Jump to content

Search the Community

Showing results for tags 'vortioxetine'.



More search options

  • Search By Tags

    Type tags separated by commas.
  • Search By Author

Content Type


Forums

  • Support
    • Read This First
    • Introductions and updates
    • Tapering
    • Symptoms and self-care
    • Finding meaning
    • Relationships and social life
  • Members only
  • Current events
    • Events, controversies, actions
    • In the media
    • Success stories: Recovery from withdrawal
    • From journals and scientific sources

Find results in...

Find results that contain...


Date Created

  • Start

    End


Last Updated

  • Start

    End


Filter by number of...

Found 10 results

  1. Hey All!! I’m so glad I found this site although it may be a little late. I fear I tapered too quickly on Brintellix and here I am experiencing withdrawal. To give you a little history, I started antidepressants in October 2016 after a very stressful job left me in a bad place. At that time, I should have listened to my husband who told me that if I quit my job, all would return to normal. Instead, I felt the only way to heal myself was to start antidepressants. I did quit my job at the same time and expected to be “healed” with my antidepressants. Unfortunately, I bounced from Lexapro to Pristiq and finally to Brintellix in November of 2015 along with Lamictal to stabilize my mood. Looking back, I’m not sure any of those drugs actually worked…I may have been going through withdrawal every time I stopped taking one. Instead of getting better with the new antidepressant I think maybe I was just getting over the withdrawal of another??? Needless to say, I very quickly got off the Lamictal in June 2016 (went from 100-50-0 in a 3 week period). I went through withdrawal from that (about 3 months before it was over completely) and started feeling more like myself. My intent was never to stay on AD forever so at the end of October, I was feeling well. I had worked through my issues with my therapist, was good at my job, and genuinely happy. However, I was still acutely aware that I still wasn’t myself. I could not feel PURE JOY. I was pretty numb. So my doc told me to taper on my Brintellix, go down to 5mg (from 10) for two weeks and then stop completely. My last day of Brintellix was November 10th. Within a week I was actually feeling more like myself than I had in years!! I was laughing with my kids and at random things on TV. I was back. About the beginning of December was when the symptoms began. I felt more FRUSTRATION than I ever had, so much madness. I felt like a toddler trying to figure out how to manage my emotions again. I worried that the depression was returning because I didn’t have my Brintellix. But it didn’t make any sense. My life had not changed. I was feeling joy—more joy than I had---but I was also experiencing these random thoughts that would not get out of my head. It felt like I had two lives going on at times. The one in my head and the one outside my head. Current Symptoms: Irrational Fears Unable to be fully present Sleep—my mind won’t STOP Erratic Menstrual Cycle that make symptoms of anxiety even worse Physical Anxiety Improvements since discontinuing: Joy Intimacy with my husband Pockets of being myself again Thank you for any advice or encouragement you have related to my symptoms. To all of you who have been doing this, you are amazing!
  2. Cigarettes at age 11. Alcohol periodically from age 13 to age 30. Valium episodically from age 18 to age 27. I have been on myriad anti-depressants since 1982 for major depression and generalized anxiety. Imipramine, desyrel, ativan. Off drugs from 1984 till 1995. Started Prozac 1995 till 2014 (did well from 1995 to 2011). Tried Wellbutrin, Cymbalta. Abilify and Trintellix from March 2014 till August 8, 2017 (depression free). Had to withdraw due to cervical dystonia and tremors which still persist. Terrible experience withdrawing from Abilify and Trintellix. Started Wellbutrin 150 mg. and Prozac 10 mg. for one week to help with withdrawal. Then increased Wellbutrin to 300 mg. and experienced ringing in ears; stopped the Wellbutrin and increased Prozac to 20 mg. (10 in A.M.; 10 in P.M.) Now on Prozac 20 mg. per day, occasional Propranolol for tremors (doesn't help). I've read that coming off Abilify can take up to 3 months or more, and it has been 2 months so far. I feel like I've spent (wasted) my entire adult life trying to feel better, first by self-medicating, then by psychiatric medicating. I'm 72 years old. I wonder if there is any hope for me.
