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  1. After 6 weeks on Trinnelix at 10 mg the neurological type sensations have been insane. I am 3 months in dealing with this now. Worst part is I don't know if any of what I experienced was due to a bad reaction to the ssris or some underlying condition that was brewing already inside me. All I know 6 weeks in on trinnelix and I'm in a hospital with muscle enzyme breakdown called rhabdomyalysis. SSRIs can be a cause but so can some crazy neurological muscular disease among other things. I had to cave in and went on zoloft 0.5 mg to be increased to 0.25mg and clorazapam 0.5 mg last week as in my mind since all this happened I now convinced myself that I have ALS and every day has been pure hell. Dr. Google has been fun. I no longer have self control. I cried daily today was one of those days after my conversation with my GP. I still don't know what is wrong with me and if Zoloft will give me the same issues as trinnelix 6 weeks from now and if once again I'll end up with rhandomyalysis. Clorazapam stopped my body twitches, which is great but my doctor gave me no reassurance as this is also a medication given to people with neurological issues hence my earlier breakdown. I already know I don't have MS clean brain MRI and CT Scan. I'm just waiting on a cspine MRI which will happen this saturday. I'm only lucky to be getting tests at this rate due to some connections through friends and family as I could not imagine living like this for another 3 months. Next is neuro appointment and waiting on the nerve study which I'm petrified of. I had spinal surgery as a kid so who knows. My problems started while on trinnelix and then a week after stopping it cold turkey after really poor advice. I took myself to the hospital 2x last week as I had burning sensations down my arm with electrical shock feeling that was new. My blood work is now good no muscle breakdown issues. They also told me to take ativan every 4 hours which is the dumbest thing I've heard. This was the advice I received from the emergency room doctor. I went back to my family doctor and told her I need to function so she gave me clorazapam until zoloft kicks in. symptoms are gone for the most part but I question why based on what I learned about the medication. As good as I felt prior, I suddenly feel like **** again and I'm noticing little twitches. I feel like my CNS is on a spin cycle in a washing machine that I just can't get out of naturally. Sorry I don't know how to add the meds under the quote so will have to put it in this way... APRIL 25 TO JUNE 5, 2019 TRINNELIX 10 MG CLORAZAPAM 2X PER DAY 0.5 MG SINCE AUGUST 22, ZOLOFT .05 MG SINCE AUGUST 22
  2. I' m a 35 year old female with a history of anxiety and I had spinal surgery due to scoliosis at age 13/14. I have rods in my spine. Over the years I had some spasms in my back which have made me stiff while trying to straighten out. These were linked to my periformis muscle. I still have a slight scoliosis so my body is not aligned well. In winter my vitamin d levels were very low at 25. I experienced massive work related stress anxiety for the past 2 years which increased in April. I had massive burn out and was overworking myself and not eating or hydrating well. I started having panic attacks and insomnia At the end of April 2019 went on anti anxiety medication, brintellix which caused bruises on my legs. Overall I felt good on the medication. I was also taking supplements, LGlutamine, Vitamin b, probiotic, magnesium. By the end of June 2019 I went to the ER due to very bad leg pains. The weekend before I had these symptoms I did a lot of very hard labour around my house and walked for 2 h. Im not very active. Also the week before I drove 8 hours straight with very short stops in between. I did the same trip back 10 hours after 3 days. Initially I ignored the leg soreness as just lactic acid build up but by thursday night I realized it was not normal. I thought I developed a blood clot. Turned out my CPK muscle enzyme was at 11, 200 so my muscles were breaking down. I was diagnosed with rhabdomyalysis cause unknown. Had to stay in the hospital for 3 days on intense IV fluid flushing. My CPK levels have been consistently down at normal since discharge which is a good sign. Rhabdomyalysis can be caused by intense workout, crush injury, ssri's which i was on but it is also linked to muscular/neurological issues. During this time I also quit my anti-anxiety meds cold turkey as apparently 4 days was enough according to my doctor. I believe I had withdrawals. Brain fog, insomnia, resless leg syndrome, vertigo those stopped. For about a week and a bit after hospital discharge I was okay then the following happened: A week after hospital discharge, I decided to go down 23 flights of stairs and carried my friends 18 month old son around a mall. Not the smartest decision after muscle breakdown. The following day my calfs were inflamed. I could barely walk on