I started on Cymbalta 60 mg 4 years ago, (after 1-2 weeks @ 30 mg); the scrip was from a psychiatrist for major depressive disorder. My depression lifted significantly. After 1 year (+/-) the psychiatrist and I agreed that my family practitioner would handle the prescription and supervision.
I was ready to go off the cymbalta and was planning to go of the meds until a couple of deaths close to me occurred. I agreed with my doc that it wasn't the time to make changes in the meds.
I'm seeing a fair amount of discussion with newcomers about skipping doses. I've created a spreadsheet that shows the % concentration decay, comparing daily dose, alternate day dosing and skipping 2 days. This chart is for Cymbalta (duloxetine) or a drug that has a 12-hour half-life.
The chart is in a spreadsheet (.xlsx). I'm going to refine it, maybe showing every 12 hours instead of every 24 and setting it up so that any half-life can be "inputted." Then I'll attach it to another