspur

    Caspur: history

    I have been taking Venlafaxine at 75mg per day for about 6 years. The side effects were becoming too annoying to contiune - mainly flat, blunt unemotional mood, drowsineess during the day (i would fall asleep at my desk whilst working (at home)) and frequent urination, especially at night, which interrupted sleep too much. I have successfully tappered off venlafaxine once before after about 10 months treatment. I did it over 9 months without any issues. Buoyed by that success, i thought i could do it again and embarked on a taper using broken pills and liquid preparations prescribed by my doctor on the UK NHS. I only took 4 months this time which wasnt that sensible , as i now know. The taper ended 5 weeks ago today (24/11/17). Since then i have experienced many and varied discontinuation symptoms both physical and emotional: - physical - nausea, diarrhea, flatulence, dizziness and swimmy feeling in the head; mild visual disturbances; mild but constant headache; mild tingling sensation in the face - emotional - depression, anxiety like i've never experiened before for no aparent reason, irritability, poor concentration; mood swings over a very short time period for no apparent reason etc The semotional symptoms come and go. I will have one or two good days followed by 2-4 days of feeling depresed, anxious, etc On the up side i do feel like im experiencing real emotions like i havent felt for year I have mananegd to control some of the symptoms with supplements such as tryptophan. i also take fish oil, B vits, vitamin C and D I exercise a lot - run 5-6 km per day and try very hard to eat well; lots of fruit and vegetables etc Any suggestions for help would be gratefully received!
  5. Hi I am new to this forum and this is my first post . I am currently on 30mg mirtazapine and 200mg of pregablin , I have been on these mess for about 3 to 4 months . I have just cut my mirtazapine from 30mg to 15mg and in the space of 4 days I have have horrible side effects , anxiety through the roof , shaking , lack of appetite poor sleep crying spells and the general feeling of feeling crap . The reason I have started to withdraw from the mirtazapine is that after 3 months I feel no benefit only get awfull side effects . No help with my anxiety and depression if anything it's made me more depressed . I have gone through withdrawing from Effexor and that was really tough , however just the drop for a few days of the mirtazapine has left me crushed , my doctor told me that mirtazapine was a easy drug to withdraw from , but after 4 days it has left me house bound . Has anyone got any idea on how I get through this or any experience in mirtazapine withdrawals
  6. Hi to all users, Its been 3 full months after my last dose of Venlafaxine. In 2018 I've been on 10mg of Escitalopram for five months then switched on Venlafaxine for another six months. I started Venlafaxin with 37mg and came up to 150mg per day XR. On January 2019 wanted to get rid of the drug since i feel that not needed anymore. Jumped from 150mg-0mg in one month (I know it was too fast, but those days i felt very good and confident, hence rapidly tapering the dosage). The first month of withdrawal, I had severe psychical symptoms, like tiredness, headache, heart racing, anxiety. After these symptoms somehow subside, starting from the month 2 till today (now I am at 3 full months after my last Venlafaxine dose) I have constant headache (don' know how to describe, its not a regular headache, but something like head/nervous system tension) and decent anxiety. My waves and windows are very recognizable, since I have periods when I feel very anxious, depressive, sensitive to sounds, feel nausea etc. and there are days when I feel better (not by much but noticeably more relaxed, with more emotions and not so severe headache/tension). Want to hear from other users who pass through these similar symptoms with constant headache and anxiety which persist of days and weeks now, if some supplements can make the situation more manageable. Hope the day when we heal will come soon... Thanks
  7. Hello, I'm new to this forum and I'm working toward tapering off of 225 mg of venlafaxine. I am a 70 year old male, that has been very active and health conscious. My weakness has been depression. I previously had two periods of feeling depressed that involved obtaining an antidepressant from my general practice doctor. I would get to the point of feeling spacey and or lethargic, then do talk therapy to get back off of the drug. These where phase one antidepressants, and I would taper off slow over say 4 to 6 months without noticeable side effects. These events occurred between 2005 to 2008 per notes I still have. I retired from Highway Engineering March 1, 2014. Many emotional events piled upon me during the next five months. The stressors where; retiring and adjustment period, daughter coming home to live with us and get a divorce, a vicious son in law (being divorced), one or two other more minor stressors that I do not recall, and a huge spiritual crisis in which I felt I had not lived as graciously as God would have wanted me to. In July 2014 I became fixated on thinking about all these things. I sat in a stupor for days, lost 15 pounds, thought the devil was speaking and accusing me of my wrongs and tempted me to deny God and just die. My wife asked me If I had thought of suicide and I admitted that I had. She called 911 and got help. They took me to a hospital and put me on suicide watch till they could transfer me to a psych ward for treatment. I was confined for a week and given many medications. I also had a physical problem that they dealt with. I was released to an out-patient psychiatrist. The psychiatrist told me he would take me off all the previous medications except for increasing my dose of venlafaxine to 225 mg. I have been on venlafaxine for four (4) years. In May 2018 I stopped drinking all alcohol and also stopped experimenting with legalized cannabis. I quickly felt a bit more energy. I put this energy toward searching the internet for information about venlafaxine and antidepressants. I have learned much, but still want to keep learning. My Psychiatris agreed to allow me to get off Venlafaxine October 4, 2017, after telling him repeatedly about my desire to and why. He reduced my venlafaxine from 225 mg to 150 mg. The short of it is that I did not make it, and went back to the full dose. After learning more about how to decrease slowly, I am ready to try again. I have sought the help of my general practice doctor, who is supportive and has reduced me to 187.5 mg. Since I know that a 10% reduction is better, I cut open a 37.5 mg capsule, counted the beads, and took 40% of those beads, 15, and added them to the 187.5 mg, for a new total of 202.5 mg. I'm also taking daily notes of my physical and mental state, and dosage. I will see my general practice doctor monthly. I will be also talking to my Psychiatrist about my plans. I plan to start talk therapy also. Does anyone have any advise or comments?
  8. Davie

    Davie

    Hello, I am a 64 year old man who has been on Antidepressants since my early thirties, I have tried most Antidepressant types from the older MSOI's the Tricyclics , onto the SSRI's none of which helped greatly! I was then introduced in 2002 to Venlafaxine 75mg tablets X2 per day ,these I had taken with little success until 2008 when I had a nervous breakdown and was immediately switched by My Doctor back onto Fluoxetine with no tapering advice given, the next 5 years were very difficult, lots of spells sick from work with Anxiety. In 2013 I was seen by a Pschyciatrist who diagnosed me with GAD and persuaded me to start Venlafaxine again as it was supposedly best for GAD. Naturally this did not work well so I tried recently (2019) to carefully wean myself off Venlafaxine over a two month period ( which was longer than my GP recommended) I was down to around 10 mg a day (1/4 of a 37.5mg tablet) for the last two weeks before stopping completely! I had a very good 4 week's after stopping, my Pschyciatrist was pleased I had successfully stopped and suggested I need no further Medication. A few days after meeting my Pschyciatrist I had a bad nights sleep and got up in the morning with Anxiety that would not go away and got worse every day - it was banging in my chest 24/ 7 and I started feeling suicidal as I could not bear the pain until I took a 37.5 mg Venlafaxine tablet and felt the Anxiety ease within an hour or so. I am now back on Venlafaxine 75mg XL along with 10 mg Diazepam a day to help my damaged nervous system repair itself. As I write this now I am 2 weeks back on the Venlafaxine and the unbearable Anxiety has now cleared but I still feel nervous & exhausted. My Doctor now says I will be on this drug long term as he has no other answers. My main concern is that this drug may continue to do irreparable damage to my nervous system and I can not get off it!
