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sleep - brain health


btdt

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http://www.cbc.ca/natureofthings/episodes/while-your-were-sleeping

 

I watched this... learned that our brain has a cleaning system that takes away toxins while we sleep... life a river taking out the garbage.  

This is apparently new and it is suspected to play a part in illness of the brain...

 

(The formation of amyloid plaques and neurofibrillary tangles are thought to contribute to the degradation of the neurons (nerve cells) in the brain and the subsequent symptoms of Alzheimer's disease. 
 

amyloid beta is increased in the day and decreased at night - being cleaned nightly is what is suspected... so it you don't sleep it could be the cause of back up in toxins... 

 

this is all as I heard it and there is a possibility I did not process it correctly... so if your really wanting to know what the show.

 

Fluid around the brain acts as a dishwasher removing waste between the brain cells as we sleep that is what I head... 

some other tidbits I recall..

 

people who tried a maze then had a dream about it did 10 x better then others who did not dream of it the maze 

 

cramming does not work... want to consolidate a memory go to bed and sleep on it... 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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I just read this message from the link to the show...  CBC staff says you may not be able to watch it in the states... :(

Is there any way you can put the broadcast on Facebook after it's done so we here in the U.S. can listen to it? Thank you so much!

  • Annette Bradford
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@Yoda Ydyxz Well yes, filmmakers travel outside of Canada to film stories. The plan is to produce a film which they can sell to broadcasters on the international market - even the US. So it may show up on Nat Geo or PBS, something like that.

 

The film includes these folks or places

Thursday, March 10, 2016 at 8 PM on CBC-TV
 
 
whileyouweresleeping2_1920.jpg
Play Media
 
 
Episode available within Canada only. Video help?
 
 
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FOR KIDS Share 
 with your children.


LISTEN
 about the serious consequences of sleep deprivation.

For thousands of years, we’ve regarded sleep as nothing more than an annihilation of consciousness. But there is one compelling fact that has always stood in the way of that view. 

“Even the Greek philosophers wondered why we needed to sleep,” says neuroscientist, Dr. Kenneth Wright.  “If sleep wasn’t important, it’s probably one of the most significant mistakes that evolution ever made.”

Yet decades of intense research have failed to discover the key function of sleep. But now, thanks to revolutionary new technology, innovative animal research and extraordinary advances in genetics, all that’s about to change.

Once seen as a blank screen, the sleeping brain is emerging as an energetic and purposeful machine.

“In parts of sleep, the brain is at least as active and maybe more active than it is during waking,” says Dr. Robert Stickgold, one of the world’s leading sleep researchers.

From regulating our weight to consolidating our memories to cleaning toxins from our brain, around the world researchers are attempting to penetrate the mysterious world of sleep and decipher its secrets – secrets that could change our lives.

 
SCENE FROM THE FILM: One study shows how sleep deprivation triggers the brain's desire for more food.

“I think the brain carries out its most sophisticated memory and brain functions while we sleep,” says Dr. Stickgold.  “I think that what happens during sleep permits what happens in the waking brain,” agrees neuroscientist, Dr. Jeff Iliff. 

Join Dr. Jennifer Gardy as she goes on an extraordinary odyssey from a city that never sleeps to an isolation chamber in the Colorado Rockies, from one of the most unique research centres in the world to the world of dreams. Her goal is simple: Discover why we sleep.
 

Credits (CLICK TO EXPAND)

director
Jeff Semple

host & narrator
Dr. Jennifer Gardy

executive producer
Dugald Maudsley

writers
Scott Harper
David Murray

executive story consultant
Dugald Maudsley

editor
David Murray

director of photography
Terry Zazulak

sound recordist
Michael Kennedy

composer
Alex Khaskin

researcher
Monika Delmos

production manager
Diane Marcotte

production coordinator
Gillian Main

visual effects designer
Mark Alberts

post production supervisor/online editor
Eric Wiegand

visual researcher
Elspeth Domville

additional camera
Jerry Vienneau
Gerald Lewis
Blinky Semple

re-recording mixer
Grant Edmonds

sfx editor
Andy Frech

assistant sfx editor
Quinn Edmonds

colour correction
Colin Moore

publicist
David McCaughna

production accountant
Rebecca Humble McCulloch

legal counsel
David Steinberg

archival material courtesy of

Dr. Scott Killgore
Infield Fly Productions
Pond5
Shutterstock
University of Rochester

special thanks

Center for Sleep and Cognition
George Ko
Ghryll Murphy
James Simon
Max Planck Institute for Ornithology
Oregon Health & Science University
Horseshoe Valley Resort
Université de Montréal
Cannery Casino
University of Colorado Boulder
Harvard University
Kathrin Dannert

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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more on brain cleaning from another source not sure on the cure stated here either but something more at least for those who can't watch the video

The study found that the glymphatics are like hidden caves that open during sleep, and, much like the body’s lymphatic system, they drain toxic waste and proteins out of the brain. The study found that copious amounts of neurotoxins are drained during the natural sleep cycles.

