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  1. Hi guys, sorry this may be a long post, I think it is okay to share my story on this. I am 21 years old, a college student about to graduate, and I have been on an SSRI for about 5 years now. I was diagnosed with ADHD and GAD when I was about 12, I have always been somewhat anxious and had issues with regulating my emotions. In 2013 my girlfriend broke up with me and I was really sad and feeling hopeless. After a few months of being down and also anxious, my doctor (pediatrician) decided to put me on 5mg of Lexapro. The Lexapro seemed to help (I think?) and I recovered somewhat quickly. Over the next few years, however, my doctor fluctuated my dosage quite a bit. I would get anxious, he would up my dosage, and then I would become a zombie and he would lower it. It did seem to blunt my emotions on a high dose. Other than that it was fine. However, the summer after my freshman college, I became extremely anxious and had an existential crisis, prompting my doctor to change me over to Zoloft and Trazodone. When starting Zoloft, I took 50mg and worked up to 100mg. It possibly helped my anxiety but my emotions became blunted again (or maybe it was depression?). I did not feel hopeless or sad, but I kind of lost the ability to have pleasure over simple things. After going through a hard time on Zoloft and Trazodone feeling empty and dull, my doctor and I decided to taper off to see if that would help. Every time I tapered, we would allow three weeks to go by to see if it helped. I went from 100mg to 75mg to 50mg to 25mg and eventually to nothing. Every time I lowered, I felt a little more in touch with my emotions. With the Trazodone, I stopped cold turkey on a dose of 50mg. When I went completely off of the Zoloft and Trazodone, I started having crying episodes, brain zaps, insomnia, anxiety, occasional anhedonia/brain fog, and severe social anxiety. After a month or two, all of these symptoms went completely away (except sometimes the anhedonia/brain fog). I was doing good and feeling very in touch with my emotions. After a few months off of the Zoloft though, the school year was coming back around, and the girl I had been dating for 2 years broke up with me unexpectedly. It devastated me and left me feeling sad and hopeless. I was crying all of the time, I was thinking about her all of the time, losing the ability to feel pleasure, and had anxiety because I still saw her every day. This continued on through the semester and I went home for winter break feeling depressed and anxious. I was feeling brain fog/anhedonia, and lost overall enthusiasm for life. It got bad enough that I knew I needed help, so I started talking to a therapist (I had seen a few before this one) and it was helping. I still was depressed, but was slowly improving. I started taking Adderall again to study for a certification exam over the break and this helped boost my mood tremendously. It cleared my mind, helped with the brain fog/anhedonia, and made me feel a little more peaceful inside (less racing thoughts). My psychiatrist decided he wanted me to take Trintellix and put me on a 5mg dose. I went back to school feeling down and anhedonic again. All the progress I made during seemed to start disappearing. I stopped taking the Adderall, and once the Trintellix seemed to start working I started becoming extremely anxious. I felt extreme depersonalization, started having weird sensory problems (visual snow, eye floaters, tinnitus, and my body started fluctuating between feeling tingly and numb) and was scared. My doctor upped my dose of Trintellix to see if that would help. I ended up taking Ativan to help with the anxiety. I was feeling less anxious but still had the sensory/depersonalization problems. Not to mention, my emotions went away again. The Ativan lowered my anxiety but made me feel completely dull and emotionless. I ended up tapering off of it and feeling better after a few months, but having a lot more anxiety/sensory issues. Since this (which was earlier in the summer), I started taking Adderall because I read a lot and it seemed my problems were kind of related to Adult ADHD. I always feel internally restless and have a hard time focusing, and taking therapeutic doses (20 mg or lower) seem to calm me down and clear my mind. Not to mention, it helps with my emotional regulation problem. Overall my academics and state of mind are improving. I have lowered the Trintellix from 20mg to 10mg over two months. I have had more sensory problems and anxiety since lowering the medicine, but it seems my emotions are slowly coming back. Every now and then, I get a nostalgic feeling that reminds me of what life used to feel like. It gives me hope. But I have been so up and down for the past 5 years, I am sick of feeling so unstable. I want to have emotions again and not deal with brain fog/anhedonia and anxiety for the rest of my life. I didn't have the former problem until taking medicine. I want the sensory problems to be gone. They only started after I started taking Trintellix. I need help with tapering off I think. Does anyone have any advice for me? I want to learn to treat my depression and anxiety in natural ways, and learn to regulate my emotions better. I want to believe I can live without taking medicine for these issues, because they only seem to exacerbate them. Do I have any hope of being stable again? I always feel uneasy inside and am constantly trying to distract my mind from this. I am sick of being anxious about these weird symptoms, everyone thinks I am crazy and writes me off. Will slowly tapering help this? I long for a day that I am not constantly thinking about being better, and can handle life's ups and downs. I am not wanting to be perfect, just to be able to not always think and worry about my mental health. I am always worrying about exercising enough, meditating enough, sleeping enough, eating well enough, and lowering stress enough. I think my issues could be related to tons of different things, but it is so hard to tell when you are put on medicines that only seem to compound the issue. School has been a big source of stress/anxiety and I am almost done, so I really want to take the time to improve my physical/mental/emotional/spiritual state of mind so life is not always this rocky. Thanks for listening, sorry this was so long.
