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Hello, Thank you so much for this site. It is really a lifesaver. I am trying to taper off of Effexor XR (Venlafaxine) after 17 years of use. In the past I unsuccessfully tried to get off of Effexor XR. My doctor attempted to taper me off in only one month. The withdrawal symptoms were so horrible that I went I back on the drug and the symptoms immediately stopped. I finally got up the courage to try to taper again. This time I tapered 4 times as slow as before, but clearly not slow enough. I was desperate to find relief from the severe anxiety attacks and insomnia side effect that I got when my Effexor was increased above 150 mg. The anxiety and insomnia immediately improved after each reduction. However, I still experience some anxiety attacks from the drug withdrawal. I am currently holding steady at 112.5 mg. of Effexor XR. I tapered from 187.5 mg. Effexor XR plus 10 mg. Viibryd, 300 Gabapentin and 25 mg. Amitriptyline (Elavil) down to 112.5 mg. Effexor XR. over the course of approximately 7 months. Gabapentin and Elavil were relatively easy for me to get off of. Probably because I was only on them for a year or two. The withdrawal only lasted 1 week after each dose reduction. The antidepressants however, were a different story. They have been hell to get of! Especially the Effexor. I reduced the antidepressant every 3 to 5 weeks by reducing by the lowest dosage pill. In June I had Transcranial Magnetic Stimulation (TMS). This treatment helped me immensely. In fact I believe that it saved me. Before the treatment my depression was severe. The TMS decreased it to mild. It also helped with the anxiety a lot. It also helped some with sleep, fatigue and sexual dysfunction. If it was not for the drug withdrawal I really think that the depression would be in remission. I am happy that I am making forward progress, but I am frustrated that I continue to suffer withdrawal symptoms and it has been 6 months since I last reduced the Effexor. I am positive that I have PAWS. I am not sure but I suspect that I may have Post SSRI Sexual Dysfunction. The withdrawal symptoms are no longer severe like they were but they are still significant. I read your post on up-dosing and reinstating. Thank you! for the advice! I would have not known better and tried to up dose way too much had I not read this. Based on the recommendation I decided to be cautious and up-dose at the lowest dose possible (1 beadlet or 0.4 mg.) It has been 1 week since up-dosing. The first night that I up-dosed I noticed that my heart raced when I drank a glass of wine and I had insomnia. I don't really know if these things had anything to do with the up-dose or if it was an effect from the alcohol. Other then this I did not notice any difference at all until today. Today I had more intense head zaps. It might be too soon to jump to any conclusions just yet. I am thinking at holding steady for 1 more week and then assessing. What do you think? Also, how would you recommend storing the beadlets? Do you think they need to be kept out of light? P.S. I hope my signature is not too confusing. Did I put it in the right place? I am very glad that I found this site and I hope that I can help others as well. Signature: 2002-2005- Effexor XR. 150 mg. 2006- (Jan.- June) increased to 225 mg. Effexor XR, July 2006? decreased to 150 mg. 2007- 2018- Effexor XR.- 150 mg. 2018- increased to 225 mg. Effexor XR, added Gabapentin 900 mg., added Amitriptyline (Elavil25 mg. 2018- (Sept.) Decreased Effexor XR to 187.5mg, added Zoloft 10 mg., (Nov.) tapered off Elavil, (Dec.) tapered off Gabapentin 2019- (Jan.) switched Zoloft to 10 mg. Viibryd., (Feb.) decreased Effexor to 150 mg., (March) tapered off Viibryd, (April) switched 37.5 mg. Effexor to 10 mg. Prozac then tapered off of Prozac.