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When do you take your tablet?


grandmaD
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Because of insomnia which is getting worse with every year and is the worst its ever been since beginning a slow (2.5% taper) I am wondering if the time you take the tablet has any bearing on it?

 

I have read that with smaller doses, it is excreted from the body a whole lot faster, so I am thinking that by bedtime it may not be in my system any more.   I am wondering if I took it at night instead, that it will be still in my system at bedtime/nightime.

 

What have you experienced?

1995-2007      20mg Aropax/Paxil for pain.  Years of up and down doses

2008                Endep, Lexapro and then Esipram (hell!) CT (oh dear!)

2009                20mg Aropax.  Tried skipping doses for a year (more hell!)

                        2010                10mg.  10% taper.  Lasted 4 months. Crashed again

2011                5% taper. 9mg-7mg (hell got even worse!)

2012                2.5% taper.  6.6mg – 5.6mg (worser still & unbearable)

2013                5% taper.  Big mistake.  5.5mg – 4.6mg  (even worserer)

2014                2.5% taper.  4.9mg – 4.5mg;    2015 2.5% taper 4.4 - 4.0mg

2016                2.5% taper.  3.9mg  Feb 3.8   Mar 3.7  May 3.6   Jul 3.5

2017                2.5% taper.  Jan 3.4;   Mar 3.35;  Apr 3.3; Oct 3; Dec 2.9;

2018                2.5% taper. Jan 2.8; Mar 2.7; Mar: 2.75; Jun 2.7; Aug 2.6; Oct 2.5; Nov 2.4; Dec 2.3

2019                Jan 2.2; Feb 2.1;

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Hmm, I have also been wondering whether the time I take my pill makes a difference. I believe it was Alto who first posted this over at PP about Paxil inhibiting its own metabolism at higher doses. But do we know at what dose exactly that this changes? I always figured it was at 5mg and below but I guess it might be different for everyone. Anyway, because of this I try to take notice on whether I feel better in the hours after I take my dose but I can't say for sure. I take my pill at 10pm and I still have issues with insomnia periodically.

a.k.a JMarie

Paxil since Mar.1998

2006-2007:40-20mg
2009: 20mg to 14mg 2010: 14mg to 10.5mg 2011: 10.5 to 7.6mg  2012: 7.5 to 6.8mg

2013: 6.7-6.3mg 2014: 6.2mg-5.8mg 2015: 5.7 to 5.15mg 2016: 5.1-4.6mg

1/19/17: 4.5mg 3/17/17: 4.4mg

6/15/17: 4.35mg 8/10/17: 4.3mg

1/29/18: 4.1mg 5/07/18: 4.0mg

7/31/18: 3.9mg

 

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That is interesting you take it at 10pm.  I guess periodic insomnia would be better than most nights.  I will try and note how I am each day but off the top of my head, I think I am better afterwards.  I am often very lethargic, heavy, weak and tired when I first get up but by morning tea I'm better.  I have just started having it at morning tea time in an effort to get it to lunch then afternoon tea and then dinner so as to give it a try.  By the way, do you take it with food?  Good idea, to prevent stomach issues.  Do you have stomach issues, forgot to ask!

 

What does this mean? "Paxil inhibiting its own metabolism at higher doses."

1995-2007      20mg Aropax/Paxil for pain.  Years of up and down doses

2008                Endep, Lexapro and then Esipram (hell!) CT (oh dear!)

2009                20mg Aropax.  Tried skipping doses for a year (more hell!)

                        2010                10mg.  10% taper.  Lasted 4 months. Crashed again

2011                5% taper. 9mg-7mg (hell got even worse!)

2012                2.5% taper.  6.6mg – 5.6mg (worser still & unbearable)

2013                5% taper.  Big mistake.  5.5mg – 4.6mg  (even worserer)

2014                2.5% taper.  4.9mg – 4.5mg;    2015 2.5% taper 4.4 - 4.0mg

2016                2.5% taper.  3.9mg  Feb 3.8   Mar 3.7  May 3.6   Jul 3.5

2017                2.5% taper.  Jan 3.4;   Mar 3.35;  Apr 3.3; Oct 3; Dec 2.9;

2018                2.5% taper. Jan 2.8; Mar 2.7; Mar: 2.75; Jun 2.7; Aug 2.6; Oct 2.5; Nov 2.4; Dec 2.3

2019                Jan 2.2; Feb 2.1;

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Since PP has been deleted I can't find the original quote but from what I can gather it has to do with the enzymes that metabolize drugs. Paxil inhibits the particular enzymes that also metabolize it so if you raise the dose the plasma levels increase substantially but if you lower the dose the levels fall rapidly because at lower doses you are losing that inhibition. This is one of the reasons thought to be responsible for Paxil's nasty WD. The lower the dose, the faster it's metabolized, the quicker it leaves your system.

