btdt Posted May 4, 2016 Share Posted May 4, 2016 I don't know what to call this it is an old blog I was searching the net for work by Gary Null, Ph.D., as he was listed by Dan999 sorry if I have the name wrong my memory suck just now it comes and goes.... as stating why we have wd... the process. So I wanted to find his work that spells it out in black and white I recall this being around long ago then it seemed to vanish from the net... while I can't find the science yet and assume it has been scrubbed from the web this blog talks about it and gives an understanding of what is going on it also touches on other issues with ssri type drugs... chronic fatigue for instance is linked and extreme personality changes.... both of which I have had and other not very popular topics... as well as the psych issues caused by high serotonin found by doing autopsies on dead psych patients... worth reading. Quote;"But why do I hear people talking about benefits from these SSRI-AntiDepressants?", you might want to ask in this stage. "They surely must work somehow don't they?" The answer is yes, they "work" somehow, but not in a very proper way. The mechanism of action on serotonergic neurons implies a lot of other neuro- endocrine responses. What actually happens when you increase serotonergic neuronal activity or elevate your serotonin levels is this: the stress hormones "Cortisol" & "Adrenaline" (Epinephrine) in the brain and body are triggered by increased serotonergic activity or elevated serotonin levels. It is a natural reaction from the body to combat the excessive serotonin levels. These released hormones, cortisol and adrenaline, are secreted from the "Adrenal Glands." They give the human personality a boost, producing a euphoric state, which can last for a prolonged period of time. In this manner SSRI-AntiDepressants initially produce the deceptive results the doctor and "patient" are both expecting. * If a patient continues to ingest a particular SSRI-antidepressant over a prolonged period of time, eventually the bodies Adrenal Glands may lose their efficiency and "Adrenal Exhaustion Syndrome" will be the end result. Adrenal Exhaustion causes levels of adrenaline initially to fall and levels of cortisol to rise. Ultimately, also cortisol levels fall. When untreated, Adrenal Exhaustion will lead to seriously declining physical health. Many (former) SSRI-AntiDepressant users reported fatigue as a long term side-effect or were diagnosed with "Chronigue Fatigue Syndrome." People suffering from stress are generally diagnosed with this disorder. Symptoms range from simple exhaustion to much more complex problems that are secondary to excessive output of adrenal hormones in the bloodstream, leading to Adrenal Exhaustion. Unlike the other hormones, it takes a long time before the Adrenal Glands have their adrenaline levels restored. Could we say that the SSRI-AntiDepressant "works" by slowly excavating the body's Adrenal Glands? * [ Actually, when a family doctor (GP) or psychiatrist is observing a patient in a "euphoric" state of being, this should ring warning bells immediately! The drug induced (iatrogenic) conditions Akathisia & Mania are well documented in the medical litarature. Drug induced Mania, an abnormally elated mental state, typically characterized by feelings of euphoria, racing thoughts and talkativeness, is a "forerunner" of Akathisia, a neurologically driven agitation ranging from mild leg tapping, feeling "caffeinated" to severe panic, an extreme manic state and hyper-sensitivity of the nervous system. Akathisia can lead to suicidal, aggressive and/or homicidal thoughts and behaviours. When a doctor or psychiatrist is observing symptoms of mania and/or akathisia in a patient, SSRI-AntiDepressant use should be discontinued immediately! The pharmaceutical companies are well informed regarding above mentioned conditions and the capacity of their antidepressant inducing these symptoms. Therefore it is strongly advised to medical professionals, physicians, to monitor a patient very closely after prescription of (SSRI) anti-depressant treatment. " Continues...The Serotonergic System, the Pineal Gland & Side-Effects of Serotonin Acting Anti-Depressants -Part 2 ;[www.antidepressantsfacts.com]" An absolutely shocking discovery was the correlation between high serotonin levels in the Pineal Gland and certain mental disorders! During autopsy on recently dead mental patients, Giarmin and Freedman (see chapter 3.a.) discovered that the Pineal Glands of those who had suffered