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Hi. This is my first post. I have been on imipramine for 6 years (clomipramine before that for 22) and am also on aripiprazole. Am reducing imipramine atm and have over 2 months come down to 100mg from 150mg. Tonight have had a glass of wine and am wondering if should avoid a second as had slight palpitations earlier after drinking it. Is this normal when reducing off imipramine? Is it safe to have another glass of wine? Thanks.

Ok so 10 weeks ago i halved my dose of citalopram from 20mg (which i was taking for 1 year) to 10mg after a fast taper for about 4 weeks alternating doses each day from 20mg to 10mg. Which after reading the info on here i now know was a bad idea. At first i felt a bit off but nothing too serious for about 6 weeks. Since then I've gradually felt worse. Syptoms are headache, fatigue, tired, anxiety, irritable, depressed and feeling a bit better for say an hour then feeling like crap again! I have been through a stressful time in my personal life lately and wondoring if it could be that. Im wondering if i should reinstate to my previous dose or hold on 10mg. Any advice would be appreciated. Thanks

MOD NOTE: Ihateeffexor created a membership and another person helped her to type the first couple of posts. Ihateeffexor is now able to post for herself. ________________________________________________________________________________________ Hello, I am actually writing on behalf of my friend who is in a very bad shape right now. She was on effexor for 1,5 years and tapered for 3 months 45 mg to 0. She had really bad withdrawal symtoms for 2 months after the last pill but then started to feel better. A couple of weeks ago she had some alcohol and partying with friends and ever since her symtoms has come back and they are much worse now. She was ok for 3 months but the alcohol seems to have made the symtoms come back, the day after she was drunk. Is this what you call kindling? And is there a chance she will recovrr from this? She is bedridden atm. Thank you all!

Hello, It's been 3.5 months since I stopped taking lexapro. I still can't get an alcohol buzz. I don't experience any euphoria just the dizziness. Has any else experienced this? Did you regain the ability to feel a buzz? This seems so unnatural. I wonder what is happening in the brain. Thanks.

Hi, I realise this is a peer support network but I am the mum of a young adult daughter who has had a severe reaction to Sertraline. She is currently detained against her will in a psychiatric hospital and our need for help and advice on her behalf is immediate as I am fearful about the effect of compulsory treatment while she is there. I'll attempt to draw out the relevant parts of the chaotic and traumatic last 3 months.She was prescribed 50mg Sertraline for anxiety at the beginning of February by a general practioner. After 2 weeks she returned feeling unwell this was upped to 100mg, then shortly afterwards to 150mg. On even the lowest dose she immediately experienced extreme night sweats, restlessness and difficulty sleeping. She also became withdrawn from loved ones, snappy and cold. She looked drugged. She started self-medicating with excessive alcohol and cannabis and developed hypomania. After 6 weeks, during which she left her home and long-term partner, she called the police for help and was detained in the local psychiatric hospital. They put her through cold turkey on all substances. After a week they started her on 75mg Quetiapine per day plus Lorazepam and Zopliclone as they felt her state of mind required. After 3 weeks she was released with multiple boxes of all 3 drugs. She was still remote from us. After a week of clean-living with us (parents and sister) during which she began to taper the Quetiapine and didn't take the other medication, she left home claiming she needed to recover in her own way and resumed alcohol and cannabis misuse. Two weeks later she is detained in the psychiatric hospital again, very withdrawn and with signs of delusional beliefs. On admittance she tested positive for Cannabis and Lorazepam. They have resumed 75mg Quetiapine and, after a spell of disruptive behaviour, Lorazepam. She is currently in isolation with a permanent staff member having become violent and is not engaging with anyone. Her father and I have not succeeded in convincing the hospital doctors that the Sertraline prescription lay at the root of all this. We have repeatedlyreasserted the precise timing of the onset of her problems and have referred them to this site, to The British Journal of Psychiatry <http://bjp.rcpsych.org/content/195/3/211>and to Katinka Blackford Newman's "The Pill That Steals Lives". One consultant is convinced that cannabis is entirely to blame despite being told that she has used it (and alcohol) previously without the ill effects.The chief consultant is looking for signs of underlying mental illness as the root cause of her problems. If anyone has ideas ideas on persuading clinicians I would be grateful. The main questions I have at the moment are: Given that she has shown extreme sensitivity to SSRIs, how dangerous for her are the Quetiapine and Lorazepam she is currently being given? It's likely that she will be started on another antipsychotic but neither she nor I will be consulted about this beforehand, so the question really extends to psychotropic drugs in general. Is it possible to tease out the effect of the Sertraline from the effects of the subsequent cannabis and alcohol use? How likely or possible is it that she had a latent, unsymptomatic mental illness that was triggered by the SSRI? Thank you for any advice. QueenieRose

