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  1. See journal articles about PSSD in Papers about Post-SSRI Sexual Disorder (PSSD) Please note that SurvivingAntidepressants is a site for tapering and recovery from withdrawal syndrome. While we see PSSD sometimes as an aspect of withdrawal syndrome (and we see gradual recovery from it as well as withdrawal syndrome), this site is not specifically for discussion of treatment of PSSD or its neurological origins (which at this time are highly speculative). If you wish to discuss symptoms, theories, and treatment of PSSD, please go to these sites: PSSDforum http://www.pssdforum.com/ Yahoo group SSRIsex (log in to http://Yahoo.com to join) Facebook group (log into Facebook.com to join) Various pages on Rxisk.org
  2. I was given 20 mg of Prozac back in 1997 for depression. I was still technically a minor back then. I had an initial "high" from the Prozac which was mistaken for me not being depressed anymore. A few months later, Prozac stopped working and I had completely lost my sexual functioning. I told my doctor about this, so I was switched to Effexor. I kept on being switched from medication to medication in an attempt to achieve the initial "high" of the Prozac and to reverse the sexual functioning but things just got worse. One day I was put on a medication called Wellbutrin and that caused a manic episode from the first dose which caused me to have to be put into an inpatient facility. I was now switched from just being depressed to having bipolar disorder. I was put on Depakote which stopped the manic episode. Depakote caused me a lot of suffering, so I decided to cold turkey the medication about 6 months later. This led to another inpatient hospitalization and now I was polydrugged with Depakote and Zyprexa. This was the first polydrug combination I was on. This combination of medications was even worse because I was sleeping at least 16 hours a day. After another 6 months or so, I cold turkeyed both of these medications and that led to another inpatient hospitalization. I was fortunate in some ways to have the Zyprexa removed and be able to function somewhat ok on just Depakote and now Klonopin. I stayed on Depakote for years but my sexual issues were never solved and I had a lot of other side effects from Depakote such as multiple sclerosis and Parkinson's disease like symptoms. In around 2005, I discovered the first person who had described the same sexual issues I experienced. It was called Post SSRI Sexual Dysfunction. I discovered forums similar to this one, and consumed books by people like Dr. Breggin. In 2007, I was able to successfully withdraw safely from all medications by switching over to lithium and valium and using a compound pharmacy to taper down. I felt a lot better and recovered from some of the damages caused by the medications. I began social drinking in 2008 because I felt like I missed out on such a big part of my life. About 6 months later, I completely lost my ability to sleep probably due to the alcohol damaging what the benzos had already damaged. I was forced into a state psych ward and given a diagnosis of bipolar NOS, psychosis, anxiety etc. After 3 or 4 months in the state psych ward, I left on a combination of Depakote ER and Ativan. I had to eventually updose the Depakote ER and switch to Klonopin again. So for the last 3 years or so, I've been on 1250 mg of Depakote ER and 3 mg of Klonopin. While I am not suffering nearly as much as I did when I was bombarded with antipsychotics like Haldol and Geodon, life isn't nearly as good as I know it could be. That's why I want to get help in coming off of the Depakote ER and Klonopin safely. My confidence level is a bit low because I feel like I may be damaged beyond repair due to being on dozens of psychiatric medications and due to the past experience with insomnia I freak out when I cannot sleep and that is what is happening now. I started to taper off of Depakote ER on 11/24/2014 and I'm on 750 mg Depakote ER now and 3 mg of Klonopin. That's my intro but I'm not sure what to do next...
  3. Hi all, Long story short. Was anorexic last year until Christmas, starting recovering from that/weight restoring in January 2016. One of the ED therapists I worked with told me anxiety peaks once weight it restored, which happened (although didn't learn this until recently) - end of April 2016 I went into psychiatric hold because the anxiety was making me suicidal. Big mistake. Doc there put me on 20mg of Citalopram. For the next month I did therapy which along with an occasional Benzo resolved the anxiety. By May the Citalopram kicked in, with all its side effects. Extreme nausea, dry heaving, insomnia, weight gain, hunger cues messed up (already were from anorexia, but worsened), acne, gynecomastia, swollen fingers, fatigue - so bad (daily nausea was excrutiating) I nearly killed myself at the end of June. But I finally found a good doc, who through the next month of tests, determined it was the meds. Began tapering first day in August, 20 mg to 15 mg. Took a supp called Serosyn with 5HTP, L-theanine, and B vitamins. Withdrawal consisted of chapped lips in in the first week, increased hunger (I could be full but my brain still screamed to eat), fatigue (different form than when on 20 mg), wired feeling and weight gain. Leveled off a bit after 3 weeks, although I should have stayed there longer (but I didn't because the effects of 20 mg have been so bad that I've been trying to get off asap). 2 and a half weeks ago went down to 10 mg. Like before, chapped lips in the first week, wired feeling persisting, continued weight gain, and insatiable hunger. As before the lips are healing, but the hunger is still messed up (early fullness, insatiable hunger). Tired still, waking up hungry even after eating a lot at night. Haven't exercised in 8 months - first b/c of anorexia recovery, by now b/c exercise messes up my hunger cues/I cannot seem to physically eat enough. Worried I've been too aggressive with the taper, and that I'm doing irreparable damage to my nervous system. I wonder if I should reinstate 15 mg (scared it won't help/cause more complications) and start a slower taper? Seriously scared reinstating will mess things up even more, but equally scared that I've dropped too fast and have messed up my nervous system irreparably (and that my hunger cues/weight, which have been messed since starting anorexia recovery, are doomed for life). tl;dr: 20 mg citalopram was full of terrible side effects, dropped to 15 and then to 10 pretty quickly, and paying the price; wondering if I should wait it out for another week to see if anything improves like the 20-15 drop, or reinstate 15 and go slower from there (also scared I'm ruined for the rest of my life, I've had to quit a lot of things because of this damn med). On the bright side, gynecomastia, acne, and such are improving as expected. But this messed up hunger is getting at me (as is the weight gain and general crap feeling that I've had ever since starting this med).
