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After 25 years on more than 20 different drugs to treat major depressive disorder, I have decided enough is enough. I've had 15 rounds of ECT, with no improvement. As a 'last resort' , my psychiatrist put me on Riluzole, which is used mainly to treat ALS. A side effect is lessening of depression. Apparently it works on the glutamate system in the brain, and not the typical neurotransmitters. I feel I have had some success with this medication. I no longer live in a deep, dark pit of despair. I do need to mention that over the last year (while being on Riluzole), I have expanded my spiritu