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  1. Hi! Was hoping someone would be able to give me any advice as I’ve been going through withdrawals for weeks now. I was put onto Citalopram 10mg in October 2019 for mild anxiety, I had no symptoms of depression. I was doing fine on this and felt good. I stayed on this until June 2020 when my anxiety got a bit worse and I upped to 20mg. Within a few days my anxiety had gotten worse, my mood was much lower and I then began to have suicidal thoughts. My doctor changed me to Venlafaxine 37.5mg even though I didn’t want swap to another drug, but trusted their advice! After a couple of weeks I decided I really just wanted to go back to Citalopram 10mg as this had worked for me before and for some reason when I began taking Venlafaxine I began to have very repetitive thoughts that I didn’t seem to be able to control. After starting Citalopram again, within a week the exact same thing happened as before- my anxiety was a lot worse, my mood was worse, I began having suicidal thoughts. All of these drug changes happened within about a month. A different doctor told me to stop taking Citalopram cold turkey, saying that I needed to be off it completely. I just went with what she’d said as I didn’t know what else to do, this was on 20th July (6 weeks ago). She said absolutely nothing about withdrawal symptoms. Within a few days I really started to feel very very down, my anxiety worse, I started to not feel motivated to do anything, not myself at all, nauseous, more tired and then began having repetitive and intrusive thoughts about self harm and suicide. A couple of weeks back I had a few days of feeling quite happy, but after this it was like my symptoms got worse, the obsessive thoughts got a lot worse and are still there now (though have now improved from that they were). My other symptoms are still there, though sometimes I feel them getting a bit better, but then find them getting worse. Just wondered if anyone had any advice. I’m guessing obsessive/repetitive thoughts are due to stopping the medication as they happened not long after but part of me worries I’m paranoid or something and it’s not a symptom of withdrawal?
  2. Caspur

    Caspur: history

    I have been taking Venlafaxine at 75mg per day for about 6 years. The side effects were becoming too annoying to contiune - mainly flat, blunt unemotional mood, drowsineess during the day (i would fall asleep at my desk whilst working (at home)) and frequent urination, especially at night, which interrupted sleep too much. I have successfully tappered off venlafaxine once before after about 10 months treatment. I did it over 9 months without any issues. Buoyed by that success, i thought i could do it again and embarked on a taper using broken pills and liquid preparations prescribed by my doctor on the UK NHS. I only took 4 months this time which wasnt that sensible , as i now know. The taper ended 5 weeks ago today (24/11/17). Since then i have experienced many and varied discontinuation symptoms both physical and emotional: - physical - nausea, diarrhea, flatulence, dizziness and swimmy feeling in the head; mild visual disturbances; mild but constant headache; mild tingling sensation in the face - emotional - depression, anxiety like i've never experiened before for no aparent reason, irritability, poor concentration; mood swings over a very short time period for no apparent reason etc The semotional symptoms come and go. I will have one or two good days followed by 2-4 days of feeling depresed, anxious, etc On the up side i do feel like im experiencing real emotions like i havent felt for year I have mananegd to control some of the symptoms with supplements such as tryptophan. i also take fish oil, B vits, vitamin C and D I exercise a lot - run 5-6 km per day and try very hard to eat well; lots of fruit and vegetables etc Any suggestions for help would be gratefully received!
  3. Hi. About 5 years ago I was prescribed Effexor 75mg for mild GAD. It seemed to work ok, but I was never really that bad to begin with. To make a long story (sort of) short, in July of 2010, I quit the effexor cold turkey. Shortly after I began having panic attacks which I now know was from withdrawals, and also head zaps. These seemed to of disappeared in August 2010. Then in September of 2010, I had a hair transplant. Minor surgery, but was given large doses of Keflex, and had local anasthesia injected that contained adrenaline to prevent excess bleeding. This made my heart race, but its a normal side effect. This is a second procedure that I had with the first being 2 years before this one. 2 days after the procedure, I was sitting at home and all of a sudden starting feeling a feeling I never in my life had before. I Although I had panic attacks from the Effexor withdrawals, these feelings were different. They felt like feeling of doom, dread, and all thoughts good or bad seemed to be amplified by 100 fold. I would be breaking out in sweats, then alternate with being freezing cold. My neck was streaked with a flushed red color, my eyelid constantly twitched, and my appetite disappeared. I lost about 25lbs in a few weeks. My mouth was constantly dry, and although I have perfect eyesight, it looked as if I was looking through a sheer veil. I would usually wake in the morning being ok, yet within a few minutes begin the cycle all over again. At work to subconciously run from the feeling, I would constantly be moving; I would walk around the block, move about the building all day, and avoid the lunchroom so I didnt have to sit in one place. I went to a psyciatrist for the first time, and he didnt act as though anything was odd. He tried to prescribe me ssris and xanax. I refused it and started going to a holistic therapist which was useless. At this point it was December of 2010. I caved in and saw another psyciatrist who prescribed me Effexor 75mg. I took this for about 3 1/2 months while seeing a psycologist who diagnosed my with anxiety NOS, and still had no relief. Then come April 2011, and I started to sporatically feel better. Not great, but I did notice improvement. My appetite returned, and I began regaining the weight I had lost, and began enjoying things once again. In June of 2011, I discontinued the psycologist, who said that it couldnt of been the Effexor giving relief since I would of seen improvement much earlier than 3 1/2 months. As the summer months of went on, I continued to improve, with many small bouts of "spells"; some larger than others. Now its Oct/Nov/Dec 2011. There are times where the feelings were completely gone for days, sometimes for weeks at a time. Christmas came and went, then the day before news years eve came and I regressed back to the way I felt many months ago. I seems like all my recovery has been thrown out the window. Thank you for reading this, as this has been a very long post. Any insights on what this can be? And what do you think has happened? I would like to add that im still on the Effexor, and am not taking any other meds or have ever done so.