  4. I will try to resume my whole psychiatric story. I started taking Risperdal for the first time when I was 18, they prescribed it to me without any clear diagnose. I was socially isolated and I didn´t know why, that´s the reason I went to the psychiatrist, I think at that time I didn´t have depression (maybe I was just "a bit sad") but Risperdal induced it to me, it was a terrible experience with suicidal thoughts included. I took it only for three months and then left it, without tapering. Then my doctor decided I had obsessive-compulsive disorder and she put me on Seroxat, I took it for a year in which my depressive episode was healed. The circumstances lead me to suddenly stop taking it, I had an unpleasant withdrawal, this time I didn´t have any psychical symtoms but apparently depression came back. I stayed seven months with this depression until I decided to start medicating myself again. I went to another doctor, after analysing me I was diagnosed "negative symtoms" of schizophrenia because of my problems to socialize and I was medicated for that. I was prescribed another neuroleptic, Solian 200 (amisulpride) which is not aproved in the USA, but it is here in Europe. At this time I was 20 years old, I took Solian for six months and I felt better again, my depression was over (but I didn´t feel euphoric or something). Then, I made the worst decission of my life: I changed doctor again. This doctor wasn´t very kind and I remember he used to boast about the things he knew and sometimes he made me feel I was stupid. He, with his knowledge, decided to take my medication off without tapering, I had a terrible withdrawal which I am still on. Just after leaving it I had a lot of physical symtoms such as: stomachache, dizziness and insomnia, my question is how much do they usually last? I had them for two months, is this normal? I will try to make more questions in another post.
  5. ☼-branyan-from-pp-genital-anesthesia-and-pssd Hey guys! Branyan here from the old PP forums. I haven't written in any SSRI or related forum in almost 2 years now. The reason being? Things for the most part have been pretty damn great. My actual life is great. I have a great career started. I am finally independent and financially stable. I've had a couple of short relationships in between now and when Paxil Progress ended. During that sexual relationship I almost NEVER had one problem. Not only that, things were pretty freaking great in that department. I never had any problems getting it up, and sex was frequent and very good. Now there is still some of the genital numbness, and spotty libido, but was scarcely a worry. So. fast forward. We broke up. Not the right time in our lives, etc etc blah blah. Now the libido and functioning goes right back down to nothing good. This has been the pattern in the post SSRI/PSSD world for almost 5-6 years now. In the relationship things work great. Outside of that relationship, even when by myself things just dont feel very good. I realize how lucky I am. I'm grateful to have what I have. I'm so lucky. I'm not even really complaining. I just kind of needed to vent because its kind of scary. And in the past the one habit I've made is obsessively trying to hook up with girls or look at porn to keep testing if things are working. And I want to be a lone for a while and do some more soul searching. The last girl i was with I was very upfront about the PSSD stuff, and we took our time to get to sex and that made all the difference. I cannot discount the emotional and psychological part of it. It's almost as if the PSSD has made those components so strong that I am now 'demi-sexual". If you look that up it basically means you can't be aroused without an emotional connection.. I've got a lot of work to do in therapy to deal with this. I need to listen to my rational mind and not the fearful part. I can do this. I'm of course open to any and all questions as I know that my story has been used as a success story for many people fearful of PSSD around the internet.
  6. Dear all, This is my first post on this forum. I just wanted to share my experience with w/d of buspirone. I stopped 30mg/day about 23 days ago. I suffered 10 days, said enough, then went back to 10 mg/day. It didn't make much difference for another week. I gave up and upped to 20mg/day 7 days ago. While some bad stuff decreased, I am having very painfaul headaches since 2 days (tonight it woke me up). W/d symptoms: some that I know from SSRI/SNRI w/d, but some special for buspirone: "hangover" headache, "hangover" dry mouth, "normal" strong headaches, very angry (I have to punch some pillows or do pushups), flu-like chills and fever (for 3 days), strange pain in the neck. I want to emphasize that it seems as bad as paroxetine. For now I can even say it's worse cause when I came back to paroxetine, all symptoms went away. Now I'm stuck in the middle of nowhere (have many terrible symptoms, while still being on high dose). So, 1st I wanted to share, 2nd I'd welcome any ideas what to do (I already bought and am trying Omega-3)... I really don't want to go back to 30/day (for many reasons); besides I don't have guarantee that even that will bring me back to state before w/d. Did anyone was relieved after coming back to original dose after such long time (>3 weeks)? Did any particular supplement help?
  7. I'm tappering off Cymbalta after starting it on december 2015. I didn't realize until it was too late, but while on cymbalta I lost the ability to feel, so i decided to quit I tought it coulnd't get worse, but now that I´m tappering I feeling even less, I guess that´s part of the withdrawal
  8. Hey everyone. I was put on Zoloft and Concerta at the age of 11 for OCD and ADHD. I have been on 200mg of Zoloft for a long time. I CT'd the 36 mg of concerta in February 2017. I did not do my diligence. I made a change with my psychiatrist in 2017 for the zoloft. That change sent me to hell. She told me I could discontinue quickly while tapering onto another drug, which I thought I needed for my "sanity." I have since fired her and am off all medications after being diagnosed with "serotonin syndrome." Within a week of tapering from 200mg to 150mg and tapering on to another drug, I began experiencing strange symptoms, which, according to my "doctor" have nothing to do with the medication: complete emotional numbness (I struggle with this already due to depression but it is so so much worse now), a deep disconnection from my identity, ego, self, and external environment, random bouts of visual problems, severe memory loss, cognitive issues and fogginess--I feel like I am walking unconsciously, with the only thoughts I am having are intrusive, detached thoughts that don't make sense to me, along with bouts of suicidal ideation and severe and uncontrollable mood swings, an inability to think, reason, rationalize or plan ahead, a lack of spontaneous thoughts, soul crushing anhedonia, akathisia, tremors, numb crying spells with no feeling of sadness underneath, feeling like I am losing my mind, severe depersonalization and derealization, severe insomnia, muscle and joint pain, back pain, complete loss of sexual functioning, generally not feeling alive or like a human being, unable to connect to my environment, friends or family. I blame myself for not doing my research about coming off these medications and I blame myself for ever even going on them, though I don't remember if that was my decision or my parents. I had a pretty strong mind despite OCD and depression before coming off the drugs. I was incredibly smart and loved fishing and now I can barely work and my passion in life means nothing to me anymore. I have been in intensive CBT for the