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  1. Hi all I'm on day 3 of tapering off venlafaxine XL 37.5, only 2 beads out at a time,I will get a scales soon because It will only get harder the more I have to count out the beads .I am going to take it extremely slowly this time.I did a taper in march 2016 and it lasted till the june and i didn't go beyond 5 beads out each day before going back to 37,5. Its been a very tough time , I have extreme anxiety,extreme iratibillaty ,intrusive thoughts,. to name a few. What I have learned since that time is to have compassion for ones self and b very patient when doing the taper . My advice to everyone is don't ever believe u cant get through it .our nervous system and soul take time to heal Over the last 3 years I have learned and practice mindfulness ,it is amazing. It has helped me to calm down during a couple of flights to the UK when starting to panic. Today I had a bad anxiety attack but I was able to snap out of the attack fairly quickly because I have been practicing it and I recommend always getting out for a walk in the sun if u can and clear your mind. Please always keep your mind open to new ways to heal.We all now its hard but don't ever let anyone break your spirit. Total respect to everyone .
  2. I started Effexor (venflaxine) excuse my spelling 75mg and buspirone 7.5 mg on Wednesday last week. Friday night I had an adverse reaction. Skin burning, dizzy, tremors, rapid heart beat, dilated pupils, muscle stiffness, I’m sure there’s more I’m forgetting right now. I did not take the meds after Friday night. Now Thursday (4am) I’ve been having withdrawal symptoms. Tremors, anxiety, insomnia, no appetite. I see my pysch today at 130. I actually went to the hospital twice in the same day because I could not sleep, eat, or relax. I couldn’t go to work but I am going to try today. I was wondering if maybe Prozac or sertraline would help me ease these withdrawal symptoms or if anyone else has experienced this after on three days of being on meds!!!
  3. All of my symptoms in bolded, for ease of quick scanning for relevance by anyone interested. I have ended up on this website after lots and lots of google research to pin down the cause of my incessant symptoms of a low-grade migraine headache and constant nausea that I have been experiencing for 10 days straight now. My Migraine History: I have been getting migraines fairly regularly (about 2 or 3 each month) since middle school. but they are pretty mild, as migraines go. About 25% of the time, one will be preceded by an aura that is a lightening-shaped blind spot or blurry vision and then the headache will be very severe. And occasionally, one will be accompanied by severe nausea. But normally, my migraines are just quite painful headaches accompanied by heightened sensitivity to light, sounds, and smells. With ibuprofen and extra sleep, they are usually completely gone within 30 hours. During puberty and especially pregnancy, my migraines were more severe in all aspects: nausea, sensory sensitivity, and pain. My Venlafaxine Withdrawal/Discontinuation Symptoms: I did not connect these symptoms to the cessation of Venlafaxine until recently because 1. I did not know that physical symptoms could be related to the cessation of antidepressants. 2. The onset of symptoms did not occur until 5 days after my last half dose of Venlafaxine. 3. I was only on Venlafaxine for 27 days (including a half-dose for the last 7 days). I only made this correlation after several days of googling possible causes, and after including symptoms that I had previously dismissed as insignificant and inconsequential in my internet searches I started experiencing a persistent nausea that did not seem like food poisoning or stomach flu (no stomach cramping, etc.) 14 days ago. There were/are waves when the nausea is worse throughout the day, and a constant malaise otherwise. Unlike the stomach "flu" or food poisoning, there is/was no stomach cramping or urge to vomit. On the 4th day of no relief, I realized that it was just like the nausea I get that sometimes accompanies my migraines. I hadn't equated it with a migraine previously, because there was no headache. I started taking ibuprofen periodically, treating it as if it were a migraine. On about the 5th day, I could feel a headache "trying to set in", which is my usual precursor to an impending migraine (although historically the nausea, if it develops, does not come on until after the headache presents). Since then, I have had no improvement in symptoms. On about day 6, I started googling possible migraine prescriptions and was considering seeing my M.D. the following day, if there was no improvement. I also started googling the combination of all my other mild/querky symptoms to see what else it could possibly be, if not a migraine. These other sporadic symptoms had each seemed inconsequential as they had come and gone here and there, and were easily dismissed. But I was starting to realize they might be related. Muscle Weakness in my biceps that I had noticed when using a steering wheel or when filing through clothing racks while shopping. Crying and/or the feeling that I needed a good cry, without provocation, that felt very similar to PMS (although this was about 10 days after my last menses). Brain Fog in the middle of conversation. I will have to concentrate really hard to remember what the conversation is about, and what I was going to say next. I will forget what my husband told me just minutes ago. Word Recall Difficulty both while texting/typing (spelling) and in conversation (vocabulary). High Pulse Rate of 88pm, which was noted at the medical appointment that I had on the fourth day after my last dose of Venlafaxine, when I felt great. Chills Hot Flashes/Feeling Flushed Sinus Congestion which was present before, but is now much worse, especially at night. Nausea that feels like "Morning" Sickness when there is 0% that I am pregnant. Yes, 0%. At times, I can tell that I will feel better if I eat, and at other times I can tell that eating will make me feel worse. My best time of day is the first 3-4 hours after waking up. Shivers not related to body temperature this one I just experienced last night, and suspect (hope!) is more likely related to my inadverdently taking 2 different antihistamines (diphenhydramine and cetrizine) at the same time! Very pronounced and fast onset of "prune skin" on the soles of my feet, followed by Extreme itchiness on the soles of my feet Another really bizarre symptom that I think might have another cause. ??? I had sprayed the soles of my feet at bedtime with magnesium oil two nights in a row, as I have done in the past when experiencing a severe migraine. I did not bathe or shower until a third night. 5 minutes into my bath, my feet (and only my feet) were EXTREMELY pruny, as if I had been soaking for more than an hour! I have found nothing online indicating that this wierd fluke may be related to the magnesium oil, nor to antidepressant withdrawal/discontinuation. After the bath, my feet were excruciatingly itchy (just the skin, not the nerves) for at least 30 minutes! After much reading on this and other similar forums, I contacted my P.A. that has been assisting in my medication management for the last 3 months. I am going to reintroduce 5 beads of Venlfaxine tonight and see if it makes a difference by the time my afternoon appointment rolls around tomorrow. She is doubtful that any of these symptoms are related to the antidepressant, so I hope this works. I really hope that my experience, along with the litany of literature I will be leaving with her tomorrow, convinces her of this very real and very under-reported issue!