The most well-known neurotoxin, called beta-amyloid plaque, is drained through these glymphatics of the brain. The problem is that studies show that the less you sleep, the less these glymphatics can work and the more beta-amyloid accumulates in the brain. The catch-22 is that the more beta-amyloid that accumulates in the brain, the worse you sleep and the worse your memory can become. (5) Beta-amyloid plaque has been indicated in numerous cognitive and memory concerns that are only now starting to be more fully understood. (6-8)

According to Ayurveda, these glymphatics are an understood system and called “tarpaka kapha,” which is the aspect of the kapha dosha that literally drains toxins from the brain into the cerebral spinal fluid. If these channels become congested, the mood can shift, memory can become compromised, and the brain can become foggy. The cause of this imbalance can be emotional trauma or the cumulative impact of stress, lack of sleep, and digestive weakness.

http://lifespa.com/cleanse-neurotoxins-from-your-brains-lymph/

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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from the article:

 

"Once seen as a blank screen, the sleeping brain is emerging as an energetic and purposeful machine."

 

those kinds of asinine assumptions don't exist in Chinese and Ayurvedic...which is why I no longer look to western medical science, in general, who are busy, most often, at reinventing the wheel...and doing it poorly as well. 

Everything Matters: Beyond Meds 

https://beyondmeds.com/

withdrawn from a cocktail of 6 psychiatric drugs that included every class of psych drug.
 

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and also from what you shared:

"According to Ayurveda, these glymphatics are an understood system and called “tarpaka kapha,” which is the aspect of the kapha dosha that literally drains toxins from the brain into the cerebral spinal fluid. If these channels become congested, the mood can shift, memory can become compromised, and the brain can become foggy. The cause of this imbalance can be emotional trauma or the cumulative impact of stress, lack of sleep, and digestive weakness.

http://lifespa.com/c...r-brains-lymph/"

 

so, yeah, Ayurveda has been on top of it for thousands of years.

 

I'm not saying western scientific medical theory is useless all the time...but for me, right now, in this particular (and also idiosyncratic) personal endeavor that is truly life and death healing...it pretty much is. 

Everything Matters: Beyond Meds 

https://beyondmeds.com/

withdrawn from a cocktail of 6 psychiatric drugs that included every class of psych drug.
 

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oh! sorry. I thought this was a different thread...I am sort of off topic...I thought it was a thread I started about alternative medicines...I got a notification and got confused. 

Everything Matters: Beyond Meds 

https://beyondmeds.com/

withdrawn from a cocktail of 6 psychiatric drugs that included every class of psych drug.
 

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oh...I see what I did...you asked me to read this in MY thread...yeah, I've still got cognitive fuzziness...can you tell  :P You asked me what I thought in that thread...I'll transfer my comments there as well since that's where you asked the question. I'm not a moderator anymore so I can't do it and also remove them here.

Everything Matters: Beyond Meds 

https://beyondmeds.com/

withdrawn from a cocktail of 6 psychiatric drugs that included every class of psych drug.
 

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Hi btdt

 

This looks really interesting unfortunately I can't watch the film in the UK but have read the information with interest as well as your tcomments about Ayuveda. My sleep is terrible and I'm not surprised the effect lack of sleep has on the brain. When I've finished my taper I might look into having a consultation with an Auyuvedic specialist.

 

Camper

Prescribed Respiridone 1.5 mg January 2014

Tapered to 1 mg May 2014

Switched to liquid Respiridone and tapered to 0.9 ml March 2015

Tapered to 0.8 ml 3 June 2015

Tapered to 0.7 ml 8 July 2015

Tapered to 0.6 ml 2 November 2015

Tapered to 0.55ml 30 November 2015

Tapered to 0.5ml 11 January 2016. Held at 0.5ml for the whole of 2016 until February 2017. Tapered to 0.45 ml 13 Feb 2017. Tapered to 0.4 ml 2 April 2017. Tapered to 0.35ml 24 July 2017. 0.33 ml end Jan 2018. 0.30ml 18 Feb 2018. 0.27ml 18 March 2018. 0.25ml 8 April 2018. 0.23 ml  1 July 2018. 0.20ml 5 August 2018. 0.17 ml 13 September 2018. 0.15ml 12 October 2018. Updosed to 0.20ml 21 November 2018 Tapered to 0.18ml 28 Jan 2019. 0.15ml 25 Feb 2019 0.13ml 29 April 2019. 0.10ml 1 June 2019. End of July 2019 relapsed now taking 3mg Respiridone daily

