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I am 70 y.o. But have had severe Restless Legs Syndrome since I was in my 20’s. I’d been on dopamine agonists all my life and switched from one to the next as each seemed to fail. In 2011 my wife arranged for me to be seen at John’s Hopkins by the lead researcher and he found that I had augmentation with each of my old drugs, that is, I would get better initially and then the drug would actually make me worse until I was on huge doses and then I would switch to the next one. The alternative to this class of drugs are the long acting slow release opiates like methadone,suboxone, and fentanyl.