  4. Hey everyone, This has been the most informative and useful website I have found thus far, so I was inclined to register. Kudos to the site Administrator and moderators for their hard work and time spent helping others while we collectively try to get through this nightmare. I have been on 150mg of Effexor XR for about 7 years now, for anxiety. I am 28 years old and I would like to be fully weaned off by the time I am 30. I want children in a few years, and I refuse to have this poison in my body during pregnancy. This is the only anti-depressant I have ever been on, originally on a 75mg dose but that stopped working after a month and my dose was increased to the 150mg. I really don't feel like he drug has done anything to help me since then. It's been a series of ups and downs which I'm sure many can relate. I began my taper just over a week ago. It's been a bit of a rough start, due to my own tardiness and ignorance, moving from Canada to the US. When I had my prescription filled here in the US for the first time, they gave me the generic brand Teva Venlafaxine. I did not foresee any issues, but it caused me panic attacks almost immediately. A permanent dizziness, headache, and heartburn, plus I was very irritable. After a week of that, and realizing the side effects weren't getting any better, I had my pharmacy order the brand name Effexor XR for me and they did so without hesitation or a Dr's note. I want to make a suggestion to those who do not have insurance. You can get a free discount card from the manufacturer (Pfizer) and get it for $30/month at participating pharmacies. I was very nervous they wouldn't accept the card. It seemed to good to be true but I can confirm, it worked for me and I purchased my months prescription for just $30 instead of the $350+ full price. You can get your discount card here: https://www.effexorxr.com/choice-card Anyways, I made a silly mistake when I received my first generic prescription. I was ready to start my taper and take some of the beads out. There were exactly 150 beads in each capsule, I started by removing 5. There were no withdrawal symptoms other than drowsiness, but the side effects I described above meant I couldn't stay on the generic brand. Since moving back to the brand name stuff, I notice there are way more beads, I stopped counting at 200 when I realized I wasn't even half way through them. Plus the beads are all different sizes. I got a really good jewelers scale from Amazon.com for just $20 which I would like to use for the remainder of my taper. I calculated 3.3% was the reduction I made by taking 5 beads out of the generic capsule. An unfortunate number to work with, since I am no good with math and neither is my partner. But I would like to maintain that 3.3% for at least a week and then bump it up to either 5 or 10% and stabilize there for a month as Admin suggests. My only concern stems from the fact that the brand name pill has an inconsistent weight, and number of beads. The number of beads don't really matter to me since I am doing it by weight anyways... but the weights vary slightly. Should I do my % calculation based on the average pill weight? Or should I be removing the beads based on the weight of each individual capsule? This is pretty much the only area where I am stumped right now. Last night I based it on that pills weight... and I don't know what to do tonight. From what I've read here it looks like I should just go by the average weight? http://survivingantidepressants.org/index.php?/topic/272-tips-for-tapering-off-effexor-and-effexor-xr-venlafaxine/ Any suggestions or advice is appreciated. I've no major withdrawal as of right now... just drowsiness. A bit of heartburn on and off and Tums do help with that. But when I focus too much on the heartburn, I begin to think I'm having a heart-attack and this causes me to (almost) panic! And frightens me when I am trying to sleep. Has this medication/withdrawal been known to cause any major heart problems? Or am I just being silly by worrying about a little bit of heartburn. Thank you in advance and I am very happy to be here.
  5. Hi all,[/size] My name is Lisa, I am a 30 year old female and I believe I've experienced protracted withdrawal. I plan on starting to taper off Effexor XR in July. Here is some of my history: [/size] Starting in 2005, I began taking Lexapro after my father got cancer and passed away 4 months later as I started having panic attacks. I am not sure when I went off Lexapro, but I know I was put on Celexa for a while as Lexapro stopped working and I have now been on Effexor XR for 6 years. In the past, when I go off an SSRI/SNRI, I end up going back on after some time because my panic attacks come back. After 6 months of therapy, I went off Effexor XR in March 2014 with a week of a half dose (37.5 mg) and then completely off, by the advice of a psychiatrist. Actually, the book she referred to recommended 2 days of a half dose and then completely off, but she extended it.[/size] Withdrawal was horrendous. Insomnia, nausea, diarrhea, dizzy, not able to concentrate, felt just SO out of it. Finally it was over in a week or so. But in late May 2015 (3 months later, thinking it was all out of my system and I was good), I had just gotten home from vacation and was about to get into the shower when BAM, I was suddenly so dizzy that I couldn't tell which way was up or down. This remained for 3 months day in and out and after a ton of tests (took meclizine (anti-dizziness pill) which did nothing, ENT looked at my sinuses/ears which were clear, inner ear tests which were normal, brain MRI which was normal), until I went back on Effexor XR in August 2014 by recommendation of a neurologist who said it was my anxiety coming back. During what I'm thinking was protracted withdrawal, I was dizzy constantly. I'd wake up from a deep sleep completely dizzy, it did not go away. I also had excruciating headaches at night and could barely sleep 2-3 hours a night because of this (I NEVER get headaches). I was also severely exhausted because of the dizziness - everything was harder, and the low amounts of sleep due to headaches. I did not understand because other than being upset of my state of being constantly dizzy, I really was not anxious. I was meditating, exercising (as much as I could - it was a feat with being dizzy), nothing significant going on in my life. I had also been going to therapy and made huge strides.. I still continue to go to therapy weekly and it's been about a year and a half now. I was so confused as to how this could be anxiety. Now I'm reading this site and I'm learning this was probably protracted withdrawal. After I started taking the Effexor XR again, within 2 weeks I felt totally better. Now that I have been back on Effexor XR since August 2014, and after learning what I've read on this site, I want to start a slow taper in July after my next vacation. My therapist believes I am ready and now I know I am after having a great suspicion that those symptoms were not due to my anxiety. I have read the advice boards and will be doing the 10% per month taper. I also will be going to the recommended doctor in Farmington, MI and have an appt with him at the end of this month.[/size] Has anyone else experienced the protracted withdrawal symptoms that I had? Any other advice or tips that you can share? I will be coming here often and hoping to make friends [/size] Thanks![/size]
  6. Hello Nice to meet you all! I'm here for two reasons. 1) I've been on Venlafaxine 150 mg for 1.5 years and I want to taper it safely but still didn't figure out the best way to do it. Every time I forget to take my daily dose I get sick for more than one full day. It's scary! I've seen a recommendation to taper antidepressants at a rate of 10% per month but isn't that unreasonably slow? It would take me more than three years to taper a medication I've been taking for only 1.5 years! Furthermore, I use generic 150mg Venlafaxine capsules that have three large beads inside, and I know there are 75mg capsules available from the same brand. So, the smallest dose is a 25mg bead that I can take from these 75mg capsules. However, 25mg seems too big a cut. I'm afraid I'll have significant withdrawal symptoms and I really need to remain functional. I would appreciate some advice. 2) I have a teenage child that was a A student but now refuses to go to school. Doctors wanted to put her on antidepressants, but we chose to take her out of school instead. She's homeschooling but still not OK. She's well in almost every other aspect (social, etc.) but gets terribly anxious at the thought of having a simple one-on-one lesson with a tutor. We think she may have had a kind of burnout event (she's very dedicated and always wants to excel) and, as any adult in this kind of situation, needs time to recover rather than be put on ADs and sent back to school. But would like to hear your opinion. Thanks in advance PS - I'm currently tapering a benzodiazepine, Ativan. I took 1mg/day for 10 years but had already hit tolerance and it was causing me horrible symptoms like brain fog. I suspect the depressive issues that led to the Venlafaxine prescription were also in part caused by this benzo.
