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ADMIN NOTE For tips for tapering your drug , find the link in this list Important topics in the Tapering forum and FAQ You cannot make a liquid from extended-release drugs, such as bupropion SR or XL, or drugs with a protective coating, such as Cymbalta (the type of Effexor XR that comes in a capsule filled with tiny beads is an exception). Many extended-release tablets are held together by a glue to retard their absorption. Mixed with water or other liquids, these tablets become a soggy glob. Otherwise, given variable solubility of drugs, what you're usually doing when you mix a tablet or content capsules with water is creating a suspension, rather than a solution. High solubility is not a requirement for a suspension. Substances that dissolve in solutions will be more reliably distributed evenly throughout the solution, but we have to work with what we've got. A suspension does not require solubility. It's a bunch of particles hanging in a liquid, hopefully fairly evenly distributed. There may be flakes or particles visible in the suspension, some sinking to the bottom of the vessel. We recommend gently shaking or stirring before drawing out a dose from a homemade suspension (avoid creating a froth, because bubbles can throw your dose measurement off), to make sure the active ingredient (the drug) is distributed throughout the liquid. We have many people tapering successfully with homemade suspensions, as well as compounded suspensions and solutions. Also see Pharmacy liquids to make suspensions Questions and answers about liquid medications Compounding pharmacies (US, UK, and elsewhere) Described below, making a liquid from Celexa tablets is only one example of how to do it. Information provided here for Celexa is relevant to making liquids from tablets of other drugs. To skip the discussion about make a liquid with Celexa tablets specifically, jump to "How To Make Liquid from Tablets or Capsules" for more general information about making homemade liquids from many drugs. Also see music321's post about serial dilution of liquids PS Originally, Rhiannon was using a small amount of ethanol to dissolve her Celexa. She later changed her method and was successfully dissolving her tablet in water only. Her topic, Making a Celexa Solution Yourself, has been merged into this topic; the early posts about Celexa have a note added at the top of the posts. Making a Celexa solution yourself A couple of folks asked me to post here about how I dissolve my Celexa and liquid taper it that way. I use a shot glass and dissolve the tablet in a small amount of water (enough to cover it) and a couple of mLs of ethanol (very pure drinking alcohol, I use "Everclear" type, available at the liquor store.) The tablet doesn't dissolve quickly, so I usually leave it there and come back in about twenty minutes. NB: Rhiannon changed her method of dissolving citalopram. She stopped using ethanol. See below quote. I stir it with the pipette to get the drug to dissolve into the ethanol (citalopram is soluble in ethanol). I don't know how well it actually dissolves but as long as it's mixed well it doesn't really matter. Then I add enough water to bring it up to 20 mL total. I mix it well and then draw up my dose for the day, and then pipette it straight into my mouth followed by a pipette full of water (both to rinse the pipette and to dilute the "shot"!) My current dose is 5.25 mg of citalopram, so given the dilution I'm using (10 mg in 20 mL) I measure 10.5 mL as my daily dose. All of this could be adapted easily to using syringes for measurement instead of a pipette. (And if you are more delicate than me you could measure it into a spoon or cup rather than squirting it straight into your mouth.) But using pipettes is really easy too, very simple to learn and do. I'll be seeing my doctor again some time this summer and like I said elsewhere, I may see about getting the citalopram liquid already made up, but it's a $15 copay and the pills are only $5. And I'm already dissolving and pipetting my other meds anyway so it's not really any particular hassle to do it this way with the citalopram. Personally this is the method I would use to taper any med. I've done the dry cutting method using a scale, and I find liquid titration easier to control. I can get my cuts as small as I want by adjusting the dilution.