Jump to content
scot

Epigenetic changes and mitochondria dysfunction

Recommended Posts

scot

Hi,

there is evidence that (psychiatric) drugs cause epigenetic changes and also mitochondrial dysfunction.If we could reverse some of the epigenetic changes or mitochondrial dysfunction,we could get some gain.

You can reverse epigenetic changes through diet eating these foods:

Garlic,Onion,cruciferous vegetables (like Brocolli etc),herbal teas,curcumin,resvervatol (found in grapes,red wine etc),lycopene(found in tomatos),quercetin(found in apples),anthocyanin(found in eggplant,plums,pomegranate,cranberries,bleuberries etc) ,probiotics,ginger,cocoa etc .

All these foods contain plenty of phytochemicals,antioxidants,vitamins etc. that may reverse some epigenetic changes done by drugs.Also,there are some  herbal mixtures of the above foods that might help to revert epigenetic changes (there is research for that)

There is also evidence that some supplements can reverse epigenetic changes like folic acid,B vitamins,glycine etc 

However,they may also cause some harm regarding to this research http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133251/

 

Also exercise,meditation,fasting,alternative medicine(ayuverda,yoga,taichi,reiki,acupuncture,body massage,naturopathy,hypnotherapy etc) can revert some epigenetic changes.

Here you can find more info:

 

http://www.researchgate.net/publication/26271506_Epigenetic_side-effects_of_common_pharmaceuticals_A_potential_new_field_in_medicine_and_pharmacology

http://journal.frontiersin.org/article/10.3389/fcell.2014.00049/full

http://journal.frontiersin.org/article/10.3389/fcell.2014.00049/full

http://europepmc.org/articles/pmc3889536

http://greyduckgarlic.com/Garlic_and_Epigenetics.html

http://www.drperlmutter.com/dietary-epigenetics-new-frontiers/

http://advances.nutrition.org/content/1/1/8.full

http://www.anti-agingfirewalls.com/2011/02/08/cancer-epigenetics-and-dietary-substances/

https://amuseamused.wordpress.com/2014/05/21/epigenetics-superpowers-and-broccoli-how-to-change-your-dna/

https://en.wikipedia.org/wiki/Nutriepigenomics#Future_directions

http://robbwolf.com/2013/04/10/epigenetics-methylation-gene-expression/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873820/

http://www.precisionnutrition.com/exercise-changes-dna

https://www.newscientist.com/article/dn23480-meditation-boosts-genes-that-promote-good-health/

 

Also,psychiatric drugs may cause mitochondrial dysfunction (http://www.globalresearch.ca/mitochondrial-collateral-damage-thanks-to-big-pharma/5447650

There is also a study that says peripheral neuropathy may be related with mitochondrial dysfunction 

http://mitochondrialdiseasenews.com/2015/09/30/study-reports-peripheral-neuropathy-associated-mitochondrial-dysfunction/

 

Some supplements that might help with mitochondrial dysfunction are:

PPQ,L-Carnosine,MitoQ,N-acetylcysteine,D-Ribose,Lipid Replacement therapy,L-carnitine,Lipoid Acid,Quercetin,probiotics etc.

Here are some links,but its better to try to take these through diet.

 

http://hplusmagazine.com/2011/03/21/rejuvenate-your-cells-by-growing-new-mitochondria/

http://www.alsearsmd.com/2013/11/your-brain-on-carnosine/

http://www.dailymail.co.uk/femail/article-2588892/Miracle-antioxidant-anti-agEing-cream-promises-847-times-effective-replenishing-skin.html

http://www.ohsu.edu/xd/about/news_events/news/2013/12-26-antioxidant-drug-knocks.cfm

http://www.cpmedical.net/newsletter/mitochondria-resuscitation-the-key-to-healing-every-disease

http://warddeanmd.com/mitochondrial-restoration-part-iii-d-ribose-and-creatine-increase-mitochondrial-energy-production/

http://www.ncbi.nlm.nih.gov/pubmed/24269541

http://www.smart-publications.com/articles/restore-mitochondrial-function-with-acetyl-l-carnitine-ALC-and-lipoic-/page-2

http://www.hindawi.com/journals/omcl/2013/154279/

http://www.foodtrients.com/news-page/anti-aging/three-step-strategy-to-reverse-mitochondrial-aging/

http://www.cpmedical.net/newsletter/effective-natural-solutions-for-mitochondrial-diseases

http://medicalxpress.com/news/2013-12-mitochondria-neurodegenerative-disease.html

https://cfsremission.wordpress.com/treatment/microflora-and-autoimmune-illnesses/changing-microfloras-by-probiotics/correcting-mitochondrial-dysfunction-via-microflora/

Share this post


Link to post
Share on other sites
scot

STUDY SHOWS MOST EPIGENETIC CHANGES HAPPEN IN COCAINE ADDICTION DURING THE PERIODS OF WITHDRAWAL

http://health-innovations.org/2015/05/28/study-shows-most-epigenetic-changes-happen-in-cocaine-addiction-during-the-periods-of-withdrawal/

 

Could this also be the case of SSRI withdrawal?So we need natural DNA methylation inhibitors. (Also curcumin and green tea are not DNA methylation inhibitors according to this study http://www.researchgate.net/publication/45584242_Natural_products_as_DNA_methyltransferase_inhibitors_A_computer-aided_discovery_approach)

 

If anyone finds any natural substances of this kind please report it here.

thanks

Share this post


Link to post
Share on other sites
Meimeiquest

That is far, far above my pay grade. But if anything, it seems it would argue for slow tapering off cocaine etc and psychotropic drugs. If you are untested in stuff like this, you might look at Amy Yasko's work (I read a doc who works with her, nancymullenmd.com, or a book by William Walsh, Nutrient Power. It is somewhat an infomercial for his protocols, but has some good information on epigenetics.