a.k.a JMarie

Paxil since Mar.1998

2006-2007:40-20mg
2009: 20mg to 14mg 2010: 14mg to 10.5mg 2011: 10.5 to 7.6mg  2012: 7.5 to 6.8mg

2013: 6.7-6.3mg 2014: 6.2mg-5.8mg 2015: 5.7 to 5.15mg 2016: 5.1-4.6mg

1/19/17: 4.5mg 3/17/17: 4.4mg

6/15/17: 4.35mg 8/10/17: 4.3mg

1/29/18: 4.1mg 5/07/18: 4.0mg

7/31/18: 3.9mg

 

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Interesting. I take my dose around 3 pm. In that way I dont have the zombified feeling in the day, as I often have a few hours after taking the dose. But sometimes I feel the dose does'nt last enough for the whole day. So that might be because the dose is quite low now.

I sleep well most of the time.

Current dose: 0! Free!  Quit June 2017.

2017: Last dose zoloft: 17 June 0,00065 mg 18 May 0, 001 mg 14 May 0,002 mg 9 May 0,003 mg 28 April 0,006 mg 19 April 0,009 mg 8 April 0,013 mg 25 March 0,019 mg 22 March 0,039 mg 18 March 0,052 mg 16 March 0,079 mg 4 March 0,086 1 March 0,099 mg 22 February 0,11 mg 15 February 0,13 mg 6 February 0,145 mg 24 January 0,15 mg 19 January 0,19 mg 10 January 0,20 mg 3 January

2016: 0,98 to 0,22 mg; 2015: 2,35 to 1,01 mg; 2014: 4,9 to 2,5 mg; 2013: 9,1 to 5,1 mg; 2012: 15,7 to 9,7 mg; 2011: Started on 25 mg - then 50 mg- dropped to 25- to 12.5 mg - back to 25 mg - after 18.75 mg started tiny tapering to 16.6 mg

Started on 25 mg Zoloft in March 2011 due to stressrelated tinnitus that gave me panicattacks. Had a terrible reaction to Zoloft from start, but was told to "hold on". After four months I was stuck. Therefore the long taper. Crazy, I know... Super sensitive to drops and have dropped by 4-6 % from the previous dose.

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I sleep ok at the moment. Some nights worse than others but not enough to cause me stress.

 

I take my meds at 5.30pm

 

I want to push it out an hour to 6.30 as I am in bed really early, and sometimes dinner isnt ready that early, which means I snack before dinner and then dont eat well.

Currently on 50mg Fluvoxamine. Reading more before the next attempt at tapering.

 

Started Lexapro 04, have been mostly on med combinations since for 12 years.

May 2015 - zeldox 80 - 100mg, fluvoxamine 200mg, dexamphetamine 10mg

Lorazepam and clonazepam on and off for over a decade. Heavily sedated with antipsychotics - mostly Zyprexa and seroquel. Many hospitalisations. Many types of therapy, last being 7 years of psychodynamic that only figured out my pain was real.

Pain meds - Lyrica 150mg palexia 100mg - discontinued eary 2016

Done ok so far but cant drop the last antidepressant without physical illness.

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In the morning, now. Except when I forget, then bedtime. :) I take thyroid meds and I've switched it around. It was thyroid meds in the morning and ssri in the evening, but I've switched them. I think it's better for me this way.

2005 St John's Wort / 2006-2012 Lexapro 20mg, 2 failed attempts to stop, tapered over 4.5 months in early 2012

January 2013 started Sertraline, over time worked up to 100mg

July 2014 Sertraline dropped from 100mg to 75mg, held for six months, slower tapering until 2019 22 Dec 3.2mg

2020 Sertraline 19 Jan 3.1mg, 26 Jan 3.0mg; 1 Mar 2.9, 7 Mar 2.8, May (some drops here) 24 May 2.5, May 29 2.4, June 21 2.3, June 28 2.2mg,  July 4 2.1mg, July 24 (or maybe a bit before) 2mg, early Nov switched to home made suspension; 29 Nov 1.8mg; approx 25 Dec 1.6mg)

2021 Some time in about Jan/Feb realised probably on more like 1.8mg and poss mixing error in making suspension; doses after 10 Feb accurate; 10 Feb 1.6mg; 7 Mar 1.4, continued monthly

10% drops until 1mg, then dropped 0.1mg monthly.

May 2022,0.1mg, now dropping 0.01mg per week

My thread here at SA: https://www.survivingantidepressants.org/topic/1775-bubbles/page/18/

CurrentSertraline: 0.08mg / Armour Thyroid

 

 

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