  7. Hi I took effaxor for 5 months 75mg. I stopped 4.5 months ago and still stuck with PSSD. How hopeful should I be, do people here recover substantially from PSSD?
  8. PLEASE READ THIS ENTIRE TOPIC BEFORE GOING OFF PRISTIQ. Pristiq comes in insufficient dosages to taper. Do not alternate doses of Pristiq to taper -- this will cause the levels of this medication in your brain to go up and down and is second only to cold-turkey in causing withdrawal symptoms. AND DON'T COLD-TURKEY EITHER!!!!!!!!! To reduce the risk of withdrawal symptoms and post-discontinuation prolonged withdrawal syndrome, as with other psychiatric drugs we recommend reducing Pristiq by 10% per month, calculated on the last dosage. (The amount of the reduction gets progressively smaller.) See Why taper by 10% of my dosage? The official prescribing information from the FDA contains this: However, Pristiq is difficult to taper "at a more gradual rate" as it comes in only 3 dosages: low, average and excessive -- and officially, the tablets cannot be split. PROTEST THIS DANGEROUS DRUG Phone Pfizer, Pristiq's manufacturer, to make a complaint: (800) 438-1985 in the US Pfizer has not provided any specific information on how to taper from a dosage of 25mg Pristiq, the lowest available dosage. They may suggest alternating dosages to taper Pristiq. Don't do this -- it's like playing ping-pong with your brain. File a complaint about the difficulty of tapering off Pristiq -- the range of dosages is inadequate. Also complain to the FDA 1-800-FDA-1088 Mon–Fri between 8:00 a.m. and 4:30 p.m. EST. Pristiq is Effexor's fancier sibling Pristiq is a drug made of Effexor's (venlafaxine) active metabolite, O-desvenlafaxine. Pristiq is to Effexor as Lexapro is to Celexa -- a tweaked and more powerful isomer molecule. In effect, Pristiq is concentrated Effexor. See http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=2464 According to Pfizer http://labeling.pfizer.com/showlabeling.aspx?id=497, Pristiq is available in extended-release tablets of 25mg, 50 mg, and 100 mg; the most common dosage is 50mg. Unlike Effexor, which is metabolized primarily by liver enzyme P450 CYP2D6, Pristiq is metabolized via conjugation and liver enzyme P450 CYP3A4. It attains peak plasma concentrations in about 7.5 hours. As a chemical, before it's put into an extended-release tablet, desvenlafaxine has a half-life of around 11 hours. Pristiq's extended-release formulation According to this paper, the extended-release formulation releases desvenlafaxine over 24 hours. The mean half-life of desvenlafaxine, without the extended-release formulation, is around 11 hours. The extended-release formulation is a monolithic matrix -- it's in the glue that holds the tablet together, not in the coating. I confirmed this in a phone conversation with Pfizer medical information (1-800-438-1985). (Thank you, oaklily, for this information about the matrix formulation.) Rather than a timed-release coating, the coating on the Pristiq tablet is only protective. The extended-release mechanism is part of the tablet matrix, or the glue that holds the tablet together. This is called a monolithic matrix tablet. If the tablet is split, the matrix is damaged and may not reliably be extended-release, depending on the size of the fragments. Larger fragments are more likely to retain some extended-release capability. When the tablet is CRUSHED, the matrix is completely destroyed. The particles should be assumed to have NO extended-release capability. A Pristiq fragment becomes desvenlafaxine, with an 11-hour half life. (Here is a description of the similar matrix formulation for quetiapine XR (Seroquel XR) .) OPTIONS FOR TAPERING PRISTIQ Since medicine knows nothing about tapering Pristiq, the following are all informal suggestions. Try any of them at your own risk. Please let us know how you do by posting in this topic. Cut up Pristiq tablets Despite the warnings not to cut it up, from reports on the Web, cutting up Pristiq tablets does seem to work for some but it makes others ill, possibly because of "dose dumping." According to Pubmed on Desvenlafaxine: "....The extended-release tablet does not dissolve in the stomach after swallowing. It slowly releases the medicine as it passes through your digestive system. You may notice the tablet coating in the stool...." The extended-release mechanism is part of the tablet matrix, or the glue that holds the tablet together. If the matrix is destroyed, the entire dose is released at once or "dumped," instead of being gradually released through the matrix formulation. Without the extended-release matrix, a Pristiq fragment becomes desvenlafaxine, with an 11-hour half life. To avoid "dose dumping" of the entire dose, you might take smaller divided doses of Pristiq, more than once a day, like immediate-release Effexor, to mimic an extended-release dose. Cut-up Pristiq seems to sometimes cause stomach upset, which may be reduced by taking it with food. Now that the 25mg tablet is available, cutting it into quarters gives you the option to taper by 6.25mg per step. If you are taking 100mg Pristiq or 50mg Pristiq, you may wish to request part of your prescription be written for 25mg tablets. (For insurance coverage of multiple dosages, your doctor most likely will have to specify taking Pristiq in "divided doses.") You may find you need a precise way to measure your tablet fragments. See Using a digital scale to measure doses As you get down to a low dose, you may wish to switch to Effexor to more precisely control dosage decreases, see below. Reducing from 100mg Pristiq to 50mg Pristiq Drug switches incur additional risk. Before trying a switch to Effexor or Prozac (fluoxetine) from 100mg Pristiq, it's probably wise to go down to 50mg Pristiq first, or 25mg if possible. Combining whole tablets, with their extended-release qualities, with tablet fragments probably makes "dose dumping" less likely or noticeable. You might use a 50mg tablet plus a 25mg tablet plus 3/4 of a 25mg tablet (18.75mg) to make the first reduction to 93.75mg 2nd reduction: a 50mg tablet plus a 25mg tablet plus 2/4 of a 25mg tablet (12.5mg) to go to 87.5mg 3rd reduction: a 50mg tablet plus a 25mg tablet plus 1/4 of a 25mg tablet (6.25mg) to go to 81.25mg 4th reduction: a 50mg tablet plus a 25mg tablet to go to 75mg 5th reduction: a 50mg tablet plus 3/4 of a 25mg tablet (18.75mg) to go to 68.75mg 6th reduction: a 50mg tablet plus 2/4 of a 25mg tablet (12.5mg) to go to 62.5mg 7th reduction: a 50mg tablet plus 1/4 of a 25mg tablet (6.25mg) to go to 56.25mg 8th reduction: a 50mg tablet If withdrawal symptoms occur, some people have found taking an additional fragment of a tablet can smooth the transition from one dosage to another. Another way to get from 100mg to 50mg or 25mg is to combine Pristiq tablets with a liquid made from immediate-release Effexor (see below). Once at 50mg or 25mg, stabilize for a month at least and consider your plan for the next stage of tapering. Have Pristiq made into smaller dosage capsules or a liquid by a compounding pharmacy Compounding pharmacies can crush the tablets