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Equinox: What are SSRIs made of?


Equinox

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Hello everyone,

i am new to this forum and first of all i want to say thank you for all the important and great work you're doing here!

I am an antidepressant surviver by myself and after almost 4 years without drug i am still struggling with the aftermath. I am looking for a deeper understanding concerning these chemicals and their destructive nature.

At the moment i want to know why and how exactly these drugs were invented and what these people had in mind when they were playing god in their laboratories.

Now to my actual question, i guess it's a quit uncommon one.
What excatly are SSRIs made of ? Paxil for example, what is the raw material for chemically producing this substance ? Is it made of oil ?  And what other chemicals are involved in the process?

And how is it manufactured? I couldn't find much about this on the internet. Maybe there's someone here that's got an answer to this question or an idea where i can find out something like this.
Maybe also there's some literature about this topic you can recommand?!

Thanks very much in advance, Equinox
 

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  • Moderator Emeritus

Welcome Equinox,

I moved your introductory post here to your own intro/update thread so we can get to know you and maybe answer some of your questions. Its a good idea to bookmark it or follow it, so its easy to find again.

 

What drugs were you taking and how did you stop? If you would like to share a little more of your story, many of us here would be interested and can probably relate to what you are going through now.

 

I don't know much about the formula of the various antidepressants, but a good place to start with learning about how they came into being is Anatomy of an Epidemic by Robert Whitaker.

 

Please feel free to write whenever you want, you will find a lot of friendly help and support here.

 

Petunia.

I'm not a doctor.  My comments are not medical advise. These are my opinions based on my own experience and what I've learned. Please discuss your situation with a medical practitioner who has knowledge of tapering and withdrawal...if you are lucky enough to find one.

My Introduction Thread

Full Drug and Withdrawal History

Brief Summary

Several SSRIs for 13 years starting 1997 (for mild to moderate partly situational anxiety) Xanax PRN ~ Various other drugs over the years for side effects

2 month 'taper' off Lexapro 2010

Short acute withdrawal, followed by 2 -3 months of improvement then delayed protracted withdrawal

DX ADHD followed by several years of stimulants and other drugs trying to manage increasing symptoms

Failed reinstatement of Lexapro and trial of Prozac (became suicidal)

May 2013 Found SA, learned about withdrawal, stopped taking drugs...healing begins.

Protracted withdrawal, with a very sensitized nervous system, slowly recovering as time passes

Supplements which have helped: Vitamin C, Magnesium, Taurine

Bad reactions: Many supplements but mostly fish oil and Vitamin D

June 2016 - Started daily juicing, mostly vegetables and lots of greens.

Aug 2016 - Oct 2016 Best window ever, felt almost completely recovered

Oct 2016 -Symptoms returned - bad days and less bad days.

April 2018 - No windows, but significant improvement, it feels like permanent full recovery is close.

VIDEO: Where did the chemical imbalance theory come from?



VIDEO: How are psychiatric diagnoses made?



VIDEO: Why do psychiatric drugs have withdrawal syndromes?



VIDEO: Can psychiatric drugs cause long-lasting negative effects?

VIDEO: Dr. Claire Weekes

 

 

 

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There are two theories on protracted withdrawal that I understand to be the closest thing the world knows to "the mechanism":

 

1.  Nerve damage - http://withdrawal.rxisk.org/new-model/complex-withdrawal-model/

2.  Dysregulation/dysfunction/gene expression challenges - http://survivingantidepressants.org/index.php?/topic/603-what-is-withdrawal-syndrome/

 

In my opinion, it's a combination of the above two hypotheses.

 

 

As to what they're made of:

 

Basic answer, molecules.  More specific answer, here's the chemical structures:  https://www.google.com/search?q=ssri+chemical+structures&num=40&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjMgtCCsL7JAhUF9R4KHXnlAQEQ_AUIBygB&biw=1129&bih=585

 

Trust me - it's not what they're made of that's causing protracted withdrawal - it's what they do to the body and how the body tries to adapt to their effects.

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Hi Equinox, welcome. 

 

I would say chemicals, in and of themselves are not destructive by nature. In fact many of them are from nature, certain salts, certain solvents, certain oils (oil is essentially very old natural composted sludge really) and then these chemicals or reagents are combined in varying ways and processes to make things chemists think will be useful some of which are medicines although I'm loath to call antidepressants medicine because they really aren't. Each 'brand' is made from combinations of different elements that effectively are designed to work on the same or similar brain receptors for reasons that are.. arbitrary at best. 

 

What is very destructive is the reaction the finished drug has when it's introduced into our bodies where it prevents a normal process in our brains, the re-uptake of neurotransmitters. I'm sorry that you're one of the people who's had ongoing trouble from that but you are not alone. I hope you'll find practical answers to the things that you're dealing with here. Whatever is in the ridiculous drugs is less important than how you go about living day to day and getting the most out of your life now without them. 

2000: Use of venlafaxine for moderate depression for two years. Tapered off with no major problems. 

2010: Venlafaxine 5 years, doses between 75-150-300. Tolerated but only partially stabilised the severe depression & escallating side effects. 

Adverse reactions to citalopram (tried before venlafaxine), sertraline & mirtazapine (tried after venlafaxine became problematic) with suicidal ideation caused. 

2014: Adverse reaction to one prozac pill which I tried to begin taking in order to stabilise the withdrawal and actually made it horrendously worse. My body & brain went on fire two hours after taking the pill and severe WD began.