  4. Hi all , I am 8 months off reinstated sertraline for a month ( by doc) and Aripropazole. History Its around 4 years back when i passed out my college and not get placed even after making to finals in many interviews .. that i decided to write competitive exam for PG. I had taken coaching but just before exam I came back and found myself unable to recall things. My brain is just like nothing in it. I found myself in despair and stopped studying. This fog is happening all the time since my engineering but I managed to get average marks sometimes and sometimes very good . There is more in back history but I ll get to it later. So, my parents took me to a psychiatrist ( family known) and he put me to Olanzapine and one more thing. He diganosed me bipolar2. I got about 10 pounds on it but its not help . Meanwhile after 4 months, with the help of a relative , I got intern in a company and I moved out with fog to a distant city. TThere in a hospital, they put me on floxetine and Amisulpride for 3 months . Then i moved to a private psychiatrist ... where it starts getting haywire . He stopped fluoxetine and Amisulpride . And put me on Venlafaxine and Seroquel... As i was interning, i get usual heat racing in between job times but my doctor convinced me to stay with it . 4 months and I just started feeling agitated due to stress. It happened that I slapped a senior on abusing me and there I left a job I never happened to get physical in my school or college .. but it happened. Doctor told me to scrap the prescription he wrote of raising Venlafaxine. And he put me paroxetine + Oxcarbazepine. In his words , it is best tolerable and has lesser side effects. I managed to get a job by my own and cracking first time. But this time there is lot of work and culture pressure. Its a startup with full of politics . Boss and his boss .. all keep on putting things. Let office aside, I started feeling some well .. overly casual ... excited .. raged .. Iits about 25 mg Paroxetine and 300/600 mg Oxcarbazepine. I had unusual violent acts .. had hit a school friend .. insomnia.. I decided to leave the paxil by asking the doctor . He said half in a week and then other half a week to off. Thats when it all started , i cannot sleep whole night and with day light i start getting a nap. I left going office with fear of state i was in . I cannot wake and even if I .. i was too tired and angry . Doctor then gave me Mirtazapine which didn't help . I resigned job telling muly boss about all and came back home. It was Nov,2015. I start getting yhese uncontrollable rage that I locked myself in a room. Parents took to a local shrink who put me on Venlafaxine+ Mirtazapine(CRF), lamotrigine, resperidal, Seroquel. The NEXT Day I woke up so fresh .. all calm like 12 yrs back .. i was smiling happy.. but it lasted only 4 hrs .. and i am doomed again . I took those meds 10 days and i decided to go off. Physical Damage. I got brain zaps as sounds with eye movement .. While on Paxil I got severe neck stiffness and movement pains - which came out as Osteophytes. Anger , heart race , memory, fog , chest pains , fatigue ... All I beared for 4 months. Reinstatement after 4 months. Father took me to another psych who put me on Sertraline+ Aripropazole+ Seroquel. I started having increases restless legs than before and the doctor asked me not to go over net. After 2 visits and when he said it wslas Aripropazole for restlessness all time.. and he is cutting it . I stopped all meds . Withdrawals in 8 months. All first symptoms with some new like utter sensitivity in teeth. It is while breathe in most of the teeth . Muscles gone from forearms .. My left hands gone ulnar neuropathy and i got surgery done when no hope lived. Right hand has stiffness too . MAnger I am living with .. I have stopped talking .. I have decided to go sit on my Shop but I was unable to understand the talk . In spite anger biuts and memory makes it difficult to adjust. I keep forgetting people faces .. important talks . So i stopped . Now I am muted all the time with burst inside . Read success stories and play CoC. This is the most I can write now.
  5. Moderator note: link to uncomfortablynumb's Benzo Forum thread Hi Everyone, About 9 years ago I jumped on the psych med-i-go-round. It was my last year in university studying human kinetics - I was really stressed, not getting much sleep, not eating very well and consuming way too much caffeine. I pretty much crashed and burned with anxiety and depression over probably a 4 month period. It was possibly due to years of stress and not knowing exactly what I wanted to do after graduation (to continue studies or find work). I was rock bottom, not being able to focus on anything and the anxiety was so bad that I isolated myself. That is when I first saw my psych. I was prescribed Celexa and that did nothing. It was my first drug and I was desperate and only gave it probably 3-4 weeks. Then I was put on Effexor. It worked wonders in about 3 or 4 weeks at 75mg or 112mg. I was back to my old energetic self and focused. I came out of my shell and was socializing again. I finished my degree and decided to forgo post-grad and start up my own business as a fitness trainer. The next 3 years were going well as I was building up clientele. Outside of work I was involved in long term relationships. Effexor was working pretty consistently. When it lost effectiveness, I would up my dose and be fine pretty soon after. I forgot to mention I was taking a pre-workout supplement (NO-Xplode or another) while on Effexor (which is probably a no, no) to give me an extra energy boost. Perhaps the meds were losing their potency and I needed another boost because coffee was not helping. Effexor then started to poop out on me. I would relapse into depression/anxiety for longer periods and upping doses was useless (I believe I went up to 187.5mg). We then tried augmenting Abilify without success. Then I switched to Pristiq which also didn't work. Then it was onto Wellbutrin to no avail. I ended up reintroducing Effexor and it worked again with the break. Not as well, but I was functioning. I began abusing pre-workout supplements just to keep me my normal energetic, positive self. Again, Effexor pooped out after a couple years. Over the next few months, I tried Zoloft and nortriptyline and another med. At this point, I was sent to a specialist. He changed my diagnosis to bipolar II even though I exhibited signs of bipolarity until I was on medication. He suggested different cocktails with lithium or Latuda. I refused. I made the stupid decision with my original psych to try Effexor one more time. Surprisingly, another break from it and it worked again. Not as well, but still got me up and going. I stayed on it for a year and weaned off this April this year. I was fine med-free for a couple months, then anxiety/depression reared it ugly head in July. Another foolish mistake I made was to go back on the Effexor from mid-July until September. I had to keep increasing the dose until it was clear my "go-to" drug was no longer an option. I began weaning off rather quickly by decreasing 37.5mg each week. I went to half of 37.5mg, then nothing. I have been completely off Effexor for the last 10 days. This is one of the longest bouts of depression/anxiety for me. It has been 4months. I have had to stop working (as I usually do when I am in this state). My job requires energy, positivity, focus. It is also a social job and depression/anxiety kinda make that impossible. It really is depressing that I have had so many relapses that it screws up my career. I wonder if I didn't go on meds in the first place if I would have relapsed. I had to wean off the drug while severely depressed/anxious. I think this has made the experience worse. I am experiencing bad insomnia, and what I think might be depersonalization (my senses seem altered, hard to describe - dream-like). I am also feeling like my mind is blank. Usually I have a nice flow of thoughts and can start conversation but it seems impossible now. It is very uncomfortable and I have isolated myself from friends. I also cannot find pleasure in ANYTHING. My concentration and memory are not very sharp. When I have weaned off in the past I do not remember it being this extremely awful. I have a few questions: Can the brain recover and balance itself? Is there anything I can do to move things along faster? Or is it probably best to explore other medical options? Should I get extensive bloodwork or an MRI done? Sorry this was such a long intro. I applaud you for reading this because it is not the most exciting story.