my left leg. I rushed to the doctor to check my CPK which were normal. My legs were ok and I was able to walk fine.After that week everything went downhill. Since June 17, I started twitching in my left bicep. The twitches spread to other parts of the body: legs, feet, back, ribs, you name it I had it. The twitches are daily some days worse than others. They are not constant and happen when I'm at rest or when I'm not moving the area. Initially I had these weird sensations in my legs as if I had bugs crawling inside or bubling. That has since ended. I also have cramps in my legs after walking or numbness primarily in the left leg. This also comes and goes. I did have a band like sensation around my head that's gone. I had one tiny tongue twitch. I have gastro issues. Before being on medication I had IBS. I started having a a right hand tremor that comes and goes. On July 23 i had a massive facial twitch on my left side. I was crying so much that day and felt my nerves building up inside me when I found out my MRI and nerve study will not happen until November. After I stopped crying the twitch happened. I thought I was having a stroke. Sometimes still get a bit of a twitch around the crease of my mouth, my eye lids are more shaky when I close them and I had a bit of a twitch to my left eye lid. I had to take predisone steroid for 5 days as my face did droop a bit. I also have tingling in my hands that come and go and burning sensations in my arms. I had electrical like sensations running from my elbow to my fingers once at night. I already had autoimmune tests and muscle related blood tests all came back normal. I had a brain mri and cspine mri, a ct scan of my brain all normal. One of the ER doctors wrote peripheral neuropathy as his diagnosis which scared me even more. He wrote that my leg reflexes are hyper but im symetrical on both sides and I'm still within the 2 to 3 range which I read is normal. During my time off brintellix I developed high anxiety thinking I have MS or ALS. I had daily crying spells. ER doctor told me to take lorazepam every 4 hours so I went to my doctor as I felt that was too much. She gave me clorazapam to take 2x per day. I was also prescribed zoloft and went from .25 mg to .75 mg over the past 3 weeks. I went to a neurologist who reassured me I have absolutely no neurological conditions and believes my symptoms are caused by high anxiety and sensitivity to ssris. Since I increased the Zoloft dose I feel wired as if I'm on some crazy drugs, I'm talking fast and have more body jerks and body tremors. The neurologist told me to go down to .50 mg. I feel extremely jittery. I don't want to be on these drugs they are messing up my system. I feel very scared of what is happening to my body.
  3. Hey everyone, I´m going to try and keep this as short as I can without leaving too much information out. I'm from Sweden and started using prozac at the age of 14. I have since then been on and off medications until now (37 years old). I am currently about 2+ months off my latest one (brintellix) so currently free of meds. I have one pack of Oxascand left and I take 10 mg on the worst days, I really try not too. I also use Imovane a few times a week to help with my sleep issues. So I´m basically here because I started researching medications this morning, I´ve felt really bad 2 weeks in a row. I suffer from both depression and general anxiety, some social anxiety as well. Having a hard time being social (it drains me), having thoughts that nobody likes me (especially at work), no self esteem and just really tired all the time. I try to work out 3 days a week to try and rebuild my brain chemistry, I read The Real Happy Pill: Power Up Your Brain by Moving Your Body by Anders Hansen and it really motivated me to not take medicine and work out instead. I have only done this for a few weeks so too soon to tell. I guess the next medicine for me to try would be Lamictal (my mood swings quite much between feeling ok and depressive, I've had hypomania a few times for a few days but only when I'm on meds) but I really want to be free of meds this time, been on different ones on and off for 23 years now. Tried Prozac, Zoloft, Cipralex, Venlafaxin, Cymbalta, Brintellix, Buspar and probably more that I don't remember. Like I said, been without meds in my system for about 2 months and this is usually when depression and anxiety kicks me in the butt and I start some new medication. Is this normal? Is it the medicine that has ruined my own chemistry or is this just me without meds? I've tried therapy as well, and cognitive behavioral therapy helped somewhat but no way near as much as I wanted. It's really bad right now and I'm just trying to hang in there. I would love to hear if anyone has had similar experiences and managed a life without meds and actually found ways to cope without it, and if so how? Is this 2-3 months thing also common? That a crash usually happens by then? It sure seems to be that way with me...