  3. Hello. About a year ago my GP suggested I try Brintollix to help anxiety. After discussing with my wife, we decided to give it a try. A few days into the medication I began having severe side effects including debilitating panic attacks, severe anxiety, insomnia and nausea. After a couple weeks of these symptoms and two trips to urgent care, I discussed withdrawing with my GP. I stopped taking the brintollix and now know I was having withdrawals. I started seeing a psychiatrist who initially prescribed xanax and celexa. The celexa was increased frequently and I was taking 60 mg within 2 months of starting it. He switched the xanax to ativan, back to xanax and then to klonopin. I was also prescribed neurontin at one point and latuda at another point. My psychiatrist then got upset that my wife and I had called too many times on the emergency line and switched me to another provider in his office. I discussed my concerns with this provider and started decreasing the celexa. The celexa has made me nauseous from day one and its never subsided. I feel like a walking zombie when Im taking the celexa. I decreased from 60mg to 5mg over several months. On 12/31/15 after being on 5 mg for a month I stopped taking it, per my provider. Now its been 5 weeks of living hell. Panic attacks, nausea, anxiety, dark cloud feeling, exhaustion, head rushes, irritability, agitation, suicidal thoughts, tightness in chest, severe back pain...its been horrible. If not for taking time off from work and my wife, I probably would have committed suicide by now. I dont know if I can continue this hell...should I reinstate or keep fighting through this? I've taken 5HTP, drink shakeology daily, and take an omega 3 pill in the AM and PM. I also take propanolol for palpitations. Thanks for any and all help...I'm fighting every single day and praying for some relief but I just cant take this anymore.
  4. ADMIN NOTE Please read this entire topic for tips about tapering vortioxetine. There are many reports on the Web about withdrawal symptoms from vortioxetine, despite their being overlooked by drug companies. Vortioxetine appears to have a withdrawal syndrome similar to almost all the antidepressants and should be tapered slowly to avoid severe or prolonged withdrawal symptoms. See Why taper by 10% of my dosage? According to https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Top According to https://www.drugs.com/pro/brintellix.html , Brintellix is available as 5mg 10mg 15mg 20mg film-coated tablets. It has a very long half-life, somewhere around 66 hours. There is no ingredient in or coating on the tablet to make it extended-release, that would be unnecessary. (In May 2016, Takeda changed the name of this drug from Brintellix to Trintellix in the US to avoid confusion with another drug.) SOLUBILITY -- MAKING YOUR OWN LIQUID The active ingredient in the tablets, vortioxetine, is slightly soluble in water. This means you or a compounding pharmacy can make a liquid suspension from vortioxetine, see How to make a liquid from tablets or capsules Brintellix is not soluble at all in water, so using a water titration you'll have a suspension not a consistent or "homeogenous" solution. It is highly soluble in a substance called DMSO, as are many psycho-neuro-active prescription medications. You can get oral or medical grade DMSO from many sources. If you want to use this and have questions about it, feel free to post them here. source: selleckchem.com Measuring a drug for tapering by 10% at a time is easier using a liquid formulation. Since vortioxetine is available in fairly low dosages, you can take part of your daily dosage as a 5mg, 10mg, or 15mg tablet and add the rest as a liquid until your dosage is less than 5mg, where you would take your entire dose as a liquid. Taking part as a tablet and part as a liquid makes it easier to switch from a tablet to a liquid. METABOLIZED BY LIVER ENZYME CYP 2D6 Vortioxetine is metabolized in the liver by several liver enzymes; however, enzyme cyp 2D6 is very important in its metabolization. Taking vortioxetine with other drugs that are metabolized in the liver, as many psychiatric drugs are, can lead to drug-drug interactions, particularly if the other drugs utilize cyp 2D6. From https://pubchem.ncbi.nlm.nih.gov/compound/vortioxetine#section=Drug-and-Medication-Information I have a friend on vortioxetine (Brintellix) so I was wondering, does anyone have any info on how tapering this drug might look like? Thanks in advance.
  5. Hi, My husband takes Mirtazapine 15mg every night, along with two psychotic drugs (Trifluoperazine & Olanzapine) for his agitation/yelling and Vortioxetine 10mg (every am) and recently Prozac 20mg. His problem was insomnia but after being put on benzos & antidepressants, it became more complex - one thing leads to another, and he has very bad daytime agitation/constant yelling, memory loss, confusion, low mood, unable to function etc... He has just started Prozac 20mg two weeks ago, to aid with tapering of Mirtazepine. His doctor agreed on 50% cut but he suffers bad withdrawal after 1 week. Previously, he was able to taper off 45mg Mirt to 30mg then to 15mg without much difficulty. So now he is on 25% cut on Mirt. Q: Is this too much considering that he is on Prozac which should help with the tapering as we understand. We are really tired of this journey as his problem was simply Insomnia and it became so much worse after he is put on these potent addictive drugs and we realised that we were trapped! Would really appreciate all your kind advice. Thank you so much!
