Epigenetic changes and mitochondria dysfunction

[scot]

Hi,

there is evidence that (psychiatric) drugs cause epigenetic changes and also mitochondrial dysfunction.If we could reverse some of the epigenetic changes or mitochondrial dysfunction,we could get some gain.

You can reverse epigenetic changes through diet eating these foods:

Garlic,Onion,cruciferous vegetables (like Brocolli etc),herbal teas,curcumin,resvervatol (found in grapes,red wine etc),lycopene(found in tomatos),quercetin(found in apples),anthocyanin(found in eggplant,plums,pomegranate,cranberries,bleuberries etc) ,probiotics,ginger,cocoa etc .

All these foods contain plenty of phytochemicals,antioxidants,vitamins etc. that may reverse some epigenetic changes done by drugs.Also,there are some  herbal mixtures of the above foods that might help to revert epigenetic changes (there is research for that)

There is also evidence that some supplements can reverse epigenetic changes like folic acid,B vitamins,glycine etc 

However,they may also cause some harm regarding to this research http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133251/

 

Also exercise,meditation,fasting,alternative medicine(ayuverda,yoga,taichi,reiki,acupuncture,body massage,naturopathy,hypnotherapy etc) can revert some epigenetic changes.

Here you can find more info:

 

http://www.researchgate.net/publication/26271506_Epigenetic_side-effects_of_common_pharmaceuticals_A_potential_new_field_in_medicine_and_pharmacology

http://journal.frontiersin.org/article/10.3389/fcell.2014.00049/full

http://journal.frontiersin.org/article/10.3389/fcell.2014.00049/full

http://europepmc.org/articles/pmc3889536

http://greyduckgarlic.com/Garlic_and_Epigenetics.html

http://www.drperlmutter.com/dietary-epigenetics-new-frontiers/

http://advances.nutrition.org/content/1/1/8.full

http://www.anti-agingfirewalls.com/2011/02/08/cancer-epigenetics-and-dietary-substances/

https://amuseamused.wordpress.com/2014/05/21/epigenetics-superpowers-and-broccoli-how-to-change-your-dna/

https://en.wikipedia.org/wiki/Nutriepigenomics#Future_directions

http://robbwolf.com/2013/04/10/epigenetics-methylation-gene-expression/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873820/

http://www.precisionnutrition.com/exercise-changes-dna

https://www.newscientist.com/article/dn23480-meditation-boosts-genes-that-promote-good-health/

 

Also,psychiatric drugs may cause mitochondrial dysfunction (http://www.globalresearch.ca/mitochondrial-collateral-damage-thanks-to-big-pharma/5447650

There is also a study that says peripheral neuropathy may be related with mitochondrial dysfunction 

http://mitochondrialdiseasenews.com/2015/09/30/study-reports-peripheral-neuropathy-associated-mitochondrial-dysfunction/

 

Some supplements that might help with mitochondrial dysfunction are:

PPQ,L-Carnosine,MitoQ,N-acetylcysteine,D-Ribose,Lipid Replacement therapy,L-carnitine,Lipoid Acid,Quercetin,probiotics etc.

Here are some links,but its better to try to take these through diet.

 

http://hplusmagazine.com/2011/03/21/rejuvenate-your-cells-by-growing-new-mitochondria/

http://www.alsearsmd.com/2013/11/your-brain-on-carnosine/

http://www.dailymail.co.uk/femail/article-2588892/Miracle-antioxidant-anti-agEing-cream-promises-847-times-effective-replenishing-skin.html

http://www.ohsu.edu/xd/about/news_events/news/2013/12-26-antioxidant-drug-knocks.cfm

http://www.cpmedical.net/newsletter/mitochondria-resuscitation-the-key-to-healing-every-disease

http://warddeanmd.com/mitochondrial-restoration-part-iii-d-ribose-and-creatine-increase-mitochondrial-energy-production/

http://www.ncbi.nlm.nih.gov/pubmed/24269541

http://www.smart-publications.com/articles/restore-mitochondrial-function-with-acetyl-l-carnitine-ALC-and-lipoic-/page-2

http://www.hindawi.com/journals/omcl/2013/154279/

http://www.foodtrients.com/news-page/anti-aging/three-step-strategy-to-reverse-mitochondrial-aging/

http://www.cpmedical.net/newsletter/effective-natural-solutions-for-mitochondrial-diseases

http://medicalxpress.com/news/2013-12-mitochondria-neurodegenerative-disease.html

https://cfsremission.wordpress.com/treatment/microflora-and-autoimmune-illnesses/changing-microfloras-by-probiotics/correcting-mitochondrial-dysfunction-via-microflora/

[scot]