and put the powder into smaller capsules by weight. Like cutting up tablets or crushing, this destroys the time-release quality, but the compounded method is much more exact. In your body, crushed Pristiq is similar to regular immediate-release Effexor, with an 11-hour half-life. You may wish to have your dose compounded to take twice a day. If you are taking 50mg Pristiq, for example, you would have 60 capsules compounded per month. Each capsule would be 1/2 of 45mg (a 10% reduction of 50mg) or 22.5mg. You would take two capsules per day, once in the morning, and once in the evening. The next month, you would have 60 capsules compounded, each capsule being 1/2 of 40.5mg (a 10% reduction of 45mg) or 20.25mg. And so forth, for each reduction. (According to my compounding pharmacy, they can put in a slow-release additive distributing absorption over 8-10 hours. This is not as long as the Pristiq time-release coating, but at least it's something. Check with your compounding pharmacy about this. See getting-custom-dosages-at-compounding-pharmacies-us-uk-and-elsewhere ) If this does not work, you may wish to switch to Effexor XR and use the bead-counting method. Regular Effexor probably wouldn't be an advantage over Pristiq compounded to custom dosages. One of our members had a desvenlafaxine liquid made by a compounding pharmacy. Most likely, this compounder used pure desvenlafaxine succinate powder to make this liquid, as desvenlafaxine tablets contain a glue that might resist being made into a liquid. But he may have a way to grind tablets up to make a suspension. A liquid would have to be immediate-release, with a half-life of around 11 hours. Generally, you'd take a drug with that short a half-life twice a day. Crush Pristiq tablets, weigh powder with a digital scale This is similar to cutting up tablets -- Pristiq is a "do not crush" medication, as it is a time-release drug. The Pristiq powder becomes desvenlafaxine, with an 11-hour half life. If you pulverize the tablet, you might take smaller divided doses of Pristiq, more than once a day, like immediate-release Effexor, to mimic an extended-release dose. In principle, this would be a more precise way of tapering than cutting up tablets: Crush the tablet Make sure the shell fragments are evenly distributed in the powder Weigh the powder for a dose with a digital scale Put the powder into an empty gelatin capsule to make it easier to ingest Peer discussion of this method starts here http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__27417 Switch to Effexor or Effexor XR Note: If you've had an adverse reaction to Effexor before, do NOT switch from Pristiq to Effexor. "Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of venlafaxine." Since the relationship is so close, switching to regular immediate-release Effexor tablets, which you can cut up or make into a liquid, this may be the best way to taper off Pristiq. Because it has a mean half-life of 5 hours, you'd have to take regular Effexor twice a day. Alternatively, you might substitute Effexor XR, which is released gradually like Pristiq and needs to be taken only once a day. You'd have the difficulty of tapering off Effexor or Effexor XR -- themselves notorious for withdrawal difficulties -- but at least you can do that gradually. See Tips for tapering off Effexor and Effexor XR (venlafaxine). According to FDA Prescribing Information for venlafaxine (Effexor), the usual dose of Effexor is 150mg per day. Since 150mg Effexor and 50mg Pristiq are both "normal" dosages of their respective drugs, they may be roughly equivalent. (If you've just quit Pristiq and are experiencing withdrawal symptoms, you may wish to reinstate a LOWER dose of Effexor XR, such as 37.5mg, to start. This may be enough to stop withdrawal symptoms and avoid a kindling reaction.) The psychiatrist who writes the 1boringoldman.com blog reports success in switching one patient from Pristiq to Effexor, then tapering Effexor, here (see comments) Another psychiatrist said when he tried this, the switch from Pristiq to Effexor was "seamless." Dr. Stuart Shipko posts here: Advice from a psychiatric pharmacist I have been corresponding with a professor at a prominent US university pharmacy department. Here is his best guess at how to taper Pristiq (he does not want his name published): Then taper off fluoxetine (Prozac). See Tips for Tapering Prozac Advice from Dr. Stephen Stahl, author of the manual Essential Psychopharmacology In his widely read psychopharmacology manual, eminent psychopharmacologist Stephen Stahl advises titration by crushing the tablets and mixing in fruit juice, see http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__14799 According to our member oaklily, Stahl is wrong. Making a liquid from Pristiq does not work, see http://survivingantidepressants.org/index.php?/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/page__view__findpost__p__24822 Dr. Stahl intends to correct his book, according to this correspondence 09/15-9/16/13 with him: Use a combination of Pristiq tablets and Effexor liquid Pristiq cannot be made into a liquid, but its close relative immediate-release Effexor (not Effexor XR) can. You may be able to go off Pristiq by taking part of your dose in lower-dose tablets and part in liquid Effexor, gradually converting to all-liquid Effexor as you get to lower dosages. This may offer a convenient and gradual path off Pristiq. Only regular immediate-release Effexor can be made into a liquid (see Tips for tapering off Effexor (venlafaxine) ). As immediate-release Effexor has a short half-life and is usually dosed twice a day, you may wish to take the liquid portion of your dosage later in the day. For example, if you are taking 100mg Pristiq, you may wish to take your daily dose as one 50mg tablet and the rest later in the evening as a liquid made from immediate-release Effexor. You can titrate the liquid by 10% of your daily dosage to taper until you get to 50mg. Then you can take a 25mg Pristiq tablet with the rest in a liquid made from immediate-release Effexor. When you get to 25mg Pristiq, you might switch to splitting the tablet and taking the rest in Effexor liquid and so on until you are taking only liquid Effexor. To do this, you will have to request a prescription for Effexor tablets as well as Pristiq from your doctor. "Bridging" with Prozac or another antidepressant Any drug change incurs additional risk. A switch to Prozac from Pristiq may not work -- they are very different drugs -- or you might have adverse reactions to Prozac. Prozac is regularly used to "bridge" off Effexor. Given that Pristiq is a sibling of Effexor and Effexor XR, it is possible that one can, similarly, use Prozac to withdraw from Pristiq. Attributed to Joseph Glenmullen, the "bridging" technique is described by a doctor here http://www.bipolarworld.net/Phelps/ph_2005/ph1354.htm Read this entire topic before attempting a switch to Prozac: The Prozac switch or "bridging" with Prozac Later, taper off Prozac. At least Prozac comes in a liquid. To do this, consult a doctor knowledgeable about this technique.