  2. I am currently on 20 mg of Adderall XR and 10 mg of Trintellix. I have been on a steady dose of both for 4 months and think I am ready to try to go down in both. Does any have any suggestions? I have no idea which to taper first. I am so sick of the brain fog I want to taper the antidepressant first, but I am not sure what interactions may occur. Could I get serotonin syndrome with this? I see that both inhibit CYP2D6, which increases each others' side effects and increases risk of serotonin syndrome. I'd really appreciate some advice, because my psychiatrist doesn't know much about it, and is not much of a help at all. I am just ready to do this the right way and feel emotions/motivation again.
  3. Cigarettes at age 11. Alcohol periodically from age 13 to age 30. Valium episodically from age 18 to age 27. I have been on myriad anti-depressants since 1982 for major depression and generalized anxiety. Imipramine, desyrel, ativan. Off drugs from 1984 till 1995. Started Prozac 1995 till 2014 (did well from 1995 to 2011). Tried Wellbutrin, Cymbalta. Abilify and Trintellix from March 2014 till August 8, 2017 (depression free). Had to withdraw due to cervical dystonia and tremors which still persist. Terrible experience withdrawing from Abilify and Trintellix. Started Wellbutrin 150 mg. and Prozac 10 mg. for one week to help with withdrawal. Then increased Wellbutrin to 300 mg. and experienced ringing in ears; stopped the Wellbutrin and increased Prozac to 20 mg. (10 in A.M.; 10 in P.M.) Now on Prozac 20 mg. per day, occasional Propranolol for tremors (doesn't help). I've read that coming off Abilify can take up to 3 months or more, and it has been 2 months so far. I feel like I've spent (wasted) my entire adult life trying to feel better, first by self-medicating, then by psychiatric medicating. I'm 72 years old. I wonder if there is any hope for me.
  4. I joined this forum last June before I began an unsuccessful taper from Celexa, however, this is my first post. I honestly had no idea until then how horrific untethering from these substances is, and how devastating it can be long term. What I really need is some good news. Is there any good news in the midst of this real-life horror story? Right now I feel completely alone. I haven't found a medical practitioner to forge a partnership for helping me discontinue successfully--or even reach the psych NP who prescribed my meds for a change when things went really wrong. So, there is no "discussing anything with a trusted healthcare practitioner". All I have is you all. So, I'm sort of pleading with you for guidance. I am still not sleeping well. I slept fine, for years on Celexa, then weaned off and threw everything out of balance. To be fair, the year prior to my discontinuation was incredibly stressful. I abruptly ended Trintellix this week (because I ran out and can't get anymore) and am taking approximately 10mg of Prozac (approximately because I'm splitting 20mg of powder roughly in half) as of today. The Prozac instantly quelled my WD symptoms from the Trintellix within the hour, and my plan is to either formulate a liquid suspension of this drug or find a doctor who will prescribe one. I have exhaustively researched how to overcome this problem. I'm an athlete, so I've stacked as many cards in my favor with diet, lifestyle and nutrition as well as I possibly can. But I can't seem to find a way through this, or make a plan that makes sense, and I'm scared I'll never be okay.
