reachingforthestars Posted October 22, 2015 Share Posted October 22, 2015 Treatment of cycling female rats with fluoxetine induces desensitization of hypothalamic 5-HT1A receptors with no change in 5-HT2A receptors http://www.sciencedirect.com/science/article/pii/S0028390802000758 Does hypothalamic post-synaptic receptors heal or will they stay desensitized after stopping antidepressants? Citalopram 40mg from 2003-2015 Jan 2015 started tapering first dropped to 35mg, Feb 30mg, March 25mg, April 20mg, May 17,5mg, June 15mg, July 12,5mg, Aug 12,5mg, Sep 0mg for 5 days because of stomac flu and after I raised to 7,5mg. All the symptoms of acute WD shaking, diarrhea, vomiting, barely could walk ect. Still didn't realize that it wasn't only stomac flu but I was also going through WD. Oct 2,5mg and crashed again badly and quickly raised to 4mg. It was then when I knew my symptoms were due to WD. Then in November after a month holding on 4mg raised to 5mg due to muscle weakness and had a VERY BAD reaction to reinstatement: akathisia(lasted for one or two weeks), insomnia, anhedonia... Drop quicly back to 4mg, Dec 3mg Jan 2016 2,6mg( in the middle of Jan after I had been on 2,6mg for a week I tried to updose to 2,8mg and immediately had bad reaction to it: akathisia for a day, andehonia got worse. The next day dropped back to 2,6mg), Feb 2,4mg( a new symptom PGAD lasted 24/7 for 2 months after that on and off), March 2,4mg, April 2,3mg, May 2,2mg, June 2,1mg, July 2,0mg( Pgad almost nonexisting, sleeping pretty good, still some anhedonia but there has been a lot of gradual progress), Aug 1,97mg-1,89mg, Sep 1,88mg-1,49mg, Oct 1,48mg- 1,70mg, Nov 0,65mg- current dose 0,5mg Link to comment Share on other sites More sharing options...
reachingforthestars Posted October 22, 2015 Author Share Posted October 22, 2015 Does anyone know can human brain make new 5-HT1A receptors? Citalopram 40mg from 2003-2015 Jan 2015 started tapering first dropped to 35mg, Feb 30mg, March 25mg, April 20mg, May 17,5mg, June 15mg, July 12,5mg, Aug 12,5mg, Sep 0mg for 5 days because of stomac flu and after I raised to 7,5mg. All the symptoms of acute WD shaking, diarrhea, vomiting, barely could walk ect. Still didn't realize that it wasn't only stomac flu but I was also going through WD. Oct 2,5mg and crashed again badly and quickly raised to 4mg. It was then when I knew my symptoms were due to WD. Then in November after a month holding on 4mg raised to 5mg due to muscle weakness and had a VERY BAD reaction to reinstatement: akathisia(lasted for one or two weeks), insomnia, anhedonia... Drop quicly back to 4mg, Dec 3mg Jan 2016 2,6mg( in the middle of Jan after I had been on 2,6mg for a week I tried to updose to 2,8mg and immediately had bad reaction to it: akathisia for a day, andehonia got worse. The next day dropped back to 2,6mg), Feb 2,4mg( a new symptom PGAD lasted 24/7 for 2 months after that on and off), March 2,4mg, April 2,3mg, May 2,2mg, June 2,1mg, July 2,0mg( Pgad almost nonexisting, sleeping pretty good, still some anhedonia but there has been a lot of gradual progress), Aug 1,97mg-1,89mg, Sep 1,88mg-1,49mg, Oct 1,48mg- 1,70mg, Nov 0,65mg- current dose 0,5mg Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted October 22, 2015 Administrator Share Posted October 22, 2015 Yes, the receptors upregulate again, but it can be a slow process. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
reachingforthestars Posted October 23, 2015 Author Share Posted October 23, 2015 That is reliefing message. Keeping up hope is so important. Citalopram 40mg from 2003-2015 Jan 2015 started tapering first dropped to 35mg, Feb 30mg, March 25mg, April 20mg, May 17,5mg, June 15mg, July 12,5mg, Aug 12,5mg, Sep 0mg for 5 days because of stomac flu and after I raised to 7,5mg. All the symptoms of acute WD shaking, diarrhea, vomiting, barely could walk ect. Still didn't realize that it wasn't only stomac flu but I was also going through WD. Oct 2,5mg and crashed again badly and quickly raised to 4mg. It was then when I knew my symptoms were due to WD. Then in November after a month holding on 4mg raised to 5mg due to muscle weakness and had a VERY BAD reaction to reinstatement: akathisia(lasted for one or two weeks), insomnia, anhedonia... Drop quicly back to 4mg, Dec 3mg Jan 2016 2,6mg( in the middle of Jan after I had been on 2,6mg for a week I tried to updose to 2,8mg and immediately had bad reaction to it: akathisia for a day, andehonia got worse. The next day dropped back to 2,6mg), Feb 2,4mg( a new symptom PGAD lasted 24/7 for 2 months after that on and off), March 2,4mg, April 2,3mg, May 2,2mg, June 2,1mg, July 2,0mg( Pgad almost nonexisting, sleeping pretty good, still some anhedonia but there has been a lot of gradual progress), Aug 1,97mg-1,89mg, Sep 1,88mg-1,49mg, Oct 1,48mg- 1,70mg, Nov 0,65mg- current dose 0,5mg Link to comment Share on other sites More sharing options...
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