STUDY SHOWS MOST EPIGENETIC CHANGES HAPPEN IN COCAINE ADDICTION DURING THE PERIODS OF WITHDRAWAL

http://health-innovations.org/2015/05/28/study-shows-most-epigenetic-changes-happen-in-cocaine-addiction-during-the-periods-of-withdrawal/

 

Could this also be the case of SSRI withdrawal?So we need natural DNA methylation inhibitors. (Also curcumin and green tea are not DNA methylation inhibitors according to this study http://www.researchgate.net/publication/45584242_Natural_products_as_DNA_methyltransferase_inhibitors_A_computer-aided_discovery_approach)

 

If anyone finds any natural substances of this kind please report it here.

thanks

[Meimeiquest]

That is far, far above my pay grade. But if anything, it seems it would argue for slow tapering off cocaine etc and psychotropic drugs. If you are untested in stuff like this, you might look at Amy Yasko's work (I read a doc who works with her, nancymullenmd.com, or a book by William Walsh, Nutrient Power. It is somewhat an infomercial for his protocols, but has some good information on epigenetics.

[scot]

That is far, far above my pay grade. But if anything, it seems it would argue for slow tapering off cocaine etc and psychotropic drugs. If you are untested in stuff like this, you might look at Amy Yasko's work (I read a doc who works with her, nancymullenmd.com, or a book by William Walsh, Nutrient Power. It is somewhat an infomercial for his protocols, but has some good information on epigenetics.

Thank you for the book you propose,I will have a read of it when I find some time.

[scot]

One more link with foods that can revert epigenetic changes.It has to do with cancer but may help us also.At the bottom says that alcohol and cocaine addiction also cause epigenetic changes,maybe same issues like psychiatric drugs.

 

http://www.anti-agingfirewalls.com/2011/02/08/cancer-epigenetics-and-dietary-substances/ 

[Meimeiquest]

Another interesting book is The Wahls Protocol by Terry Wahls. She remitted very serious multiple sclerosis (she was in a zero gravity wheelchair) with dietary interventions.

[scot]

Another interesting book is The Wahls Protocol by Terry Wahls. She remitted very serious multiple sclerosis (she was in a zero gravity wheelchair) with dietary interventions.

Yep,I know the story of Terry Wahls.She had multiple sclerosis and she managed to recover using foods that correct the mitochondrial dysfunction. 

 

[scot]

If anyone could access any of these articles and tell us a list of the most potent natural DNA methylation inhibitors it would be great.

 

http://www.ncbi.nlm.nih.gov/pubmed/25487010

http://www.ncbi.nlm.nih.gov/pubmed/26547065

http://www.ncbi.nlm.nih.gov/pubmed/26303417

[scot]

Hi Marmite,

I really appreciate your comments regarding my effort.

I have already posted these things on the Dr. Healy website.

 

Regarding the term "Epigenetic" :We  inherit our DNA(genes) from our parents.The way we live (diet,stress,drugs etc) changes which genes are off and on,through some mechanisms called epigenetics,which can cause illness.Psychiatric drugs turn also genes off and on also through epigenetic changes.The good thing is that epigenetic changes are reversible.If we find ways to reverse those epigenetic changes done by drugs we may reverse our conditions that drugs caused us.For example this article (28 October 2015) says that early fetal exposure to alcohol reduces dopamine and increases prolactin in the brain through epigenetic changes.Applying a substance that reverses these epigenetic changes done by alkohol (called DNA methylation inhibitor) reversed those changes and restored normal functionality of dopamine and prolactin. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140699

(However the substances used are "toxic" ,so no-one should use them). So,if we find some natural DNA methylation inhibitors from plants,vegetables etc we may "remove" those changes done by the drugs to our brain/body and restore its functionality in the pro-drug state.This way,we can also supress "bad" genes we have inherited from our parents that can cause extra illness (cancer,neurological diseases etc).

The following article says that,although mice were born to be fat etc they became normal after using some vitamins through reversing epigenetic changes.This way,"bad" genes were suppressed and "good" genes were turned on.

http://www.nature.com/news/1998/030728/full/news030728-12.html

http://www.scienceinschool.org/2014/issue28/epigenetics

Also,I read yesterday and I was surprised, that Vince Guliano,a 80+ old years old man,through such diet,exercise,intermittent fasting etc is able to have sex on this age! http://www.vincegiuliano.name/

 

Also,regarding latest research that many mental issues(depression,anxiety,alzheimer etc) may be due to inflammation on the brain,these substances work as anti-inflammatory,which can also help.

 

So,"epigenetics" is a mechanism that turns genes "on" and "off" ,good or bad.

 

Sorry for speaking a lot,I hope you find my writings useful.

thank you

[scot]

A more recent article about epigenetics with info how to reverse changes done by drugs etc

 

Epigenetics across the human lifespan

http://www.researchgate.net/publication/266390065_Epigenetics_across_the_human_lifespan

[scot]

Regarding the fact that drugs may also damage mitochondria,we have to get rid of these damaged mitochondria.This process is called autophagy (or mitophagy for mitochondria).The most powerful method to induce autophagy is through fasting.Fasting is one of the most important ways for "healing".Recent research proves that,also fasting has been used for thousands of years throughout the world to heal the human body from illnesses.