last few months, though it doesn't work because I literally cannot put thoughts together myself, my only thoughts are intrusive it seems. Doctors don't believe me and after doing the research I am not surprised. I understand it is too late for me to reinstate and that I am in for the battle of my life. I have been doing some things to help myself, though I have not seen improvement and don't expect to for years: meditation, engagement in life and things I used to enjoy, pursuing goals even though I don't care about them, eating nutrient dense foods, walking and light exercise, and hyperbaric oxygen therapy. Since I was on these drugs a long time and since I started as a kid I am feeling pretty hopeless that I can get better even though many people keep telling me I can. I expect to deal with OCD, depression, sexual issues the rest of my life but I don't expect to be an emotionless, anhedonic, depersonalized, cognitively impaired zombie who can barely function for the rest of my life. I am looking for hope mainly, a place to come to where people understand, and somewhere I can also offer hope to others who are going through the same. I don't think I can do this by myself anymore, and it is hard to go through all of this when my family and friends don't really understand. It is incredibly difficult to be around people who seemingly are enjoying life and taking for granted their humanity. It is incredibly isolating to be going through severe depression, depersonalization, and cognitive impairment that no one on my therapy team seems to understand. I cannot process my pain or emotions or my past trauma as I cannot access it on an emotional level. I want so badly to integrate my past pain into my life and recover from my life trauma but I cannot do it in this state. As I type this, I am so disconnected that I don't even feel the emotional pain of all of this. I wish you all healing and prosperity and hope that I will someday improve somewhat, at least to the point where I can enjoy fishing again. All I want to do right now is isolate and avoid people and everything that reminds me of what is missing in my life, but am fighting this urge and trying to stay engaged. I am hoping for some advice or hope from others who CT'd or rapid tapered at the advice of a doctor. I know I am afraid right now even though I cannot feel it in my body or mind. I am lost and am not getting the direction I need from therapy because they think I am just depressed, but this is not just depression. I don't expect to go through life without any suffering but this seems a bit too much to handle most days.
  9. Shar244

    Shar244

    I was taking 50mg Sertraline daily (prescribed for anxiety) for 2 months in 2016. I stopped taking them instantly due to various side effects; insomnia followed by extreme fatigue and when the sexual dysfunction kicked in that was the last straw for me. I suffered for roughly 3 months with vertigo and nausea. I believe I am left with PSSD and also cognitive issues. I have been anti-depressant free since December 2016 I have experienced two or three ‘windows’ I think they are called? The PSSD has probably improved overall 10% day to day in the last two years. Recovery stories give me hope
  10. Hello, After a couple of months of reading some of the posts on this forum, I have decided to join, because basically it seems that I have PSSD. As you will see from my signature strip, I have been on escitalopram at various doses for just over 7 years (finally came off in January of this year (2017)). My history on this drug probably looks a bit confusing. Basically I went on the drug late in 2009 for anxiety that I was suffering. I only intended to be on it for a short time – maybe 6 months – whilst I made some important decisions about my future. But my doctor at that time provided no guidance on coming off the drug. I came off very quickly and crashed. It basically took me about 3 attempts like this to finally realise I could not come off it quickly. In the end it has been a long and slow process with some bumps along the way, but finally I am off the drug – but it took 7 years. I am male and now in my mid-thirties. Anyway, whilst on the drug I suffered from sexual side effects, which from what I have read is very common. But it was in late 2013 that I found out just how much the drug was affecting me. I started a relationship with a girl who although I liked much, I could feel no deep emotion with. Basically I could not fall in love with her. At first I could not understand what was wrong with me, but one day shortly into our relationship I suspected the drug. After a simple ‘Google search’ I had the answer. This combined with the sexual side effects of the drug just made it impossible for me really and in early 2014 we split up. It was at this point that I realised no matter what, I had to get off the drug. It took 2 further attempts of slow tapering but finally I have managed it. I am now almost 5 months off the drug, but seems I have PSSD. At the end of December 2016 I reduced from 10mg every other day to just 5mg every third day. A few days after doing this I could feel something changing sexually – more normal feeling was coming back. And about a week later I had a couple of days of what I would say was completely normal function returning. However this only lasted a couple of days. Shortly after this I took the last tablet. I was now off the drug. About 2 weeks later I once again had a couple of days of everything returning to normal sexually. Again this only lasted temporarily. Then a period of 3 weeks of the numbness and erection difficulties. Then - 5 weeks after taking the last tablet - I again had a period of 2 days of normal functioning – this time I thought it was going to be for good, but unfortunately not. And that was the last time I experienced what I consider everything being normal. Since then I have returned to the numbness, lack of drive and erection difficulties that I had whilst on the drug. I have had the odd day or two in recent weeks where the numbness reduces a bit and there is a little bit of sensitivity, but only a very tiny improvement for a day or so. Then back to full numbness. Also I have developed a ache/pain in my testicles that radiates at times into the top of my legs and buttocks. I can’t remember exactly when this started but I think it was around 6 weeks after being off the drug. I also feel emotionally flat – I don’t think I could fall in love with somebody. I think that issue is still there. I can cry at times, but can’t feel any real happiness for anything. I guess like so many people here I feel the most desperate I have ever done in my life and just looking to talk with others in a similar situation. These past months have seemed like an eternity and every day is such a struggle. I am hoping somebody can give me some hope, because right now I can’t feel much of it. Also I do have a few questions which if anybody can give some sort of an answer to I would be so grateful. 1) Why did I have 3 separate periods of normal sexual function in the immediate period of coming off the drug (first 5 weeks) and then nothing further? 2) the ache/pain that I feel in the testicles – is this part of PSSD? 3) one of the things that really worries me is the fact that I noticed a change to my sexual function after taking just one tablet (God only knows why I did not stop taking them there and then) but as I only planned to be on the medication for a short time, it did not bother me too much. Does this immediate reaction to the drug combined with my long-term use of it mean it more likely my recovery will be a very long time, or worse still that I never recover? Thanks very much for reading.