  9. I'm brand new to this site. I have been on the ride of psych drugs since my late teens. I started with sertraline, which I went off of cold turkey after six months. I self-medicated with drugs and alcohol for the next decade. Was put on paroxetine at age 29. Went off quickly when I became pregnant. I went back on paroxetine in 2012 and was on it for six years. It didn't help much, I gained a ton of weight and had decreased sex drive. In 2018, I went into crisis and began a horrific journey of medication chaos for the next two years. I can list all of the drugs I was put on, but not the length of time or dose for each: venlafaxine, fluoxetine, risperidone, escitalopram, bupropion, propranolol, trazadone, aripiprazole, lithium, lorazepam, lamotrigine, and a variety of other nonpsych drugs to counteract different side effects from these drugs. In the late summer of 2019, I began to taper off all medications with the assistance of my psychiatrist. I took my last dose of psych meds on November 17, 2019. I've been med free for over nine months. My mental health continues to be very difficult, but I am glad that I'm not compounding these issues with the torturous effects of psych meds. I know that psych meds seem to offer relief to some people, but they made things worse for me. I now work as a Peer Wellness Specialist to help others living with mental health challenges navigate their recovery. I'm just seeking connection to others who have had similar experiences with psych meds, as well as looking for more information to help others who decide to go off meds or need support with the meds they are on. Thanks for being here!
  10. I was tood by my doctor to stop my Effexor cold turkey as my side effects were bad and she said that as i was obly on it for 8 months it shouldn't be an issue. I was on citalopram for 8 years before that. That was on 2dec, i was ok very irritated argumentative and bad brain zaps but mentally i was fine. Then Christmas came and some bad news brought me down and I couldn't grt out of my bed for three days then rhe panic came stronger than i have ever felt. I am so frightened and dont know how to cope. I started taking the Effexor 75 again 4 days ago but im still struggling and dont know what to do. Please help
  11. Hi guys, So here I am after being off antids for about 6 months, having tapered too quickly and suffering the consequences. I was latterly taking Citalopram 30mg, Lamotrigine 150mg and Venlafaxine 75mg. Summer 2015 I was officially diagnosed with major depression, which had obviously been there for a long, long time but had at that time got particularly bad. This was due to psychological issues, alcohol and drug abuse but wouldn't shift despite years of work fixing these. Now I know the long term citalopram use was probably making the depression worse. Around that time I saw 4 different psychologists and got 4 different opinions on how to recover/which meds to take. This of course was a ridiculous situation so I took matters into my own hands, taking what I thought was the 'best' advice and integrating it with my own research and experience . Following the 'advice' of one of the psychiatrists I added 75mg of Venlafaxine to the Citalopram and Lamotrgine. At the same time I'd heard about l-methylfolate so gradually ramped up to 15mg daily with b-6 and b-12. I know starting 2 things at once is not advisable but I was desperate and could hardly function. Within a couple of weeks something kicked the worst of the depression into touch which was a massive relief. After a couple of months on the 3 med cocktail the side effects were really starting to get to me so it was time to get off this stuff. Yes, I know, I did it all too quickly which is why I am where I am now....I should have listened more closely to the advice here :-) Hoping for a little advice and encouragement about my nervous system which in the last 3 months or so has got worse even though I stopped all meds 6 months ago. The lamotrigine taper had me shouting angrily at my wife a number of times - the intensity of the rage was incredible but passed quite quickly. She was very brave to be able to get through that! Citalopram taper was surprisingly easy. The final stages of the Venlafaxine withdrawl was tricky. I was down to 1 bead and if I didn't take it within a few hours I'd get head zaps, restless legs etc. At some point I had to stop so I did and put with these symptoms for a week or so. After all this I was however very fatigued which has improved to an acceptable level over the last 3 months. The fatigue was probably also due to recovering from the major depression. Right now I have anxiety issues, very easily stressed/snappy, can't sleep more than 5 hours a night and impossible to catch up with sleep during daytime as on the verge of dropping off I wake with intense terror/fear. Often trouble breathing properly, tight stomach and I am very sensitive to noise, light and touch. I also have panic attacks when the stress is high in my life. These have been occurring for a long time though and haven't really changed with changes in meds. Having done years of therapy and some bodywork I know that these are physical symptoms and I have quite a healthy psychological make up. I also do a lot of things to look after my physical and mental health which I won't go into here. On the plus side, I don't have the general low mood caused by taking Citalopram for years, blurred vision, muscle tightness, sexual problems, cognition and memory problems, sense of not being fully present + other well known side effects from these meds. I am having thoughts about re-introducing a very small amount of Citalopram or Venlafaxine - not sure which one of these is causing the nervous system issues - probably both. I'm aware that the likelihood of this helping after 6 months is low, but I'm willing to try to alleviate symptoms. Advice on this is very welcome! As my name suggests, I do finally feel alive after 16 years on these meds - something about taking them was just not 'right'. Even though I'm suffering right now I'd rather be here. I hope this gives some encouragement to others and also serves as a warning about what happens when you taper too quickly! Thanks to mods and users alike for this wonderful resource. Cheers
  12. Hello everyone. My name is Christa. I am from the Netherlands Europe so please don't mind if my English isn't all that. For the past 25 years I was first on paroxetine and the most years on venlafaxine 150 and later 75 mg. For. Years this was fine by me. Until I started reading about tapering. A view more years went by and in the back of my mind there always was the feeling that I was done with those drugs. So finally I went to my doctor. Only to hear that my medication was to hard to stop. So some time more went by. But still I wanted to. So I went back to my doctor and I told her...... Listen. That depression for 25 years ago.... I think it's gone now don't you think so? The time I first got. The drugs was totally different from where I am today. I am in a stable situation. Steady job. Husband. Animals. No white picked fence tough. But still she told me it can't be done. Well........ I am the kind of person who does not take no for an answer. So I started counting beads. Until I was at 37.5 mg. And then there was a surprise. I got capsules from 37.5 mg and Inside each capsule there were 3 smaal tablets. So the first week I took out 1 tiny pill from my daily capsule. A small whitdrawel would come for a view days. About 3 days. So I waited until my body was used to the lower amount and as soon as I felt ready I decreased the dose again. I did this until I was at 10 somewhat mg. And there it got scary. Still from 10mg to 0 is still a 100% change. And from there the real withdrawal began. I could not do it. So I did read about the prosac bridge. Bridging the gapp between venlafaxine and no medication. Because prosaic has a long half life time it's very handy in this case. So I called my doctor again and told her I was willing to try a different kind and I wanted prosac. I never had the plan to switch to a new antidepressant but I did not tell her. For a week I took my 10mg venlafaxine and I took one tablet of 10mg of prosac. After that week I stopped the venlafaxine. For. 3 more days I took half a tablet of prosac. And then stopped completely. I can te you that's scary. I was waiting for some relaps or something bad to happen. But it didn't. Nothing. I slipped out of my antidepressants. But than....... Reality hit like a truck. All of a sudden I was back in the real world emotion came back. Crying laughing angry everything came back. So I took a view weeks of from work to adjust. People a. Careful with me now. They can't play me anymore. I am no longer the dosile Christa who was a bit weird and just happy to have work. The new Christa has her own ideas. Things she will do and things she won't. Christa is thinking again. I am strong and people notice. I am no longer ugly bettie who takes all the crappy jobs. I am building my future. It been 4 months now si ds I stopped my medication. My stomach is still upset. I am often not friendly and harsh. But people have admiration for that I am this strong. I have claimed my live and my territory and it works. It's been a hard Rollercoaster road. But it can be done and you can too Thanks