from specified mental disorders, showed a considerable excess of serotonin in their Pineal Glands. The average amount of serotonin found in the Pineal Glands of normal persons is about 3.14 to 3.52 micrograms per gram of tissue. One schizophrenic was found to have a Pineal Gland containing 10 micrograms of serotonin, around 3 times higher, while another patient, a sufferer from delirium tremens, had a Pineal Gland containing 22.82 micrograms of serotonin, around 10 times higher then the average amount! This is a most interesting research contemplating the similarities between symptoms of schizophrenia or schizophrenic psychosis and SSRI-AntiDepressant induced perception changes, altered states of consciousness, disturbed sense of reality and out of character behaviour in severe cases. As a direct result from the actions of the SSRI-AntiDepressant (disruption of the natural serotonin cycle), serotonin levels in the Pineal Gland could gradually increase to excessive amounts comparable to the excessive amounts of serotonin in the Pineal Glands of recently dead mental patients. Hence, the production of psychoactive serotonin derivatives increases, which can lead to excessive amounts of these molecules in the brain. The combined effects of suppression of REM sleep, excessive amounts of serotonin in the Pineal Gland, as well as elevated levels of psychoactive serotonin derivatives, could make an individual experience hypnogogic dream-like states (which depersonalise an individual from their own emotions) to full blown "hallucinatory psychosis." ( A; B; C) "Continues...The Serotonergic System, the Pineal Gland & Side-Effects of Serotonin Acting Anti-Depressants -Part 3;[www.antidepressantsfacts.com] Charly Groenendijk"SSRI-AntiDepressants certainly don't raise your serotonin levels in a gentle manner. They prevent serotonin from being removed from the synaptic cleft. As a result, a lot of excess firing takes place and therefore more serotonin remains in the synaptic cleft. In this manner, the (receiving) post-synaptic receptors get bombarded with serotonin. According to Gary Null, Ph.D., all this over stimulation causes a decrease in the number of post-synaptic receptors. Depending on the intensity and duration of blocking re-uptake, around 30% to 40% of the post-synaptic receptors will be eliminated (Eli Lilly, the manufacturer of Prozac, would knew about the disappearance of receptors from their laboratory experiments). It is not established whether or not receptors ever come back after discontinuing an SSRI-AntiDepressant. The damage may be permanent or not. Apparently this is not the only neuro damage caused by SSRI-AntiDepressants. In a recent study, researchers saw marked changes in the axon terminals (nerve endings) of serotonergic neurons in rats, treated with SSRI-AntiDepressants. The terminals shrivelled or took on corkscrew shapes. These changes were similar to those observed with the serotonin booster drug "Ecstasy" (MDMA). In studies with baboons who were treated with Ecstasy, researchers used Positron Emission Tomography (PET) to take brain scans of them. The researchers found that Ecstasy was toxic to the brain and damaged the axon terminals (nerve endings) of serotonergic neurons. This damage was still present in the baboons 7 years after discontinuing the drug. Later studies in humans who had used Ecstasy, documented the same damage at serotonergic neurons as observed with the baboons. Likewise, the SSRI-AntiDepressant induced brain damage observed in the rats, could be present in humans as well. "Continues...End quotes.Be shocked! Some more facts; Dr. Ann Blake Tracy, a PhD in Psychology and Health Sciences, has specialized for 10 years in adverse reactions to serotonergic medications. She is the executive director of the International Coalition for Drug Awareness (www.drugawareness.org) and author of the book PROZAC: PANACEA OR PANDORA? [www.rense.com] go here;[www.drugawareness.org] more. http://grahamhancock.com/phorum/read.php?3,676342,676397 If anyone can find the original work by Gary Null I would sure like to see it. peace all WARNING THIS WILL BE LONG Had a car accident in 85 Codeine was the pain med when I was release from hosp continuous use till 89 Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above. One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking. As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/ There is a crack in everything ..That's how the light gets in Link to comment Share on other sites More sharing options...