  4. Hey All!! I’m so glad I found this site although it may be a little late. I fear I tapered too quickly on Brintellix and here I am experiencing withdrawal. To give you a little history, I started antidepressants in October 2016 after a very stressful job left me in a bad place. At that time, I should have listened to my husband who told me that if I quit my job, all would return to normal. Instead, I felt the only way to heal myself was to start antidepressants. I did quit my job at the same time and expected to be “healed” with my antidepressants. Unfortunately, I bounced from Lexapro to Pristiq and finally to Brintellix in November of 2015 along with Lamictal to stabilize my mood. Looking back, I’m not sure any of those drugs actually worked…I may have been going through withdrawal every time I stopped taking one. Instead of getting better with the new antidepressant I think maybe I was just getting over the withdrawal of another??? Needless to say, I very quickly got off the Lamictal in June 2016 (went from 100-50-0 in a 3 week period). I went through withdrawal from that (about 3 months before it was over completely) and started feeling more like myself. My intent was never to stay on AD forever so at the end of October, I was feeling well. I had worked through my issues with my therapist, was good at my job, and genuinely happy. However, I was still acutely aware that I still wasn’t myself. I could not feel PURE JOY. I was pretty numb. So my doc told me to taper on my Brintellix, go down to 5mg (from 10) for two weeks and then stop completely. My last day of Brintellix was November 10th. Within a week I was actually feeling more like myself than I had in years!! I was laughing with my kids and at random things on TV. I was back. About the beginning of December was when the symptoms began. I felt more FRUSTRATION than I ever had, so much madness. I felt like a toddler trying to figure out how to manage my emotions again. I worried that the depression was returning because I didn’t have my Brintellix. But it didn’t make any sense. My life had not changed. I was feeling joy—more joy than I had---but I was also experiencing these random thoughts that would not get out of my head. It felt like I had two lives going on at times. The one in my head and the one outside my head. Current Symptoms: Irrational Fears Unable to be fully present Sleep—my mind won’t STOP Erratic Menstrual Cycle that make symptoms of anxiety even worse Physical Anxiety Improvements since discontinuing: Joy Intimacy with my husband Pockets of being myself again Thank you for any advice or encouragement you have related to my symptoms. To all of you who have been doing this, you are amazing!