  13. Hi I am new to this forum and this is my first post . I am currently on 30mg mirtazapine and 200mg of pregablin , I have been on these mess for about 3 to 4 months . I have just cut my mirtazapine from 30mg to 15mg and in the space of 4 days I have have horrible side effects , anxiety through the roof , shaking , lack of appetite poor sleep crying spells and the general feeling of feeling crap . The reason I have started to withdraw from the mirtazapine is that after 3 months I feel no benefit only get awfull side effects . No help with my anxiety and depression if anything it's made me more depressed . I have gone through withdrawing from Effexor and that was really tough , however just the drop for a few days of the mirtazapine has left me crushed , my doctor told me that mirtazapine was a easy drug to withdraw from , but after 4 days it has left me house bound . Has anyone got any idea on how I get through this or any experience in mirtazapine withdrawals
  14. I was starting my third effexor taper 7/2015 -6/2016 and down to 3 mg untill nerve conditions of numbness, buzzing, tingling, burning and buzzing sensations in limbs started. I didn't know what was happening and neither did my doctors and thought I had some other illness such as MS, fibromyalgia etc. Did numerous tests with no diagnosis. Anxiety and insomnia was at an all time high so Doctor reinstated full 37.5 mg dose on 6/30 and up to 75 mg in 1 week. Because the nerve conditions also were not allowing me to sleep the doc gave me clonazepam. Later I was then given lyrica to help with the nerve conditions. but After a one week trail of lyrica in August I discontinued immediately due to some paradoxical effects of jerks and muscle fasciculations and also decided the clonazepam might also be a culprit and started a 4 week taper with the help of mirtazapine for sleep. While this was going on only through the course of my own research did I come to the conclusion that the nerve conditions I was suffering were initially from SNRI withdrawal symptoms. September faired better as the initial withdrawal symptoms seemed like they were being resolved after a few months back on effexor so then I figured the effexor was helping with that...Great! but.... As soon as I was done with the clonazepam some of the initial nerve symptoms I experienced in June have returned. Not sure if the clonazepam was masking it. So now my issue is that I'm at a higher dose of the effexor than when I started and the withdrawal symptoms has not been entirely reversed and don't know what to do at this point? Taper off effexor? I'm still using mirtazapine for sleep because because the nerve condition of either a jerk, adrenaline surge, numbness etc will keep me up. Please help me I'm desperate!!!
  15. Hello, I was started on Effexor 75 mg a year ago for anxiety and OCD. I tried cutting my dose in half 2-3 months ago to 37.5 mg not realizing about withdrawal symptoms. I have never struggled with depression but since changing the dose have been really depressed. 3 weeks ago my doctor added Prozac saying it would help but it doesn’t seem to. I am so frustrated and feel like Effexor has caused me more problems than good. Since I tapered so quickly I don’t know if I should go back up to 75 on Effexor or increase my Prozac or what to do. I feel like my doctors aren’t sure what I should do either as he told me it’s up to me to decide my taper on my own thanks for your time and help in advance
  16. dowdaller

    dowdaller: Hello

    Hi everyone my name is pete I am from Ireland, I am currently med free for the last 8 months I was on a cocktail of meds before that including zanex, olanzaipine, and Effexor I weaned off these meds over a two year period under supervision. I found this tough but I made it, I am currently finding it tough at the moment hence I joined the forum. I suffer from anxiety ocd and depression.
  17. Do/did you have depression as wd symptom? Sometimes I'm in an extremely bad mood and very exhausted - it is in fact very similar to my original depression. It always gets better in the evening.
  18. Hi guys I just wanted to start by saying thank you so much for putting this site together. I can't begin to tell you how much it has helped and educated me in a short time. Im roughly 23 weeks cold turkey from 37.5mg effexor, I was on that for maybe 5 years before that 75mg for roughly 12 years. I don't have any medical history records available and can't remember the exact times because my memory is so screwed. I honestly could be years off when estimating the dosage changes. I stopped cold turkey because I initially forgot to take it and didn't feel as though it was of any therapeutic benefit to me anymore anyway. Doctors had previously told me I was on a "baby" dose. A relationship had ended a few months before and I wanted to start a new life. I was going to take back control not put anymore of this crap (efexor) in my body, reclaim it from the drug company and start doing all the things I really wanted to do with my life. I realised there would be discontinuation symptoms because of previous reductions and times I had forgotten to take it in the past. I thought maybe a month or 2 at most and I would be back to normal. I could do this, besides I was on the lowest dose available, positive about the future, I had quit other (recreational) drugs throughout my life, I'd worked my way through depression and anxiety years ago and I could get through this. I can be very stubborn when it comes to some things and I'd decided in my head no matter how bad it got I wouldn't be taking another efexor for the rest of my life. I hated the doctors for prescribing it and telling me to stay on it or trying to get me to raise it even. The drug companies for making it. And both for making me feel like I needed to take it so it was a kinda "up yours" to them all. 5 months later I'm still suffering major symptoms and my life is still on hold. Although some have faded others seem to get worse particularly the insomnia and anxiety even suicidal thoughts I think this may be also due to the fact I've realised that its not going anyway and I may be like this for years or maybe forever? Makes it bloody hard to relax. I get it now that it was pretty reckless to stop so suddenly like that after such a long time. So I hate to say it but after not being able to go to work the last couple of weeks Im coming to the realisation that I may need to go back on to a very low dose and slowly taper of that. Is this a good idea? Do you think it would ease discon symptoms for me to just start taking maybe half again and taper at 10%? If so how long before tapering? Will getting back on efexor have any side effects in itself? And also theoretically will discon symptoms last longer because I stopped so suddenly? whether I start taking it again or not. I read a lot in the tapering of efexor thread but I'm finding it very hard to concentrate at the moment and find the answers amongst all the good info there. Thank you to anyone who has taken the time read all this and reply. Your awesome.