btdt Posted May 18, 2016 Author Share Posted May 18, 2016 Endocrine Dysfunction Much research has centred around the endocrine system of ME/CFS patients. Particular interest has been paid to the hypothalamic-pituitary-adrenal (HPA) axis which is responsible for the stress response. A number of abnormalities have been observed in ME/CFS patients with regards to this including low cortisol and DHEA sulphate levels as well as altered melatonin metabolism (6). Cortisol and DHEA-S work in synergy to control how the body reacts to stress. Low levels affect your ability to deal with stress and can cause fatigue, low blood pressure, hypoglycemia, poor brain function and a number of other problems common to ME/CFS sufferers. Melatonin is a hormone whose main action appears to be to induce sleep. During the day the pineal gland, stimulated by light signals the body to produce serotonin and other chemicals to 'wake the body up'. When light levels fall the pineal gland signals the production of melatonin in place of serotonin, preparing the body for sleep. If melatonin production is disturbed as it has been seen to be in ME/CFS then this can cause disruption to sleep as is commonly seen in ME/CFS patients. Adding weight to this hypothesis is the fact that low doses of hydrocortisone (cortisol) have been shown to improve symptoms in a number of studies (7, 8). Many physicians also prescribe DHEA and melatonin in low doses for their patients and many find that they are of great benefit. " Other research, also centered around brain function, found that ME/CFS patients have differences in genes responsible for serotonin production which leads to lower reservoirs of serotonin, the chemical responsible for maintaining positive moods and also healthy sleep cycles, amongst other functions (17). Finally, a study again using twins, found evidence of immune dysfunction indicating a possible genetic susceptibility (18)." http://www.ei-resource.org/illness-information/environmental-illnesses/chronic-fatigue-syndrome-cfs-myalgic-encephalopathy-me/ WARNING THIS WILL BE LONG Had a car accident in 85 Codeine was the pain med when I was release from hosp continuous use till 89 Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above. One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking. As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/ There is a crack in everything ..That's how the light gets in Link to comment Share on other sites More sharing options...
Futurerecovery Posted May 19, 2016 Share Posted May 19, 2016 Thank you. I would like to know where I can find this study: " In a recent study, researchers saw marked changes in the axon terminals (nerve endings) of serotonergic neurons in rats, treated with SSRI-AntiDepressants. The terminals shrivelled or took on corkscrew shapes." Since taking Escitalopram for a few days more than a year ago, I can not access certain areas of my brain anymore. It feels as if areas of my brain are cut off. I find this sentence interesting: "It is not established whether or not receptors ever come back after discontinuing an SSRI-AntiDepressant. " I also find this part interesting: "If a patient continues to ingest a particular SSRI-antidepressant over a prolonged period of time, eventually the bodies Adrenal Glands may lose their efficiency and "Adrenal Exhaustion Syndrome" will be the end result. Adrenal Exhaustion causes levels of adrenaline initially to fall and levels of cortisol to rise." Since taking Escitalopram for a few days more than one year ago I can not perceive adrenaline anymore and my heart is calm all the time. But according to a blood test my adrenal glands are apparently alright. German fMRI study about PSSD http://survivingantidepressants.org/index.php?/topic/14351-take-part-in-new-pssd-study/ Please also complete this questionnaire in order to possibly promote Italian PSSD research if you have PSSD / Post-SSRI PGAD:http://survivingantidepressants.org/index.php?/topic/4587-persistent-genital-arousal-disorder-pgad/?p=247055 Link to comment Share on other sites More sharing options...