Share this post


Link to post
Share on other sites
scot

That is far, far above my pay grade. But if anything, it seems it would argue for slow tapering off cocaine etc and psychotropic drugs. If you are untested in stuff like this, you might look at Amy Yasko's work (I read a doc who works with her, nancymullenmd.com, or a book by William Walsh, Nutrient Power. It is somewhat an infomercial for his protocols, but has some good information on epigenetics.

Thank you for the book you propose,I will have a read of it when I find some time.

Share this post


Link to post
Share on other sites
Meimeiquest

Another interesting book is The Wahls Protocol by Terry Wahls. She remitted very serious multiple sclerosis (she was in a zero gravity wheelchair) with dietary interventions.

Share this post


Link to post
Share on other sites
scot

Another interesting book is The Wahls Protocol by Terry Wahls. She remitted very serious multiple sclerosis (she was in a zero gravity wheelchair) with dietary interventions.

Yep,I know the story of Terry Wahls.She had multiple sclerosis and she managed to recover using foods that correct the mitochondrial dysfunction. 

 

Share this post


Link to post
Share on other sites
scot

Hi Marmite,

I really appreciate your comments regarding my effort.

I have already posted these things on the Dr. Healy website.

 

Regarding the term "Epigenetic" :We  inherit our DNA(genes) from our parents.The way we live (diet,stress,drugs etc) changes which genes are off and on,through some mechanisms called epigenetics,which can cause illness.Psychiatric drugs turn also genes off and on also through epigenetic changes.The good thing is that epigenetic changes are reversible.If we find ways to reverse those epigenetic changes done by drugs we may reverse our conditions that drugs caused us.For example this article (28 October 2015) says that early fetal exposure to alcohol reduces dopamine and increases prolactin in the brain through epigenetic changes.Applying a substance that reverses these epigenetic changes done by alkohol (called DNA methylation inhibitor) reversed those changes and restored normal functionality of dopamine and prolactin. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140699

(However the substances used are "toxic" ,so no-one should use them). So,if we find some natural DNA methylation inhibitors from plants,vegetables etc we may "remove" those changes done by the drugs to our brain/body and restore its functionality in the pro-drug state.This way,we can also supress "bad" genes we have inherited from our parents that can cause extra illness (cancer,neurological diseases etc).

The following article says that,although mice were born to be fat etc they became normal after using some vitamins through reversing epigenetic changes.This way,"bad" genes were suppressed and "good" genes were turned on.

http://www.nature.com/news/1998/030728/full/news030728-12.html

http://www.scienceinschool.org/2014/issue28/epigenetics

Also,I read yesterday and I was surprised, that Vince Guliano,a 80+ old years old man,through such diet,exercise,intermittent fasting etc is able to have sex on this age! http://www.vincegiuliano.name/

 

Also,regarding latest research that many mental issues(depression,anxiety,alzheimer etc) may be due to inflammation on the brain,these substances work as anti-inflammatory,which can also help.

 

So,"epigenetics" is a mechanism that turns genes "on" and "off" ,good or bad.

 

Sorry for speaking a lot,I hope you find my writings useful.

thank you

Share this post


Link to post
Share on other sites
scot

Regarding the fact that drugs may also damage mitochondria,we have to get rid of these damaged mitochondria.This process is called autophagy (or mitophagy for mitochondria).The most powerful method to induce autophagy is through fasting.Fasting is one of the most important ways for "healing".Recent research proves that,also fasting has been used for thousands of years throughout the world to heal the human body from illnesses.

So,fasting can remove damaged mitochondria(also damaged proteins,toxic stubstances  etc) through autophagy and turns on genetic repair mechanism of the body.There are many ways for fasting,one of the easiest is to try to have meals at least after 12 hours(best 15-16 hours).E.g. you can eat at 5 o clock in the afternoon and then eat again next morning and so on.

Here are some resources,you can find many more on the internet:

 

http://www.anti-agingfirewalls.com/2013/04/19/autophagy-the-housekeeper-in-every-cell-that-fights-aging-2/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/

http://www.marksdailyapple.com/health-benefits-of-intermittent-fasting/#axzz3rVsF1j6P

http://www.sott.net/article/258260-Intermittent-fasting-is-a-powerful-healing-modality

http://www.telegraph.co.uk/news/uknews/10878625/Fasting-for-three-days-can-regenerate-entire-immune-system-study-finds.html

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630798/

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


×
×
  • Create New...