  5. Hello everyone, Short history: I have a long history of On/Off misc. antidepressant use for various periods, icluding SSRIs & SNRIs and atypicals. In previous times, when I went off medication I didn't experience withdrawal but I guess that this bombardment of my brain with various chemicals left it scarred and vulnerable. My first withdrawal occured when I went off 150mg of Effexor XR (Venlafaxine). I took it for only 2 months (July-August 2015) and I experienced withdrawal over the course of 6 months (September 2015 - February 2016), in which I was pretty much disabled and all I did was wait until things will get better. Current state: After a reoccurence of severe depression, I felt desperate and went back on antidepressants. The psychiatrist suggested Vortioxetine (Brintellix/Trintellix), a "brand new" drug. I started from a dose of 5mg which I took for 1 week, then went up to 10mg which I took for 2 weeks, after that I went up to 15mg, severe itching ensued so I dropped back to 10mg. I stopped taking it after 1 week without tapering because Vortioxetine has a long half life. All in all, I took it for 4-5 weeks, and have been off it since August 2016. About a week after discontinuing, a myriad of symptoms appeared: Tight muscles in head/traps/shoulders/stomach, hot flashes, extreme irritability and agitation, impaired cognition (no concentration, focus, memory etc...), anhedonia, no motivation, akathisia, jaw pain. In general, I feel like my brain has been fried. Currently, I feel very confused and discouraged. Sometimes it seems that it's getting slightly better, sometimes I feel that no change occured and I'm still experiencing the symptoms in the same strength. I haven't tried any other medications apart from Propranolol in an effort to reduce the akathisia but it didn't help. I'm extremely hopeless, I cannot continue my life in this manner. I will meet the psychiatrist in the next week to discuss reinstatement, although I feel it will be the final nail in my brain's coffin. If anyone has any suggestions or can share his/her Vortioxetine experience I would be happy to hear. Thanks
  6. ADMIN NOTE Please read this entire topic for tips about tapering vortioxetine. There are many reports on the Web about withdrawal symptoms from vortioxetine, despite their being overlooked by drug companies. Vortioxetine appears to have a withdrawal syndrome similar to almost all the antidepressants and should be tapered slowly to avoid severe or prolonged withdrawal symptoms. See Why taper by 10% of my dosage? According to https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Top According to https://www.drugs.com/pro/brintellix.html , Brintellix is available as 5mg 10mg 15mg 20mg film-coated tablets. It has a very long half-life, somewhere around 66 hours. There is no ingredient in or coating on the tablet to make it extended-release, that would be unnecessary. (In May 2016, Takeda changed the name of this drug from Brintellix to Trintellix in the US to avoid confusion with another drug.) More biochemical detail about vortioxetine at DrugBank. Vortioxetine is metabolized in the liver by several liver enzymes; however, enzyme cyp 2D6 is very important in its metabolization. Taking vortioxetine with other drugs that are metabolized in the liver, as many psychiatric drugs are, can lead to drug-drug interactions, particularly if the other drugs utilize cyp 2D6. From https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Drug-and-Medication-Information Check for drug-drug interactions. Reduce by splitting tablets Depending on your daily dosage, you may be able to taper by dry-cutting tablets. For example, if you are taking 20mg per day, you may request that your prescription be filled with a combination of 10mg and 5mg tablets with the intention of splitting one 5mg tablet into fourths (1.25mg per quarter tablet). This will enable you to reduce from 20mg to 18.75mg, 17.50mg, 16.25mg, 15mg, 13.75mg, 12.5mg, 10mg -- all reductions within the 10% guideline. (Your doctor will have to specify the reason, such as "take x mg in the a.m. and x mg in the p.m.", for most insurance to cover this type of prescription). At 10mg, you will want to get your prescription filled with two 5mg tablets. At this point, to maintain a reduction rate of 10%, you will need to either 1) use a digital scale to weight tablet fragments of 1mg active ingredient (mgai) or less; OR 2) convert one 5mg tablet into a liquid to measure with an oral syringe. (See below.) Use a digital scale to measure doses If you are very sensitive to dosage reductions, you may wish to weigh tablet fragments, see Using a digital scale to measure doses Taper with vortioxetine liquid Measuring a drug for tapering by 10% at a time is easier using a liquid formulation. Since vortioxetine is available in fairly low dosages, you can take part of your daily dosage as a 5mg, 10mg, or 15mg tablet and add the rest as a liquid until your dosage is less than 5mg, where you would take your entire dose as a liquid. Taking part as a tablet and part as a liquid makes it easier to switch from a tablet to a liquid. Vortioxetine liquid may be available by prescription in some countries (other than the U.S). Check with your pharmacist. Make your own vortioxetine liquid The active ingredient in the tablets, vortioxetine, is slightly soluble in water. This means you or a compounding pharmacy can make a liquid suspension from vortioxetine, see How to make a liquid from tablets or capsules A liquid will be a suspension, not a consistent or "homeogenous" solution. Vortioxetine is highly soluble in ethanol and a substance called DMSO, as are many psycho-neuro-active prescription medications. Ethanol is readily available in vodka. You can get oral or medical grade DMSO from many sources. If you have questions about this, feel free to post them in this topic. Have a compounding pharmacy make custom capsule dosages or a liquid or for tapering Compounding pharmacies can make capsules of the drug in any dosage or a liquid from the tablets. You will need a prescription written for the custom compound. The only drawback is this can be expensive. I have a friend on vortioxetine (Brintellix) so I was wondering, does anyone have any info on how tapering this drug might look like? Thanks in advance.
