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  1. MODERATOR'S NOTE: Because antipsychotic drugs hit many different receptors at different strengths, linear ratios of equivalence are close to impossible and the recommended equivalence is only an approximation. Thus, we recommend that members only use AP switching as a last ditch effort to get off their drug. Members should first try tapering their current AP very slowly (cuts of less than 5% per month if necessary) or holding the dose to stabilize for a long period if withdrawal symptoms are too intense. If a crossover to another drug is attempted, the member should find the minimum dose that is within range of the recommended equivalency which doesn't worsen their symptoms (or does so minimally). The crossover between drugs should be slow and symptom-based (gradual enough to avoid a worsening of symptoms). ------------------------------------------- A potentially useful resource: Dose Equivalents for Second-Generation Antipsychotics: The Minimum Effective Dose Method The article includes a huge table of equivalent doses and studies. Here's the dose data extracted: Table 2. Minimum Effective Doses of Second-Generation Antipsychotic Drugs and Dose Equivalents Drug Minimum Effective Dose OLA 1 mg Equivalent RIS 1 mg Equivalent HAL 1 mg Equivalent CPZ 100 mg Equivalent Amisulpride − − − − − Aripiprazole 10 1.33 (1) 5 (2.5) 2.5 (2.2) 4 (3.6) Asenapine 10 1.33 (1) 5 (2.5) 2.5 (2.2) 4 (3.6) Clozapine 300? 40 (30) 150 (75) 75 (67) 120 (107) Haloperidol 4 (4.5) 0.53 (0.45) 2 (1.13) 1 1.6 Iloperidone 8a (12) 1.07a (1.2) 4a (3) 2a (2.7) 3.2a (4.3) Lurasidone 40 5,33 (4) 20 (10) 10 (8.9) 16 (14.2) Olanzapine 7.5 (10) 1 3.75 (2.5) 1.88 (2.2) 3 (3.6) Paliperidone 3 (6) 0.4 (0.6) 1.5 (1.5) 0.75 (1.3) 1.2 (2.1) Quetiapine 150 (250) 20 (25) 75 (62.5) 37.5 (55.6) 60 (88.9) Risperidone 2 (4) 0.27 (0.4) 1 0.5 (0.9) 0.8 (1.4) Sertindole 12 (16) 1.60 (1.6) 6 (4) 3 (3.6) 4.8 (5.7) Ziprasidone 40 (80) 5.33 (8) 20 (20) 10 (17.8) 16 (28.4) Zotepine − − − − −
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