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I am currently on 20 mg of Adderall XR and 10 mg of Trintellix. I have been on a steady dose of both for 4 months and think I am ready to try to go down in both. Does any have any suggestions? I have no idea which to taper first. I am so sick of the brain fog I want to taper the antidepressant first, but I am not sure what interactions may occur. Could I get serotonin syndrome with this? I see that both inhibit CYP2D6, which increases each others' side effects and increases risk of serotonin syndrome. I'd really appreciate some advice, because my psychiatrist doesn't know much about it, and is not much of a help at all. I am just ready to do this the right way and feel emotions/motivation again.