  19. Hi everyone I'm Dane, Please scroll down to "Long story short" for antidepressant story or continue for the full picture. 43 year old gay male, from Sydney who has had a couple of years of unstable mental health after being successfully medicated on Zoloft 100mg for around 7-8 years. The dates are foggy. I notice people leave there hx (history) of medications and experiences at the bottom of the posts, if someone could advise me on how to do that, id be very appreciative. Id like to play by the rules. My main issue has always been anxiety. In 1995 I had my first horrific panic attack. And nothing has been the same. My life isn't awful or terrible. I have a lot to be grateful and thankful for, however as time goes on, I'm finding things more difficult. Ive seen this website many times, but felt it was best to join and contribute/learn. I generally have been anxious rather than depressed, however the anxiety and feeling out of control led to me feeling quite down and dark. In my 20's i climbed out of it but when any stress or changes were added like a relationship, a job, a responsibility - I would become overwhelmed with that was being asked of me and get easily stressed and feel like I couldn't cope with life's demands. This has been a common reason for my anxiety. When I hit 30 in 2008 I was really beginning to suffer. I felt very alone, I was job swapping a lot, starting jobs and quitting, very unstable and sexual experiences ramped up. Seeking out novelty and sex and also what's known as "cruising". I then started to feel difficulties just going outside. I was super anxious about even going to the local shops, it got worse and worse and had to be brought back home to live with family. I felt completely failed as a person. I felt i was a burden and couldn't understand why and what was leading me to not be able to cope with life. I developed agoraphobia. I went on Zoloft and that worked for many years. I got two degrees during that time, I graduated, i was working, had friends but never feeling 100 percent. The agoraphobia never really left me at all. Sometimes I could travel long distances and other times I couldn't leave my suburb. Its fluctuates a lot. However I learned to drive a car, and can drive locally and have a job. My issues are finding the right medication or therapist combo. Long story short: 2018 I noticed Zoloft not working as well, I had some challenges with resurfacing anxiety. Went to 200mg, no result. Went onto Lexapro (escitalopram) 20mg, no change really, some side effects. Maybe 20% better. Side note: Ive done pharmacogenomics testing for metabolism of meds (Lexapro a no go anyway). I checked into clinic to wean off it April 2019 and started Effexor at 75mg. Over the course of a year that was increased to 225mg. It would seemingly work for a time at each dose increase and then take a tumble. The other theory I have is that I'm not that depressed really. In April of this year (2020) I went back to switch to Pristiq 100 and Valdoxan was added at 25mg an evening. Pristiq was shown to perhaps work due to metabolism. At the 12 week mark id had mayve 4 or 5 days feeling great. The other times I felt speedy, emotional, numb, sedated, as if the norepinephrine side was working full force, but no the serotonin. I had the energy extreme without the mood. Not fun. I am now down to 50mg Pristiq for two weeks 4-18th of August. I have been given Seroquel 50mg XR to help with the DROP to 0 - in Australia you cannot get 25mg doses. Now Seroquel has worked as PRN but will it work coming off the Pristiq? I'm feeling very poly medicated. And feel I need a HUGE scale back. Medication Journey: 5 medications August 2020 Zoloft 100mg 2012 - 2018 (stopped working) Increased to 200mg (no effect) Escitalopram 20mg Dec 2018 - no noticeable effect except side effects Venlafaxine started April 2019: 75mg (6 weeks) 112mg (6 weeks) 150 (3 months) 187.5 (3 months) 225 (7 weeks.) Each dose increase it just kept failing after an initial boost/response Pristiq 100mg & Valdoxan 25mg (May 2020) Pristiq 50mg & Valdoxan 25mg (August 2020 - due to side effects)
  20. I feel devastated still - nearly 8 years after a brutally swift taper from Effexor. I did not know better then. Apparently nor did the doctor. Seven years at 150 mg of Effexor - then down to zero in about five days. Obviously my story is a lot longer than this and all kinds of hellzone has happened between then and now ... involving another drug I was forced on for many months because of the protracted withdrawal. (which these doctors do not believe in as you know) And I have only just learned that what is included in what I have been suffering for a while now, has a name - vulvodynia. (then there is the burning sensation throughout various parts of the rest of my body). I am so scared because life is over if this is all there is now. Surely there is some kind of wonderful holistic herbal miracle remedy to take or something - a solution for CNS damage. I am drug-free now and want to stay that way and wish I always had been. Unbelievably for all of those years I didn’t really know what I was really taking - I never gave informed consent. If I had the knowledge then I would never have given consent at all. Meanwhile I need to heal or there is no life left.
  21. Have been off venlafaxine since November 2017 ( after 16 years) ; went on trazodone and Reboxetine until Nov 2018 and have been drug free since. However really struggling recently despite taking omega 3 / CBD / exercises etc. Problems include fatigue, very low mood, anxiety, no interest in what’s happening around me, can be upset by the most minor event etc. Tempted to try some other drug that may help as I am finding it really hard. How long do the withdrawal effects last and is there hope in persevering?
  22. Hey all! This is my first post here and I'm so glad I found this forum. I've been feeling desperate for months. My question is about drug-induced derealization. I took the combo of Effexor + Valdoxan and only felt good for a month while being on them. In hindsight I almost seemed manic. Then, suddenly, I got very strong derealization that lasted for weeks. It lifted a bit for a few feeks and then came about again when I had a drink one night. I have now tapered off Effexor, I took my last pill about three weeks ago. Three days ago I also started tapering off Valdoxan. I take Oxazepam to cope with the symptoms. I feel like I broke my brain for good. The only other time I've felt derealization was when I ate a hash brownie and clearly it was too much for me. I used to be a caring and fun person before going on the antidepressants. Right now I feel like I'm just completely empty inside. I do and feel things because I know I have to, but I seriously don't care about anything at all. When I do feel emotion, it's mostly fear or worry. Has anyone else expierienced drug-induced DR? Did it go away when you started to withdraw from the drug? How do you cope with this?