  11. Hello. Altostrata I saw your clip on the youtube where you talked about your experience with the medication. I took one week medication Paxil and It did completely destroyed me.. when I stopped taking this medication I felt so bad and did not know what was happening to me .. then I went to a lot of doctors first with a neurologist who prescribed it and Of course he did not know anything about why I felt so bad... I was doing a lot of analysis and review at doctor, and everything was fine ... even the magnetic resonance of the head, but still I felt so sick.... When I stopped the drug I had a bad concentration, bad memory, forgetfulness, bad sleep, poor libido, poor erection, muscles I do not feel always, Im tired, I can not get muscle inflammation after I exercise, I dont have passion for some things It simply destroyed myself - That drug. I spent so much time try to descover how to reverse this condition and every time i hit wall... the time can only help. I took it for one week, and now its past 5 yrs i feel the same ..im having same symptopms when I stopped that drug? Is it possible that im damaged for life? Please Altostrata, can you tell me this... After 9 yrs did you recover fully in sence that your memory, concentration, muscles and libido is as good as it was before you took that drug?
  12. Hello, Im a 28yo male, from Brazil, and Im desperate! - 2005 start taking Paroxetine 40mg, no big deal, worked quite nice. - 2006 stopped cold turkey, not more than a week with brain zaps and I was fine. - 2007 anxiety and depression came back, like when I wasnt on Paroxetine. - 2007 back to Paroxetine. I was "normal" again. - 2013 depression started again, transitioned to LexaPro 15 + Wellbutrin XL 300 with very few problems, 2 weeks and I was fine. - 2015 dropped Wellbutrin cold turkey without problems. - 04/2017 Transition to Pristiq 50, for five days I took half lexapro pill + half pristiq, the problems started, nausea, headaches, muscle stifness, neck pain, after these 5 days, things were the same... starting feeling miserable =(, I talked to my MD, she said to taper off Pristiq, 25mg for 5 days than 12,5 for five more than, stop taking. First drop and the brain zaps started, insomnia kicked in hard. - 05/12/2017 one week without Pristiq, I cant handle what Im feeling anymore, the zaps are driving me insane, I cant sleep properly, my body and head aches, my concentration is gone. Called my MD and she prescribed me lexotan to help ease the symptons. Still not taking it. I dont know if what Im experiencing is withdrawal from Lexapro or Pristiq, I DONT KNOW WHAT TO DO!!, should I go back to Lexapro and try tapering it slowly or should I keep going like I am? I just want to get rid of the freaking zaps! Im quite desperate, sorry for my bad english!
  13. Authoritative sources documenting Post-SSRI Sexual Disorder (PSSD), more fallout from antidepressant withdrawal syndrome. There are many, many anecdotal reports about this on the Web. ------- Bahrick, Audrey S., and Mark M. Harris, "Sexual Side Effects of Antidepressant Medications: An Informed Consent Accountability Gap." Journal Of Contemporary Psychotherapy, Vol 39(2), June 2009, pp 135-143. No PubMed abstract. Full text here. Abstract from the paper: Sexual side effects of antidepressant medications are far more common than initially reported, and their scope, quality, and duration remain poorly captured in the literature. Antidepressant treatment emergent sexual dysfunctions may decrease clients’ quality of life, complicate psychotherapy, and damage the treatment alliance. Potential damage to the treatment alliance is greatest when clients have not been adequately informed of risks related to sexual side effects. It had previously been assumed that sexual side effects always resolve shortly after medications are discontinued. Emerging evidence, however, suggests that in some individuals, sexual dysfunction side effects may persist indefinitely. The authors argue that all psychologists should be well-informed about sexual side effects risks of antidepressant medications, should routinely conduct a pre-medication baseline assessment of sexual functioning, and take an active role in the informed consent process. ------- Farnsworth K, Dinsmore W. Persistent sexual dysfunction in genitourinary medicine clinic attendees induced by selective serotonin reuptake inhibitors. International Journal of STD & AIDS [serial online]. 2009;20(1):68-69. No PubMed abstract. Full text here. From this letter to the journal editor: Sir: It is widely known that selective serotonin reuptake inhibitors (SSRIs) can cause various types of sexual dysfunction (SD) and recent studies have shown that prevalence may be as high as 60%1 among SSRI users. Emerging evidence shows that in some patients SD may persist and even worsen, long after treatment cessation. It is this group of long-term post-SSRI treatment sufferers that we are concerned with here.... ------- Csoka AB, Bahrick A, Mehtonen O. Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors. Journal of Sexual Medicine [serial online]. January 2008;5(1):227-233. Abstract at http://www.ncbi.nlm.nih.gov/pubmed/18173768 Full text here."]Full text here.[/url] INTRODUCTION: Sexual dysfunctions such as low libido, anorgasmia, genital anesthesia, and erectile dysfunction are very common in patients taking selective serotonin reuptake inhibitors (SSRIs). It has been assumed that these side effects always resolve after discontinuing treatment, but recently, four cases were presented in which sexual function did not return to baseline. Here, we describe three more cases. Case #1: A 29-year-old with apparently permanent erectile dysfunction after taking fluoxetine 20 mg once daily for a 4-month period in 1996. Case #2: A 44-year-old male with persistent loss of libido, genital anesthesia, ejaculatory anhedonia, and erectile dysfunction after taking 20-mg once daily citalopram for 18 months. Case #3: A 28-year-old male with persistent loss of libido, genital anesthesia, and ejaculatory anhedonia since taking several different SSRIs over a 2-year period from 2003-2005. RESULTS: No psychological issues related to sexuality were found in any of the three cases, and all common causes of sexual dysfunction such as decreased testosterone, increased prolactin or diabetes were ruled