Supplements magnesium and fish oil and folic acid, vitamin D

started HRT transdermal patches 18 Sept 2018 Evorel Sequi (estradiol) and Evorel Conti (estradiol & .norethisterone) . 4 Dec 7.5mg mirtazapine stopped immediately due to side affects. Stopped HRT 13.12.18. Gluten free since 30.11.18

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Somewhere I posted an article from mercola.com (whatever his name is worth) about how important sleep is, but when they looked at more "primitive" people groups, they weren't sleeping as much as they expected...but they were resting quietly for a good long stretch through the night, and that seemed to work. At least I hope so...resting is something we can control.

1st round Prozac 1989/90, clear depression symptoms. 2nd round Prozac started 1999 when admitted to dr. I was tired. Prozac pooped out, switch to Cymbalta 3/2006. Diagnosed with bipolar disorder due to mania 6/2006--then I was taken abruptly off Cymbalta and didn't know I had SSRI withdrawal. Lots of meds for my intractable "bipolar" symptoms.

Zyprexa started about 9/06, mostly 5mg. Tapered 4/12 through12/29/12

Wellbutrin. XL 300 mg started 1/07, tapered 1/18/13 through 7/8/13

Oxazepam mostly continuously since 6/06, 30mg since 12/12, tapered 1.17.14 through 8.26.15

11/06 Lithium 600mg twice daily, 2.2.14 400mg TID DIY liquid, 2.12.14 1150mg, 3.2.14 1100mg, 3.18.14 1075mg, 4/14 updose to 1100mg, 6.1.14 900 mg capsules 7.8.14 810mg, 8.17.14 725mg, 8.24.24 700mg...10.22.14 487.5mg, 3.9.15 475mg, 4.1.15 462.5mg 4.21.15 450mg 8.11.15 375mg, 11.28.15 362.5mg, back to 375mg four days later, 3.4.16 updose to 475 (too much going on to risk trouble)

9/4/13 Toprol-XL 25mg daily for sudden hypertension, tapered 11.12.13 through 5.3.14, last 10 days or so switched to atenolol

7.4.14 Started Walsh Protocol

56 years old

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Hi btdt

 

This looks really interesting unfortunately I can't watch the film in the UK but have read the information with interest as well as your tcomments about Ayuveda. My sleep is terrible and I'm not surprised the effect lack of sleep has on the brain. When I've finished my taper I might look into having a consultation with an Auyuvedic specialist.

 

Camper

I am still struggling with sleep but not as bad as before it makes sense why 3-4 days without sleep made me stupid. Glad those days are gone... hope they stay gone. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Share on other sites

Somewhere I posted an article from mercola.com (whatever his name is worth) about how important sleep is, but when they looked at more "primitive" people groups, they weren't sleeping as much as they expected...but they were resting quietly for a good long stretch through the night, and that seemed to work. At least I hope so...resting is something we can control.

video says no but it is better than nothing I think

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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glymphatic system

 

comment on this video

The work of Maiken Needergard, her spouse Dr. Steven A. Goldman, and associated researchers is in my view worthy of a Nobel Prize.  Also see their work on chimeric mice into which they introduced human glial cells. They found that the human cells improved both brain physiology and behavioral performance, an impressive followup to the study described in the video.  Evidently, it is not just increased neurons but better support cells that explain performance differences between humans and other species. Even more jaw dropping for me was how ignorant of this work many scientists with whom I talked at the Society for Neuroscience Convention held in late 2013 were.

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Best sleep position for your brain... I will just tell you it is to sleep on your side then back stomach last... 

http://mentalhealthdaily.com/2015/08/29/best-sleep-position-for-your-brain-lateral-on-your-side/

 

But as I was innocently reading along I find this:

 

Additional thoughts…

It is also known that neurodegenerative diseases like dementia are associated with sleep abnormalities.  Those with neurodegenerative diseases often have difficulty falling asleep and staying asleep – which we now know may increase memory impairment due to insufficient waste clearance.  With this knowledge, perhaps the link between sleeping pills and dementia is partially related to the fact that users aren’t getting enough sleep.

as with Eve I bite the apple 

http://mentalhealthdaily.com/2015/02/20/dementia-linked-to-benzodiazepines-sleeping-pills-anticholinergics/

This is another kettle of fish.

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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