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  1. Tomorrow morning I’m starting the dreadful journey of withdrawing from Effexor. Currently taking 300mg mane. I’ve been taking for >10 years, so I’m expecting the worst. My GP is very much onside, thank goodness. Over the last 4 years, I’ve taken myself off quetiapine, nitrazepam, regular lorazepam (up to 8mg per day), dihydrocodeine and tapentadol (opiate). I’m still taking OxyContin and Pregabalin. I suppose I’ll have to get off them sometime.
  2. Hi everybody, I am in my mid 40s and I have had dysthymia and recurrent major depression episodes since I was 16. Needless to say that I have been on lots of antidepressants over the years for short and long periods. I have had also periods without medication. Now I am on venlafaxne (AKA effexor) 150mg/day. I think that I started taking it in 2014 but I can't remember for sure. Now I feel that after these years its benefits have decreased, it has pooped out basically and, what's worse, it has slowly, very slowly making worse my sex life. I din't realize at first but my libido has gone down and down and unfortunately it has made for me very difficult to get an orgasm. Further, I believe that has de-sensitized my penis, not completely but I am sure it has because I feel so much less when I touch myself or have sex. I hope that these problems are reversible but I have read of PSSD, so I am worried. I have just started tapering venlafaxine today, I am cutting the 150 mg tablet of 1/4, it's not a very precise thing unfortunately, the tablets are not made for being cut. Anyway I am thinking to stay on this dosage of about 112,5 mg for about 10 days before going on 75 mg for further ten days, then I would go on 37,5 for ten days and eventually I would stop. Is this schedule too ambitious? I need your advice please. Thanks for reading this
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