out. Erectile capacity is temporarily restored for Case #1 with injectable alprostadil, and for Case #2 with oral sildenafil, but their other symptoms remain. Case #3 has had some reversal of symptoms with extended-release methylphenidate, although it is not yet known if these prosexual effects will persist when the drug is discontinued. CONCLUSION: SSRIs can cause long-term effects on all aspects of the sexual response cycle that may persist after they are discontinued. Mechanistic hypotheses including persistent endocrine and epigenetic gene expression alterations were briefly discussed. ------- Kauffman, R., Murdock A. "Prolonged Post-Treatment Genital Anesthesia and Sexual Dysfunction Following Discontinuation of Citalopram and the Atypical Antidepressant Nefazodone." The Open Women Health Journal, 2007 (1), 1-3. No Pubmed abstract. Full text here. Abstract from the paper: SSRI therapy is commonly associated with sexual side effects, but it is assumed that these distressing symptoms resolve with termination of therapy. The atypical antidepressant nefazodone is infrequently associated with sexual dysfunction and may be substituted for SSRI’s when sexual symptoms are intolerable. Recently, scattered case reports of persistent sexual dysfunction and genital anesthesia persisting well after termination of SSRI antidepressant therapy have surfaced. In each case, the underlying depressive disorder was in remission. Case: A 32-year old women with major depression was treated with citalopram but switched to nefazodone after 4 weeks of therapy due to genital anesthesia and orgasmic dysfunction. These symptoms continued following institution of nefazodone therapy and have persisted for over a year since termination of antidepressant treatment. Her depression remains in full remission. Discussion: It is likely that persistent post-treatment genital anesthesia and other sexual side effects are underreported, and physicians should be aware of this bothersome phenomenon. Formal post-treatment surveillance for this condition is war- ranted. Pharmacogenomic research may ultimately allow physicians to predict who is at risk for antidepressant induced sexual side effects. ------- Bahrick, Audrey S, "Post-SSRI Sexual Dysfunction." ASAP Tablet, Vol 7(3), Sept 2006, pg 2. No PubMed abstract. Full text here. From the article: Post-market research has now firmly established that the SSRIs and SNRIs can significantly affect most every aspect of sexual functioning at rates significantly higher than the 5-15% reported in pre-market trials. Depending on definitions of sexual dysfunction and methodology, post-market prevalence studies have found rates between 36% and 98%. The 5 to 15% rates of SSRI and SNRI-induced sexual side-effects listed in the current drug-insert literature are based on information obtained in the initial trials via spontaneous reports of individuals who had been on the medications for a short time. The differences in reported rates between the pre-market trials and post-market prevalence studies are an artifact of methodology; we now know that when individuals are directly asked about their experience of sexual side effects via either a structured clinical interview or a self-report inventory, we obtain vastly different rate information than if we rely on individuals to spontaneously volunteer personally sensitive information about changes in sexual functioning.... ------- Csoka AB, Shipko S. "Persistent sexual side effects after SSRI discontinuation." Psychother Psychosom. 2006;75(3):187-8. No PubMed abstract. Full text here. ------- Bolton J, Sareen J, Reiss J. Genital anaesthesia persisting six years after sertraline discontinuation. Journal of Sex & Marital Therapy [serial online]. July 2006;32(4):327-330. Full text here. ------- Also see references here http://www.nationmaster.com/encyclopedia/Post-SSRI-Sexual-Dysfunction ^ Bahrick A. Post SSRI Sexual Dysfunction. American Society for the Advancement of Pharmacotherapy Tablet 2006; 7:2-10. ^ Kauffman, RP. Persistent Sexual Side Effects after Discontinuation of Psychotropic Medications Primary Psychiatry. 2008;15:24. ^ Zajecka J, Mitchell S, Fawcett J. Treatment-emergent changes in sexual function with selective serotonin reuptake inhibitors as measured with the rush sexual inventory Psychopharmacol. Bull. 1997;33:755-60. PMID 9493488. ^ Balon, R. SSRI-associated sexual dysfunction Am J Psychiatry. 2006;163:1504-1509. PMID 16946173. ^ Montejo AL, Llorca G, Izquierdo JA, Carrasco JL, Daniel E, Perez-Sola V, Vicens E, Bousono M, Sanchez-Iglesias S, Franco M, Cabezudo A, Rubio V, Ortega MA, Puigdellivol M, Domenech JR, Allue B, Saez C, Mezquita B, Galvez I, Pacheco L, de Miguel E. Sexual dysfunction with antidepressive agents. Effect of the change to amineptine in patients with sexual dysfunction secondary to SSRI. Actas Esp Psiquiatr. 1999;27:23-34. PMID 10380144. ^ a b Csoka AB, Shipko S. Persistent sexual side effects after SSRI discontinuation. Psychother Psychosom 2006;75:187-8. PMID 16636635. ^ Bolton JM, Sareen J, Reiss JP. Genital anaesthesia persisting six years after sertraline discontinuation. J. Sex Marital Ther. 2006;32:327-30. PMID 16709553. ^ Kauffman RP, Murdock A. Prolonged Post-Treatment Genital Anesthesia and Sexual Dysfunction Following Discontinuation of Citalopram and the Atypical Antidepressant Nefazodone. The Open Women’s Health Journal. 2007;1:1-3. ^ Csoka AB, Bahrick AS, Mehtonen O-P. Persistent Sexual Dysfunction after Discontinuation of Selective Serotonin Reuptake Inhibitors (SSRIs). J Sex Med. 2008; 5:227-33. ^ Goldmeier D, Leiblum SR. Persistent genital arousal in women - a new syndrome entity Int J STD & AIDS 2006; 17:215-6. PMID 16595040. ^ Goldmeier D, Bell C, Richardson D. Withdrawal of selective serotonin reuptake inhibitors (SSRIs) may cause increased atrial natriuretic peptide (ANP) and persistent sexual arousal in women? J Sex Med. 2006;3:376. PMID 16490037. ^ Leiblum SR, Goldmeier D.Persistent genital arousal disorder in women: case reports of association with anti-depressant usage and withdrawal.J Sex Marital Ther. 2008;34:150-9 PMID 18224549. ^ Adson DE, Kotlyar M. Premature ejaculation associated with citalopram withdrawal. Ann Pharmacother. 