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I have recently found out that Sudafed (Psuedoephedrine) increases Norepinephrine in the brain. I looked this up because I noticed that when I take Sudafed, I become more energetic, more alert, more awake...at least for a while. The effect lasts for about 5 hours. http://www.drugbank.ca/drugs/DB00852 An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem] Perhaps for those of you, who like me, experience extreme drowsiness during withdrawal, maybe Sudafed can help? Especially when bridging with an SSRI from an SNRI like Pristiq or Effexor? I found this blog, which mentions the same Sudafed effect that I have noticed, as well as the ADD medication Straterra, have any of you tried it or a similar medication to help with drowsiness type of withdrawal? http://accidentalscientist.com/2005/08/the-sudafed-test-for-adhd.html Also: http://www.fpnotebook.com/ent/pharm/Dcngstnt.htm A phenethylamine and a diastereomer of ephedrine with sympathomimetic property. Pseudoephedrine displaces norepinephrine from storage vesicles in presynaptic neurones, thereby releasing norepinephrine into the neuronal synapses where it stimulates primarily alpha-adrenergic receptors. It also has weak direct agonist activity at alpha- and beta- adrenergic receptors. Receptor stimulation results in vasoconstriction and decreases nasal and sinus congestion.