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  1. Original topic title: Olanzapine cold turkey (out of presumptuous stupidity, I destroyed myself, and now I am trying to save at least a part of my being) On October 20, 2021, I started olanzapine 2.5mg. per day (which I was advised to split into two doses, to take half in the morning and the other half in the evening), recommended to me by a psychiatrist as a remedy for chronic insomnia, and on November 11, 2021 I abruptly stopped using this medicine, as I read in internet about its extreme neurotoxicity. On the evening of November 14, 2021, something terrible happened to me: something seemed to be turned off in my psyche forever, I lost my whole self, i.e. my emotions, interests, hopes, dreams, hobbies, motivation, flexible intellect, and ultimately the will to live. I tried to restart olanzapine on November 15, 2021, but at that time I did not know anything about effective strategies for reinstatement of the drug, and therefore, already on November 16, 2021, I stopped olanzapine again, but, exhausted by insomnia, had to take 25 mg. quetiapine, which have been in my medicine cabinet for many years without use. On November 17, I impulsively returned to olanzapine, but after a couple of days I stopped drinking it again in order to resume taking it at the end of November, but this comeback was also extremely short-lived and did not exceed the duration of the same couple of days. On November 29, 2021, I took olanzapine for the last time, but the neurotransmitter chaos, provoked by my stupid thrashings, seems to have done me irreparable damage. Over the next three and a half months, I tried to pull myself out of this anhedonic pit with various supplements (I tried fish oil, 5-HTP, St. John's wort, green tea extract, tyrosine, biotin, citicoline, Alpha GPC) multivitamin complexes (I mean B vitamins), peptides (for two weeks I was regularly injected intramuscularly with cortexin) and even psychopharmacological drugs prescribed to me by other psychiatrists, but with drugs of this class I again behaved as haphazardly as possible (about 8-10 times during these months I took phenazepam at a dosage of 0.5 mg., it at least minimally relieved anxiety; 5-7 times I drank hydroxyzine at a dosage of 0.25 mg at night, but it did not help me sleep at all; for three or four days I took a combination of venlafaxine, lamotrigine and trazodone, and once I took two capsules sulpiride, the content of the active substance in which was 100 mg., and one tablet of phenibut at a dosage of 250 mg.). Now I realize that my behavior during these months was absolutely suicidal, and probably only the prompt reinstatement of olanzapine could have saved me, but now almost three and a half months have passed since the last dose of this medication, so my chances of self-preservation seem for me absolutely ghostly. I hope that something else can be done in this situation: I have already completely lost hope for rehabilitation, I have practically not slept all these months due to permanent panic and bouts of neurocognitive hypochondria, I don’t understand how I still haven’t made suicide, because it is unnatural to live in such a state.
  2. Hi all, I hope everyone is feeling well and "managing" as well as they can. My current status = I have previously tapered venlafaxine too quick (without realising) from 150mg, and am now somewhat stable on 12.5mg. Ive just got a script for a higher dose (75mg) so that I can taper with the microbeads super slowly from now on. Im curious about something and would like some other peoples opinions (if allowed). Ive looked into opioid addiction and withdrawal methods online and have come across the ancient herbal remedy called iboga/ibogaine therapy - and Im really interested in what Im reading about it..... to the point where I am actually considering going to a Holland to a treatment centre for ibogaine and ayahuasca therapy. Ive also learned a lot from Ben Greenfield about healing your brain from depression and trauma using psychedelic plants in a controlled clinical setting to re-set any negative blocks. What does anybody else think about this and I would love to know if anyone has tried this for both opioid withdrawal and as a cure for depression/stress/anxiety/PTSD. I hope its allowed but I have pasted the link to the podcast. Its so fascinating!!! https://bengreenfieldfitness.com/podcast/biohacking-podcasts/apollo-neuroscience/
  3. Tomorrow morning I’m starting the dreadful journey of withdrawing from Effexor. Currently taking 300mg mane. I’ve been taking for >10 years, so I’m expecting the worst. My GP is very much onside, thank goodness. Over the last 4 years, I’ve taken myself off quetiapine, nitrazepam, regular lorazepam (up to 8mg per day), dihydrocodeine and tapentadol (opiate). I’m still taking OxyContin and Pregabalin. I suppose I’ll have to get off them sometime.
  4. Hi everybody, I am in my mid 40s and I have had dysthymia and recurrent major depression episodes since I was 16. Needless to say that I have been on lots of antidepressants over the years for short and long periods. I have had also periods without medication. Now I am on venlafaxne (AKA effexor) 150mg/day. I think that I started taking it in 2014 but I can't remember for sure. Now I feel that after these years its benefits have decreased, it has pooped out basically and, what's worse, it has slowly, very slowly making worse my sex life. I din't realize at first but my libido has gone down and down and unfortunately it has made for me very difficult to get an orgasm. Further, I believe that has de-sensitized my penis, not completely but I am sure it has because I feel so much less when I touch myself or have sex. I hope that these problems are reversible but I have read of PSSD, so I am worried. I have just started tapering venlafaxine today, I am cutting the 150 mg tablet of 1/4, it's not a very precise thing unfortunately, the tablets are not made for being cut. Anyway I am thinking to stay on this dosage of about 112,5 mg for about 10 days before going on 75 mg for further ten days, then I would go on 37,5 for ten days and eventually I would stop. Is this schedule too ambitious? I need your advice please. Thanks for reading this
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