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  1. Hi, I'm a Spanish member who developed neuropathic pain in both legs during 2 months of successive trials with 3 ADs (2 weeks desvenlafaxine, 2 weeks amitriptyline, 4 weeks imipramine), during last December and January mostly. The pain subsided mildly but not totally after stopping them and now the pain is usually a 6 and a 7.5 during waves, I really don't have actual windows. I do take mirtazapine 15 mg and tolerate it well since 2 years ago, when it was prescribed to deal with very severe IBS pain. But the combination with the aforementioned ADs shattered my nervous system, my IBS pain (which was a 5) disappeared and was replaced by this torture in my legs. It's now 4 months off the ADs that destroyed me, I am desperate for other people's experiences since I don't think I'm any better after all this time... PS: I have an extreme food intolerance with the IBS, I've been practically disabled for the last 3 years (30 now) and unable to eat anything appart from white meat, white fish and rice. Recent electromiogram is negative for neuropathy, lumbar RM shows Schmorl's hernia with edema in L5, but Drs don't think that's the cause of the burning pains. This is my history with meds: I began with extreme IBS pain, and my first year tried all kinds of natural approaches and diets. I ended up eating 3-4 things and still with crippling pain. Then... Dec 2018 to Sep 2019: Mirtazapine 15 (pain reduced from 7-8 to a 5) Sep 2019 to Oct 2019: Mirtazapine 15 + Olanzapine 2.5 Nov 2019 (2 weeks): Mirtazapine 15 + Duloxetine 30 (gave me extreme nausea after 12 days, but it was working for the pain) Dec 2019 (2 weeks): Mirtazapine 15 + Desvenlafaxine 50 (5/10 IBS pain disappears and 7/10 neuropathic pain appears in both legs) Dec 2019 to January 2020 (2 weeks): Mirtazapine 15 + Amitriptyline 20 (burning gets worse) January 2020 to Feb 2020 (4 weeks): Mirtazapine 15 + Imipramine 25 (burning gets much worse, I'm ready to quit after 2 weeks, but Dr claims the pain will subside if I keep taking it, after 4 weeks the pain is brutal, I stop imipramine on the 10th of Feb and keep just the mirtazapine, pain gets a bit better) March 2020 to April 2020 (1 month): I stop mirtazapine to see if it's causing the burning pain, with inconclusive findings. After a month WD kicks in, can't sleep and the pain is way worse, I reintroduce and symptoms calm down after 3-4 weeks. I still take the mirtazapine 15 and haven't done more changes.
  2. Roxyrich

    Reinstatement worries

    I know this is going to be controversial, but has anyone heard of anyone reinstating an ssri after an adverse reaction. You might just dismiss this and say no its impossible, once damaged by an ssri in the form of an adverse reaction, there's no going back. This is where it gets controversial. Let's say your about to end it all , is it just game over ,or one would say , surely it's worth a try, in the ultimate form of life or death.
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