2003;37:1804-6. PMID 14632589. ^ Hines RN, Adams J, Buck GM, Faber W, Holson JF, Jacobson SW, Keszler M, McMartin K, Segraves RT, Singer LT, Sipes IG, Williams PL. NTP-CERHR Expert panel report on the reproductive and developmental toxicity of fluoxetine.NIH Publication No. 05-4471. 2004;1-211. ^ Maciag D, Simpson KL, Coppinger D, Lu Y, Wang Y, Lin RC, Paul IA. Neonatal Antidepressant Exposure has Lasting Effects on Behavior and Serotonin Circuitry. Neuropsychopharmacology. 2006;31:47-57. PMID 16012532. ^ de Jong TR, Snaphaan LJ, Pattij T, Veening JG, Waldinger MD, Cools AR, Olivier B. Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats. Eur Neuropsychopharmacol. 2006;16:39-48. PMID 16107310. ^ Maciag D, Coppinger D, Paul IA. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT(1) receptor stimulation during development. Brain Res. 2006;1125:171-5. PMID 17101120. ^ Hansen HH, Mikkelsen JD. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. Eur J Pharmacol. 1998;352:307-15. PMID 9716368. ^ Raap DK, Garcia F, Muma NA, Wolf WA, Battaglia G, van de Kar LD. Sustained desensitization of hypothalamic 5-Hydroxytryptamine1A receptors after discontinuation of fluoxetine: inhibited neuroendocrine responses to 8-hydroxy-2-(Dipropylamino)Tetralin in the absence of changes in Gi/o/z proteins. J Pharmacol Exp Ther. 1999;288:561-7. PMID 9918559. ^ Faure C, Ouissame MF, Nasser H. Long-term adaptive changes induced by serotonergic antidepressant drugs. Expert Rev Neurother. 2006;6:235-45. PMID 16466303. ^ Palotas M, Palotas A, Puskas LG, Kitajka K, Pakaski M, Janka Z, Molnar J, Penke B, Kalman J. Gene expression profile analysis of the rat cortex following treatment with imipramine and citalopram. Int J Neuropsychopharmacol. 2004;7:401-13. PMID 15315716. ^ Kalman J, Palotas A, Juhasz A, Rimanoczy A, Hugyecz M, Kovacs Z, Galsi G, Szabo Z, Pakaski M, Feher LZ, Janka Z, Puskas LG. Impact of venlafaxine on gene expression profile in lymphocytes of the elderly with major depression--evolution of antidepressants and the role of the "neuro-immune" system. Neurochem Res. 2005;30:1429-38. PMID 16341940. ^ Yamada M, Yamada M, Higuchi T. Antidepressant-elicited changes in gene expression: remodeling of neuronal circuits as a new hypothesis for drug efficacy. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:999-1009. PMID 15975701. ^ Boehm C, Newrzella D, Herberger S, Schramm N, Eisenhardt G, Schenk V, Sonntag-Buck V, Sorgenfrei O. Effects of antidepressant treatment on gene expression profile in mouse brain: cell type-specific transcription profiling using laser microdissection and microarray analysis. J Neurochem. 2006; 97 Suppl 1:44-9. PMID 16515540. ^ Hyman SE. Even chromatin gets the blues. Nat Neurosci. 2006;9:465-6. PMID 16568101. ^ Newton SS, Duman RS. Chromatin Remodeling: A Novel Mechanism of Psychotropic Drug Action (Relates to article by Cassel, et al. FastForward 2 May 2006). Mol Pharmacol. 2006;70:440-3. PMID 16728645. ^ Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006;9:519-25. PMID 16501568. ^ Cassel S, Carouge D, Gensburger C, Anglard P, Burgun C, Dietrich JB, Aunis D, Zwiller J. Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Mol Pharmacol. 2006;70:487-92. PMID 16670375. ^ Altar CA, Laeng P, Jurata LW, Brockman JA, Lemire A, Bullard J, Bukhman YV, Young TA, Charles V, Palfreyman MG. Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways. J Neurosci. 2004;24:2667-77. PMID 15028759. ^ Tsankova NM, Kumar A, Nestler EJ. Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci. 2004;24:5603-10. PMID 15201333. ^ Cohen AJ. Antidepressant-Induced Sexual Dysfunction Associated with Low Serum Free Testosterone. Psychiatry Online 1999. ^ Tanrikut C, Schlegel PN. Antidepressant-associated changes in semen parameters. Urology. 2007;69:185.e5-7. PMID 17270655. ^ Szyf M. Toward a Discipline of Pharmacoepigenomics. Current Pharmacogenomics 2004;2:357-377. ^ Lacasse JR, Leo J. Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature. PLoS Medicine 2005;2:e392. ^ Moncrieff J, Cohen D. Do Antidepressants Cure or Create Abnormal Brain States? PLoS Medicine 2006;3:e240. ^ Damsa C, Bumb A, Bianchi-Demicheli F, Vidailhet P, Sterck R, Andreoli A, Beyenburg S. "Dopamine-dependent" side effects of selective serotonin reuptake inhibitors: a clinical review. J Clin Psychiatry. 2004;65:1064-8. PMID 15323590. ^ Keltner NL, McAfee KM, Taylor CL. Mechanisms and treatments of SSRI-induced sexual dysfunction. Perspect Psychiatr Care. 2002 Jul-Sep;38(3):111-6. PMID 12385082.
  14. Sex Med Rev. 2017 Oct;5(4):429-433. doi: 10.1016/j.sxmr.2017.05.002. Epub 2017 Jun 20. Sexual Consequences of Post-SSRI Syndrome. Reisman Y1. Abstract at https://www.ncbi.nlm.nih.gov/pubmed/28642048 INTRODUCTION: Sexual dysfunctions are well-known side effects of selective serotonin reuptake inhibitor (SSRI) use. Altered libido, erectile dysfunction, vaginal dryness, ejaculatory disorders, and orgasmic problems are frequently reported by patients treated with SSRIs. Moreover, these antidepressant-emergent sexual dysfunctions do not always resolve after discontinuation of the medication and can persist indefinitely. These complaints are termed post-SSRI sexual dysfunctions (PSSD). AIM: To examine the existence of this clinical entity, possible theoretical mechanisms, possible risk factors, and possible treatment modalities. METHODS: Through literature research and clinical experience, the available information about PSSD is reviewed. MAIN OUTCOME MEASURES: Summary of the current literature with insights into possible causes and management options. RESULTS: There are some indications that antidepressant-emergent sexual dysfunctions do not always resolve after discontinuation of the medication and can persist indefinitely in some individuals. Although some or all sexual side effects that start with the use of SSRIs might continue after stopping the medication, other sexual complaints can develop. Decreased capacity to experience sexual pleasure is the most frequent characteristic of this syndrome. CONCLUSION: The research and understanding of PSSD remain limited and not well understood; however, the data support the existence of PSSD, which can have a substantial effect on the quality of life of these patients. More research is warranted to show the cause and possible mechanisms of PSSD that could lead to the correct diagnosis and treatment. Reisman Y. Sexual Consequences of Post-SSRI Syndrome. Sex Med Rev 2017;5:429-433.