  9. Hello Surviving Antidepressant friends Around 18 months ago I posted this thread desperately seeking help for tapering gone wrong. I had been on a treatment dose of 300mg of Effexor, which I had reduced around 80%. I went to a psychiatrist to seek advice on tapering and bridging and he told me the amount I was on was almost nothing and there would be no issue if I tapered off over a couple of weeks. That caused the worst withdrawal I have ever had, including what felt like 48 hours of suicidal panic attacks and inability to sleep. My memory from that time is blurry. Anyway. After that I tapered back on to Effexor until the worst of the discontinuation syndrome subsided, which ended up being back up to 10mg, or 30 beads. I stayed that way for around 8 months before trying to go off again. I would take my dose every morning in the same place, around the same time, by pouring out the little beads onto my hand, counting them, taking them, then brushing my teeth. The next time I started going off I reduced by 1-3 beads every 3-4 days (more at the beginning, fewer at the end). I also conducted a little placebo conditioning experiment with myself, where I replaced the lost beads with white 100s and 1000s (I think Americans call them sprinkles?). I figured, after reading up on the classical conditioning mechanism in the placebo effect, that the eight months of "ritual" around taking the drug might be sufficient to allow the placebo sugar beads to have the same effect as the drug on my brain. Once there were no more drug beads I continued "taking" the 100s and 1000s each morning for a few weeks. I'm not going to recommend the placebo approach outright for obvious reasons (I am not a doctor or scientist; my understanding of the placebo effect is probably rudimentary). However, in my specific case, the experience of going from 30 beads to 0 beads, was a million times better the second time than the first. Other factors that likely helped: It was about 5 times slower than the first time; I had adjusted to the 30 bead dose before I started; I took even longer gaps between reductions of the last beads; I was not working as much as I went through this process. Now. While it was easier than the first time, it was still not easy. I felt churned up emotionally and was super irritable, I had rage flashes, my anxiety increased hugely, anhedonia returned, I had nausea, and my muscles, particularly in my legs, spasmed and twitched, often violently. I could, however, sleep for the most part, and none of these symptoms got too much in the way of life (granted I was not working very much and I work for myself anyway; it would have interfered if I worked for someone else). It helped to know that if I could just get through those few weeks then things would probably get better. These symptoms lasted around 2 weeks after the final drug dose, which was early April 2017. And things did get better. For me, most of the side effects of the drugs have now gone. Most significantly, my sense of self and my creativity have returned. It had felt like they were being numbed or muted by the drugs, and I couldn't access them. Off the drugs I now have access to them. Similarly, my ability to enjoy sex has improved, and I don't feel like that side of me is muted either. The above is really tremendous; feeling like yourself again instead of a weird muted robot alien is a big relief. However, while I consider the drug withdrawal to be 100% successful and 100% the right decision for me, I should caveat that with the following context: The drugs appeared to be muting extreme unresolved emotional distress, both from childhood stuff and from rape and sexual assault from a few years ago. The pain from this sort of exploded when the drugs went away. My primary diagnoses are anxiety and major depression, but it appears even those were symptoms of childhood stuff. When I came off the drugs it was the first time I had been drug free in around 13 years. I am highly sensitive and have a big emotional world, but I never learned how to regulate stimulation and emotion, and then had it muted by drugs. When I came off the drugs the emotions and stimulation were pretty extreme and often overwhelming. I took from that that I should learn skills of emotion regulation though, rather than that I should go back on the drugs. Even with only 3-4 months of practice, I am hugely improved and the emotions and stimulation overwhelm me much less frequently. (Now they inform my creative work and my service work, and are real positive assets for me, albeit ones that require sensitivity and management.) I have the great privilege of being able not to work for a while while I recover fully, which is lucky because I cannot currently work. I put that down to unresolved trauma that has now come to the fore rather than drug withdrawal. I am doing deep dive work with my psychologist that is helping more than any other talk therapy I've done, and I think that work will be sufficient to return me to work eventually. I see her weekly. That work is also subsidised by the government because it is about recovery from sexual trauma, meaning for now I do not pay anything for it (another enormous privilege). I have a partner who is extraordinarily supportive and gets what is happening for me. He judges fair contribution to the relationship by reference to each partner's capacity, and thinks that because he has more capacity right now it is fair that he do more housework, financial contribution etc than me. This has allowed me not to push myself beyond capacity, which has meant I have recovered more quickly. In conclusion, while I am currently not working and my capacity to do a lot of things is severely restricted, I could not be happier that I am off the drugs. I feel like I have real issues (childhood trauma and sexual trauma) that require serious work, but now I feel like I am actually properly addressing them, instead of having them be muted yet just as destructive. I also no longer have the drug side effects interfering with my ability to enjoy things, make music and comedy, have intimacy with my partner, meaning recovery feels more authentic and there is more joy in it. Things still hurt a lot, but my world feels real in a way it wasn't on the drugs. It's hard to explain to anyone who hasn't come off these drugs before. In simple terms: I have hope. I can experience joy and enjoyment. I am excited about what the rest of my life might bring. Even while I know that I am in the middle of pretty extreme emotional upheaval and trauma processing, life is better than it has ever been. I am finally able to be fully, authentically myself, in ways that the drugs (and the trauma and mental health issues) got in the way of. I am optimistic.
