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  1. Hi all, first post here. I'm an amitriptyline taker originally for tension headache at 50 mg. I quit cold turkey after 9 months without knowledge of withdrawal, went back on for 9 months to re-balance. I've been reducing by 5 mg per month for 1 year until I got down to 15 mg. I'm now reducing by 1 mg monthly as withdrawals since getting down to 15 mg have had a bigger impact on my mental health. I've been reading about the possible methods of withdrawal and am wondering if anyone has had more success from a simple taper, reduced potency or half-life approach? More information here: https://www.mentalhealthexcellence.org/wp-content/uploads/2013/08/RxISK-Guide-to-Stopping-Antidepressants.pdf Any input welcome! Thank you.
  2. Hi, I'm new here I'm a 32-year-old woman from Denmark. I found you because I want to safely taper off of my low-dose Amitriptyline 10 mg. But as I read about withdrawal, I came across "post-acute withdrawal syndrome" or "protracted withdrawal" and I got chills because suddenly what has been happening since 2017 made sense! Long story short(er), I was on Venlafaxine/Effexor for 8 years because of generalized anxiety and body pains. In 2017 I tapered off from 2 capsules/150 mg, reducing with 1/4 pill every 2 weeks, so I was off them after a little under 4 months. (I didn't know about safely tapering off, only now have I come across your guide :)). By going off so "slowly" - well, compared to my doctor who told me I could do it cold turkey(!) - I didn't get the extreme side effects i would normally get when I would go up or down in dose. I felt the same when I stopped my dose and for the next 2 months, I was completely fine. But 2 months after I had taken my last dose, I started getting pain in my body, and after 2 more months, at the end of January 2018, from one day to the next I started having an extreme inner shaking/hightened fight-flight-response. It was like I had gotten a shock and I just stayed in that state every second of every day. Never being able to rest was so bad that I wanted to kill myself. It's so difficult to explain the sensation to anyone, so I usually use sleep deprivation as a related example: Sleep deprivation should be the worst form of torture and I get it now - stressing your body every second of every day is completely unbearable and you just want to die. I did sleep, though, but only 4-5 hours every night and I was never tired. My cortisol levels were high so I was checked for Cushing's (cortisol producing tumor) which meant I couldn't take any medicine to help me for 7 months because I needed accurate cortisol results (I didn't have any tumor, though). And also, nothing helped me, not benzodiazepines, sleeping pills, CBD oil or high doses of beta-blockers. After 7 months, my friend who had experienced the same "shaking" after a whiplash and after only a week had wanted to jump out the window from her apartment on the 3rd floor, recommended a low dose of Amitriptyline and that reduced the shaking by 30 % and after a month by 50 % (I only took 5 mg to begin with, though, and it worked after just a few hours, very weird). My symptoms then started to become predominantly psychological instead, like I would cry all the time. It opened up a deep developmental trauma wound that I started therapy for in December 2018. After that and body therapy like The Rosen Method, my symptoms are gradually decreasing. (I also have like 20 other symptoms, like body pain, fatigue etc.). Now, almost 2 years after I came off venlafaxin, I'm 50 % better than I was in December 2018, but my sympathetic nervous system is still firing too much. I thought that being on antidepressants for so many years, from I was 22 until I was 30 had made me so numb that I couldn't process all the stuff I had been through earlier in my life - and I still think that's partly the case - but now I see that there's an entire half of the picture I didn't know about!! That this must have been post-acute withdrawal syndrome!! So not only did I have all the past trauma that came up now that I didn't have something to artificially shut it down, at the same time my brain was also struggling with getting chemically back in balance! Woooow... #MindBlown! I don't even know what I feel... I feel so angry and want to sue someone, but that's not really possible I guess. I have missed work for almost 2 years, I'm only now starting a 10-hour internship. I can't believe you can go from feeling fine to 4 months AFTER you stopped the medicine get these extreme reactions. Has anyone else experienced something like that? And I still want to come off of the Amitriptyline, but slowly. It's only 10 mg, and this week I'm taking 9 mg. After I've done this for 2 days, I do feel some side effects like a bit of insomnia and hightened fight-flight, but it's minor. And might be because I made an oral solution from my tablets and now I read you should try to stay on your dose for 4 days before you reduce it. I did calculations based on the advice of the 10 % reductions of the new dose every month, and if I jump off at 0,1 mg, it will take me 43 months. It seems like a long time, but I would rather do this safely this time! Wow, I'm still in shock that it was protracted withdrawal symptoms that almost had me commit suicide, because no doctor could tell me what I was experiencing. I'm so glad I found you! And I also want to ask you if anyone has ever gotten completely over this syndrome, can your brain adjust completely? TIA
  3. Hello everyone. I am new to this site and I am looking for advice and guidance through this journey. I have been taking 25mg of amitriptyline for a couple years now and would really like to stop as I seem to have some side effects from it. Recently I have been doing research and learned that this drug is really bad. At first when I started taking it, it seemed like a lifesaver. I had it prescribed for stomach/intestinal issues I was having. It helped greatly. But as time went on things changed. I get severe dry mouth, sometimes racing heartbeat, and severe dry/peeling skin. Any advice for me would be greatly appreciated.