  5. ADMIN NOTE Please read this entire topic for tips about tapering vortioxetine. There are many reports on the Web about withdrawal symptoms from vortioxetine, despite their being overlooked by drug companies. Vortioxetine appears to have a withdrawal syndrome similar to almost all the antidepressants and should be tapered slowly to avoid severe or prolonged withdrawal symptoms. See Why taper by 10% of my dosage? According to https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Top According to https://www.drugs.com/pro/brintellix.html , Brintellix is available as 5mg 10mg 15mg 20mg film-coated tablets. It has a very long half-life, somewhere around 66 hours. There is no ingredient in or coating on the tablet to make it extended-release, that would be unnecessary. (In May 2016, Takeda changed the name of this drug from Brintellix to Trintellix in the US to avoid confusion with another drug.) More biochemical detail about vortioxetine at DrugBank. Vortioxetine is metabolized in the liver by several liver enzymes; however, enzyme cyp 2D6 is very important in its metabolization. Taking vortioxetine with other drugs that are metabolized in the liver, as many psychiatric drugs are, can lead to drug-drug interactions, particularly if the other drugs utilize cyp 2D6. From https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Drug-and-Medication-Information Check for drug-drug interactions. Reduce by splitting tablets Depending on your daily dosage, you may be able to taper by dry-cutting tablets. For example, if you are taking 20mg per day, you may request that your prescription be filled with a combination of 10mg and 5mg tablets with the intention of splitting one 5mg tablet into fourths (1.25mg per quarter tablet). This will enable you to reduce from 20mg to 18.75mg, 17.50mg, 16.25mg, 15mg, 13.75mg, 12.5mg, 10mg -- all reductions within the 10% guideline. (Your doctor will have to specify the reason, such as "take x mg in the a.m. and x mg in the p.m.", for most insurance to cover this type of prescription). At 10mg, you will want to get your prescription filled with two 5mg tablets. At this point, to maintain a reduction rate of 10%, you will need to either 1) use a digital scale to weight tablet fragments of 1mg active ingredient (mgai) or less; OR 2) convert one 5mg tablet into a liquid to measure with an oral syringe. (See below.) Use a digital scale to measure doses If you are very sensitive to dosage reductions, you may wish to weigh tablet fragments, see Using a digital scale to measure doses Taper with vortioxetine liquid Measuring a drug for tapering by 10% at a time is easier using a liquid formulation. Since vortioxetine is available in fairly low dosages, you can take part of your daily dosage as a 5mg, 10mg, or 15mg tablet and add the rest as a liquid until your dosage is less than 5mg, where you would take your entire dose as a liquid. Taking part as a tablet and part as a liquid makes it easier to switch from a tablet to a liquid. Vortioxetine liquid may be available by prescription in some countries (other than the U.S). Check with your pharmacist. Make your own vortioxetine liquid The active ingredient in the tablets, vortioxetine, is slightly soluble in water. This means you or a compounding pharmacy can make a liquid suspension from vortioxetine, see How to make a liquid from tablets or capsules A liquid will be a suspension, not a consistent or "homeogenous" solution. Vortioxetine is highly soluble in ethanol and a substance called DMSO, as are many psycho-neuro-active prescription medications. Ethanol is readily available in vodka. You can get oral or medical grade DMSO from many sources. If you have questions about this, feel free to post them in this topic. Have a compounding pharmacy make custom capsule dosages or a liquid or for tapering Compounding pharmacies can make capsules of the drug in any dosage or a liquid from the tablets. You will need a prescription written for the custom compound. The only drawback is this can be expensive. I have a friend on vortioxetine (Brintellix) so I was wondering, does anyone have any info on how tapering this drug might look like? Thanks in advance.