  15. Sex Med Rev. 2018 Jan;6(1):29-34. doi: 10.1016/j.sxmr.2017.07.002. Epub 2017 Aug 1. Post-SSRI Sexual Dysfunction: A Literature Review. Bala A1, Nguyen HMT1, Hellstrom WJG2. Abstract at https://www.ncbi.nlm.nih.gov/pubmed/28778697 INTRODUCTION: Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of drug. Post-SSRI sexual dysfunction (PSSD) is a condition in which patients continue to have sexual side effects after discontinuation of SSRI use. The prevalence of persistent sexual side effects after discontinuing SSRIs is unknown. The recognition and study of PSSD will increase our knowledge base of this underreported and distressing condition. AIM: To provide coverage of the current literature on PSSD, update information on the pathophysiology of PSSD, and discuss potential management options. METHODS: Comprehensive review of literature pertaining to PSSD. MAIN OUTCOME MEASURES: The symptoms, classification, pathophysiology, diagnostic considerations, and management of PSSD were reviewed. RESULTS: Common PSSD symptoms include genital anesthesia, pleasure-less or weak orgasm, decreased sex drive, erectile dysfunction, and premature ejaculation. Different theories have been proposed to explain the pathophysiology of PSSD: epigenetic gene expression theory, cytochrome actions, dopamine-serotonin interactions, proopiomelanocortin and melanocortin effects, serotonin neurotoxicity, downregulation of 5-hydroxytryptamine receptor 1A, and hormonal changes in the central and peripheral nervous systems. The diagnosis of PSSD is achieved by excluding all other etiologies of sexual dysfunction. Treating PSSD is challenging, and many strategies have been suggested and tried, including serotonergic antagonists and dopaminergic agonists. There is still no definitive treatment for PSSD. Low-power laser irradiation and phototherapy have shown some promising results. CONCLUSION: PSSD is a debilitating condition that adversely affects quality of life. Further studies are warranted to investigate the prevalence, pathophysiology, and treatment of PSSD. Bala A, Nguyen HMT, Hellstrom WJG. Post-SSRI Sexual Dysfunction: A Literature Review. Sex Med Rev 2018;6:29-34.
  16. NOTE: This topic has been merged with a very similar one posted in the Tapering discussion, so there is some duplication of post subject matter. ~Jemima Hello everyone, I am currently tapering off of Zoloft, 25mgs, after a very short time of taking it [7 weeks] due to the fact that I do not like the emotional numbing it causes. I love to feel a range and depth of emotions. My taper plan is half a pill for 2 weeks, than a quarter of a pill for another two weeks, and then completely stopping. I don't really have a pill cutter to taper more slowly, although I have considered slowing the taper. My withdrawal so far has included emotional breakdowns [can not stop crying due to the thought of being emotionally numb forever], and increased anxiety, which I am on Ativan for. I hope that I am not emotionally numb forever...I'm scared of never being able to feel again. I start crying because I fear that all of my senses will be reduced forever and I will live in a world without color. I am going to begin day 6 of the taper today...currently at half a pill or about 11.5 mgs...wish me luck.. theelt712
  17. A year ago I came off effexor and Prozac. !! I developed insomnia, obsessive ruminations.. I felt very stressed!! All the time. Then one day I realized... I have no libido!! No sexual or emotional energy. I felt numb!! I tried suicide.. I somehow believed I was damaged. I went downhill fast. I quit my job, lost my fiance. I tried to end my life. I ended up in the psych ward. Long story short. I met a yogi. I was in a bad place in my head. Non stop ruminations. Chronic disabling insomnia. Complete numbness. I began to meditate and practice yoga. In other words, I gained awareness of my mind, and how it was making me sick. I abstained from masturbation for the past eight months. I've mastered my mind. I found God! Now,just in the past two months, my body has regained it's natural warmness. I feel once again , Pleasure! My body tingles with sensations in which I thought I've lost forever. I started feeling emotional last month . Someone in this movie was crying, and I felt his pain.. And I cried.. My stomach dropped and my breath left me. I let go. My depression is almost gone too!! I find myself laughing..! Even smiling!! Loving. . feeling peace, at last. I haven't felt this in years.. When I used to participate in negative conversations, I became consumed with hopelessness. I negative feedback loop if you will. I bought into the idea that I was damned for life. My mind wouldn't let go of this idea, until I gained awareness of my mind and it's conditioned cycles of repetitive negative thought. Feeding my depression. Now, I wake up, spend ten minutes watching what my mind comes up with, and I breath..gently.. And they come and go.. As I'm typing this, I have full bodily sensation. The nerves in my body feel alive. Much love to everyone!! Never give up!!