  4. Beachpea

    Beachpea: Amitriptyline tapering

    Can amitriptyline be tapered with the water method? I asked in my introduction two days ago and have not received a response. Are there directions anywhere on how to find information on this website? I honestly find this site very confusing. I use a computer. I would appreciate any tips. Searching for amitriptyline has not divulged any concrete information on tapering off this drug.
  5. About 5 years ago I took a lot of antibiotics for what turned out to be a jaw infection. This resulted in continuing gut problems, (gastritis, esophagitis) and also a condition called burning mouth syndrome. During this time repeated use of acid-reducing drugs (PPI's) started giving me side effects, particularly insomnia and anxiety, and I wound up being given psych drugs (all at low doses) as well. During 2017 I got better, with mixed results on weaning: - February 2017: My first attempt to go from .25 mg daily clonazepam to .125 mg clonazepam resulted in almost immediate withdrawal symptoms, such as insomnia, anxiety, extreme nausea. I went back up to the original dose and the symptoms quickly disappeared - September 2017: Stopped taking 10 mg. Celexa cold turkey, with no withdrawal issues. - October 2017 through December 2017; under the direction of a psychiatrist, reduced from .25 mg to .125 mg with minimal side effects, using alternating doses according to a schedule developed by Cara Tannenbaum. Very minimal nausea, worked quite well. December 2017: Happened to skip a dose of amitriptyline and realized how refreshed and energetic I felt the next day. Decided to take it every other day for two weeks, then stop. Felt great - my dry mouth (a side effect of the drug) disappeared, and so did my burning mouth! I was over the moon. Then at about week three I started having stomach pain, and was waking up with acid in my throat; I was even burping up acid. I had a vitreous detachment in my right eye. There were two solid days where my body shook and I had constant diarrhea. I felt manic. PPI's helped with the acid, but again I developed insomnia and anxiety, and more stomach pain. The psychiatrist suggested Benadryl, which did not help much. It seemed like everything I tried caused stomach distress. I had to resume taking 10 mg. of the amitriptyline , and also eventually went back up to .25 clonazepam to help with anxiety. These are the only drugs I currently take. Since then I have not regained my health. I lost 20 lbs. those first couple of months, and am considered anorexic. I eat six small meals a day, trying to gain weight but without success. During an endoscopy in May 2018 my GI doc at the time suspected gastroparesis, since he did not observe any stomach peristalsis during the procedure. Since I was already following eating guidelines for gastroparesis, I decided not to be tested since I would probably not want to take any drugs for it. With resumption of the amitriptyline, dry, burning mouth came back in a much more severe form - it flares all the time. Could I have become hypersensitive to this drug? I now routinely have swelling in my throat, mouth, and belly. I have also been recently diagnosed with SIBO - small intestine bacterial overgrowth, and IBS. A nutritionist I am now seeing suspects I may have histamine intolerance, which the amitriptyline probably makes worse. I have a very accurate (to 0.1 mg) analytical scale and can shave the amitriptyline pills down. In March 2019 I went down from 10 to 9 mg., and had manageable nausea. I held at 9 mg for six weeks. When I went down to 8 mg. the nausea and and mouth pain were intense - but this particular time I alternated between 9 and 8 for a week, which I didn't do with the first taper. Maybe that was a mistake. At this point, the doctors look at me like I am totally out of my mind - how can such small doses have such big effects? I feel the amitriptyline is hurting my body, and making my gut dysfunctional (it slows motility, for example, which is bad for both gastroparesis and SIBO). So I need to get off of it, but this last taper scared the heck out of me. Words of advice and/or encouragement are appreciated! Thanks in advance ...