  6. I was on 5mg of Trintellix for a little over a month to treat negative thoughts/mild depression. I had dealt with some anxiety before but stemming from rumination, not creating major physical symptoms. After a while on the trintellix I had a panic attack unlike anything I had ever had before. It really scared me. My psychiatrist said “hmm, that’s weird” stay on it if you can, so I did. The next couple weeks I actually felt pretty good. The trintellix gave me some space from my negative thinking. But then I had a couple more panic attacks and decided I was done with it - the panic was way worse than anything I had experienced before I went on the trintellix. The doctor said I could just stop taking the trintellix bc it was only 5mg. I should mention that I am highly sensitive to drugs. I was okay at first when I stopped but then I progressively started having more anxiety and more panic. Now I’m 5 weeks from my last dose and I have almost constant anxiety, nausea, waves of intense panic, diarrhea, nausea, heart palpitations. I’m taking .25 of Ativan daily as needed to help. I am in a way worse state than I was when I started the drugs. I keep telling myself that this must be from the trintellix since I never experienced panic attacks and intense anxiety before I started this medication, but I’m starting to give myself even more anxiety that there is something else horribly wrong.
  7. Hello, im new here i taking brintellix/trintellix 10mg in the morning and olanzapine 5mg, rivotril (clonazepam/Klonopin ) in the evening taken it last year...i always scared thought how i tapering all that drugs i read many horrible story of the side effects, i dont want forever taking a drugs...im sorry for my english grammar.
  8. Hey everyone, I’m hopeful this site can help me figure out what to do or how to even cope. I’m a 37 year old, successful salesman, an extrovert, generally positive individual. I’ve always had anxiety as a big part of my life and also struggle with just excessive worrying. I was out on Paxil while in college around the year 2000. I was having major anxiety and depression with dealing with being gay and the 40mg of Paxil seemed to do the trick. Long story short, 17 years have passed and i had a bit of a rough year dating this year, and a doc decided to put me on trintellix because it was so much safer and better for you. He also thought it would be very easy to switch from Paxil. This was in August of this year. Id always wanted to get off of Paxil, and had only been taking 10 milligrams since around 2012. I accepted this change as an opportunity to get off the drug. I thought it worked. I noticed as my time with trintellix went on, i was incredibly tired, fatigued, and the worrying went on and on. Eventually suicidal thoughts came on and i went from 19mg trintellix, to 5mg trintellix, to off everything December first. I am not sure if i was having Paxil withdrawal or if the trintellix was affecting me. Anyways, it’s now the day after Christmas, 26 days after the last dose of trintellix, and i am riddled with anxiety. I’m not having panic attacks like I’m used to, but just a general anxiety and feeling of dread. I’m very concerned this is the new me. Could it still be the Paxil? I have had days as well where i feel really great about things as well since December first. It’s like I’m either really happy and full of optimism or full of dread and hipelessness with anxiety. I have so so much to be thankful for. I want to feel good again. Does anyone have any insight? I don’t know what else to do. The psychiatrist wants to put me on 10mg of Prozac because he feels i should be better by now. I don’t want to get back on SSRIs if i don’t have to. Sincerely, Feeling alone in Dallas
  9. Loreli

    Loreli:Trintellix

    Hi, I found this site after watching the you tube video. I have been very concerned about the foggy headed feeling I always have. I also can't remember things unless I write them down. I also have blunted emotions and low libido. And even though I'm taking Trintellix I still feel depressed. It does control my anxiety and my running mind. I call it ruminating. I would really like to be off this medicine but after exploring this site I realize it's not going to be easy. I'm debating on when to start my taper because I have a couple of big events coming up. I have a family wedding in May and a big family reunion in June. I don't want to be sick for them. Maybe I wont feel bad until I get to the lower doses? Or should I wait to taper later in the summer?