  6. After very careful tapering off, I have just completed 3 weeks without any Venlafaxine which I had been taking since 2005 In 2005, I had weaned myself off Seroxat but allowed myself to be bullied by my spouse (a sufferer from endogenous depression controlled by medication) and, at that time, work colleagues, into taking another anti-depressant. Happily retired for over 10 years, my spouse's depression under control and a general feeling of being over-drugged, I decided in April, in the spring, with the days lengthening, after discussion with my GP, gently to wean myself off the pills. I was hoping to do it all without having to own up to my spouse but my symptoms post stopping are quite severe and I cannot dissemble. So, while not announcing it from the rooftops or posting it on Facebook, I am telling my friends and family what I am up to to explain occasionally disconcerting behaviour. Unfortunately, both husband and sister have suggested what I am doing is not necessary though most friends I have told are most supportive. So here I am, weepy, upset stomach, off my food, aggressive being told by my nearest and dearest I'm depressed. i found this website and decided to get it off my chest. I know I am in for the long haul but I'm determined I'm not going to be dissuaded this time. I need to know what the real me is like now. Just need a pat on the head I suppose
  7. Hello all, My name is Chris, a 24 year old student currently living in the Netherlands. I started taking 37,5 mg of Efexor about 2,5 years ago, after being addicted to weed for about 5 years (I live in the Netherlands). I was suffering from heavy anxiety, making it impossible to function properly at school. The Efexor put me back on track and made me feel good again, up to the point where, about 4 months ago, i felt so good i did not think i needed the Efexor anymore. I discussed with my doctor about going off the medicine, after which he suggested that i first started taking efexor every other day. Right around the same time I started taking efexor every other day, me and my ex girlfriend were getting back together to give it another go. She said she supported me all the way on this, i felt good about it and after taking it every other day for about a month, i quit the efexor entirely. That's were it started to go wrong. due to the light withdrawal symptoms i was getting i was not able to give my (now ex girlfriend again) enough attention as i used to before (she really, really needs a lot of attention) and we had quite a couple of fights, resulting in her leaving me. But still, all in all, I felt like i could pull through and beat this thing on my own. Then, after about 2,5 months being entirely off the efexor I suddenly started feeling down again, did not have any will or energy at all to perform whatever tasks i needed to do.. the withdrawal symptoms had suddenly hit me with all its power. I went back to my doctor, and started taking methylphenidate to help me remain calm, as I also have been diagnosed with ADHD. This has helped a little, but i still don't feel anywhere near how i felt 6 months ago, when i was a social, fun guy with high confidence. Right now i'm having some relatively good days where i just get through my day without feeling large amounts of anxiety, but thats about it. My breathing is almost always way too heavy (im diagnosed with chronic hyperventilation) since quitting the antidepressants, i have bags under my eyes on a daily basis and sometimes i have chest pains. I dont even exactly know why i came here, or what my goal is by posting this, but it would just be nice to talk to people that understand what i'm going through right now. I sometimes think about just going back to the Efexor and start living the good life again, but wouldn't that be the easy way out?
  8. PLEASE READ THIS ENTIRE TOPIC BEFORE GOING OFF PRISTIQ. Pristiq comes in insufficient dosages to taper. Do not alternate doses of Pristiq to taper -- this will cause the levels of this medication in your brain to go up and down and is second only to cold-turkey in causing withdrawal symptoms. AND DON'T COLD-TURKEY EITHER!!!!!!!!! To reduce the risk of withdrawal symptoms and post-discontinuation prolonged withdrawal syndrome, as with other psychiatric drugs we recommend reducing Pristiq by 10% per month, calculated on the last dosage. (The amount of the reduction gets progressively smaller.) See Why taper by 10% of my dosage? The official prescribing information from the FDA contains this: However, Pristiq is difficult to taper "at a more gradual rate" as it comes in only 3 dosages: low, average and excessive -- and officially, the tablets cannot be split. PROTEST THIS DANGEROUS DRUG Phone Pfizer, Pristiq's manufacturer, to make a complaint: (800) 438-1985 in the US Pfizer has not provided any specific information on how to taper from a dosage of 25mg Pristiq, the lowest available dosage. They may suggest alternating dosages to taper Pristiq. Don't do this -- it's like playing ping-pong with your brain. File a complaint about the difficulty of tapering off Pristiq -- the range of dosages is inadequate. Also complain to the FDA 1-800-FDA-1088 Mon–Fri between 8:00 a.m. and 4:30 p.m. EST. Pristiq is Effexor's fancier sibling Pristiq is a drug made of Effexor's (venlafaxine) active metabolite, O-desvenlafaxine. Pristiq is to Effexor as Lexapro is to Celexa -- a tweaked and more powerful isomer molecule. In effect, Pristiq is concentrated Effexor. See http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=2464 According to Pfizer http://labeling.pfizer.com/showlabeling.aspx?id=497, Pristiq is available in extended-release tablets of 25mg, 50 mg, and 100 mg; the most common dosage is 50mg. Unlike Effexor, which is metabolized primarily by liver enzyme P450 CYP2D6, Pristiq is metabolized via conjugation and liver enzyme P450 CYP3A4. It attains peak plasma concentrations in about 7.5 hours. As a chemical, before it's put into an extended-release tablet, desvenlafaxine has a half-life of around 11 hours. Pristiq's extended-release formulation According to this paper, the extended-release formulation releases desvenlafaxine over 24 hours. The mean half-life of desvenlafaxine, without the extended-release formulation, is around 11 hours. The extended-release formulation is a monolithic matrix -- it's in the glue that holds the tablet together, not in the coating. I confirmed this in a phone conversation with Pfizer medical information (1-800-438-1985). (Thank you, oaklily, for this information about the matrix formulation.) Rather than a timed-release coating, the coating on the Pristiq tablet is only protective. The extended-release mechanism is part of the tablet matrix, or the glue that holds the tablet together. This is called a monolithic matrix tablet. If the tablet is split, the matrix is damaged and may not reliably be extended-release, depending on the size of the fragments. Larger fragments are more likely to retain some extended-release capability. When the tablet is CRUSHED, the matrix is completely destroyed. The particles should be assumed to have NO extended-release capability. A Pristiq fragment becomes desvenlafaxine, with an 11-hour half life. (Here is a description of the similar matrix formulation for quetiapine XR (Seroquel XR) .) OPTIONS FOR TAPERING PRISTIQ Since medicine knows nothing about tapering Pristiq, the following are all informal suggestions. Try any of them at your own risk. Please let us know how you do by posting in this topic. Cut up Pristiq tablets Despite