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Drugs Found Ineffective for Veterans’ Stress


Patience

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From The New York Times

 

http://www.nytimes.com/2011/08/03/health/research/03psych.html

 

======================================================

Drugs widely prescribed to treat severe post-traumatic stress symptoms for veterans are no more effective than placebos and come with serious side effects, including weight gain and fatigue, researchers reported on Tuesday.

 

The surprising finding, from the largest study of its kind in veterans, challenges current treatment standards so directly that it could alter practice soon, some experts said.

 

Ten percent to 20 percent of those who see heavy combat develop lasting symptoms of post-traumatic stress disorder, and about a fifth of those who get treatment receive a prescription for a so-called antipsychotic medication, according to government numbers.

 

The new study, published in The Journal of the American Medical Association, focused on one medication, Risperdal. But experts said that its results most likely extend to the entire class, including drugs like Seroquel, Geodon and Abilify.

 

“I think it’s a very important study” given how frequently the drugs have been prescribed, said Dr. Charles Hoge, a senior scientist at the Walter Reed Army Institute of Research, who was not involved in the study but wrote an editorial accompanying it. He added, “It definitely calls into question the use of antipsychotics in general for PTSD.”

 

The use of such drugs has grown sharply over the past decade, as thousands of returning soldiers and Marines have found that their post-traumatic stress symptoms do not respond to antidepressants, the only drugs backed by scientific evidence for the disorder. Doctors have turned to antipsychotics, which strongly affect mood, to augment treatment, based almost entirely on their experience with them and how they expect them to work.

 

To test those assumptions, a team of researchers affiliated with the Veterans Affairs medical system had 123 veterans with the disorder begin a regimen that added Risperdal to their treatment. Some of the patients served in Vietnam, others in Iraq or Afghanistan; all had tried courses of antidepressant treatment and found little relief.

 

After six months of treatment, these veterans were doing no better than a similar group of 124 veterans, who were given a placebo. About 5 percent in both groups recovered, and 10 percent to 20 percent reported at least some improvement, based on standardized measures.

 

“We didn’t find any suggestion that the drug treatment was having an overall benefit on their lives,” said Dr. John H. Krystal, the director of the clinical neurosciences division of the Department of Veterans Affairs’ National Center for PTSD and the lead author of the study.

 

Dr. Krystal said the benefits many doctors thought they were getting from the drugs “quite possibly came from simply engaging the patient in treatment, and not from the medication.” He said that antipsychotic drugs might help certain people with psychotic features as well as post-traumatic symptoms, but that the study was not designed to identify them.

 

...

 

Yet studies suggest that talk therapy, alone or in combination with antidepressants, can accelerate the relief of common symptoms, like nightmares and reclusive behavior. These psychotherapies tend to include relaxation skills; incrementally increased exposure to stress triggers; and challenging some inaccurate assumptions that fuel anxiety.

 

Time, too, should be taken into consideration, recent research has found. “We’re finding that about 24 months after a one-year deployment is about enough” for the body to reset itself physiologically, Dr. Hoge said.

1989 to 2008: Prozac then Paxil then Celexa.

Numerous attempts to quit.

Then I got off the SSRI poop-out merry-go-round.

11-12 week taper.

 

Muddy water, let stand, becomes clear

If you're going through hell, keep walking

The only way out is through

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Peter Levine has studied PTSD for many years and believes that trauma is stored in the body and that's where healing work needs to be focused. Two of his books are

Waking the Tiger, which is mostly theory and Healing Trauma, which is just exercises for healing.

1989 to 2008: Prozac then Paxil then Celexa.

Numerous attempts to quit.

Then I got off the SSRI poop-out merry-go-round.

11-12 week taper.

 

Muddy water, let stand, becomes clear

If you're going through hell, keep walking

The only way out is through

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Share on other sites

  • Administrator

Great find, Patience, thank you.

 

Just goes to show -- antidepressants were thrown at vets on the theory they were good for whatever, just like everyone else.

 

I feel sorry for the poor vets whose brains have been pounded by all kinds of psych drugs over the years.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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Y'know, it's too bad many of us here don't want to reveal our identities (for good reasons obviously), as it would be great every time psychiatry has a major f-up like this, we could all engage in a mocking "slow clap."

 

I just heard of this phenomenon on a student loan website where people are "slow clapping" for Congresses' idiocy re the debt ceiling and an (expected) upcoming credit downgrade, which will more than likely have a catastrophic impact on their loans' interest rates.

 

Maybe some day down the line psychiatric survivors will start an internet meme where they too "slow clap" for psychiatry!

 

LINK: http://slowclapforcongress.com/

Been on SSRIs since 1998:

1998-2005: Paxil in varying doses

2005-present: Lexapro.

2006-early '08: Effexor AND Lexapro! Good thing I got off the Effexor rather quickly (within a year).

 

**PSYCHIATRY: TAKE YOUR CHEMICAL IMBALANCE AND CHOKE ON IT!

APA=FUBAR

FDA=SNAFU

NIMH=LMFAO

 

Currently tapering Lexapro ~10% every month:

 

STARTING: 15 mg

11/7/10: 13.5 mg

12/7/10: 12.2 mg

1/6/11: 10.9 mg

2/3/11: 9.8 mg

3/3/11: 8.8 mg

4/1/11: 7.8 mg

4/29/11: 7 mg

5/27/11: 6.4 mg

6/24/11: 5.7 mg

7/22/11: 5 mg

8/18/11: 4.5 mg

9/14/11: 4 mg

10/13/11: 3.6 mg

11/9/11: 3.2 mg

12/7/11: 2.6 mg

1/3/12: 2.1 mg

2/2/12: 1.8 mg

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On a tragic, related note, Army suicides have now hit an all-time record: http://www.washingtonpost.com/blogs/checkpoint-washington/post/army-suicides-hit-record-in-july/2011/08/12/gIQAPWaQBJ_blog.html

 

Now, there are obviously many lurking variables here (like the simple fact that many vets are either ashamed to seek out help or think it will hurt their career to have mental health diagnoses on their background check) BUT the fact remains that when they do get help, it's often not real help, but often just some antipsychotic like Seroquel.

 

Wow, yet another failure for the US. Go team :angry:

Been on SSRIs since 1998:

1998-2005: Paxil in varying doses

2005-present: Lexapro.

2006-early '08: Effexor AND Lexapro! Good thing I got off the Effexor rather quickly (within a year).

 

**PSYCHIATRY: TAKE YOUR CHEMICAL IMBALANCE AND CHOKE ON IT!

APA=FUBAR

FDA=SNAFU

NIMH=LMFAO

 

Currently tapering Lexapro ~10% every month:

 

STARTING: 15 mg

11/7/10: 13.5 mg

12/7/10: 12.2 mg

1/6/11: 10.9 mg

2/3/11: 9.8 mg

3/3/11: 8.8 mg

4/1/11: 7.8 mg

4/29/11: 7 mg

5/27/11: 6.4 mg

6/24/11: 5.7 mg

7/22/11: 5 mg

8/18/11: 4.5 mg

9/14/11: 4 mg

10/13/11: 3.6 mg

11/9/11: 3.2 mg

12/7/11: 2.6 mg

1/3/12: 2.1 mg

2/2/12: 1.8 mg

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