  10. Hi all , I am 8 months off reinstated sertraline for a month ( by doc) and Aripropazole. History Its around 4 years back when i passed out my college and not get placed even after making to finals in many interviews .. that i decided to write competitive exam for PG. I had taken coaching but just before exam I came back and found myself unable to recall things. My brain is just like nothing in it. I found myself in despair and stopped studying. This fog is happening all the time since my engineering but I managed to get average marks sometimes and sometimes very good . There is more in back history but I ll get to it later. So, my parents took me to a psychiatrist ( family known) and he put me to Olanzapine and one more thing. He diganosed me bipolar2. I got about 10 pounds on it but its not help . Meanwhile after 4 months, with the help of a relative , I got intern in a company and I moved out with fog to a distant city. TThere in a hospital, they put me on floxetine and Amisulpride for 3 months . Then i moved to a private psychiatrist ... where it starts getting haywire . He stopped fluoxetine and Amisulpride . And put me on Venlafaxine and Seroquel... As i was interning, i get usual heat racing in between job times but my doctor convinced me to stay with it . 4 months and I just started feeling agitated due to stress. It happened that I slapped a senior on abusing me and there I left a job I never happened to get physical in my school or college .. but it happened. Doctor told me to scrap the prescription he wrote of raising Venlafaxine. And he put me paroxetine + Oxcarbazepine. In his words , it is best tolerable and has lesser side effects. I managed to get a job by my own and cracking first time. But this time there is lot of work and culture pressure. Its a startup with full of politics . Boss and his boss .. all keep on putting things. Let office aside, I started feeling some well .. overly casual ... excited .. raged .. Iits about 25 mg Paroxetine and 300/600 mg Oxcarbazepine. I had unusual violent acts .. had hit a school friend .. insomnia.. I decided to leave the paxil by asking the doctor . He said half in a week and then other half a week to off. Thats when it all started , i cannot sleep whole night and with day light i start getting a nap. I left going office with fear of state i was in . I cannot wake and even if I .. i was too tired and angry . Doctor then gave me Mirtazapine which didn't help . I resigned job telling muly boss about all and came back home. It was Nov,2015. I start getting yhese uncontrollable rage that I locked myself in a room. Parents took to a local shrink who put me on Venlafaxine+ Mirtazapine(CRF), lamotrigine, resperidal, Seroquel. The NEXT Day I woke up so fresh .. all calm like 12 yrs back .. i was smiling happy.. but it lasted only 4 hrs .. and i am doomed again . I took those meds 10 days and i decided to go off. Physical Damage. I got brain zaps as sounds with eye movement .. While on Paxil I got severe neck stiffness and movement pains - which came out as Osteophytes. Anger , heart race , memory, fog , chest pains , fatigue ... All I beared for 4 months. Reinstatement after 4 months. Father took me to another psych who put me on Sertraline+ Aripropazole+ Seroquel. I started having increases restless legs than before and the doctor asked me not to go over net. After 2 visits and when he said it wslas Aripropazole for restlessness all time.. and he is cutting it . I stopped all meds . Withdrawals in 8 months. All first symptoms with some new like utter sensitivity in teeth. It is while breathe in most of the teeth . Muscles gone from forearms .. My left hands gone ulnar neuropathy and i got surgery done when no hope lived. Right hand has stiffness too . MAnger I am living with .. I have stopped talking .. I have decided to go sit on my Shop but I was unable to understand the talk . In spite anger biuts and memory makes it difficult to adjust. I keep forgetting people faces .. important talks . So i stopped . Now I am muted all the time with burst inside . Read success stories and play CoC. This is the most I can write now.
  11. Hello all. I've been shadowing this forum for a while, and I'd like to begin by thanking everyone involved (Altostrata in particular) for providing such a caring environment for all the battered brains out there. A lot of my questions have been answered already by virtue of all the great information here. Still, one feels a particular solace in telling their own story, and I'd like to do just that. I am twenty four, and I have been more or less continuously medicated since I was sixteen. I was a troubled and difficult teenager, and a drug addled and dysfunctional brain seems to be my reward. I've been prescribed various stimulants, but (thank god) I've mostly neglected them over the years. I've run the gamut of anti-depressants from prozac, to lexapro, and then onto Effexor. I don't really remember having any issues with the prozac and lexapro, except the sort of general malaise one experiences on those drugs. Effexor has been a different story. I've been on it now for about four years. A year ago I noticed a strange sort of free-floating despair from time to time, the sort of thing I'd struggled with years earlier in high school. But unlike before it's appearance was alarming and irregular, and it seemed somehow “unnatural”. It was clear something was changing, either my brain chemistry or the effect of the drug, or both. Whatever the cause, it didn't seem to have much to do with circumstance. A few months later I decided to come off the drug. I went down over a period of two months. The effects were highly unpleasant but not unbearable, the strongest symptom being fatigue. I was completely off the drug for about three weeks. The effects during those three weeks were slightly different than they had been while still weening. Along with the fatigue came a deep underlying anxiety, and a sort of anxious hopelessness that would wash over me a few times a day. I decided after three weeks that I couldn't deal with the withdrawal symptoms anymore, especially since they hadn't show any signs of abating. I went up to 75 mgs, and was able to remain there for one to two months. The worst was over, though I still suffered from fatigue (I would often have to take a nap in the late afternoon) and began to have cravings for alcohol for the first time in my life. I imagine that my cravings were somehow compensatory, and I've heard of other people experiencing them while on or withdrawing from these types of medications. Eventually I went back up to 150 mgs of the Effexor, and after feeling a little drugged for a few days I returned to my normal self. It took a few more months to work up the courage to try to taper off again. This time I was prescribed 40 mgs of Prozac to “soften” the effects of the withdrawal. I slowed my descent a bit and two months passed before I reached 75 mgs. The symptoms were bothersome but tolerable throughout, and I managed to maintain a diet and mild exercise routine. Great changes were beginning to occur in my life around this time. I'd rather not go into lots of detail, but I'll just say that I managed to address certain things that had haunted me for many years. As these inner tensions began to dissolve the world suddenly seemed alive and brimming with meaning. Colors appeared more vivid, and everything seemed to be suffused with a kind of mystery. This period is somewhat hazy, but I think I must have been convinced by this shift that I would be able to quickly withdraw from my drugs, so strong was my sense of well-being. I took only a month to come off the last 75 mgs, and because of some mistakes while measuring my doses, my taper was somewhat erratic. This period was pretty horrendous. The effects of these drugs come so close to your basic 'poles of being' that it's really hard to describe them in any kind of reliable way. But there was a certain manic and anxious character to this period that had been mostly absent from the previous withdrawal. Some of these new symptoms came in waves, while others were more or less constant. Twice I got into very intense arguments with my father over dinner, both of which ended with me sobbing and hyperventilating (which is quite unusual for me). Sometime before the arguments I had felt a kind of mounting irreversible tension, one that quickly transformed into aggression. There was something strangely primitive and hyper masculine about it, like my mind and body were preparing to fight off an enemy or predator. Deeply strange stuff, I've never experienced anything like it. Once off the meds I only lasted a week before deciding to go back on the Effexor. Here I made another error. I was so panicked and anxious to get rid of my symptoms that I went back up very quickly. 10 mgs for a few days, 35 mgs for two days, 75 mgs for three days, and then back up to the full 150 mgs. Somehow it didn't occur to me at the time that I might have been rushing things. The first day back on the 150 mgs was wonderful. That earlier sense of joy and clarity returned, colors had that dark and enhanced quality again. I was overwhelmed with relief and gratitude. But, to my horror, the “manic” type symptoms returned the next day. They returned, and then they seemed to get worse. Two to three times a day I'd have those indescribable surges of raw feeling, and a pervasive tense/drugged sensation returned as well. Fearing that I'd gone up too fast I quickly went down to 75 mgs, which seemed to help for a bit. But the surges and the tension remained. It's been about a week and a half since I've made this last switch, and the symptoms continue. I've read on this site that it can take three to six weeks to stabilize at a given dose, so it seems like I still have some time before I can expect any kind of peace. What's complicated this whole thing is this new way of seeing that's opened up to me. Not only do I have the fear that I'll never be “normal” again, but also a fear that this recent revelation will be torn from me. In short, I feel like I have more to lose now than I did before, that returning to “normal” would be just agonizing as not recovering at all. Still, I have the sense that the transformation I experienced is real and is a lasting one, and that it's just been obscured by the effects of the withdrawal. Plus “it” hasn't disappeared entirely, and at least once a day I'll feel that sense of peace, well-being and heightened interest in things seep through. Still, it's strange how little comfort those moments provide when the hell starts. I apologized if this was overly long or indulgent in any way. I have a few questions for you guys. Firstly, does any of this sound familiar? Am I within the range of what's considered “normal” for this kind of thing? (I think I am but it never hurts to be reassured) Should these new “manic” symptoms disappear eventually? It sounds like they're the sort of nervous system issues that Altostrata describes in his/her theory, though I don't remember all the details at the moment. My greatest fear is that I somehow won't be able to stabilize at this dose, and that I therefore will never reach a comfortable place from which I can withdraw again. Also, does anyone have any idea why my second withdrawal attempt was so different from the first? The addition of the prozac maybe? It goes without saying that my next withdrawal will be much slower. I don't have any more illusions as far as that goes. Also, I should mention that I'm no longer on the prozac. Thanks in advance for all comments! Wonderful place you've got here.