the warnings not to cut it up, from reports on the Web, cutting up Pristiq tablets does seem to work for some but it makes others ill, possibly because of "dose dumping." According to Pubmed on Desvenlafaxine: "....The extended-release tablet does not dissolve in the stomach after swallowing. It slowly releases the medicine as it passes through your digestive system. You may notice the tablet coating in the stool...." The extended-release mechanism is part of the tablet matrix, or the glue that holds the tablet together. If the matrix is destroyed, the entire dose is released at once or "dumped," instead of being gradually released through the matrix formulation. Without the extended-release matrix, a Pristiq fragment becomes desvenlafaxine, with an 11-hour half life. To avoid "dose dumping" of the entire dose, you might take smaller divided doses of Pristiq, more than once a day, like immediate-release Effexor, to mimic an extended-release dose. Cut-up Pristiq seems to sometimes cause stomach upset, which may be reduced by taking it with food. Now that the 25mg tablet is available, cutting it into quarters gives you the option to taper by 6.25mg per step. If you are taking 100mg Pristiq or 50mg Pristiq, you may wish to request part of your prescription be written for 25mg tablets. (For insurance coverage of multiple dosages, your doctor most likely will have to specify taking Pristiq in "divided doses.") You may find you need a precise way to measure your tablet fragments. See Using a digital scale to measure doses As you get down to a low dose, you may wish to switch to Effexor to more precisely control dosage decreases, see below. Reducing from 100mg Pristiq to 50mg Pristiq Drug switches incur additional risk. Before trying a switch to Effexor or Prozac (fluoxetine) from 100mg Pristiq, it's probably wise to go down to 50mg Pristiq first, or 25mg if possible. Combining whole tablets, with their extended-release qualities, with tablet fragments probably makes "dose dumping" less likely or noticeable. You might use a 50mg tablet plus a 25mg tablet plus 3/4 of a 25mg tablet (18.75mg) to make the first reduction to 93.75mg 2nd reduction: a 50mg tablet plus a 25mg tablet plus 2/4 of a 25mg tablet (12.5mg) to go to 87.5mg 3rd reduction: a 50mg tablet plus a 25mg tablet plus 1/4 of a 25mg tablet (6.25mg) to go to 81.25mg 4th reduction: a 50mg tablet plus a 25mg tablet to go to 75mg 5th reduction: a 50mg tablet plus 3/4 of a 25mg tablet (18.75mg) to go to 68.75mg 6th reduction: a 50mg tablet plus 2/4 of a 25mg tablet (12.5mg) to go to 62.5mg 7th reduction: a 50mg tablet plus 1/4 of a 25mg tablet (6.25mg) to go to 56.25mg 8th reduction: a 50mg tablet If withdrawal symptoms occur, some people have found taking an additional fragment of a tablet can smooth the transition from one dosage to another. Another way to get from 100mg to 50mg or 25mg is to combine Pristiq tablets with a liquid made from immediate-release Effexor (see below). Once at 50mg or 25mg, stabilize for a month at least and consider your plan for the next stage of tapering. Use a combination of Pristiq tablets and Effexor liquid Pristiq cannot be made into a liquid, but its close relative immediate-release Effexor (not Effexor XR) can. You may be able to go off Pristiq by taking part of your dose in lower-dose tablets and part in liquid Effexor, gradually converting to all-liquid Effexor as you get to lower dosages. This may offer a convenient and gradual path off Pristiq. Only regular immediate-release Effexor can be made into a liquid (see Tips for tapering off Effexor (venlafaxine) ). As immediate-release Effexor has a short half-life and is usually dosed twice a day, you may wish to take the liquid portion of your dosage later in the day. For example, if you are taking 100mg Pristiq, you may wish to take your daily dose as one 50mg tablet and the rest later in the evening as a liquid made from immediate-release Effexor. You can titrate the liquid by 10% of your daily dosage to taper until you get to 50mg. Then you can take a 25mg Pristiq tablet with the rest in a liquid made from immediate-release Effexor. When you get to 25mg Pristiq, you might switch to splitting the tablet and taking the rest in Effexor liquid and so on until you are taking only liquid Effexor. To do this, you will have to request a prescription for Effexor tablets as well as Pristiq from your doctor. Have Pristiq made into smaller dosage capsules or a liquid by a compounding pharmacy Compounding pharmacies can crush the tablets and put the powder into smaller capsules by weight. Like cutting up tablets or crushing, this destroys the time-release quality, but the compounded method is much more exact. In your body, crushed Pristiq is similar to regular immediate-release Effexor, with an 11-hour half-life. You may wish to have your dose compounded to take twice a day. If you are taking 50mg Pristiq, for example, you would have 60 capsules compounded per month. Each capsule would be 1/2 of 45mg (a 10% reduction of 50mg) or 22.5mg. You would take two capsules per day, once in the morning, and once in the evening. The next month, you would have 60 capsules compounded, each capsule being 1/2 of 40.5mg (a 10% reduction of 45mg) or 20.25mg. And so forth, for each reduction. (According to my compounding pharmacy, they can put in a slow-release additive distributing absorption over 8-10 hours. This is not as long as the Pristiq time-release coating, but at least it's something. Check with your compounding pharmacy about this. See getting-custom-dosages-at-compounding-pharmacies-us-uk-and-elsewhere ) If this does not work, you may wish to switch to Effexor XR and use the bead-counting method. Regular Effexor probably wouldn't be an advantage over Pristiq compounded to custom dosages. One of our members had a desvenlafaxine liquid made by a compounding pharmacy. Most likely, this compounder used pure desvenlafaxine succinate powder to make this liquid, as desvenlafaxine tablets contain a glue that might resist being made into a liquid. But he may have a way to grind tablets up to make a suspension. A liquid would have to be immediate-release, with a half-life of around 11 hours. Generally, you'd take a drug with that short a half-life twice a day. Crush Pristiq tablets, weigh powder with a digital scale This is similar to cutting up tablets -- Pristiq is a "do not crush" medication, as it is a time-release drug. The Pristiq powder becomes desvenlafaxine, with an 11-hour half life. If you pulverize the tablet, you might take smaller divided doses of Pristiq, more than once a day, like immediate-release Effexor, to mimic an extended-release dose. In principle, this would be a more precise way of tapering than cutting up tablets: Crush the tablet Make sure the shell fragments are evenly distributed in the powder Weigh the powder for a dose with a digital scale Put the powder into an empty gelatin capsule to make it easier to ingest Peer discussion of this method starts here http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__27417 Switch to Effexor or Effexor XR Note: If you've had an adverse reaction to Effexor before, do NOT switch from Pristiq to Effexor. "Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of venlafaxine." Since the relationship is so close, switching to regular immediate-release Effexor tablets, which you can cut up or make into a liquid, this may be the best way to taper off Pristiq. Because it has a mean half-life of 5 hours, you'd have to take regular Effexor twice a day. Alternatively, you might