  7. Hello. About a year ago my GP suggested I try Brintollix to help anxiety. After discussing with my wife, we decided to give it a try. A few days into the medication I began having severe side effects including debilitating panic attacks, severe anxiety, insomnia and nausea. After a couple weeks of these symptoms and two trips to urgent care, I discussed withdrawing with my GP. I stopped taking the brintollix and now know I was having withdrawals. I started seeing a psychiatrist who initially prescribed xanax and celexa. The celexa was increased frequently and I was taking 60 mg within 2 months of starting it. He switched the xanax to ativan, back to xanax and then to klonopin. I was also prescribed neurontin at one point and latuda at another point. My psychiatrist then got upset that my wife and I had called too many times on the emergency line and switched me to another provider in his office. I discussed my concerns with this provider and started decreasing the celexa. The celexa has made me nauseous from day one and its never subsided. I feel like a walking zombie when Im taking the celexa. I decreased from 60mg to 5mg over several months. On 12/31/15 after being on 5 mg for a month I stopped taking it, per my provider. Now its been 5 weeks of living hell. Panic attacks, nausea, anxiety, dark cloud feeling, exhaustion, head rushes, irritability, agitation, suicidal thoughts, tightness in chest, severe back pain...its been horrible. If not for taking time off from work and my wife, I probably would have committed suicide by now. I dont know if I can continue this hell...should I reinstate or keep fighting through this? I've taken 5HTP, drink shakeology daily, and take an omega 3 pill in the AM and PM. I also take propanolol for palpitations. Thanks for any and all help...I'm fighting every single day and praying for some relief but I just cant take this anymore.
  8. Dear all, I have been on drugs for 20 years. Initial cause for going on drugs was insomnia (impossible to sleep and fear of not being able to sleep), anxiety, depression. Treatment was amitryptilline 150 mg. (Elavil). Then the medication was gradually tapered and the sleeping problem reoccured. I then never stopped drugs. I developped Pure O : fear of not being able to sleep so I did not sleep, unable to go to work because of lack of sleep and terrible anxiety. For many years I was on Prozac and it contributed to destroy my marriage.It made me mean. from 2007 to 2017 I was on all possible ssris, anafranil, but also all types of neuroleptics xeroquel 50 mg, risperdal for a short time...... I am now still unable to sleep in other places or when there are wifi waves, unable to sleep in the same bed as someone, and cant work because of extreme anxiety. After a suicidal attempt due to anafranil poop out I am now on brintellix 10 mg and think I must let my brain stabilize before doing any changes. I have no home and boyfriend so I am staying by a friend. I try to develop a mindfulness attitude to accept how my life has been ruined. has anybody developped this kind of obsessions, how do you address them? Do you know how i will taper Brintellix since I have ocd and as soon as I make a change my own brain thinks "this is going to make your insomnia and anxiety worse". Are people also disabled from drugs and requested disability? Thank you. Current drugs Brintellix 10 mg, Nozinan 20 mg, Zopiclone 7,5 mg
  9. wombles

    wombles