  10. Hello! About two months ago I have stopped taking Celexa (20mg) and Wellbutrin (150XR) and started Trintellix (5mg). For the first week, it was like a miracle. I was super clear and felt really balanced (not manic or just "better") then the itching started. If I don't take an antihistamine it is unbearable, but I really wanted this relief to continue so I figured it was a small price to pay. Unfortunately, over the last month I have developed vision and stomach issues, agitation, pain, swelling and numbness in my hands, arms, feet, major muscle spasms and a general feeling of discomfort. These symptoms come and go. Over the past 2 years I've become involved in different therapies and modalities of healing for PTSD and the myriad of issues that it causes. Because of the healing I've experienced and the support I currently have, I believe it's a good time to try tapering off the Trintellix and giving my brain a chance to reboot and see how it goes. Since I'm already on the smallest dosage, 5 mg, I was hoping to get some advice on making my own liquid dosage and how best to proceed. Thank you! Diagnosed w/ Early Childhood PTSD, Major Depressive Disorder Medicated with a variety of AD meds off and on for 42 years
  11. Touchtheclouds87

    Touchtheclouds87 off Paxil

    I was on Paxil for 6 years. The doctor took me from 40mg to 0mg in 8 weeks. I had to get off it because I was so depressed about sexual dysfuntion. Had a psychotic episode followed by the most horrendous depression and acute anxiety. Had to go back on paxil for a year. Then switched to lithium then switched to lamotrigine. I came off paxil the second time over a 6 month period and it was OK. No major withdrawal issues. It's just like everybody says come of the meds slowly and it will be OK.
  12. Hello everyone, Short history: I have a long history of On/Off misc. antidepressant use for various periods, icluding SSRIs & SNRIs and atypicals. In previous times, when I went off medication I didn't experience withdrawal but I guess that this bombardment of my brain with various chemicals left it scarred and vulnerable. My first withdrawal occured when I went off 150mg of Effexor XR (Venlafaxine). I took it for only 2 months (July-August 2015) and I experienced withdrawal over the course of 6 months (September 2015 - February 2016), in which I was pretty much disabled and all I did was wait until things will get better. Current state: After a reoccurence of severe depression, I felt desperate and went back on antidepressants. The psychiatrist suggested Vortioxetine (Brintellix/Trintellix), a "brand new" drug. I started from a dose of 5mg which I took for 1 week, then went up to 10mg which I took for 2 weeks, after that I went up to 15mg, severe itching ensued so I dropped back to 10mg. I stopped taking it after 1 week without tapering because Vortioxetine has a long half life. All in all, I took it for 4-5 weeks, and have been off it since August 2016. About a week after discontinuing, a myriad of symptoms appeared: Tight muscles in head/traps/shoulders/stomach, hot flashes, extreme irritability and agitation, impaired cognition (no concentration, focus, memory etc...), anhedonia, no motivation, akathisia, jaw pain. In general, I feel like my brain has been fried. Currently, I feel very confused and discouraged. Sometimes it seems that it's getting slightly better, sometimes I feel that no change occured and I'm still experiencing the symptoms in the same strength. I haven't tried any other medications apart from Propranolol in an effort to reduce the akathisia but it didn't help. I'm extremely hopeless, I cannot continue my life in this manner. I will meet the psychiatrist in the next week to discuss reinstatement, although I feel it will be the final nail in my brain's coffin. If anyone has any suggestions or can share his/her Vortioxetine experience I would be happy to hear. Thanks
  13. Hey everyone, I'm posting this in a relatively scared/anxious state. I've been doubting every day whether this will actually ever get better, and the thought of this lasting for the rest of my life is terrifying. So, my background: I took Trintellix 10 mg (started at 5 mg for a week, then increased) for about 2.5 months. It also has gone by the names Brintellix and vortioxetine. My psychiatrist at the time said that I didn't have to taper off, since it says in the accompanying informational booklet that there's no possibility of adverse effects when discontinuing such a low dose. So, I stopped cold turkey. I had been off of plenty of antidepressants in the past, and never experienced a real problem, and I thought I knew what to expect from the withdrawal. It was standard at first. Occasional brain zaps, vertigo, etc. I had a couple alarming incidents where for a period of 5-10 seconds, I would become completely