  12. I joined this site a couple of weeks ago. After finding that paxilprogress was no more. I was devastated. That site may have truly saved my life in some of my darkest moments. What is one to do? When essentially you've self-destructed in front of everyone you love; because of a nasty little "non-habit-forming" pill that's been shoved down your throat for decades. So here I am. Time (weeks really) has eluded me. I meant to reach out sooner. I'm just hoping I'm not reaching out too late. I feel like such a horrible failure. I know better than that at some level, know that maybe I failed but that I just have to pick up the broken pieces and keep moving forward. But I'm so I'll. I'm so weak. I'm so alone. And I feel so helpless. My life may not have been a picnic before the introduction of SSRIs. But this is one situation in which the grass was truly greener on the side of which I was already standing. Before popping that first "innocent" little pink pill, prescribed by a doctor who had seen me only once and only spent 10 minutes "getting to know me". I couldn't tell you who that doctor was, I never saw him again. Nevertheless he was the first in probably nearly a hundred who have insisted upon continuing the saga. And what better did I know? I was unhappy before the meds. I was often unstable on them. And I was clueless as to why I was saying and doing psychotic things (that I often didn't remember, or just have "snippets" of memory after the fact) and so violently ill when I decided I simply no longer wanted to take the pills. Or was even 12 hours late on a dose. (More about that and my travels down genetic testing road and CYP450 mutations later.) All that being said; Hello to all in these forums. I'm the antisocial one. The antisocial one that sometimes doesn't know when it's appropriate to shut up. Or how to appropriately ask for help. But if you've been through it (psych med-wise), I probably have too. And vice versa.
  13. PLEASE READ THIS ENTIRE TOPIC BEFORE GOING OFF PRISTIQ. Pristiq comes in insufficient dosages to taper. Do not alternate doses of Pristiq to taper -- this will cause the levels of this medication in your brain to go up and down and is second only to cold-turkey in causing withdrawal symptoms. AND DON'T COLD-TURKEY EITHER!!!!!!!!! To reduce the risk of withdrawal symptoms and post-discontinuation prolonged withdrawal syndrome, as with other psychiatric drugs we recommend reducing Pristiq by 10% per month, calculated on the last dosage. (The amount of the reduction gets progressively smaller.) See Why taper by 10% of my dosage? The official prescribing information from the FDA contains this: However, Pristiq is difficult to taper "at a more gradual rate" as it comes in only 3 dosages: low, average and excessive -- and officially, the tablets cannot be split. PROTEST THIS DANGEROUS DRUG Phone Pfizer, Pristiq's manufacturer, to make a complaint: (800) 438-1985 in the US Pfizer has not provided any specific information on how to taper from a dosage of 25mg Pristiq, the lowest available dosage. They may suggest alternating dosages to taper Pristiq. Don't do this -- it's like playing ping-pong with your brain. File a complaint about the difficulty of tapering off Pristiq -- the range of dosages is inadequate. Also complain to the FDA 1-800-FDA-1088 Mon–Fri between 8:00 a.m. and 4:30 p.m. EST. Pristiq is Effexor's fancier sibling Pristiq is a drug made of Effexor's (venlafaxine) active metabolite, O-desvenlafaxine. Pristiq is to Effexor as Lexapro is to Celexa -- a tweaked and more powerful isomer molecule. In effect, Pristiq is concentrated Effexor. See http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=2464 According to Pfizer http://labeling.pfizer.com/showlabeling.aspx?id=497, Pristiq is available in extended-release tablets of 25mg, 50 mg, and 100 mg; the most common dosage is 50mg. Unlike Effexor, which is metabolized primarily by liver enzyme P450 CYP2D6, Pristiq is metabolized via conjugation and liver enzyme P450 CYP3A4. It attains peak plasma concentrations in about 7.5 hours. As a chemical, before it's put into an extended-release tablet, desvenlafaxine has a half-life of around 11 hours. Pristiq's extended-release formulation According to this paper, the extended-release formulation releases desvenlafaxine over 24 hours. The mean half-life of desvenlafaxine, without the extended-release formulation, is around 11 hours. The extended-release formulation is a monolithic matrix -- it's in the glue that holds the tablet together, not in the coating. I confirmed this in a phone conversation with Pfizer medical information (1-800-438-1985). (Thank you, oaklily, for this information about the matrix formulation.) Rather than a timed-release coating, the coating on the Pristiq tablet is only protective. The extended-release mechanism is part of the tablet matrix, or the glue that holds the tablet together. This is called a monolithic matrix tablet. If the tablet is split, the matrix is damaged and may not reliably be extended-release, depending on the size of the fragments. Larger fragments are more likely to retain some extended-release capability. When the tablet is CRUSHED, the matrix is completely destroyed. The particles should be assumed to have NO extended-release capability. A Pristiq fragment becomes desvenlafaxine, with an 11-hour half life. (Here is a description of the similar matrix formulation for quetiapine XR (Seroquel XR) .) OPTIONS FOR TAPERING PRISTIQ Since medicine knows nothing about tapering Pristiq, the following are all informal suggestions. Try any of them at your own risk. Please let us know how you do by posting in this topic. Cut up Pristiq tablets Despite the warnings not to cut it up, from reports on the Web, cutting up Pristiq tablets does seem to work for some but it makes others ill, possibly because of "dose dumping." According to Pubmed on Desvenlafaxine: "....The extended-release tablet does not dissolve in the stomach after swallowing. It slowly releases the medicine as it passes through your digestive system. You may notice the tablet coating in the stool...." The extended-release mechanism is part of the tablet matrix, or the glue that holds the tablet together. If the matrix is destroyed, the entire dose is released at once or "dumped," instead of being gradually released through the matrix formulation. Without the extended-release matrix, a Pristiq fragment becomes desvenlafaxine, with an 11-hour half life. To avoid "dose dumping" of the entire dose, you might take smaller divided doses of Pristiq, more than once a day, like immediate-release Effexor, to mimic an extended-release dose. Cut-up Pristiq seems to sometimes cause stomach upset, which may be reduced by taking it with food. Now that the 25mg tablet is available, cutting it into quarters gives you the option to taper by 6.25mg per step. If you are taking 100mg Pristiq or 50mg Pristiq, you may wish to request part of your prescription be written for 25mg tablets. (For insurance coverage of multiple dosages, your doctor most likely will have to specify taking Pristiq in "divided doses.") You may find you need a precise way to measure your tablet fragments. See Using a digital scale to measure doses As you get down to a low dose, you may wish to switch to Effexor to more precisely control dosage decreases, see below. Reducing from 100mg Pristiq to 50mg Pristiq Drug switches incur additional risk. Before trying a switch to Effexor or Prozac (fluoxetine) from 100mg Pristiq, it's probably wise to go down to 50mg Pristiq first, or 25mg if possible. Combining whole tablets, with their extended-release qualities, with tablet fragments probably makes "dose dumping" less likely or noticeable. You might use a 50mg tablet plus a 25mg tablet plus 3/4 of a 25mg tablet (18.75mg) to make the first reduction to 93.75mg 2nd reduction: a 50mg tablet plus a 25mg tablet plus 2/4 of a 25mg tablet (12.5mg) to go to 87.5mg 3rd reduction: a 50mg tablet