    Hi all, I have only just started reading all the wonderful, hope-giving posts on this forum. I have been on Effexor for 20+ years and while I had ups and downs it did seem to do the job mostly, although in saying that I would have fatigue which I would put down to the depression - but who knows?? Anyway a couple of years ago I got very fatigued and was diagnosed with Ceoliac Disease, so went GF and started to feel really good, then after about 10 months the fatigue set in again, my Dr felt I should increase the Effexor. Now in the past I am aware that Effexor raises my BP and ( it can also cause lactation in non pregnant women as after seeing a psychiatrist years ago who said "these are safe, some people take up to 10 a day with no effects! " so dutifully me took 5 as instructed of (I think either 75mg or 150mg memory shot sorry!) then started to lactate!! Anyhoo had my meds increased again this time which led me to a hypertensive crises! So after seeing several doctors and finding that the cause was the Effexor (which I tried to tell them!) I was taken off that and looking back now even though I did wean off over several months I probably didn't go slow enough on the last 37.5mg. I was sick with flu at the time so I felt crap anyway! After 6 weeks I had suicidal thoughts so another doc tried Valdoxan which sent me to sleep within 20 mins of having it - not good when you do shift work! So next to try was Zoloft which did nothing, then went on Brintellix and was assured it would lift the brain fog - unfortunetly it made me even more scatterbrained. Not to mention while having all these meds especially after the raised BP I was having new symptoms and still debilitating fatigue. Whenever I increased the meds I would get short of breath or rather air hunger, this may be due to adrenal fatigue? The last 18 months have been a roller coaster ride for sure but it still fascinates me that after going GF I am more sensitive to the meds. Perhaps as the gut healed I absorb more? I have had recent tests with my new integrative GP which shows my endocrine glands are exhausted and I have low levels of all my minerals. So I am now on 8mg of Brintellix which I have to roughly guess by cutting the tabs ( I notice with these ones whether I am becoming more suspicious but the tabs are an oval shape with no middle score so is it manufacturers way of making more money as it is harder to halve them?? )I am so cynical with the world and angry and irritated a lot of the time. Thankfully I have a wonderful supportive husband! Sorry for long waffle!
  10. I am withdrawing from Duloxetine 30mg and my doctor has taken me down to 20mg every other day and 10mg of Brintellix every other day. I am not sleeping at all and my head feels foggy all the time. Since I have been on Duloxetine I have had feelings of depression, anxiety, tired all the time and did not realise all this time that Duloxetine is obviously not right for me. I have been on Duloxetine for 1 year.
  11. Hi Courageous ones. I'm happy and frightened to be here. I'm new, 56, not tech or math savvy. Dx 1986 Generalized Anxiety Disorder, Panic Disorder, Major Depressive Episodes. Prescribed Xanax for 30 years beginning 1/4 mg 3 times per day as needed and ending prescription 1 mg/ day as needed. The highest dose I ever too was 1/2 mg, three times a day but always at least 1/2 mg per day towards the end, then hit suddenly stopped working, was taken off, experienced severe PAWS for 3 weeks and psychiatrist then put me on Klonapin 1mg, twice a day which I take faithfully and have been on for 5 months now with two, unsuccessful taper attempts in the time as I was cutting to much to quickly even though it was doctor's advice. ANTIDEPRESSANTS ;( in order of being prescribed over 30 year course); Desipramine, Parnate, Prozac, Trazadone, Paxil, Celexa, Cymbalta, Remeron, currently Trintellix 15mg once a day. I'm sure their may be others I've forgotten. Since Xanax tolerence and severe PAWS in autumn of 2016, I have had to for lose on my home!E, move in with elderly parents, surrender pets, give up professional career and placed on government disability (1/3 my job pay) and having many financial woes. I would like to start to taper the Klonapin off successfully then, about a year after that, taper Trintellix antidepressant. Is this sound or is it better to taper the antidepressant first? All knowledge, experience, encouragement and tips are accepted with gratitude. Peace & Love, Mellow please
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