  6. Hello everyone, Short history: I have a long history of On/Off misc. antidepressant use for various periods, icluding SSRIs & SNRIs and atypicals. In previous times, when I went off medication I didn't experience withdrawal but I guess that this bombardment of my brain with various chemicals left it scarred and vulnerable. My first withdrawal occured when I went off 150mg of Effexor XR (Venlafaxine). I took it for only 2 months (July-August 2015) and I experienced withdrawal over the course of 6 months (September 2015 - February 2016), in which I was pretty much disabled and all I did was wait until things will get better. Current state: After a reoccurence of severe depression, I felt desperate and went back on antidepressants. The psychiatrist suggested Vortioxetine (Brintellix/Trintellix), a "brand new" drug. I started from a dose of 5mg which I took for 1 week, then went up to 10mg which I took for 2 weeks, after that I went up to 15mg, severe itching ensued so I dropped back to 10mg. I stopped taking it after 1 week without tapering because Vortioxetine has a long half life. All in all, I took it for 4-5 weeks, and have been off it since August 2016. About a week after discontinuing, a myriad of symptoms appeared: Tight muscles in head/traps/shoulders/stomach, hot flashes, extreme irritability and agitation, impaired cognition (no concentration, focus, memory etc...), anhedonia, no motivation, akathisia, jaw pain. In general, I feel like my brain has been fried. Currently, I feel very confused and discouraged. Sometimes it seems that it's getting slightly better, sometimes I feel that no change occured and I'm still experiencing the symptoms in the same strength. I haven't tried any other medications apart from Propranolol in an effort to reduce the akathisia but it didn't help. I'm extremely hopeless, I cannot continue my life in this manner. I will meet the psychiatrist in the next week to discuss reinstatement, although I feel it will be the final nail in my brain's coffin. If anyone has any suggestions or can share his/her Vortioxetine experience I would be happy to hear. Thanks
  7. Dear all, I have been on drugs for 20 years. Initial cause for going on drugs was insomnia (impossible to sleep and fear of not being able to sleep), anxiety, depression. Treatment was amitryptilline 150 mg. (Elavil). Then the medication was gradually tapered and the sleeping problem reoccured. I then never stopped drugs. I developped Pure O : fear of not being able to sleep so I did not sleep, unable to go to work because of lack of sleep and terrible anxiety. For many years I was on Prozac and it contributed to destroy my marriage.It made me mean. from 2007 to 2017 I was on all possible ssris, anafranil, but also all types of neuroleptics xeroquel 50 mg, risperdal for a short time...... I am now still unable to sleep in other places or when there are wifi waves, unable to sleep in the same bed as someone, and cant work because of extreme anxiety. After a suicidal attempt due to anafranil poop out I am now on brintellix 10 mg and think I must let my brain stabilize before doing any changes. I have no home and boyfriend so I am staying by a friend. I try to develop a mindfulness attitude to accept how my life has been ruined. has anybody developped this kind of obsessions, how do you address them? Do you know how i will taper Brintellix since I have ocd and as soon as I make a change my own brain thinks "this is going to make your insomnia and anxiety worse". Are people also disabled from drugs and requested disability? Thank you. Current drugs Brintellix 10 mg, Nozinan 20 mg, Zopiclone 7,5 mg
  8. I am withdrawing from Duloxetine 30mg and my doctor has taken me down to 20mg every other day and 10mg of Brintellix every other day. I am not sleeping at all and my head feels foggy all the time. Since I have been on Duloxetine I have had feelings of depression, anxiety, tired all the time and did not realise all this time that Duloxetine is obviously not right for me. I have been on Duloxetine for 1 year.
  9. Hi Courageous ones. I'm happy and frightened to be here. I'm new, 56, not tech or math savvy. Dx 1986 Generalized Anxiety Disorder, Panic Disorder, Major Depressive Episodes. Prescribed Xanax for 30 years beginning 1/4 mg 3 times per day as needed and ending prescription 1 mg/ day as needed. The highest dose I ever too was 1/2 mg, three times a day but always at least 1/2 mg per day towards the end, then hit suddenly stopped working, was taken off, experienced severe PAWS for 3 weeks and psychiatrist then put me on Klonapin 1mg, twice a day which I take faithfully and have been on for 5 months now with two, unsuccessful taper attempts in the time as I was cutting to much to quickly even though it was doctor's advice. ANTIDEPRESSANTS ;( in order of being prescribed over 30 year course); Desipramine, Parnate, Prozac, Trazadone, Paxil, Celexa, Cymbalta, Remeron, currently Trintellix 15mg once a day. I'm sure their may be others I've forgotten. Since Xanax tolerence and severe PAWS in autumn of 2016, I have had to for lose on my home!E, move in with elderly parents, surrender pets, give up professional career and placed on government disability (1/3 my job pay) and having many financial woes. I would like to start to taper the Klonapin off successfully then, about a year after that, taper Trintellix antidepressant. Is this sound or is it better to taper the antidepressant first? All knowledge, experience, encouragement and tips are accepted with gratitude. Peace & Love, Mellow please