plus a 25mg tablet plus 1/4 of a 25mg tablet (6.25mg) to go to 81.25mg 4th reduction: a 50mg tablet plus a 25mg tablet to go to 75mg 5th reduction: a 50mg tablet plus 3/4 of a 25mg tablet (18.75mg) to go to 68.75mg 6th reduction: a 50mg tablet plus 2/4 of a 25mg tablet (12.5mg) to go to 62.5mg 7th reduction: a 50mg tablet plus 1/4 of a 25mg tablet (6.25mg) to go to 56.25mg 8th reduction: a 50mg tablet If withdrawal symptoms occur, some people have found taking an additional fragment of a tablet can smooth the transition from one dosage to another. Another way to get from 100mg to 50mg or 25mg is to combine Pristiq tablets with a liquid made from immediate-release Effexor (see below). Once at 50mg or 25mg, stabilize for a month at least and consider your plan for the next stage of tapering. Have Pristiq made into smaller dosage capsules or a liquid by a compounding pharmacy Compounding pharmacies can crush the tablets and put the powder into smaller capsules by weight. Like cutting up tablets or crushing, this destroys the time-release quality, but the compounded method is much more exact. In your body, crushed Pristiq is similar to regular immediate-release Effexor, with an 11-hour half-life. You may wish to have your dose compounded to take twice a day. If you are taking 50mg Pristiq, for example, you would have 60 capsules compounded per month. Each capsule would be 1/2 of 45mg (a 10% reduction of 50mg) or 22.5mg. You would take two capsules per day, once in the morning, and once in the evening. The next month, you would have 60 capsules compounded, each capsule being 1/2 of 40.5mg (a 10% reduction of 45mg) or 20.25mg. And so forth, for each reduction. (According to my compounding pharmacy, they can put in a slow-release additive distributing absorption over 8-10 hours. This is not as long as the Pristiq time-release coating, but at least it's something. Check with your compounding pharmacy about this. See getting-custom-dosages-at-compounding-pharmacies-us-uk-and-elsewhere ) If this does not work, you may wish to switch to Effexor XR and use the bead-counting method. Regular Effexor probably wouldn't be an advantage over Pristiq compounded to custom dosages. One of our members had a desvenlafaxine liquid made by a compounding pharmacy. Most likely, this compounder used pure desvenlafaxine succinate powder to make this liquid, as desvenlafaxine tablets contain a glue that might resist being made into a liquid. But he may have a way to grind tablets up to make a suspension. A liquid would have to be immediate-release, with a half-life of around 11 hours. Generally, you'd take a drug with that short a half-life twice a day. Crush Pristiq tablets, weigh powder with a digital scale This is similar to cutting up tablets -- Pristiq is a "do not crush" medication, as it is a time-release drug. The Pristiq powder becomes desvenlafaxine, with an 11-hour half life. If you pulverize the tablet, you might take smaller divided doses of Pristiq, more than once a day, like immediate-release Effexor, to mimic an extended-release dose. In principle, this would be a more precise way of tapering than cutting up tablets: Crush the tablet Make sure the shell fragments are evenly distributed in the powder Weigh the powder for a dose with a digital scale Put the powder into an empty gelatin capsule to make it easier to ingest Peer discussion of this method starts here http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__27417 Switch to Effexor or Effexor XR Note: If you've had an adverse reaction to Effexor before, do NOT switch from Pristiq to Effexor. "Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of venlafaxine." Since the relationship is so close, switching to regular immediate-release Effexor tablets, which you can cut up or make into a liquid, this may be the best way to taper off Pristiq. Because it has a mean half-life of 5 hours, you'd have to take regular Effexor twice a day. Alternatively, you might substitute Effexor XR, which is released gradually like Pristiq and needs to be taken only once a day. You'd have the difficulty of tapering off Effexor or Effexor XR -- themselves notorious for withdrawal difficulties -- but at least you can do that gradually. See Tips for tapering off Effexor and Effexor XR (venlafaxine). According to FDA Prescribing Information for venlafaxine (Effexor), the usual dose of Effexor is 150mg per day. Since 150mg Effexor and 50mg Pristiq are both "normal" dosages of their respective drugs, they may be roughly equivalent. (If you've just quit Pristiq and are experiencing withdrawal symptoms, you may wish to reinstate a LOWER dose of Effexor XR, such as 37.5mg, to start. This may be enough to stop withdrawal symptoms and avoid a kindling reaction.) The psychiatrist who writes the 1boringoldman.com blog reports success in switching one patient from Pristiq to Effexor, then tapering Effexor, here (see comments) Another psychiatrist said when he tried this, the switch from Pristiq to Effexor was "seamless." Dr. Stuart Shipko posts here: Advice from a psychiatric pharmacist I have been corresponding with a professor at a prominent US university pharmacy department. Here is his best guess at how to taper Pristiq (he does not want his name published): Then taper off fluoxetine (Prozac). See Tips for Tapering Prozac Advice from Dr. Stephen Stahl, author of the manual Essential Psychopharmacology In his widely read psychopharmacology manual, eminent psychopharmacologist Stephen Stahl advises titration by crushing the tablets and mixing in fruit juice, see http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__14799 According to our member oaklily, Stahl is wrong. Making a liquid from Pristiq does not work, see http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__24822 Dr. Stahl intends to correct his book, according to this correspondence 09/15-9/16/13 with him: Use a combination of Pristiq tablets and Effexor liquid Pristiq cannot be made into a liquid, but its close relative immediate-release Effexor (not Effexor XR) can. You may be able to go off Pristiq by taking part of your dose in lower-dose tablets and part in liquid Effexor, gradually converting to all-liquid Effexor as you get to lower dosages. This may offer a convenient and gradual path off Pristiq. Only regular immediate-release Effexor can be made into a liquid (see Tips for tapering off Effexor (venlafaxine) ). As immediate-release Effexor has a short half-life and is usually dosed twice a day, you may wish to take the liquid portion of your dosage later in the day. For example, if you are taking 100mg Pristiq, you may wish to take your daily dose as one 50mg tablet and the rest later in the evening as a liquid made from immediate-release Effexor. You can titrate the liquid by 10% of your daily dosage to taper until you get to 50mg. Then you can take a 25mg Pristiq tablet with the rest in a liquid made from immediate-release Effexor. When you get to 25mg Pristiq, you might switch to splitting the tablet and taking the rest in Effexor liquid and so on until you are taking only liquid Effexor. To do this, you will have to request a prescription for Effexor tablets as well as Pristiq from your doctor. "Bridging" with Prozac or another antidepressant Any drug change incurs additional risk. A switch to Prozac from Pristiq may not work -- they are very different drugs -- or you might have adverse reactions to Prozac. Prozac is regularly used to "bridge" off Effexor. Given that Pristiq is a sibling of Effexor and Effexor XR, it is possible that one can, similarly, use Prozac to withdraw from Pristiq. Attributed to Joseph Glenmullen, the "bridging" technique is described by a doctor here http://www.bipolarworld.net/Phelps/ph_2005/ph1354.htm Read this entire topic before attempting a switch to Prozac: The Prozac switch or "bridging" with Prozac Later, taper off Prozac. At least Prozac comes in a liquid. To do this, consult a doctor knowledgeable about this technique.