  6. I've successfully tapered off other medications in the past, but am really struggling with this one. I was on 25 mg Amitriptyline since 2015. Last year, I tried tapering off and ended up back on, but gratefully, only at 12.5. I was originally put on this to help with IBS-C pain and found it helped my migraines as well. I'm 64 and am seeing cognitive issues and complete constipation, both of which are well-documented as side effects and why seniors should not be on this drug. So I really want to see how I do off it. Last week, I went down to 10 mg (I have those pills as well). But I'm really feeling withdrawal effects. The problem is that I'm not sure Amitriptyline HCL is stable in water. Here's what I read: http://www.pharminfotech.co.nz/manual/Formulation/mixtures/amitriptyline.html Indeed, as the article states, the liquid was really bitter and had a weird localized effect when I tried to taper this way last year. And I can't cut the pills down to make small enough doses because the pill is already tiny. The best I can do is cut the 10 mg into four (2.5 mg), but from what I'm reading, that is too big of a jump. My doctor is useless about these things. He says the drug can't cause these problems because of the low dose and that I can just stop taking it at this point because the dose is so low I won't have withdrawal. I'd appreciate any suggestions on what I can do to taper under these circumstances. Thanks, Susan
  7. We are in Columbus, Ohio and my son's pediatrician doesn't have experience with these brain altering medicines and just seems to know dosages. we are going through a very rough time and have to make a decision about stopping Ami and go through horrible withdrawal symptoms (which he gets as we have tried reducing it just by 10 mg) So i need your advice whatever you can give, please. I don't want to go to another inexperienced doctor. Anyway let me tell you all the details and I am sorry its long one so that you have a whole scenario. it started in a wrong way. The GI doctor couldn't figure out anything and then we had a new pediatrician who immediately diagnosed him with CVS. I wa impressed and did what she asked me to do as my son was third day into his cycle and his high school had started (freshman). She prescribed Ami 50 mg. By the time we got time to read more about it, which my husband and me always do with any new medicine, we already had given one dose to my son. We realized it was a heavy dose to start with but first time we didn't read about a medicine and probably made the biggest mistake. Anyway we still didn't read the white papers etc to know that dosage shouldn't be changed drastically. Next day my son was like a zombie and extremely irritable. So we reduced the dose into half. He was completely recovered from puke cycle the first day itself and after reducing the dose to half he was doing great in every way. We though we found a wonder drug. We confirmed with pediatrician about reducing dosage and she was happy we did! Our happiness lasted only 5 days. 6th day after passing stools (as the cycle always start) he started throwing up a bit and then lot of dry heaving with uncomfortable tummy. Those are his symptoms of CVS every cycle. So we thought its his cycle. It was a weekend so we waited until Monday and called the doctor. Like any other doctor who just know various emergency medicine names, she prescribed imitrex etc. Nothing was helping and by Friday we thought Ami at least is not working, lets stop it. Then I had an idea that 50mg worked,so lets try giving it. And it worked like a charm. Anyway after 2 days again, due to side effects, to make him go to school, we reduced the dose to 40 mg this time. Unfortunately the cycle started again in 5 days, weekend again. We tried giving 50 mg Ami that night and again it worked like a charm. But again we reduced to 40 mg on Monday, due to drowsiness and hadn't still realized that all the cycles since 2 weeks were withdrawal effects of reducing the dosage. This time on 2 days of 40 mg, my son started having urine retention and we reduced the dosage to 30 mg. Somehow while thinking about it that night I realized that previous 2 episodes must be withdrawal effects as I remembered reading people could not stop it. i woke up at night and started reading and was assured they were withdrawal effects. And as expected the next day while he was on 30 mg, the withdrawal effects started. That was last Friday. We thought about it and decided to go 50 mg and stick to it. We read that side effects go away after some time. This time it took 3 days for him to recover from withdrawal effects after starting him back on 50 mg, we still thought its okay. But then 2 days later he started throwing up again and I started wondering what to do. The doctor kept telling us to go cold turkey or reduce drastically. But finally 4 more days later (continuing 50mg), we decided to reduce by 5 mg every week. He is throwing up every morning and canot go to school. He is better later in the evening. But every mornig its horrible. Please help from your experience what do you think we should we do? Can we redcue 5 mg every week since he has had 50 mg for 7-8 days only on a regular basis? Please, please anyone experienced tell me whatever you think we should do.
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