  18. SadDoll

    SadDoll

    Hiya, I'm Laur I dont know where to start. I'm new, kinda. I've been a lurker on this site on and off since 2015 but I've never joined until now. I'm a 24 year old woman from Ireland who was put on antidepressants when I was 18/19 for OCD, depression and suicidal tendancies. I was first given 20mg of lustral in late 2011 and it didnt affect my sex drive or emotions in any way. I didnt take them everyday though, I forgot a lot of the time. Then in late 2013 I was switched to 150mg of lustral. I dont think I took them every day either until I made an effort to take them regularly only to quit them one day out of the blue cold turkey sometime in early 2014. Stupid, I know. At the time I was constantly either stoned and/or drunk so I wasn't very responsible, to say the least. On top of this, I was binge drinking a lot, a few nights a week, and smoking weed nearly everyday from late 2012- 2016 as well as being constantly dependant on a dangerous recreational drug for about a year in 2013. Oh and I wasnt eating properly, so my nutrition was bad on top of this. Anyway, I haven't touched an antidepressant since Spring of 2014 but I have absolutely no libido to speak of, as well as no pleasure 'down there'. Sex for me feels like nothing at all every single time. No arousal. No sensation. I think maybe once or twice I had some slight sexual feeling with an ex boyfriend sometime last year. But it wasn't anywhere near my sexual function pre PSSD. On top of this, I worry so much that I wont be able to fall in love, that I'm incapable of romantic feeling. This bothers me the most because that has been my fear for about 5 years now. And I read online that antidepressants destroy your romantic feelings forever. I dont know how true that is, but it makes me want to die. Ironically, that is what my OCD focused on. The fear of never falling in love. So the doctors presribed me a higher dose of a new pill. I feel like I'm trapped in my own worst nightmare and I feel anhedonic and dead inside. I'm reluctant to post here as I dont want to make anyone feel hopeless from my story. And I'm afraid of other people's stories making me feel even more hopeless. I'm down in the depths of hell here. I feel empty and broken and incapable of love and feeling anything positive at all. Please, can someone offer me some hope? I feel like the fact that I was on a very high dosage (150mg), constantly high for the best part of 4 years, dependant on alcohol, plus a history of past substance abuse, PLUS the fact that I quit cold turkey means that I dont have any hope of recovering. I cant recall what it feels like to feel aroused and I cant imagine ever getting better. Please no negative comments as I'm very suicidal as it is
  19. I'm working on a book on antidepressants and intimacy - Regaining The Edge. We all know that antidepressants can blunt emotions and cause physical side effects, many of which interfere with intimate relationships directly (sexual side effects) and indirectly (e.g.., weight gain, nausea, diarrhoea, etc...). I want to fill the book with people's stories, the wisdom of experience. I am interested in strategies that worked to manage these side effects (and why and how they worked), as well as highlighting the daily struggle that many of us being treated for depression and other mental ills face, both with our mental health, but also the consequences of our treatment. There is a questionnaire on my site at RegainingTheEdge.com, as well as a contact form. I am also interviewing people one-on-one, either face-to-face if you live on the east coast of Australia, or via Skype or email if you live elsewhere. You can follow me on Facebook at https://www.facebook.com/regaintheedge. Please take the time to share your story with me - this is an important issue, one that has received scant regard to date. Michael
  20. theloneranger86

    Pudendal Nerve Entrapment PNE

    Hey Alto and other members on the forum Has anyone in withdrawal ever tested for PNE (Pudendal Nerve Entrapment) / other pelvic dysfunctions ? Could this be a complication from the trauma ? Didn't see a single thread about this on the forum so thought of bringing this up ?
  21. potions

    PSSD Lawsuit

    Hi everyone! If you have taken an SSRI or an SNRI such as Zoloft, prozac, luvox, and you still experience sexual dysfunction after coming off the drug (in the form of genital numbness, reduced pleasure response, inability to orgasm, erectile dysfunction, etc) please fill this form out to help us end PSSD for good! https://docs.google.com/forms/d/e/1FAIpQLSc4NixcXLN_sRV-4jSIWeDAYvQ1V96F-8B0MR8GuDpbjbD3rg/viewform
  22. A produced video explaining how child psychiatry has cured me, not:
  23. Hi all...... I am new here. Searched google 'how to recover from risperidone' and found this site. I don't know how things work here, but I am sharing my experience. I was misdiagnosed with Bipolar disorder and took the medicine for 3 months. The details of the drugs are in my signature. Its been almost two months since I quit the medicines cold turkey. I am now suffering from withdrawal symptoms. Sexual dysfunction, ie.. no sex drive which is driving me crazy. I watch porn, but not able to get excited now. I am deeply depressed. Suicidal thoughts are coming to me thinking about my life. I have just completed graduation in B.tech in engineering. I was not able to write the final exams well because of memory problems, no interest to study, which was during my medication period. Now i am thinking what I will become in life, I can't function properly as a human being. In the morning I feel like sleeping more. I feel tiredness while trying to become active after waking up. So after breakfast I lay in bed again. In the evenings I will become more active till I sleep. Is this normal? Will I be able to lead my normal life back? If so how much time will it take to recover? Reply please........ I am in need of help.
  24. Hello everyone , At first i would like to introduce myself. I am a 24 year old boy from Italy and have been taking citalopram for several months. The exact time you can see in my signature. Already during the intake of citalopram I noticed a strongly sunken libido and I could not hold any strong erections anymore. As many of you were told me that these side effects disappear at the settle. Now I have stopped the drug since june and the sexual dysfunction have become worse. I still can get only a lacking erection. Genital numbness is present throughout and the libido is equally very low. So I unfortunately suffer as many others of PSSD and have already tried various supplements, but I could not see any improvement. My next try for a cure would be bupropion(150mg daily) and inositol (18mg daily). I have read that different people have noticed with these medications improvements. Now to my question: Can I take these 2 supplements (bupropion and inositol) together? My psychiatrist said it would not be a problem, but he can not imagine that inositol would change anything. I would take 150mg bupropion in the morning and in 18g inositol in the evening. So would you say that its Okay if i try a medication by connecting this 2 supplements together or would you rather to took first bupropion for 4 weeks and maybe after inositol if nothing changes. Im sorry for my bad english and i hope to get some advice! Greets, jescowhite
  25. The cause of antidepressant-induced sexual dysfunction is multfactorial, as many hormonal systems are disrupted. J Clin Psychopharmacol. 2009 Apr;29(2):157-64. doi: 10.1097/JCP.0b013e31819c76e9. Sexual dysfunction, depression, and the impact of antidepressants. Kennedy SH1, Rizvi S. Abstract from http://www.ncbi.nlm.nih.gov/pubmed/19512977Full text http://www.mediafire.com/download/t92z22kzoxrh3z7/09_Kennedy_Sexual_Dysfunction%2C_Depression%2C_and_Antidepressants.pdf Sexual dysfunction is a common symptom of depression. Although decreased libido is most often reported, difficulties with arousal, resulting in vaginal dryness in women and erectile dysfunction in men, and absent or delayed orgasm are also prevalent. Sexual dysfunction is also a frequent adverse effect of treatment with most antidepressants and is one of the predominant reasons for premature drug discontinuation. Selective serotonin reuptake inhibitors are the most widely prescribed antidepressants and have significant effects on arousal and orgasm compared with antidepressants that target norepinephrine, dopamine, and melatonin systems. The availability of an antidepressant that does not cause or exacerbate sexual dysfunction represents an advance in pharmacotherapy for mood disorders and should reduce treatment noncompliance and decrease the need for switching antidepressants or adding antidotes. The purpose of this review was to provide an update on the prevalence, psychobiology, and relative adverse effect burden of sexual dysfunction associated with different antidepressants.
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