  14. Hi Everyone, I've been reading the site for a few hours and am really grateful for so many of the contributors who share so much of their time, heart, and knowledge to help others come off medications they no longer want to be on. I am going to start tapering off this weekend of 75mg of Venlafaxine, which I found out through another Dr. I never should have been on to begin with. I have an estrogen problem that cannot be solved with SSRIs and became diagnosed with severe depression after the birth of my first and only child who is now 6. I went untreated for 2.5 years until I had a suicidal desire in Feb 2016, after that incident I got a diagnosis and went on 50mg of Sertraline and later up to 75mg. I took Trazadone to sleep at 25mg due to the insomnia caused by the Sertraline. One of my sisters and my mother also suffer from depression and my sister mentioned Wellbutrin worked really well for her so I asked my Dr. to switch since I felt like an emotionless robot. My insurance wouldn't cover the name brand so she prescribed Venlafaxine at 75mg and I have been at that does for 1 year and 3 months. I will post updates here about my progress and look forward to reading about others too. I'm not sure how to do the signature with the dosage part but will try... 8/2019 - 75mg of Venlafaxine
  15. Hello everyone! I am 26 years old. I tapered off 150 mg XR a little to quickly. I was on it for about two years. I was off completely for about a month. But the anxiety kept getting worse. The pressure in the top of my chest and bottom of throat. It's hard to describe. Also it was hard for me to speak. I was extremely irritable and edgy! I felt dead and wanted to die. The withdrawal just made me feel this way. I took 25 mg IR yesterday. This morning I took 25 mg. This afternoon i will take the second dose of 25. How long do you guise separate your doses of IR? I am also going to do the 10% deduction of the current amount. I am doing the math, this is going to take a very long time! But that's ok, my fault for taking it. When i get this low is it best to make it into liquid form? I watched the video and I understand. in 4 weeks my next dose will be 22.5 mg.
  16. I was given amitriptyline for severe insomnia and fluoxetine for cognitive function 30 years ago, after 6 months bedridden with Epstein Barr/Chronic Fatigue. Both were very successful, and I was able to return to work and later retire. I stopped amitriptyline a few years ago, no longer needed. Kept taking fluoxetine, which may not have been needed anymore. Fluoxetine "pooped out" early this year and I became very apathetic and anhedonic. I was put on 75 mg Effexor mid-April, without any washout period for the fluoxetine - neither I nor, apparently, my doctor, knew any better. It was very good at mood and energy improvement, but I had fairly bad physical side effects, and asked for lower dose. 37.5 mg still caused bad side effects. Like a fool, I stopped cold turkey one month ago. I knew I should count beads and taper, but simply could not force myself to put one more mg of this stuff into my body. Now I am paying the piper, and paying a lot. I found this site a few weeks ago, and have been looking for others who have severe physical WD symptoms. I may be lucky in that I have no emotional or cognitive symptoms, or unlucky in that I seem to have all of the physical ones. First 3 days off, my feet and calves swelled up like water balloons, along with neck and shoulder pain 24/7, which is still ongoing, but better. Muscle spasms in thigh muscles that made me actually scream one night during first week off. Chest tightness (muscle spasm?) that almost sent me to the ER several times. Shortness of breath has not gotten better so far, and insomnia is very severe. I feel terrible in the morning and all day until around 5 PM, then I seem to have a surge of wakefulness that lasts until 1 or 2 AM. Fatigue will not let up. I can't reinstate Effexor, as the side effects while taking it were much the same as WD, only less severe.
  17. It has been years since I took medications, I was 16 when I took them in 2009, and went through a few different brands. I have copied some of my introduction story to make things easier for me. http://survivingantidepressants.org/index.php?/topic/5232-%E2%98%BC-hello-charliebrown-script-free/#entry67166 Starting with Fluoxetine 10mg for 1 month. Then Venlafaxine for 1 month at 75mg then, 3 months at 150mg. 1 month of Clonazepam 0.5mg as I was tapered off Venlafaxine and onto Sertraline 50mg. Then I took Sertraline 100mg for 4 months. Still experiencing panic attacks, agoraphobia and paranoia. I went to the hospital during a panic attack and was given Lorazepam 1mg for 1 week. This is when my psychiatrist added Risperidone on top of the Sertraline. Risperidone started at 0.25mg for 3 days, then 0.5mg for one week, raised to 1.0mg for one week. After two weeks I had a check-up I told the Dr. I wasn't feeling anything and I believe he may have misinterpreted that as "no effects" but when I said it I meant that I felt no emotions. My dose was raised to 1.5mg daily. After 3 days of 1.5mg I began experiencing Akathisia with no relief of anxiety. With no options in perceived sight I took all of the remaining Risperidone. Approx forty 0.5mg pills. My Parents caught me and called 911. At the hospital I was given charcoal and passed out, waking hours later. After being discharged I continued to take Sertraline as prescribed for 2 months. With no reduction in my anxiety and my emotions being basically non existant I decided to "take the good with the bad" and feel some kind of emotion. Over the next month and a half I slowly weaned myself off Sertraline. Popping open the capsule and throwing away 3-5 tiny XR beads a day. So that's my age, meds and taper strategy. How long it took to regain all my emotions and bodily functions is a hard one to answer. It took about 6 months before I felt much of anything. Then the bad emotions came back, sadness, anger. Slowly over the next two years I had many days that were blank and void of anything, days full of sadness, but also days where a light would shine and I would be happy. Feelings were coming back in waves and leaving again. I joined this website in late 2013 and at that point I had some emotional range, a libido but no sexual pleasure. So i guess it took about 3 years off medications to regain a good emotional range and my youthful lust. I'm finally writing this success story because in the past year the lack of sexual pleasure and anhedonia are not a problem for me anymore. The feelings slowly came back in waves, sometimes weak, but getting stronger and stronger. Now I feel great when I hug someone or see a friend smile. Sometimes the feelings can even be overwhelming. Like my heart is ready to burst. I don't know what else to add except, it's been almost 7 years since I took medications and I am a whole new person! Don't give up hope! Things are constantly changing, even if you don't notice. I didn't notice the change until it was right in my face!