Hi Everyone, Here's my story... I was diagnosed with depression shortly after the birth of my 4th child 13 years ago. I tried talk therapy for a year or so as I did not want to be put on medication. Eventually, though, I was still low enough emotionally that I consented to see a psychiatrist. Of course, I was put on medication - Cymbalta, I believe 60 mg. I now know that seeing a psychiatrist = prescription. Full stop. Wish I had stayed with my original instinct and stayed away from the psychiatrist/medicine. Anyway, the Cymbalta seemed to help me at first and my mood lifted. (Side note - many people in my life have no idea that I suffer from depression. I am high functioning and seem to always "soldier on" no matter how bad I am feeling internally. Self-contempt is probably my dominant struggle and it is not uncommon for me to wish I could end my own life, though I have never attempted to do so.) A year or so later, I was at a low point again and discovered that a family member had success with Wellbutrin, so we decided to add it. I started at 150 mg. I cannot recall my initial thoughts or perceptions about whether it helped. After 3 years of talk therapy (plus 2 years of meds), I had a period of stability and felt ready to discontinue talking with my counselor. I was up and down emotionally after that, but did not return to the counselor. I found yoga in that season which taught me about meditation and the breath and found some relief there. At one point, I had felt well for a season and told my dr that I wanted to get off Cymbalta. He advised me according to the package instructions to quickly bump down, alternating days and then stop within a week. Big mistake! The blackness of my depression returned with a vengeance. I went back to 60 mg of Cymbalta immediately. About 4 years ago, I learned about the MTHFR gene mutation and how taking methyfolate could help with depression. My doctor agreed to put me on Deplin 15 mg. I later did a 23andme genetic test and found that I did not have the mutation and discontinued the Deplin. I had an additional season of feeling well and talked to my dr again about getting off Cymbalta. This time, we used a compounding pharmacy to make capsule doses so that I could bump down more gradually. I went from 60 mg to 45 mg to 30 mg to 15 mg without incident. I don't remember exactly how long I stayed at each dose, but it was roughly from June - August that we attempted this taper. However, once I got to 15 mg, all my depression symptoms returned. This year, I have experienced another very low season beginning in June. I've been experiencing insomnia and lethargy as well as a loss of interest in social activities. About 6 weeks ago, my doctor suggested I up my dosage of Cymbalta to 90 mg. Although I did not really want to do so, I agreed since I was so miserable. I still feel miserable and don't see any real improvement. Throughout the past 13 years, I have attempted to change my diet and exercise significantly, moving toward less processed foods, lifting weights for a season, eliminating sugar (except for alcohol - see below) and yoga. It's interesting, though, that I have felt at times like maybe I have an eating disorder when I haven't been able to stick with the changes I want to make and have used food for emotional comfort. I will also add that in these years, after being a teetotaler until my 30's, my alcohol use has increased significantly. When I first found that I enjoyed the occasional drink (probably 12 years ago), I would have a glass of wine or a margarita with my husband or with friends when out to dinner. Little by little in the past 2 years, I have started to wonder what is wrong with me - it's as if I have no off switch. If I have one glass of wine, I am more likely than not to finish the whole bottle. This summer, I have experienced loss of memory after an evening of finishing a bottle of wine. I've started to wonder whether I'm an alcoholic. Then I googled Cymbalta and alcohol and found a lot of anecdotes about others experiencing similar problems with having no off switch! Astounding! I don't want to put all the blame on Cymbalta, but I have to realize that at the least, it's working against me. I wonder if my food issues are similarly driven. In short, I am more convinced that ever that I want to get off Cymbalta. I think I need to find a functional medicine doc who can help me with this. I welcome anyone's input or feedback. I've been reading this site and others and have seen the tapering recommendations. Is there any hope for me in being successful getting off Cymbalta?