substitute Effexor XR, which is released gradually like Pristiq and needs to be taken only once a day. You'd have the difficulty of tapering off Effexor or Effexor XR -- themselves notorious for withdrawal difficulties -- but at least you can do that gradually. See Tips for tapering off Effexor and Effexor XR (venlafaxine). According to FDA Prescribing Information for venlafaxine (Effexor), the usual dose of Effexor is 150mg per day. Since 150mg Effexor and 50mg Pristiq are both "normal" dosages of their respective drugs, they may be roughly equivalent. (See discussion of Effexor and Pristiq dosage equivalency starting http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__42249 ) The psychiatrist who writes the 1boringoldman.com blog reports success in switching one patient from Pristiq to Effexor, then tapering Effexor, here (see comments) Another psychiatrist said when he tried this, the switch from Pristiq to Effexor was "seamless." Dr. Stuart Shipko posts here: Advice from a psychiatric pharmacist I have been corresponding with a professor at a prominent US university pharmacy department. Here is his best guess at how to taper Pristiq (he does not want his name published): Then taper off fluoxetine (Prozac). See Tips for Tapering Prozac Advice from Dr. Stephen Stahl, author of the manual Essential Psychopharmacology In his widely read psychopharmacology manual, eminent psychopharmacologist Stephen Stahl advises titration by crushing the tablets and mixing in fruit juice, see http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__14799 According to our member oaklily, Stahl is wrong. Making a liquid from Pristiq does not work, see http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__24822 Dr. Stahl intends to correct his book, according to this correspondence 09/15-9/16/13 with him: "Bridging" with Prozac or another antidepressant Any drug change incurs additional risk. A switch to Prozac from Pristiq may not work -- they are very different drugs -- or you might have adverse reactions to Prozac. Prozac is regularly used to "bridge" off Effexor. Given that Pristiq is a sibling of Effexor and Effexor XR, it is possible that one can, similarly, use Prozac to withdraw from Pristiq. Attributed to Joseph Glenmullen, the "bridging" technique is described by a doctor here http://www.bipolarworld.net/Phelps/ph_2005/ph1354.htm Read this entire topic before attempting a switch to Prozac: The Prozac switch or "bridging" with Prozac Later, taper off Prozac. At least Prozac comes in a liquid. To do this, consult a doctor knowledgeable about this technique.
  9. Hi I am new to this forum and this is my first post . I am currently on 30mg mirtazapine and 200mg of pregablin , I have been on these mess for about 3 to 4 months . I have just cut my mirtazapine from 30mg to 15mg and in the space of 4 days I have have horrible side effects , anxiety through the roof , shaking , lack of appetite poor sleep crying spells and the general feeling of feeling crap . The reason I have started to withdraw from the mirtazapine is that after 3 months I feel no benefit only get awfull side effects . No help with my anxiety and depression if anything it's made me more depressed . I have gone through withdrawing from Effexor and that was really tough , however just the drop for a few days of the mirtazapine has left me crushed , my doctor told me that mirtazapine was a easy drug to withdraw from , but after 4 days it has left me house bound . Has anyone got any idea on how I get through this or any experience in mirtazapine withdrawals
  10. Ok My name's Adam. I'm 48. I suffer with A&D. I was on 40mg Citalopram for about 8 years. My psychiatrist moved me on to Effexor about 10 weeks ago. The drug hasn't agreed with me, and I'm n the process of tapering off. I was initially on 75mg immediate release (sold tablet), and was taking one a day (people have said this should have been a split dose. Anyway, that's in the past. My tapering history is that I've been taking 3/4 of a tablet - about 58 mg for the last 4 weeks. I think my depression has worsened over last 2 weeks, BUT that may be attributable to life's circumstances.(divorce). My questions are: 1. Am I withdrawing from Effexor, or perhaps SSRI's in general? i.e. Is this really a Citalopram withdrawal considering I've only been on Effexor for a very short time. 2. How slowly should I taper off Effexor, and in what increments? 3. Do I need to split my dose and take twice a day? At present I'm taking the 58mg in one dose Answers to the above and any other advice appreciated. Thanks Adam
  11. Hello, I'm new to this forum and I'm working toward tapering off of 225 mg of venlafaxine. I am a 70 year old male, that has been very active and health conscious. My weakness has been depression. I previously had two periods of feeling depressed that involved obtaining an antidepressant from my general practice doctor. I would get to the point of feeling spacey and or lethargic, then do talk therapy to get back off of the drug. These where phase one antidepressants, and I would taper off slow over say 4 to 6 months without noticeable side effects. These events occurred between 2005 to 2008 per notes I still have. I retired from Highway Engineering March 1, 2014. Many emotional events piled upon me during the next five months. The stressors where; retiring and adjustment period, daughter coming home to live with us and get a divorce, a vicious son in law (being divorced), one or two other more minor stressors that I do not recall, and a huge spiritual crisis in which I felt I had not lived as graciously as God would have wanted me to. In July 2014 I became fixated on thinking about all these things. I sat in a stupor for days, lost 15 pounds, thought the devil was speaking and accusing me of my wrongs and tempted me to deny God and just die. My wife asked me If I had thought of suicide and I admitted that I had. She called 911 and got help. They took me to a hospital and put me on suicide watch till they could transfer me to a psych ward for treatment. I was confined for a week and given many medications. I also had a physical problem that they dealt with. I was released to an out-patient psychiatrist. The psychiatrist told me he would take me off all the previous medications except for increasing my dose of venlafaxine to 225 mg. I have been on venlafaxine for four (4) years. In May 2018 I stopped drinking all alcohol and also stopped experimenting with legalized cannabis. I quickly felt a bit more energy. I put this energy toward searching the internet for information about venlafaxine and antidepressants. I have learned much, but still want to keep learning. My Psychiatris agreed to allow me to get off Venlafaxine October 4, 2017, after telling him repeatedly about my desire to and why. He reduced my venlafaxine from 225 mg to 150 mg. The short of it is that I did not make it, and went back to the full dose. After learning more about how to decrease slowly, I am ready to try again. I have sought the help of my general practice doctor, who is supportive and has reduced me to 187.5 mg. Since I know that a 10% reduction is better, I cut open a 37.5 mg capsule, counted the beads, and took 40% of those beads, 15, and added them to the 187.5 mg, for a new total of 202.5 mg. I'm also taking daily notes of my physical and mental state, and dosage. I will see my general practice doctor monthly. I will be also talking to my Psychiatrist about my plans. I plan to start talk therapy also. Does anyone have any advise or comments?