  18. All of my symptoms in bolded, for ease of quick scanning for relevance by anyone interested. I have ended up on this website after lots and lots of google research to pin down the cause of my incessant symptoms of a low-grade migraine headache and constant nausea that I have been experiencing for 10 days straight now. My Migraine History: I have been getting migraines fairly regularly (about 2 or 3 each month) since middle school. but they are pretty mild, as migraines go. About 25% of the time, one will be preceded by an aura that is a lightening-shaped blind spot or blurry vision and then the headache will be very severe. And occasionally, one will be accompanied by severe nausea. But normally, my migraines are just quite painful headaches accompanied by heightened sensitivity to light, sounds, and smells. With ibuprofen and extra sleep, they are usually completely gone within 30 hours. During puberty and especially pregnancy, my migraines were more severe in all aspects: nausea, sensory sensitivity, and pain. My Venlafaxine Withdrawal/Discontinuation Symptoms: I did not connect these symptoms to the cessation of Venlafaxine until recently because 1. I did not know that physical symptoms could be related to the cessation of antidepressants. 2. The onset of symptoms did not occur until 5 days after my last half dose of Venlafaxine. 3. I was only on Venlafaxine for 27 days (including a half-dose for the last 7 days). I only made this correlation after several days of googling possible causes, and after including symptoms that I had previously dismissed as insignificant and inconsequential in my internet searches I started experiencing a persistent nausea that did not seem like food poisoning or stomach flu (no stomach cramping, etc.) 14 days ago. There were/are waves when the nausea is worse throughout the day, and a constant malaise otherwise. Unlike the stomach "flu" or food poisoning, there is/was no stomach cramping or urge to vomit. On the 4th day of no relief, I realized that it was just like the nausea I get that sometimes accompanies my migraines. I hadn't equated it with a migraine previously, because there was no headache. I started taking ibuprofen periodically, treating it as if it were a migraine. On about the 5th day, I could feel a headache "trying to set in", which is my usual precursor to an impending migraine (although historically the nausea, if it develops, does not come on until after the headache presents). Since then, I have had no improvement in symptoms. On about day 6, I started googling possible migraine prescriptions and was considering seeing my M.D. the following day, if there was no improvement. I also started googling the combination of all my other mild/querky symptoms to see what else it could possibly be, if not a migraine. These other sporadic symptoms had each seemed inconsequential as they had come and gone here and there, and were easily dismissed. But I was starting to realize they might be related. Muscle Weakness in my biceps that I had noticed when using a steering wheel or when filing through clothing racks while shopping. Crying and/or the feeling that I needed a good cry, without provocation, that felt very similar to PMS (although this was about 10 days after my last menses). Brain Fog in the middle of conversation. I will have to concentrate really hard to remember what the conversation is about, and what I was going to say next. I will forget what my husband told me just minutes ago. Word Recall Difficulty both while texting/typing (spelling) and in conversation (vocabulary). High Pulse Rate of 88pm, which was noted at the medical appointment that I had on the fourth day after my last dose of Venlafaxine, when I felt great. Chills Hot Flashes/Feeling Flushed Sinus Congestion which was present before, but is now much worse, especially at night. Nausea that feels like "Morning" Sickness when there is 0% that I am pregnant. Yes, 0%. At times, I can tell that I will feel better if I eat, and at other times I can tell that eating will make me feel worse. My best time of day is the first 3-4 hours after waking up. Shivers not related to body temperature this one I just experienced last night, and suspect (hope!) is more likely related to my inadverdently taking 2 different antihistamines (diphenhydramine and cetrizine) at the same time! Very pronounced and fast onset of "prune skin" on the soles of my feet, followed by Extreme itchiness on the soles of my feet Another really bizarre symptom that I think might have another cause. ??? I had sprayed the soles of my feet at bedtime with magnesium oil two nights in a row, as I have done in the past when experiencing a severe migraine. I did not bathe or shower until a third night. 5 minutes into my bath, my feet (and only my feet) were EXTREMELY pruny, as if I had been soaking for more than an hour! I have found nothing online indicating that this wierd fluke may be related to the magnesium oil, nor to antidepressant withdrawal/discontinuation. After the bath, my feet were excruciatingly itchy (just the skin, not the nerves) for at least 30 minutes! After much reading on this and other similar forums, I contacted my P.A. that has been assisting in my medication management for the last 3 months. I am going to reintroduce 5 beads of Venlfaxine tonight and see if it makes a difference by the time my afternoon appointment rolls around tomorrow. She is doubtful that any of these symptoms are related to the antidepressant, so I hope this works. I really hope that my experience, along with the litany of literature I will be leaving with her tomorrow, convinces her of this very real and very under-reported issue!
  19. Moderator note: link to uncomfortablynumb's Benzo Forum thread Hi Everyone, About 9 years ago I jumped on the psych med-i-go-round. It was my last year in university studying human kinetics - I was really stressed, not getting much sleep, not eating very well and consuming way too much caffeine. I pretty much crashed and burned with anxiety and depression over probably a 4 month period. It was possibly due to years of stress and not knowing exactly what I wanted to do after graduation (to continue studies or find work). I was rock bottom, not being able to focus on anything and the anxiety was so bad that I isolated myself. That is when I first saw my psych. I was prescribed Celexa and that did nothing. It was my first drug and I was desperate and only gave it probably 3-4 weeks. Then I was put on Effexor. It worked wonders in about 3 or 4 weeks at 75mg or 112mg. I was back to my old energetic self and focused. I came out of my shell and was socializing again. I finished my degree and decided to forgo post-grad and start up my own business as a fitness trainer. The next 3 years were going well as I was building up clientele. Outside of work I was involved in long term relationships. Effexor was working pretty consistently. When it lost effectiveness, I would up my dose and be fine pretty soon after. I forgot to mention I was taking a pre-workout supplement (NO-Xplode or another) while on Effexor (which is probably a no, no) to give me an extra energy boost. Perhaps the meds were losing their potency and I needed another boost because coffee was not helping. Effexor then started to poop out on me. I would relapse into depression/anxiety for longer periods and upping doses was useless (I believe I went up to 187.5mg). We then tried augmenting Abilify without success. Then I switched to Pristiq which also didn't work. Then it was onto Wellbutrin to no avail. I ended up reintroducing Effexor and it worked again with the break. Not as well, but I was functioning. I began abusing pre-workout supplements just to keep me my normal energetic, positive self. Again, Effexor pooped out after a couple years. Over the next few months, I tried Zoloft and nortriptyline and another med. At this point, I was sent to a specialist. He changed my diagnosis to bipolar II even though I exhibited signs of bipolarity until I was on medication. He suggested different cocktails with lithium or Latuda. I refused. I made the stupid decision with my original psych to try Effexor one more time. Surprisingly, another break from it and it worked again. Not as well, but still got me up and going. I stayed on it for a year and weaned off this April this year. I was fine med-free for a couple months, then anxiety/depression reared it ugly head in July. Another foolish mistake I made was to go back on the Effexor from mid-July until September. I had to keep increasing the dose until it was clear my "go-to" drug was no longer an option. I began weaning off rather quickly by decreasing 37.5mg each week. I went to half of 37.5mg, then nothing. I have been completely off Effexor for the last 10 days. This is one of the longest bouts of depression/anxiety for me. It has been 4months. I have had to stop working (as I usually do when I am in this state). My job requires energy, positivity, focus. It is also a social job and depression/anxiety kinda make that impossible. It really is depressing that I have had so many relapses that it screws up my career. I wonder if I didn't go on meds in the first place if I would have relapsed. I had to wean off the drug while severely depressed/anxious. I think this has made the experience worse. I am experiencing bad insomnia, and what I think might be depersonalization (my senses seem altered, hard to describe - dream-like). I am also feeling like my mind is blank. Usually I have a nice flow of thoughts and can start conversation but it seems impossible now. It is very uncomfortable and I have isolated myself from friends. I also cannot find pleasure in ANYTHING. My concentration and memory are not very sharp. When I have weaned off in the past I do not remember it being this extremely awful. I have a few questions: Can the brain recover and balance itself? Is there anything I can do to move things along faster? Or is it probably best to explore other medical options? Should I get extensive bloodwork or an MRI done? Sorry this was such a long intro. I applaud you for reading this because it is not the most exciting story.