  10. Hey guys, I've actually read this website a lot in the past year but never actually joined. I decided today would be a good as day as any. I have a question that I think everyone here has probably asked before- am I gonna be ok? Here's my situation (stick with me, it's a long story). I'm turning 23 next month, and throughout high school I never dealt with much anxiety aside from two or three panic attacks brought on by smoking weed. I didn't know what they were at the time so I chalked it up to bad drugs or whatever. Anyway, after I graduated in 2012 I started experimenting with different drugs in college and I ended up having what I think was a really bad acid trip, or even perhaps serotonin syndrome, in April of 2013. I took a few tabs and immediately had a horrible reaction that ended with me blacking out on the floor and waking up with a few minor scrapes and bruises. i was pretty much fine for about 2 or 3 months after that, but in August I started having weird visuals and light headedness. I also had some panic attacks, which had never happened sober before. Thinking the bad trip had messed me up, I went to the doctor with my symptoms and was diagnosed with anxiety disorder and panic attacks. Looking back on it I'm sure the bad trip didn't help but since I was ok for a few months after and my anxiety symptoms didn't really surface until August, i don't think the bad trip necessarily caused my anxiety. It probably would have happened either way. Anyway, I was prescribed citalopram and it worked amazing for 2.5 years. I had minimal anxiety and panic attacks. However, I gained about 60 pounds and had some sexual side effects (without getting too graphic). Thinking the medicine was causing the weight gain, I went to a new doctor and was prescribed pristiq. Pristiq also worked, though I noticed I couldn't drink on it or I would have a panic attack. The downside was that it wasn't covered by insurance and was VERY expensive. Still, I felt pretty good and because I was so ignorant about the drugs I decided to try and stop cold turkey back in May of this year. I lasted about a weekend with the horrible withdrawal symptoms before I went back to my doctor to explain what happened. She told me that it was normal to experience a withdrawal when stopping cold turkey and prescribed Effexor as something similar to pristiq that would be covered by insurance. It didn't help at all and I still felt like I was going through withdrawals. After about 2 weeks i asked to try and go back to the citalopram and she recommended lexapro as an improved version of citalopram, so i tried that for about 6 weeks. It actually made me feel worse. I went back, desperate to find something to help me, and was prescribed brintellix(trintellix) which after two weeks did nothing. Finally I had enough and asked my doctor about stopping all antidepressants. She told me to cut them in half for a week and then take a half every other day for a week. At this point I had become a veteran of online message boards and I knew that taper was very aggressive so I did two weeks of half a pill and two weeks of half a pill every other day. I took my last pill on August 30th, exactly 90 days ago. I've gone through every symptom imaginable. Brain zaps, panic attacks, weird muscle twitches including eyelids and finger jerks, extreme derealization/depersonalization, horrible chest pains that sent me to the ER convinced I was having a heart attack, jaw pain, weird visuals, and bouts of crying at the slightest provocation. Since I'm about 90 days in, I figured I'd see some improvement by now. While the brain zaps have thankfully stopped, all my other symptoms are still coming and going. Some days I'll have no chest pain but I'll have twitches and depersonalization. Or some days I won't really have much twitching but I'll have visuals and jaw pain. I guess my question is this- can I expect these symptoms to eventually go away, or do I have to learn to live with them as this is the best I'll get? Is this my normal anxiety disorder or still withdrawal symptoms? Am I stuck like this? Please only positive comments, I'm a super negative person by nature and I'm trying to remain positive. Thanks in advance for any replies. Edit- I should add that I don't do any drugs anymore, I stopped everything other than drinking as soon as I started my antidepressant in 2013. I haven't drank this summer either, I've tried but it just makes my withdrawal symptoms worse so I've stayed away. I've also been working out every other day (lifting weights and doing core workouts) to try and feel a little better. My diet has been better and I've lost about 30 pounds since May, and I've just started a new career that I'm excited about. I SHOULD be doing much better but these withdrawals/anxiety have just been killing me all year. Just some context for my question. Thanks again
×

Important Information

By using this site, you agree to our Terms of Use.