  12. Hi to all users, Its been 3 full months after my last dose of Venlafaxine. In 2018 I've been on 10mg of Escitalopram for five months then switched on Venlafaxine for another six months. I started Venlafaxin with 37mg and came up to 150mg per day XR. On January 2019 wanted to get rid of the drug since i feel that not needed anymore. Jumped from 150mg-0mg in one month (I know it was too fast, but those days i felt very good and confident, hence rapidly tapering the dosage). The first month of withdrawal, I had severe psychical symptoms, like tiredness, headache, heart racing, anxiety. After these symptoms somehow subside, starting from the month 2 till today (now I am at 3 full months after my last Venlafaxine dose) I have constant headache (don' know how to describe, its not a regular headache, but something like head/nervous system tension) and decent anxiety. My waves and windows are very recognizable, since I have periods when I feel very anxious, depressive, sensitive to sounds, feel nausea etc. and there are days when I feel better (not by much but noticeably more relaxed, with more emotions and not so severe headache/tension). Want to hear from other users who pass through these similar symptoms with constant headache and anxiety which persist of days and weeks now, if some supplements can make the situation more manageable. Hope the day when we heal will come soon... Thanks
  13. Have been off venlafaxine since November 2017 ( after 16 years) ; went on trazodone and Reboxetine until Nov 2018 and have been drug free since. However really struggling recently despite taking omega 3 / CBD / exercises etc. Problems include fatigue, very low mood, anxiety, no interest in what’s happening around me, can be upset by the most minor event etc. Tempted to try some other drug that may help as I am finding it really hard. How long do the withdrawal effects last and is there hope in persevering?
  14. I have been on meds since I was around 18, I am now 33, I have been tapering off all my meds for the last year now, I have managed to get off venlafaxine xr 75mg which I tapered off for around 4 - 6 months, and quetiapine 50mg over the last 12 months, I was on 200mg at one point and also tapered off diazapam 10mg, and also propranolol 10mg, I have been off all meds now for nearly 3 months and have been fine, I have been at the gym most days and eating healthy, I was starting to look good again and becoming myself again, I have not been human while on meds for the last lots of years, I was finally starting to enjoy life and then the last few weeks my sleep has been getting very fractured and I have been waking up very early with extreme brain fog, it feels like my head is going to explode sometimes, now the last 2 nights I have not slept at all and feel like death, I even took 2 melatonin tablets and they did nothing, what on earth is going on? I am worried I have done some serious damage to my brain, I am too worried to go and get checked at the doctors as I could not handle news that I have some brain disease, I have read that meds can cause effects many months after, can anyone give any advice/peace of mind?
  15. I have been on citalopram since 2009 then it stopped working. The Dr put me on citalopram and mirtazapine combination which worked for a while then that stopped working. The Dr then put me on mirtazapine and Venlafaxine 150mg XL combination which workes for a while again ans then stopped working. The Dr put me on amitriptyline 50mg saying thay would be the best drug for me while i took 8 months to slowly remove each bead from Venlafaxine capsule to come off it. As soon as I took my last beed i went into crazy angry depression. The dr increased my dosage of amitriptyline from 50mg to 150mg but the side effects were horrible and at this point i got sick of these meds and decided to quit CT. I had horrible withdrawal symptoms and i started acting like a child and not being able to walk, had balance problems. I reinstated back to 50mg amitriptyline since april 2018 and i have been getting worse. I cannot sleep. My vision is so badly affected that i have grainy vision and floaters have increased dramatically . I see after images and it's as if the lights have been turned off. When i begin to fall asleep, i start to have dreams before i actually fall asleep and my brain keep. Waking up just before i am about to sleep. I cannot follow conversations, I mishear things all the time. I am totally dependant on others and i feel people think i have gone crazy. I don't know what to do i am getting worse and worse. I often trip, lose my balance. I hardly have any short term memory and cannot do simplest of things. I cannot even watch anything on TV as i cannot follow.it I'm having major concentration problems. I don't know how. I'm writing this. I cannot work or drive. Please you have no idea how i am putting these sentences together. I need urgent help. Please advice. I have no energy, no appetite. If I'm posting this in the wrong place, please accept my appology as I can hardly read and understand things. P
  16. magnesi

    Achilles tendon pain

    Hello, My Achilles tendon of the left leg hurts a lot (the one of the right leg only a little). I've been trying to avoid impact, warm up well before exercising and apply heat (cold worsens the situation), but the pain is getting worse. I can not even walk without limping! I'm almost reaching 50% of my initial dose of 150mg venlafaxine (Effexor) and somewhere around the 40% I started having muscle and joint pain. During my withdrawal from benzodiazepine last year, this type of pain was my main problem. At one point I became bedridden. Will it be the same with the antidepressant? I'm very scared! In particular, I don't know what to do in relation to my Achilles tendon pain. Should I see a doctor? I am sure he/she will prescribe a bunch of medication, muscle relaxants, etc. that I do not want and can not take, and perhaps some useless and time consuming physical therapy. Has anyone had this kind of problem? What did you do? Thank you for your ideas!
  17. New here, so will hope to fill in fuller history later. I am 71 and have had depression to varying degrees 1977 to date. Managed to work full time 1964-2001, though. 12 years on irregular shift pattern 1964-1977. Last month, went to new younger GP who arranged blood tests, (after I had given him my list of ill-health symptoms!) Blood, mostly OK, but indicated low folic acid, he said. I am on 5mg daily folic acid tab for last 5 weeks. I do feel better (carrying out lots of small projects in my retirement). Had so many ups and downs in last 40 years, though, that I think this may be a placebo effect. However, a more positive side of me thinks I may be on the way to breaking through the wall where "the drugs don't work anymore" at 225mg Venlafaxine slow release. I have been on Losec (Omeprazole 10mg) for decades, too. I read that it can spoil your absorption of certain vital items in the vitamin B family, at least? Thanks for reading, all.
