Anyone read this?

[Bellisimo]

https://www.psychologytoday.com/blog/mad-in-america/201106/now-antidepressant-induced-chronic-depression-has-name-tardive-dysphoria

[btdt]

it is here

http://survivingantidepressants.org/index.php?/topic/343-el-mallakh-2011-tardive-dysphoria-the-role-of-long-term-antidepressant-use-in-inducing-chronic-depression/

 

http://survivingantidepressants.org/index.php?/topic/3659-copingmechanism-overcoming-tardive-dysphoria-%E2%80%93-where-the-hell-do-i-go-from-here/

[Bellisimo]

oki i had missed that  

[nz11]

I hadnt seen this one. (printed and filed)

 

When Fava first raised this issue in the 1990s, several American researchers wrote that this was a valid concern, which needed to be investigated. One who did so was Rif El-Mallakh at the University of Louisville School of Medicine. He has periodically revisited this issue, and in a paper (link is external) published in the June issue of Medical Hypotheses, he provides an overview of “emerging evidence that, in some individuals, persistent use of antidepressants may be pro-depressant.”

[btdt]

link to above discussed paper here

http://www.madnessradio.net/files/tardivedysphoriadarticle.pdf

 

Paul Andrews study here

http://journal.frontiersin.org/article/10.3389/fpsyg.2011.00159/abstract

 

 

Ed Piggot

http://psychrights.org/research/digest/AntiDepressants/STARDTaleandTrailofBiasPiggot2011.pdf

 

I have not read it all but hope to when I am in better reading shape ...

 

and I got all this from one source here for the nutshell view 

https://groups.yahoo.com/neo/groups/consumer_survivor_issues/conversations/topics/2841

[nz11]

The historical context for these dispiriting results is this: In the 1960s, at the start of the antidepressant era, experts in this disorder regularly wrote that depression was an episodic disorder, which could be expected to clear up with time. As Dean Schuyler, head of the depression section at the NIMH explained in a 1974 book, most depressive episodes “will run their course and terminate with virtually complete recovery without specific intervention.”

 

In 1969, George Winokur, a psychiatrist at Washington University, made the same point: “Assurance can be given to a patient and to his family that subsequent episodes of illness after a first mania or even a first depression will not tend toward a more chronic course.”

 

But now here we are 40 years later, with perhaps ten percent of American adults taking an antidepressant, and researchers are writing about “oppositional tolerance,” and drug-induced “tardive dysphoria.” That is surely a health outcomes story that needs to investigated, and if we want to put this into an even sharper moral context, we need only consider this: Many teenagers are now being prescribed an antidepressant, and when they take the drug, their brains will develop “oppositional tolerance” to it. What percentage of these youth will end up with drug-induced tardive dysphoria, and thus suffer a lifetime of chronic depression?

......................//...........................

Was aware of the schuyler quote but the Winokur quote was a new one.

[westcoast]

Just the other day I read a matter-of-fact statement in an old-ish study that explored the role of dopamine in depression, along these lines: "We know that antidepressant use in [youth, maybe childhood] leads to [chronic?] depression in adulthood." I'll do my best to find it again. I find that researchers were more candid until approximately the year 2000. Then the wagon-circling began.

I'd like to build a "family tree" of all the researchers who wrote up the clinical trials for at least the main drugs. There are names that repeat, year after year. Keller, of course, and Nemeroff, but also Thase, Donner, and Trivedi. Thase, relatively recently, lent his name to the horrorshow that is Brintellix. It was launched in 2014 with such promise that it was a cruelty to the people who believed the hype. Targets SIX serotonin receptors! No sexual side effects! There is no way they reported the data accurately, given the virtual intolerability of the drug as reported by users on crazyboards.
 

[rapunzel2]

I hadnt seen this one. (printed and filed)

 

When Fava first raised this issue in the 1990s, several American researchers wrote that this was a valid concern, which needed to be investigated. One who did so was Rif El-Mallakh at the University of Louisville School of Medicine. He has periodically revisited this issue, and in a paper (link is external) published in the June issue of Medical Hypotheses, he provides an overview of “emerging evidence that, in some individuals, persistent use of antidepressants may be pro-depressant.”

is it possible to see this article somewhere?

[ChessieCat]

Hi Rapunzel, The link for the article (abstract below) is the first one in btdt's post # 5 above.

 

This is an article about the paper Antidepressants Make Things Worse in the Long Term.

 

 

From:  http://scicurve.com/paper/22296314

 

Tardive dysphoria: the role of long term antidepressant use in-inducing chronic depression.

 

Medical hypotheses, 2011; 76 (6) doi:10.1016/j.mehy.2011.01.020

 

Authors: El-Mallakh Rif S, Gao Yonglin, Jeannie Roberts R

 

Abstract:

 

BACKGROUND: Treatment-resistant and chronic depression appear to be increasing. The recent identification of antidepressant tachyphylaxis, the loss of antidepressant efficacy over time, is only a partial explanation. This is an emerging evidence that, in some individuals, persistent use of antidepressants may be prodepressant.

 

METHODS: A literature search of PubMed utilizing the terms: antidepressant tachyphylaxis, treatment-resistant depression, chronic depression, and antidepressant tolerance was performed, and relevant articles were used.

 

RESULTS: Depressed patients who ultimately become treatment resistant frequently have had a positive initial response to antidepressants and invariably have received these agents for prolonged time periods at high doses. Parallels between this course and tardive dyskinesia are noted. It is proposed that neuroplastic processes related to dendritic arborization may underlie the treatment resistant depression that occurs in the setting of chronic antidepressant use. Since the prodepressant effect is seen after prolonged antidepressant use, the term tardive dysphoria is proposed.

 

CONCLUSIONS: Tardive dysphoria, needs to be considered in studies of treatment resistant depression, and should be examined in blinded, randomized antidepressant discontinuation trials.

[rapunzel2]

thanks A LOT!!!

[btdt]

One more thing comes to my mind side effects and long term use side effects.  The warning at the FDA for Effexor bloomed after it went off patent... if you look up the history of changes to this one drugs side effects it is astounding... 30 plus pages of side effects some mild some critical to health. 

 

When we think of this:

 

 Tardive dysphoria, needs to be considered in studies of treatment resistant depression, and should be examined in blinded, randomized antidepressant discontinuation trials.

 

In the context of long term use ... the harm beyond even Tardive dysphoria becomes exponential.  

 

Being a long term user who has learned screaming from the roof tops only gets me a sore throat... these studies need to be done yesterday... the pitfall as always is funding. Pharma surely wants no part in lessening its sales and increasing it payout for damages and lawyer... not sure about lawyers as they are on payroll and may not make any more but the rest they have no interest in and pharma is the big daddy of funding in medical science or so it seems to me. 

 

So when I think of the teenagers who are starting now... and how our countries will look in another 50 years ... it is disheartening to remain unheard.  It seems it will always be and genetic variant a mental illness or some other personal failure to thrive... getting any consensus in the general population to the true damage of these drugs will take a miracle so get your asses praying. It seems to me we will never convince our doctors or the science folk who are pharma funded but if the general population hears of the damage often enough perhaps we can slow down the damage from the grass roots front.  When I was a kid I heard the damage of street drugs how horrid they were... so I did not take them... (if I had I would have known my bad reaction to prozac as a drug reaction not a sudden mental illness) ... 

We need to talk to people grass roots style and let them know these drugs are dangerous we need to tell our experience the worst of it to real people in hopes of sparing them the same pain. 

 

peace all