Spring 2014: CEASED ALL ANTIDEPRESSANTS. Did take occasional lorazepam (two weeks at first followed by the occasional half tablet at night sometimes.

2014: WD: living hell for five months, gradually improved a little by little for almost a year and a half but with frequent heart palpitations, weakness and anxiety and very poor sleep. Struggled to do things both physically & mentally but was improving slowly. 

2015: WD relapse with full symptoms. anxiety/panic triggered beyond initial anxiety resurgence by a couple of small half doses of Lorazepam that seem to have restarted all the WD symptoms I had in the beginning & ruined all the progress I had made. 

2017: Bad reaction to propranolol beta blockers. Nervous system kindled into violent shaking like withdrawal again. Alerting system on overdrive. 

 

Current Supplements: Omega 3 & Vitamin C, magnesium, potassium, pre/probiotics, brewer's yeast. 

 

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At the moment i want to know why and how exactly these drugs were invented and what these people had in mind when they were playing god in their laboratories.

 

As well as Petu's rec book by Whitaker i rec a book by Healy called 'Pharmageddon' its a walk through the historical timeline to how we got to where we are now.

Its a brilliant piece of work. I learnt a whole heap reading this.

 

oh yeah one more thing a person called Candice Pert i believe was responsible for getting these drugs across the bloodbrain barrier and then went on to say i have created a monster

 

http://www.drugawareness.org/i-am-alarmed-at-the-monster-ssrisnri-antidepressants-i-created-dr-candace-pert/

Thought for the day: Lets stand up, and let’s speak out , together. G Olsen

We have until the 14th. Feb 2018. 

URGENT REQUEST Please consider submitting  for the petition on Prescribed Drug Dependence and Withdrawal currently awaiting its third consideration at the Scottish Parliament. You don't even have to be from Scotland. By clicking on the link below you can read some of the previous submissions but be warned many of them are quite harrowing.

http://www.parliament.scot/GettingInvolved/Petitions/PE01651   

Please tell them about your problems taking and withdrawing from antidepressants and/or benzos.

Send by email to petitions@parliament.scot and quote PE01651 in the subject heading. Keep to a maximum of 3 sides of A4 and you can't name for legal reasons any doctor you have consulted. Tell them if you wish to remain anonymous. We need the numbers to help convince the committee members we are not isolated cases. You have until mid February. Thank you

Recovering paxil addict

None of the published articles shed light on what ssri's ... actually do or what their hazards might be. Healy 2013. 

This is so true, with anything you get on these drugs, dependance, tapering, withdrawal symptoms, side effects, just silent. And if there is something mentioned then their is a serious disconnect between what is said and reality! 

  "Every time I read of a multi-person shooting, I always presume that person had just started a SSRI or had just stopped."  Dr Mosher. Me too! 

Over two decades later, the number of antidepressant prescriptions a year is slightly more than the number of people in the Western world. Most (nine out of 10) prescriptions are for patients who faced difficulties on stopping, equating to about a tenth of the population. These patients are often advised to continue treatment because their difficulties indicate they need ongoing treatment, just as a person with diabetes needs insulin. Healy 2015

I believe the ssri era will soon stand as one of the most shameful in the history of medicine. Healy 2015

Let people help people ... in a natural, kind, non-addictive (and non-big pharma) way. J Broadley 2017

 

 

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Thanks for that post Osk.

Hey osk I wonder if the molecular structure off ssris(paxil say ) is similar to ecstacy tablets....something i have thought about but been too scared to look into as i dont think i am able to absorb the resulting humiliation that may result.

Apparently these are a form of hypnotic type drugs..?

Apparently the best way to sell worthless goods is to 'advertise' ...sadly it seems to be working.

Thought for the day: Lets stand up, and let’s speak out , together. G Olsen

We have until the 14th. Feb 2018. 

URGENT REQUEST Please consider submitting  for the petition on Prescribed Drug Dependence and Withdrawal currently awaiting its third consideration at the Scottish Parliament. You don't even have to be from Scotland. By clicking on the link below you can read some of the previous submissions but be warned many of them are quite harrowing.

http://www.parliament.scot/GettingInvolved/Petitions/PE01651   

Please tell them about your problems taking and withdrawing from antidepressants and/or benzos.

Send by email to petitions@parliament.scot and quote PE01651 in the subject heading. Keep to a maximum of 3 sides of A4 and you can't name for legal reasons any doctor you have consulted. Tell them if you wish to remain anonymous. We need the numbers to help convince the committee members we are not isolated cases. You have until mid February. Thank you

Recovering paxil addict

None of the published articles shed light on what ssri's ... actually do or what their hazards might be. Healy 2013. 

This is so true, with anything you get on these drugs, dependance, tapering, withdrawal symptoms, side effects, just silent. And if there is something mentioned then their is a serious disconnect between what is said and reality! 

  "Every time I read of a multi-person shooting, I always presume that person had just started a SSRI or had just stopped."  Dr Mosher. Me too! 

Over two decades later, the number of antidepressant prescriptions a year is slightly more than the number of people in the Western world. Most (nine out of 10) prescriptions are for patients who faced difficulties on stopping, equating to about a tenth of the population. These patients are often advised to continue treatment because their difficulties indicate they need ongoing treatment, just as a person with diabetes needs insulin. Healy 2015

I believe the ssri era will soon stand as one of the most shameful in the history of medicine. Healy 2015

Let people help people ... in a natural, kind, non-addictive (and non-big pharma) way. J Broadley 2017

 

 

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  • 3 months later...

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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