  18. Been on venlafaxine XR for 7 or 8 years. My ex wife recommended I get on it to control some minor anxiety and to help me control my temper. It worked wonders for her, so why not me too. I went to my PCP and asked him if it would help, he said yes and prescribed 75mg. About 1 or 2 years ago I went from 75mg to 37.5 mg. Didn't have to taper or anything and had no withdrawal symptoms. I am in a point in my life where I now believe I no longer need this medication. My PCP said I could just stop taking it since I was on the lowest dose. Well, I knew that wasn't going to work since I had 1 week a while ago where I didn't take it, basically because I just forgot to, and had HORRIBLE withdrawal symptoms. So I started going what I do best, googling, and I found this site. So I decided to figure out a way to wean off of it slowly and keep my dr in the loop, just in case. Originally I emptied the beads out of 7 capsules, 1 at a time and counted them. They were between 93 and 106 beads in each capsule. So I decided to drop down to 90 beads for 3 weeks. Then I would try reducing by 5 beads per pill for a bit and if I handle that well, then I could try 10. Once I got down to 20 beads or so, I figured I'd just start removing 1 or 2 beads since the percentage of beads is much higher with that low of a total. But then yesterday I came across this. http://survivingantidepressants.org/topic/12797-effexor-capsules-vary-in-bead-count-and-weight/ and this http://survivingantidepressants.org/topic/1596-using-a-digital-scale-to-measure-doses/ Is this microtapering only for people who are super sensitive to drops? More importantly am I ******* up my brain by doing a certain number of beads rather then by weight? Since apparently 90 beads can be a different mg dosage of drug in each capsule since the pills are filled by weight and not number of beads. If I need to weigh every capsule, I'm fine with that, as I'll do whatever it take to get off this drug. Thanks.
  19. 1968creative

    1968creative: Tapering advice needed

    I’ve been on many different A/D’s for over 20 years. Currently on 150mg/Venlafaxine XR for the last 2 years. I’ve also been on benzo’s for the same amount of time. (Mainly Valium). I’d like to come off the Venlafaxine first, but have a couple of questions. 1. What is the recommended taper regime? 2. Accepting we’re all different, what can I expect by way of withdrawal reduction symptoms? My anxiety is already Sky-high, and my mood is not good. 3. Bit of a controversial question... but is it reasonable to say/think that possibly the people in this group are the ‘unlucky’ one’s? And for the purpose of explaining what I mean... Is it possible that 90% do it without serious bother, and this group is for those understandably struggling? I don’t know. The only reason I ask is that whilst it’s acknowledged as one of the harder A/D’s to come off, some people can’t praise it enough, and others are going through hell, often having to reinstate. 4. I don’t know whom to turn to re. Supporting my withdrawal, as the general consensus amongst psychiatrists is that you can come off in say 5 weeks or so, and at the other end of the spectrum, you’ve got people saying take one bead out a week etc. 5. Finally... I’ve heard about something called the Prozac bridge. Has anyone tried this? In summary, I’m scared! Thanks Adam
  20. My introductory post. I have a sleep disorder associated with Fibromyalgia. Fibro also is associated with anxiety and depression and inability to relax the muscles. So, Venlafaxine has been a real help for me to live a normal life for 20 years. But I'm 68 and want to get off. Today is the 6th day following a failed tapering, my second. My first tapering was a year ago. I have a terrible sleep disturbance: I have a panic attack while falling asleep. My husband is helping me find a better psychiatrist, one who is experienced with both a sleep disorder and tapering. But this time around as I tried to fall asleep a loud buzzing sound and vibrating sensation occurred inside my right nasal passage. As I type this I am aware it sounds unbelievable. It's so embarrassing. "Doctor, I have a bee in my nose." Well, I googled "my own snoring wakes me up" and found Sleep-Doctor http://sleep-doctor.com/blog/does-your-own-snoring-wake-you-up-from-sleep/ . Anyone have a similar weird sleep disorder? I bet it was due to tapering - some kind of neurological trauma. I'm exhausted. Last night I finally slept through the night.
  21. Hi Everyone, I found this forum through the recent New Yorker article and have already found it very helpful. Here's a brief version of my story... I was put on Effexor XR at the age of 15 to treat severe anxiety (I was given a diagnosis of Generalized Anxiety Disorder). At the time I was dealing with teenage hormones and a suicide in the immediate family and having regular panic attacks. As I got closer to 30 I decided I wanted to know what life was like without them, and wondered if being put on them at such a young age had impacted my emotional development. I felt like I had reached a point of relative stability in my life (stopped drinking, good support system). Going off Effexor ended up being a disaster - in hindsight it seems like it was a very fast taper and I reached the point of not being able to get out of bed in the morning due to anxiety. I found a new psychiatrist who put me on Lexapro and Xanax (not every day, to take as needed). I felt very good on Lexapro but I gained about 50 lbs in one year. She then added Wellbutrin into the mix, which didn't make me feel as good. I felt very agitated and had a hard time concentrating. At this time my psychiatrist was fixated on my weight and wanted to increase my Wellbutrin while going down on the Lexapro. We'd have arguments about it where I tried to explain how bad the Wellbutrin made me feel, despite the weight loss benefit. Eventually we parted ways and I am now trying to taper off everything for the first time in my adult life with another psychiatrist. I'm currently 4 weeks off Lexapro and on 100 mg of Wellbutrin. I am in therapy weekly in addition to seeing my psychiatrist monthly. I started taking fish oil after reading this site and am trying to integrate some dietary changes in addition to my regular yoga/meditation practice. I struggle with feeling a lack of agency over my own life and feeling helpless. The constant focus on and discussion of my weight over the past few years has also not been great. On my bad days I have feelings of hopelessness and despair and occasional depersonalization. I don't have an expectation that I will feel great all of the time, I just want to feel some level of control over my mental and emotional state. Reading this site helps me because I feel like I am not alone. You guys have already helped me so I want to say thank you and I hope I can learn more - the concept of windows and waves is really useful. Today is a window which is why I'm able to write this - I've had two good days and that feels really encouraging. In the meantime if there are any suggestions for additional supplements or lifestyle changes I'm all ears!
  22. Hi. I was on Venlafaxine for 4 weeks - 2 weeks at 37.5mg and 2 weeks at 75mg but I had a bad reaction to it so my doctor changed me to 29mg of Fluoxetine. I had to take 37.5 of Venlafaxine with the Fluoxetine for a week and then stoo the Venlafaxine. I have been on just the 20mg of Fluoxetine for 2 weeks and feel awful! I am sweating, shaky, nauseous and anxious. Is this the withdrawals from Venlafaxine or side effects of Fluoxetine please? Would appreciate some advice and how to deal with it. Thanks.