btdt Posted May 20, 2016 Author Share Posted May 20, 2016 Thank you. I would like to know where I can find this study: " In a recent study, researchers saw marked changes in the axon terminals (nerve endings) of serotonergic neurons in rats, treated with SSRI-AntiDepressants. The terminals shrivelled or took on corkscrew shapes." Since taking Escitalopram for a few days more than a year ago, I can not access certain areas of my brain anymore. It feels as if areas of my brain are cut off. I find this sentence interesting: "It is not established whether or not receptors ever come back after discontinuing an SSRI-AntiDepressant. " I also find this part interesting: "If a patient continues to ingest a particular SSRI-antidepressant over a prolonged period of time, eventually the bodies Adrenal Glands may lose their efficiency and "Adrenal Exhaustion Syndrome" will be the end result. Adrenal Exhaustion causes levels of adrenaline initially to fall and levels of cortisol to rise." Since taking Escitalopram for a few days more than one year ago I can not perceive adrenaline anymore and my heart is calm all the time. But according to a blood test my adrenal glands are apparently alright. The Serotonergic System, the Pineal Gland & Side-Effects of Serotonin Acting Anti-Depressants -Part 3;[www.antidepressantsfacts.com] Charly Groenendijk I found the reference to it at the above link it is also here http://www.amazon.com/Anti-Depressant-Fact-Book-Doctor-Prozac/dp/073820451X page 38 it may be that Breggins books tells more about the study if you care to look it is in chapter two and the link lists all the sources for his data Brain-Disabling Treatments in Psychiatry: Drugs, Electroshock, and ... https://books.google.com/books?isbn=0826129358 Peter R. Breggin, MD - 2007 - Medical It is not likely that neurons or other cells will turn out to appear or function normally ... (2000) found that 4 days of high doses of serotonin-stimulating drugs, ... and truncated axons and, in some cases, made the cells look corkscrew in form. ... their research may reflect on the potential effects of chronic SSRI use in humans. WARNING THIS WILL BE LONG Had a car accident in 85 Codeine was the pain med when I was release from hosp continuous use till 89 Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above. One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking. As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/ There is a crack in everything ..That's how the light gets in Link to comment Share on other sites More sharing options...
btdt Posted May 20, 2016 Author Share Posted May 20, 2016 http://www.rense.com/ufo6/braincell.htm ABSTRACT TO THE STUDY CITED IN THE MEDIA REPORT ABOVE Brain Research, 2000 Mar 6;858(1):92-105 Comparative study of fluoxetine, sibutramine, sertraline and dexfenfluramine on the morphology of serotonergic nerve terminals using serotonin immunohistochemistry. Kalia M, O'Callaghan JP, Miller DB, Kramer M Department of Biochemistry, Molecular Pharmacology and Anesthesiology, Jefferson Medical College, Thomas Jefferson University, 233 South 10th Street, Suite 309, Philadelphia, PA, USA [Record supplied by publisher] We compared the effects of treatment with high doses of fluoxetine, sibutramine, sertraline, and dexfenfluramine for 4 days on brain serotonergic nerve terminals in rats. Methylenedioxymethamphetamine (MDMA) and 5,7-dihydroxytryptamine (5,7-DHT) were used as positive controls because both compounds deplete brain serotonin. Food intake and body weight changes were also monitored and yoked, pair-fed animals were used to control for possible changes in morphology due to nutritional deficits. Fluoxetine, sibutramine, sertraline and dexfenfluramine all produced a significant reduction in body weight. Fluoxetine, sibutramine and sertraline treatment resulted in no depletion of brain serotonin but produced morphological abnormalities in the serotonergic immunoreactive nerve network. In contrast, dexfenfluramine and MDMA depleted brain serotonin and produced morphological changes in the serotonin nerve network. These results indicate that even though fluoxetine, sibutramine and sertraline do not deplete brain serotonin, they do produce morphological changes in several brain regions (as identified by serotonin immunohistochemistry). Dexfenfluramine and MDMA, on the other hand, markedly deplete brain serotonin and also produce morphological changes. Collectively, these results lend support to the concept that all compounds acting on brain serotonin systems, whether capable of producing serotonin depletion or not, could produce similar effects on the morphology of cerebral serotonin systems. WARNING THIS WILL BE LONG Had a car accident in 85 Codeine was the pain med when I was release from hosp continuous use till 89 Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above. One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking. As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/ There is a crack in everything ..That's how the light gets in Link to comment Share on other sites More sharing options...
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