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Serotonin receptors upregulated, so...(geeky)


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If the theory of up-regulated serotonin receptor sites is true as an explanation for depression, this could be a compensatory measure taken by the brain as a result of anxiety, acute stress responses, environmental factors, and even other medications.


Seems to me that only non-pharmacological interventions would have any real long-term therapeutic value. Ie. cognitive behavioral therapy, altered thinking process, etc.


Any thoughts?

Vaulted on to 20mg Lexapro in 2004.

Consistently on until 2009, roughly.

Stopped, cold turkey. <----naïve, didn't know any better. :(

Experienced irritability, dysphoria, and - you guessed it - depression.

Went off and on, on and off for a while.

Experimented with Wellbutrin and Zoloft.

On 10mg fluoxetine hcl for the last 2 years.


I believe my erratic medication behavior has compounded my

depression 10 fold, and has made it very hard to live without

AD's. Have gone 2 years without them before, and had to

return. It's that bad.

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2010  Fluoxetine 20mg.  2011  Escitalopram 20mg.  2013 Tapered badly and destabilised CNS.  Effexor 150mg. 

2015 Begin using info at SurvivingAntidepressants.  Cut 10% - bad w/d 2 months, held 1 month. 

Micro-tapering: four weekly 0.4% cuts, hold 4 weeks (struggling with symptoms).

8 month hold.

2017 Micro-tapering: four weekly 1% cuts, hold 4 weeks (symptoms almost non-existent).

2020 Still micro-tapering. Just over 2/3 of the way off effexor. Minimal symptoms, - and sleeping well.
Supplements: Fish oil, vitamin C, iron, oat-straw tea, nettle tea.

2023 Now on 7 micro-beads of Effexor. Minimal symptoms but much more time needed between drops.

 'The possibility of renewal exists so long as life exists.'  Dr Gabor Mate.

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