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FDA warns of heart risks with high doses of Celexa


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Aug 24, 10:35 AM EDT

 

FDA warns of heart risks with high doses of Celexa

 

WASHINGTON (AP) -- Federal health regulators are warning doctors not to prescribe high doses of the antidepressant Celexa, because of the risk of fatal heart complications.

 

The Food and Drug Administration said in an online posting that the drug can interfere with the heart's electrical activity at doses above 40 milligrams.

 

The label for Celexa previously stated that some patients should receive 60 milligrams, but the FDA has eliminated that language. "Studies did not show a benefit in treatment of depression at doses higher than 40 mg per day," the FDA states.

 

The new label will emphasize that Celexa should not be used in patients with congestive heart failure and other conditions that affect the heart's pumping action.

 

Drugmaker Forest Laboratories sells Celexa in doses of 10, 20 and 40 milligrams

 

© 2011 The Associated Press. All rights reserved.

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The US FDA posting is here

History is approximate; I didn't track my dosages.

 

1995 - started zoloft/sertraline for depression

1995-2008 - sertraline ranged from 100-200mg, may have gone as high as 250mg

2006 - 2009 - added welbutrin/budeprion SR, 150 mg

sometime in 2009-2010 - stopped budeprion c/t

sometime around 2009-2010, Tapered down sertraline w/o guidance to 50 mg, then 25mg.

~ feb 2010, stopped sertraline.

~ Apr 2010, resumed 25mg low dose (really bad business trip)

Oct 2010, stopped sertraline

Jan 2011 - another bad business trip "breaks" my sleep.

 

current issues include insomnia, anxiety, GI distress, depression.

Taking multivitamins, Vitamin D, fish oil, Chinese herbs, ~ 0.5mg melatonin in the evening.

Going to therapy and acupuncture once a week.

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Another disgusting discovery! It's been known for a very long time that 60mg Celexa is not more "effective" than 40mg.

 

Let me see: Risky Lexapro dosages would pencil out to anything above 10mg-15mg. Wait for the other shoe to drop.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Does not surprise me!

 

On Lexapro I've often felt "weird" with my heart rate and stuff. Maybe I'm reading too much into it, but something didnt feel right.

Off Lexapro since 3rd November 2011.

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All of the SSRIs prolong the QT interval in the heartbeat, which is the basis for the Celexa warning. Eventually, all of them will have similar warnings.

 

It's just criminal that anyone is getting 60mg Celexa.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Agreed. I actually heard from a woman on the other site that their son was on something like 40mg Lexapro, which is about equivalent to 80mg Celexa! I couldnt believe it!

Off Lexapro since 3rd November 2011.

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