  23. Hi everybody! I am Julz, a 33 year-old female - polydrugged to my eye-balls Ten years ago, I fell into anorexia and depression, soon unveiling terrible anxiety. I was referred to a psychiatrist (in France) who prescribed me medication and also gave me psychotherapy. Regarding the medication, different combinations and doses where tried and I eventually found myself on a prescription which seemed to suit my troubled mind (Escitalopram, venlafaxine, clonazepam and diazepam) - did it ever do anything? I still haven't got a clue. I trusted this doctor. This is my initial prescription: Escitalopram: 20mg 20mg 20mg - (yes, that is 60mg...!!!) Venlafaxine(MR): - - 75mg - Clonazepam: - 2mg - 2mg Diazepam: - - - 10mg Time passed and psychologically, a lot changed. I moved away from where I used to live, totally changed my environment, and went for a fresh start. But I was still taking my medication as prescribed. My General Practitioner (in charge of my prescription in my new environment) convinced me to lower the Escitalopram (on the grounds that it was "bad for my heart") and I managed, between 2011 and 2013, to come from 60mg/day to 15mg. How? By jumping 5mg at a time every now and again. I had no idea... again, I more or less trusted this doctor who was willing to prescribe me the drugs I was clearly physically dependent on. The withdrawals I experienced were uneventful. I did feel something was happening but within a few days, I always felt the same as before the drop. Between 2010 and 2014, a LOT had changed as I finally got an MSc BUT I had fallen into terrible exhaustion and had no life. How did I get my degree? A struggle every day. I then began to question this cocktail of drugs, I'd been on them for 10 years and was still taking them as prescribed because I was physically dependent. That was clear enough! It then hit me: my meds were probably incapacitating me rather than providing any help! The realisation came as in January 2013, after I managed to lower my Escitalopram intake from 20 to 15mg/day in a single 5mg step (...), I began to feel even more tired during the day, exhausted - I simply had to nap every single day. After some personal research, I went to my GP and told him I didn't believe in keeping our focus on the Escitalopram because it seemed that the more I decreased it, the more sleepy I'd get during the day, considering my benzo intake (at that point, I was taking 3 hours' naps), and I could not live like that! Fortunately, before I was able to drop a pill here and there as instructed by my GP, I found the BenzoBuddy website and managed to find a taper method to gradually come off clonazepam. From December 2014 to July 2015, I came from 4mg to 2mg and am now below 1.9mg and still tapering off successfully. I decided to join Surviving Antidepressants as I want off ALL any medication which alters who I am. I believe in other ways to manage my weaknesses - I am not ill, I have a tendency to be anxious and this is not new, I was an anxious child but I had emotions too. I'd like my emotions and my whole life back... I realise I know NOTHING about anti-depressants, I surely did not know about Escitalopram's potency and am still in shock from the news. My initial plans (supported by a psychiatrist I saw in February 2015) were to come off clonazepam (bz), then diazepam (bz), then Escitalopram, then Venlafaxine. In the light of what I read on this wonderful site, I wonder whether I should stay of Valium (diazepam) while at least tapering off Escitalopram, when I am done with clonazepam... I realise I need knowledge myself because sadly, doctors haven't been helpful at all... so far... Thanks for welcoming me on your wonderful Forum! Julz xxx
  24. Hi guys, So here I am after being off antids for about 6 months, having tapered too quickly and suffering the consequences. I was latterly taking Citalopram 30mg, Lamotrigine 150mg and Venlafaxine 75mg. Summer 2015 I was officially diagnosed with major depression, which had obviously been there for a long, long time but had at that time got particularly bad. This was due to psychological issues, alcohol and drug abuse but wouldn't shift despite years of work fixing these. Now I know the long term citalopram use was probably making the depression worse. Around that time I saw 4 different psychologists and got 4 different opinions on how to recover/which meds to take. This of course was a ridiculous situation so I took matters into my own hands, taking what I thought was the 'best' advice and integrating it with my own research and experience . Following the 'advice' of one of the psychiatrists I added 75mg of Venlafaxine to the Citalopram and Lamotrgine. At the same time I'd heard about l-methylfolate so gradually ramped up to 15mg daily with b-6 and b-12. I know starting 2 things at once is not advisable but I was desperate and could hardly function. Within a couple of weeks something kicked the worst of the depression into touch which was a massive relief. After a couple of months on the 3 med cocktail the side effects were really starting to get to me so it was time to get off this stuff. Yes, I know, I did it all too quickly which is why I am where I am now....I should have listened more closely to the advice here :-) Hoping for a little advice and encouragement about my nervous system which in the last 3 months or so has got worse even though I stopped all meds 6 months ago. The lamotrigine taper had me shouting angrily at my wife a number of times - the intensity of the rage was incredible but passed quite quickly. She was very brave to be able to get through that! Citalopram taper was surprisingly easy. The final stages of the Venlafaxine withdrawl was tricky. I was down to 1 bead and if I didn't take it within a few hours I'd get head zaps, restless legs etc. At some point I had to stop so I did and put with these symptoms for a week or so. After all this I was however very fatigued which has improved to an acceptable level over the last 3 months. The fatigue was probably also due to recovering from the major depression. Right now I have anxiety issues, very easily stressed/snappy, can't sleep more than 5 hours a night and impossible to catch up with sleep during daytime as on the verge of dropping off I wake with intense terror/fear. Often trouble breathing properly, tight stomach and I am very sensitive to noise, light and touch. I also have panic attacks when the stress is high in my life. These have been occurring for a long time though and haven't really changed with changes in meds. Having done years of therapy and some bodywork I know that these are physical symptoms and I have quite a healthy psychological make up. I also do a lot of things to look after my physical and mental health which I won't go into here. On the plus side, I don't have the general low mood caused by taking Citalopram for years, blurred vision, muscle tightness, sexual problems, cognition and memory problems, sense of not being fully present + other well known side effects from these meds. I am having thoughts about re-introducing a very small amount of Citalopram or Venlafaxine - not sure which one of these is causing the nervous system issues - probably both. I'm aware that the likelihood of this helping after 6 months is low, but I'm willing to try to alleviate symptoms. Advice on this is very welcome! As my name suggests, I do finally feel alive after 16 years on these meds - something about taking them was just not 'right'. Even though I'm suffering right now I'd rather be here. I hope this gives some encouragement to others and also serves as a warning about what happens when you taper too quickly! Thanks to mods and users alike for this wonderful resource. Cheers
  25. Hello everyone! I am 26 years old. I tapered off 150 mg XR a little to quickly. I was on it for about two years. I was off completely for about a month. But the anxiety kept getting worse. The pressure in the top of my chest and bottom of throat. It's hard to describe. Also it was hard for me to speak. I was extremely irritable and edgy! I felt dead and wanted to die. The withdrawal just made me feel this way. I took 25 mg IR yesterday. This morning I took 25 mg. This afternoon i will take the second dose of 25. How long do you guise separate your doses of IR? I am also going to do the 10% deduction of the current amount. I am doing the math, this is going to take a very long time! But that's ok, my fault for taking it. When i get this low is it best to make it into liquid form? I watched the video and I understand. in 4 weeks my next dose will be 22.5 mg.
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