I started Paxil in 2009 due to severe panic attacks which caused me to drop out of college twice. I was wary of medication and pushed it off as long as I could, but I was really at my wits end and relented. For about the first month & a half to two months on Paxil I felt very good, almost euphoric. Slowly after those initial months, as I look back on it now, Paxil started to eat away at the core of me. Access to true emotions started to get harder and harder, sleep was less deeper dreamless even, sexual desire slowly became little to none, my mind became hazy and foggy. My mind was in such a haze that I completely forgot what it was like to be normal, to have complete clear cognitive function. I was not even aware of the entire affect Paxil was having on me. I started to taper off in the summer of 2011. Insomnia was the biggest reason. I had an inkling Paxil could be the cause and was willing to try anything to sleep again. I suffered excruciating withdrawals, brain zaps, IBS like my insides were being turned inside out, headaches like none other, and nausea. This lasted for about a month & a half then the withdrawals started to lessen. I know I should have consulted w my psych about wanting to get off Paxil. But he himself I'm pretty sure was taking the same meds he was prescribing. He was absolutely flat emotionally and I got the feeling he literally lacked the emotional capacity to care. I hope you can understand why I was reticent. After a yr off of Paxil I was still having the same side effects I had while on the drug. I had no idea it could still effect me. I was looking at any alternatives, was it my diet, was it emotional trauma (my parents got divorced in 2010) just anything other than Paxil, I mean I got off them right? There is no way they can STILL be affecting me?. Finally in 2013, the summer after my graduation I did a little research, maybe Paxil could still affect me? I found Paxil progress and a couple other sites that answered that question in the affirmative. So here I am today in 2015 feeling a lot better than I once did a few yrs ago. I still get side effects from time to time burping, bad gas, IBS, nasal drip, haze and some others. My counselor still thinks I need meds and won't believe paxil was the cause of my depression. It feels good to share this w ppl who understand.

So, I've often seen people write of having things cause them problems. They'll say something was too activating, or caused withdrawal symptoms. Yesterday afternoon I began having numbness of my face, a headache, and a slight swimmy-head feeling. I hadn't made any real cuts, other than shaving 0.375 mg off my venlafaxine (from 74 to 73 mg gross weight) the week before, and I didn't think there was any way that could be the problem. I can say that over my 20 years on these meds that I have been rather obtuse in making connections about things. For instance, I just remembered I was on Prozac when I drove off with the gas nozzle still in my car! I never thought the weird, disconnected feeling I was having that day might have had to do with Prozac! I've been quite the victim of what Peter Breggin refers to as "spellbinding." Anyway, it finally dawned on me today that I had eaten a bunch of Life Saver gummy candies as I was driving around yesterday. I'm still prone to my sweet tooth and I KNOW that stuff is junk and not worth eating, but.... I usually have chocolate after dinner but haven't noticed any connection with feeling weird on that one, nor the coffee I have in the mornings. So, I'm thinking it was the sugar. When you have made the connection between a substance and a bad reaction, what was the substance, what was the reaction and how did you make the connection? SG