confused/disoriented, forgetting where/who I was for those brief periods. From what I understand, those couldn't be absence seizures because I was fully aware that I was having them. They were a bit scary, but they sort of just stopped, and those haven't resurfaced since. However, about 6 weeks after I had stopped taking the drug, the real symptoms surfaced, seemingly overnight, and they've persisted to the present moment. I went to sleep one night with a lot of stress on my mind, and woke up with a sore neck (which has since gone away), as well as all of my current symptoms: disorientation/confusion, random moderate bouts of vertigo, and an inability to visually process information like I used to. I can't look at pictures or screens anymore, because my eyes get tired instantly; it's like they don't know where to look, and trying to move them is exhausting. I also can't drive, and I can't work. I feel disabled, and the only clue I've gotten is from a different psychiatrist (not the one who prescribed the medication), telling me that these symptoms sound consistent with SNRI discontinuation syndrome, even though Trintellix isn't a strict SNRI. For obvious reasons, I haven't taken any other medications since I stopped Trintellix, and I luckily wasn't on any others at the time of discontinuation. Simply put, this has ruined my life. I can't enjoy anything in this current state, because I feel so detached, and even the seemingly-easy task of sitting down and enjoying a movie has become exhausting and daunting. I haven't really felt any enjoyment or happiness since this all started about 4 weeks ago. As far as I can tell, it also hasn't gotten any better. I'm terrified at the prospect of this being permanent. I'm terrified at the prospect of this even lasting another month. Every day feels like agony for me. Out of nowhere, my life has basically been put on hold, and I'm not sure whether I'll ever be able to get back to it. Any advice or experience with similar symptoms would be much appreciated. I feel like I'm losing my mind. Thanks, and hope your journeys are going better than mine.
  14. I'm 32, I have a 6 year old, and I've decided I want to have another child finally. My GYN says, when you find out you're pregnant, just quit taking your medications. Wtf? I've been on wellbutrin xl, metoprolol, a beta blocker for heart rate associated with anxiety, and random benzos for about 5 years. I've been on and off of zoloft, which was rough. I take trazodone at night for sleep. And I've been on trintellix for a while now also, and I'm up to 20mg. Lately I've been so lethargic and having a hard time with any task, even getting dressed, brushing my teeth, much less actually cleaning up. I've also not been able to really get out of the house if I'm alone. I haven't had a xanax in over a week, so that's good, but idk what's going on. I've gained a ton of weight, constantly getting sick with something, and my skin looks terrible, and my eyes stay sunken in. I really want to come off of all my medications and rely on a more natural approach. I'm tired of feeling like a dead person walking around, and I want to feel things like I used to. I'm also running out of time to decide to quit everything and have another child. Where should I start tapering? Thanks for any advice.
  15. Hi Courageous ones. I'm happy and frightened to be here. I'm new, 56, not tech or math savvy. Dx 1986 Generalized Anxiety Disorder, Panic Disorder, Major Depressive Episodes. Prescribed Xanax for 30 years beginning 1/4 mg 3 times per day as needed and ending prescription 1 mg/ day as needed. The highest dose I ever too was 1/2 mg, three times a day but always at least 1/2 mg per day towards the end, then hit suddenly stopped working, was taken off, experienced severe PAWS for 3 weeks and psychiatrist then put me on Klonapin 1mg, twice a day which I take faithfully and have been on for 5 months now with two, unsuccessful taper attempts in the time as I was cutting to much to quickly even though it was doctor's advice. ANTIDEPRESSANTS ;( in order of being prescribed over 30 year course); Desipramine, Parnate, Prozac, Trazadone, Paxil, Celexa, Cymbalta, Remeron, currently Trintellix 15mg once a day. I'm sure their may be others I've forgotten. Since Xanax tolerence and severe PAWS in autumn of 2016, I have had to for lose on my home!E, move in with elderly parents, surrender pets, give up professional career and placed on government disability (1/3 my job pay) and having many financial woes. I would like to start to taper the Klonapin off successfully then, about a year after that, taper Trintellix antidepressant. Is this sound or is it better to taper the antidepressant first? All knowledge, experience, encouragement and tips are accepted with gratitude. Peace & Love, Mellow please
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