  20. I feel devastated still - nearly 8 years after a brutally swift taper from Effexor. I did not know better then. Apparently nor did the doctor. Seven years at 150 mg of Effexor - then down to zero in about five days. Obviously my story is a lot longer than this and all kinds of hellzone has happened between then and now ... involving another drug I was forced on for many months because of the protracted withdrawal. (which these doctors do not believe in as you know) And I have only just learned that what is included in what I have been suffering for a while now, has a name - vulvodynia. (then there is the burning sensation throughout various parts of the rest of my body). I am so scared because life is over if this is all there is now. Surely there is some kind of wonderful holistic herbal miracle remedy to take or something - a solution for CNS damage. I am drug-free now and want to stay that way and wish I always had been. Unbelievably for all of those years I didn’t really know what I was really taking - I never gave informed consent. If I had the knowledge then I would never have given consent at all. Meanwhile I need to heal or there is no life left.
  21. I started Effexor (venflaxine) excuse my spelling 75mg and buspirone 7.5 mg on Wednesday last week. Friday night I had an adverse reaction. Skin burning, dizzy, tremors, rapid heart beat, dilated pupils, muscle stiffness, I’m sure there’s more I’m forgetting right now. I did not take the meds after Friday night. Now Thursday (4am) I’ve been having withdrawal symptoms. Tremors, anxiety, insomnia, no appetite. I see my pysch today at 130. I actually went to the hospital twice in the same day because I could not sleep, eat, or relax. I couldn’t go to work but I am going to try today. I was wondering if maybe Prozac or sertraline would help me ease these withdrawal symptoms or if anyone else has experienced this after on three days of being on meds!!!
  22. After very careful tapering off, I have just completed 3 weeks without any Venlafaxine which I had been taking since 2005 In 2005, I had weaned myself off Seroxat but allowed myself to be bullied by my spouse (a sufferer from endogenous depression controlled by medication) and, at that time, work colleagues, into taking another anti-depressant. Happily retired for over 10 years, my spouse's depression under control and a general feeling of being over-drugged, I decided in April, in the spring, with the days lengthening, after discussion with my GP, gently to wean myself off the pills. I was hoping to do it all without having to own up to my spouse but my symptoms post stopping are quite severe and I cannot dissemble. So, while not announcing it from the rooftops or posting it on Facebook, I am telling my friends and family what I am up to to explain occasionally disconcerting behaviour. Unfortunately, both husband and sister have suggested what I am doing is not necessary though most friends I have told are most supportive. So here I am, weepy, upset stomach, off my food, aggressive being told by my nearest and dearest I'm depressed. i found this website and decided to get it off my chest. I know I am in for the long haul but I'm determined I'm not going to be dissuaded this time. I need to know what the real me is like now. Just need a pat on the head I suppose
  23. Hello all, My name is Chris, a 24 year old student currently living in the Netherlands. I started taking 37,5 mg of Efexor about 2,5 years ago, after being addicted to weed for about 5 years (I live in the Netherlands). I was suffering from heavy anxiety, making it impossible to function properly at school. The Efexor put me back on track and made me feel good again, up to the point where, about 4 months ago, i felt so good i did not think i needed the Efexor anymore. I discussed with my doctor about going off the medicine, after which he suggested that i first started taking efexor every other day. Right around the same time I started taking efexor every other day, me and my ex girlfriend were getting back together to give it another go. She said she supported me all the way on this, i felt good about it and after taking it every other day for about a month, i quit the efexor entirely. That's were it started to go wrong. due to the light withdrawal symptoms i was getting i was not able to give my (now ex girlfriend again) enough attention as i used to before (she really, really needs a lot of attention) and we had quite a couple of fights, resulting in her leaving me. But still, all in all, I felt like i could pull through and beat this thing on my own. Then, after about 2,5 months being entirely off the efexor I suddenly started feeling down again, did not have any will or energy at all to perform whatever tasks i needed to do.. the withdrawal symptoms had suddenly hit me with all its power. I went back to my doctor, and started taking methylphenidate to help me remain calm, as I also have been diagnosed with ADHD. This has helped a little, but i still don't feel anywhere near how i felt 6 months ago, when i was a social, fun guy with high confidence. Right now i'm having some relatively good days where i just get through my day without feeling large amounts of anxiety, but thats about it. My breathing is almost always way too heavy (im diagnosed with chronic hyperventilation) since quitting the antidepressants, i have bags under my eyes on a daily basis and sometimes i have chest pains. I dont even exactly know why i came here, or what my goal is by posting this, but it would just be nice to talk to people that understand what i'm going through right now. I sometimes think about just going back to the Efexor and start living the good life again, but wouldn't that be the easy way out?
  24. Ok My name's Adam. I'm 48. I suffer with A&D. I was on 40mg Citalopram for about 8 years. My psychiatrist moved me on to Effexor about 10 weeks ago. The drug hasn't agreed with me, and I'm n the process of tapering off. I was initially on 75mg immediate release (sold tablet), and was taking one a day (people have said this should have been a split dose. Anyway, that's in the past. My tapering history is that I've been taking 3/4 of a tablet - about 58 mg for the last 4 weeks. I think my depression has worsened over last 2 weeks, BUT that may be attributable to life's circumstances.(divorce). My questions are: 1. Am I withdrawing from Effexor, or perhaps SSRI's in general? i.e. Is this really a Citalopram withdrawal considering I've only been on Effexor for a very short time. 2. How slowly should I taper off Effexor, and in what increments? 3. Do I need to split my dose and take twice a day? At present I'm taking the 58mg in one dose Answers to the above and any other advice appreciated. Thanks Adam
  25. Have been off venlafaxine since November 2017 ( after 16 years) ; went on trazodone and Reboxetine until Nov 2018 and have been drug free since. However really struggling recently despite taking omega 3 / CBD / exercises etc. Problems include fatigue, very low mood, anxiety, no interest in what’s happening around me, can be upset by the most minor event etc. Tempted to try some other drug that may help as I am finding it really hard. How long do the withdrawal effects last and is there hope in persevering?
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