Hello, everyone. I'm new here, but was a long-time reader over at Paxil Progress before it shut down. I actually thought a couple weeks ago how far I'd come and thought, "I should post a success story!" because I hadn't felt PAWS symptoms in an entire year by that point. Well. Today and yesterday, I've hit a rough spot. Let me start with that necessary evil, backstory. In late 2011 I was prescribed Abilify for the off-label treatment of trichotillomania, or compulsive hair-pulling. I did not have depression, anxiety, or any psychiatric disorder; my doctor prescribed this solely for the pulling. When I decided it wasn't working, my doctor told me I could just stop. No taper - cold-turkey. So I did. A week after stopping, I experienced the scariest few days of my life. I was sobbing on the floor of my dorm bathroom, having panic attacks in the middle of class - when I managed to make it to class, that is - and felt eerily detached from myself, like I was living a dream and going through the motions, but couldn't feel anything...and yet was constantly about to fall to pieces in a hysterical mass of tears and panic. Then, about four days later, it ended. Boom, just like that - I was at work one evening, and suddenly felt like myself again. I had no idea that this was my brain's first reaction to quitting the Abilify, and that many more were to come. I experienced this again, in varying intensity (but always very intense and life-disrupting) several times over the next months. When I became pregnant with my first child, I felt myself "stick at a baseline" below my normal, as though my brain delayed healing because it knew I needed to focus on the pregnancy more. But I wasn't normal, or myself, or happy. I was ...some other person entirely, the whole 9 months. Then, as soon as I gave birth, the PAWS returned with a vengeance. A year later, I began a regimen of Amino Fuel, l-glutamine, and magnesium. I immediately saw marked improvement: my windows became longer, and I felt more and more like myself during them; the waves grew shorter and less intense. By 2014, I had two or three days of feeling bummed out every 7 weeks or so, and felt like me most of the time now, even in my waves. My improvements were so good that by summer of that year, I could even feel safe drinking coffee again, enjoying wine, etc., which I hadn't been able to do without triggering waves until then. In spring 2015, I became pregnant again. I had a couple days of feeling bummed out as my hormones leveled out, but no PAWS symptoms for the entire pregnancy. I felt like me. I was happy, ecstatic even, to have another child (whereas the first time, I was so depressed it tainted the entire experience). Upon giving birth, I did have a few days of severe baby blues, including a panic attack - I think it was the combination of epidural drugs and hormonal crash with perhaps a still slightly sensitive nervous system? I had my placenta encapsulated, so I took that and magnesium for a few weeks; within four days, I felt 99% better, then back to myself a week or so postpartum. Two nights ago, I chainsmoked a ton of cigarettes (and I haven't smoked cigarettes in over a year, just vaping low nicotine on an ecig) and drank a good amount of hard liquor (which I also haven't done in over a year). The next morning, I woke up feeling like my early days of PAWS: pounding heart, sweat, too much adrenaline/panic, the world is falling apart, etc. I calmed down after thirty minutes or less, but since then I've felt like I'm in a wave again - bummed out, random crying, lack of appetite, and more than anything this...relentless panic that I've done damage to my brain again, ruined my progress...or - the BIG worry, and hopefully the most ridiculous? Please weigh in - that I was never better at all. That because of my 2nd pregnancy, I just delayed symptoms and now my PAWS is back to stay. I realize logically that doesn't make much sense, because I have gotten immensely better over the years, hence this pregnancy was so much better than my first. Anyway. I realize *technically* I haven't been symptom-free for a year, since I had a panic attack (or perhaps a combo of a wave and postpartum crash or baby blues) this past February. But still, that didn't feel much like a wave the way this does. And it's been a while since I've had one like this - since 2014, most of my waves were "morning-only" where for a couple days I'd have symptoms in the morning, and they'd end very suddenly by noon. This one's been going on all day for the last two days, ever since the cigarettes and hard liquor I had at a wedding. I'm sorry for such a long post. My brain is going a mile a minute with worry. I guess I want reassurance that I won't be this way forever...that my progress isn't all gone because of one stupid night of excess (which I definitely will not be repeating). Also, just looking for opinions on how long my recovery's been - 4 and half years. That's a long time, especially since I only took Abilify three months. Is it possible it's taking so long because of my pregnancies, during which no waves or windows occurred (so I'm guessing, no healing for 18 months total during these last few years)? Thank you for your help. I just hate feeling this way again after SO LONG feeling like myself, no symptoms, and would love reassurance. Taylor

Hi I'm Lauren, I'm 24, and have been on and off meds since I was 18. I was put on 5mg of lexapro at 18, with strattera 70mg for ADD. I was on both for about 2 years, strattera did nothing for me. And I tapered off lexapro slowly after two years with no problems except brain zaps for a few weeks. Depression never came back. I had a baby when I was 21, and came down with post partum depression and was put on Wellbutrin for 2 months. It made me feel crazy, very up and down and much more depressed so I tapered off quite fast, and was fine afterwards. Suffered no real withdrawal. I was then put on adderall xr 10mg twice a day for ADD the end of 2012, it helped my anxiety and my focus immensely, but I then became allergic and stopped December 2013; I was then started on concerta 30mg for about a week, but it made me feel like a zombie, and also became allergic..so my doctor switched me to Vyvanse 30mg, and after 2 months, I am now on vyvanse 50mg and lexapro 10mg. In January this year, I was put back on escitalopram (lexapro) , due to depression and anxiety returning from home issues. I was then upped to 10mg lexapro (actually escitalopram) and began feeling better... Than I felt nothing after about 2 months, and two weeks ago decided I didnt want to be on antidepressants anymore, and started (by myself) alternating my dosages. Huge mistake. I did 5 mg one day, 10mg the next, then 5mg... For only about 5 days. I began to feel VERY depressed and teary and spoke to a friend who uses this site and she told me alternating was very wrong. So deep in depression last week (Wednesday) I drank beer and liquor. Ended up getting too drunk and blacking out very quickly. Quicker than usual. I became erratic, and bumped my head a few times and woke up with a bruise on my head.... Since then, Ive been back on 10mg every day. But have been having headaches since Wednesday, dizziness, listless, depressed, No energy or motivation, and not feeling like myself... Not wanting to converse, I feel out of it, unable to smile.. But this alternates. Two days ago I felt like myself again, and then this comes back. I feel as if Ive been hungover for a week. I am also still on vyvanse, and some days since then, my add meds work and sometimes dont. Today I took my meds like normal, and my vyvanse felt stronger than usual... I just want to feel like myself again. I dont know if this is from drinking with my meds, bumping my head or alternating my dosages for 5 days. Please help. I was fine when it was just me and the vyvanse.