  23. Hello, I'm new to this forum and I'm working toward tapering off of 225 mg of venlafaxine. I am a 70 year old male, that has been very active and health conscious. My weakness has been depression. I previously had two periods of feeling depressed that involved obtaining an antidepressant from my general practice doctor. I would get to the point of feeling spacey and or lethargic, then do talk therapy to get back off of the drug. These where phase one antidepressants, and I would taper off slow over say 4 to 6 months without noticeable side effects. These events occurred between 2005 to 2008 per notes I still have. I retired from Highway Engineering March 1, 2014. Many emotional events piled upon me during the next five months. The stressors where; retiring and adjustment period, daughter coming home to live with us and get a divorce, a vicious son in law (being divorced), one or two other more minor stressors that I do not recall, and a huge spiritual crisis in which I felt I had not lived as graciously as God would have wanted me to. In July 2014 I became fixated on thinking about all these things. I sat in a stupor for days, lost 15 pounds, thought the devil was speaking and accusing me of my wrongs and tempted me to deny God and just die. My wife asked me If I had thought of suicide and I admitted that I had. She called 911 and got help. They took me to a hospital and put me on suicide watch till they could transfer me to a psych ward for treatment. I was confined for a week and given many medications. I also had a physical problem that they dealt with. I was released to an out-patient psychiatrist. The psychiatrist told me he would take me off all the previous medications except for increasing my dose of venlafaxine to 225 mg. I have been on venlafaxine for four (4) years. In May 2018 I stopped drinking all alcohol and also stopped experimenting with legalized cannabis. I quickly felt a bit more energy. I put this energy toward searching the internet for information about venlafaxine and antidepressants. I have learned much, but still want to keep learning. My Psychiatris agreed to allow me to get off Venlafaxine October 4, 2017, after telling him repeatedly about my desire to and why. He reduced my venlafaxine from 225 mg to 150 mg. The short of it is that I did not make it, and went back to the full dose. After learning more about how to decrease slowly, I am ready to try again. I have sought the help of my general practice doctor, who is supportive and has reduced me to 187.5 mg. Since I know that a 10% reduction is better, I cut open a 37.5 mg capsule, counted the beads, and took 40% of those beads, 15, and added them to the 187.5 mg, for a new total of 202.5 mg. I'm also taking daily notes of my physical and mental state, and dosage. I will see my general practice doctor monthly. I will be also talking to my Psychiatrist about my plans. I plan to start talk therapy also. Does anyone have any advise or comments?
  24. I have been on meds since I was around 18, I am now 33, I have been tapering off all my meds for the last year now, I have managed to get off venlafaxine xr 75mg which I tapered off for around 4 - 6 months, and quetiapine 50mg over the last 12 months, I was on 200mg at one point and also tapered off diazapam 10mg, and also propranolol 10mg, I have been off all meds now for nearly 3 months and have been fine, I have been at the gym most days and eating healthy, I was starting to look good again and becoming myself again, I have not been human while on meds for the last lots of years, I was finally starting to enjoy life and then the last few weeks my sleep has been getting very fractured and I have been waking up very early with extreme brain fog, it feels like my head is going to explode sometimes, now the last 2 nights I have not slept at all and feel like death, I even took 2 melatonin tablets and they did nothing, what on earth is going on? I am worried I have done some serious damage to my brain, I am too worried to go and get checked at the doctors as I could not handle news that I have some brain disease, I have read that meds can cause effects many months after, can anyone give any advice/peace of mind?
  25. Moderator note: link to uncomfortablynumb's Benzo Forum thread Hi Everyone, About 9 years ago I jumped on the psych med-i-go-round. It was my last year in university studying human kinetics - I was really stressed, not getting much sleep, not eating very well and consuming way too much caffeine. I pretty much crashed and burned with anxiety and depression over probably a 4 month period. It was possibly due to years of stress and not knowing exactly what I wanted to do after graduation (to continue studies or find work). I was rock bottom, not being able to focus on anything and the anxiety was so bad that I isolated myself. That is when I first saw my psych. I was prescribed Celexa and that did nothing. It was my first drug and I was desperate and only gave it probably 3-4 weeks. Then I was put on Effexor. It worked wonders in about 3 or 4 weeks at 75mg or 112mg. I was back to my old energetic self and focused. I came out of my shell and was socializing again. I finished my degree and decided to forgo post-grad and start up my own business as a fitness trainer. The next 3 years were going well as I was building up clientele. Outside of work I was involved in long term relationships. Effexor was working pretty consistently. When it lost effectiveness, I would up my dose and be fine pretty soon after. I forgot to mention I was taking a pre-workout supplement (NO-Xplode or another) while on Effexor (which is probably a no, no) to give me an extra energy boost. Perhaps the meds were losing their potency and I needed another boost because coffee was not helping. Effexor then started to poop out on me. I would relapse into depression/anxiety for longer periods and upping doses was useless (I believe I went up to 187.5mg). We then tried augmenting Abilify without success. Then I switched to Pristiq which also didn't work. Then it was onto Wellbutrin to no avail. I ended up reintroducing Effexor and it worked again with the break. Not as well, but I was functioning. I began abusing pre-workout supplements just to keep me my normal energetic, positive self. Again, Effexor pooped out after a couple years. Over the next few months, I tried Zoloft and nortriptyline and another med. At this point, I was sent to a specialist. He changed my diagnosis to bipolar II even though I exhibited signs of bipolarity until I was on medication. He suggested different cocktails with lithium or Latuda. I refused. I made the stupid decision with my original psych to try Effexor one more time. Surprisingly, another break from it and it worked again. Not as well, but still got me up and going. I stayed on it for a year and weaned off this April this year. I was fine med-free for a couple months, then anxiety/depression reared it ugly head in July. Another foolish mistake I made was to go back on the Effexor from mid-July until September. I had to keep increasing the dose until it was clear my "go-to" drug was no longer an option. I began weaning off rather quickly by decreasing 37.5mg each week. I went to half of 37.5mg, then nothing. I have been completely off Effexor for the last 10 days. This is one of the longest bouts of depression/anxiety for me. It has been 4months. I have had to stop working (as I usually do when I am in this state). My job requires energy, positivity, focus. It is also a social job and depression/anxiety kinda make that impossible. It really is depressing that I have had so many relapses that it screws up my career. I wonder if I didn't go on meds in the first place if I would have relapsed. I had to wean off the drug while severely depressed/anxious. I think this has made the experience worse. I am experiencing bad insomnia, and what I think might be depersonalization (my senses seem altered, hard to describe - dream-like). I am also feeling like my mind is blank. Usually I have a nice flow of thoughts and can start conversation but it seems impossible now. It is very uncomfortable and I have isolated myself from friends. I also cannot find pleasure in ANYTHING. My concentration and memory are not very sharp. When I have weaned off in the past I do not remember it being this extremely awful. I have a few questions: Can the brain recover and balance itself? Is there anything I can do to move things along faster? Or is it probably best to explore other medical options? Should I get extensive bloodwork or an MRI done? Sorry this was such a long intro. I applaud you for reading this because it is not the most exciting story.
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