So,fasting can remove damaged mitochondria(also damaged proteins,toxic stubstances  etc) through autophagy and turns on genetic repair mechanism of the body.There are many ways for fasting,one of the easiest is to try to have meals at least after 12 hours(best 15-16 hours).E.g. you can eat at 5 o clock in the afternoon and then eat again next morning and so on.

Here are some resources,you can find many more on the internet:

 

http://www.anti-agingfirewalls.com/2013/04/19/autophagy-the-housekeeper-in-every-cell-that-fights-aging-2/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/

http://www.marksdailyapple.com/health-benefits-of-intermittent-fasting/#axzz3rVsF1j6P

http://www.sott.net/article/258260-Intermittent-fasting-is-a-powerful-healing-modality

http://www.telegraph.co.uk/news/uknews/10878625/Fasting-for-three-days-can-regenerate-entire-immune-system-study-finds.html

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630798/

[Altostrata]

Epigenetics and, lately, mitochondrial dysfunction are the latest fads in naturopathic medicine, borrowed from genetic research in "translational medicine", meaning research conducted for the purpose of drug development. As usual, when naturopathic medicine get hold of a medical fad, it dumbs it down to an easily understood, but wrong, pop health idea.

 

An example is "chemical imbalance", a dead end hypothesis in actual science that went viral, which naturopathic medicine adopted and proposed to correct with supplements, etc. To this day, many naturopaths will sell expensive but useless supplement programs to correct your "serotonin deficiency" or whatever.

 

Another example is the MTHFR craze of some years back. The solution for poor folate metabolism is not a complex supplement regimen but to eat more fresh leafy green vegetables, which contain folate.

 

There's a lot of good in a naturopathic approach, but also a lot of nonsense as it borrows sciencey ideas that sound plausible, no matter how poorly evidenced, and derives fringy but expensive non-drug remedies accordingly.

 

A general analogy to grasp epigenetics: The cells in the body self-regulate driven by genetic scripts. You might envision a thermometer as a cell "genetically scripted" to measure temperature. The mechanism often depends on the expansion rate of a metal within the thermometer, which expands with heat and contracts when cooled.

 

Epigenetics would describe the properties of the atoms within the metal. Epigenetics investigates the biochemistry of genetically programmed molecular "switches" within a cell. The switches are constantly adjusting to the environment. They do not permanently change the genetic script, they are an expression of and limited by the genetic script. This simply is the way genes work.

 

Epigenetics has become a focus of research because those molecular switches are potential drug targets. The theory is they define specific phenotypes (genetic profiles) susceptible to diseases. Very little is know about how they work even in defined diseases like type 1 diabetes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763387/x

 

Aspects of neuroplasticity are no doubt controlled by genetics, though nothing is known about this.

 

Saying "All body functions, including neuroplasticity, are controlled by genetic scripts particular to the individual" pretty much cover this without getting lost in the weeds of biomolecular action in epigenetics.

 

The hand-flapping about mitochondria likewise is about basic cell function. Even experts are confused by the extremely complex Krebs cycle. Saying mitochondria are important to brain function is merely saying that the brain is full of living cells. The best way to keep your cells producing energy is to get good nutrition and exercise -- that's the basis of psychiatrist Christopher Palmer's "Brain Energy" miracle cure.

 

Sure, a keto diet is better for you than a junk food diet, any diet that minimizes sugar and increases fresh vegetable intake would be better. Humans evolved as omnivores eating seeds, tubers, fruit, etc., but most of us are sedentary and do not need extra carbs in any form. But keto is not the ultimate cure, and it's not for everybody (some people do better with some complex cards, and keto is a First World diet for people who can afford to buy lots of protein).

 

These are other areas where nobody knows anything, but sciencey jargon on social media sounds like they do. This site has been in operation going on 12 years, our topics are graveyards of alt-med blather, and epigenetics and mitochondria hypotheses are yet two more examples.

[PeaceInside]

@Altostrata I love your response to this thread. It seems to me, through both my experience of PAWS and trying different methodologies of healing, that the basics really are the best: eating a diet rich in fruits and vegetables with healthy fats, protein, and healthy carbs, getting the right amount and right kind of movement and exercise for where my body is each day, creating space and time for real rest and relaxation daily, and engaging with joy as much as possible every day. I personally do not think there is any targeted therapy or immediate cure for PAWS because it is both the limbic system of the brain and central nervous system that need to go through a process of healing and change. It has been my experience of working with these two things that slowly, steadily, and consistently incorporating the above into my life that has led to healing.