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Questions and answers about liquid medications, use by date, expiry


lionboy

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I'm having some difficulty getting my mirtazapine tablets to dissolve properly in the water. I have noticed a white film on the bottom of the bottle after I have taken my dose. What am I doing wrong?

 

 

Mirtazapine 15mg - Start: June 2018 - Began Tapering by Skipping Pills March 2019 - CT April 29th 2019 - Restart May 8th 2019

 

Began Tapering Properly on November 27th 2019

 

2.64 December 3 2022

2.58 January 4 2023

2.52 January 21 2023

2.46 January 28 2023

2.4 February 4 2023

2.34 February 2023

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  • 3 years later...

Hi all,

I read in the forum that most diluted AD could be kept in the fridge covered for 3-4 days.

I am tapering with escitalopram diluted twice, and noticed on the 3rd day that the taste of the liquid (tastes bitter and chemical) was waning.

Has anyone experienced the same waning taste on 3rd day with that drug?

I have therefore been consuming the solution over 2 days since. My rationale is that is the taste is waning, then maybe its effect as well but I might be completely wrong.

If anyone has some guidance on this, I would be happy to hear. 

Cheers!

 

01-2019 / 07-2019 Mirtazapine for burn out symptoms (insomnia mostly)
07-2019 / 12-2020 Escitalopram 10mg
12-2020 / 07-2021 Escitalopram 5mg, fine overall
08-2021 Escitalopram 5mg every other day start tapering and fine
09-2021 Escitalopram 5mg every 3 days tapering continue and ok
10-2021 Escitalopram 5mg every 3 days tapering and starting to feel tiredness and also depressed
11-2021 Back to Escitalopram 5mg every other day. Improving

05 to 09-2022: Tapering 10% every 3 weeks. Fine.

10 to mid 12-2022: Tapering 10% every 2 weeks. Fine.

Mid 12-2022 to mid Jan -2023: Tapering 10% every week. Fine.

End Jan 2023: Edgyness appearing, then dysphoric mood. Am holding on 0.65mg dose for the moment.

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  • Moderator Emeritus
On 1/12/2023 at 1:47 AM, TheCircle said:

I am tapering with escitalopram diluted twice, and noticed on the 3rd day that the taste of the liquid (tastes bitter and chemical) was waning.

 

On 1/12/2023 at 1:47 AM, TheCircle said:

I have therefore been consuming the solution over 2 days since. My rationale is that is the taste is waning, then maybe its effect as well but I might be completely wrong.

I do not believe that the fact that the taste is waning is any indication that the active ingredient is changing.  I believe that your diluted liquid should still be good for 3 or 4 days.  

Please do not private message me.  Only tag me for urgent questions about tapering and reinstating - thank you.  

 

***Please note this is not medical advice.  Discuss any decisions about your medical care with a doctor who understands psych meds and how to withdraw from them, if you can find one.

 

Lexapro   Started Apr 15 2010 - 10 mg;  started taper August 2017, recent taper info: Apr 2 '20  0.18 mg; Jul 16  0.17 mg, Aug 23  0.16 mg, Oct 7  0.15 mg, Nov 8 - 0.14, Jan 16 '21 - 0.13, Feb 7 - 0.12, Feb 22 - 0.11, Mar 26 - 0.10, May 21 - 0.09, June 15 - 0.08 Aug 16 - 0.07, Oct 6 - 0.06, Nov 21 0.05, Dec. 17 0.04, Jan 14 '22 0.03, Feb 19 0.02, Apr 18 0.01, May 15 0.005,  Jul 8, 0.00.  Psych Drug Free as of July 8, 2022!!  Woohoo!!!

other meds: Levothyroxine 75 mg

magnesium in small amounts at 4 AM, before bed

suppl AM: fish oil, flax oil, vit C, vit E, multivitamin, zinc

suppl 8 PM: magnesium 350 mg, extended release vitamin C, melatonin 2 mg

 

Paxil 2002 - 2010, switched to Lexapro 2010 

Trazodone 50 mg. 2002 - 2019, fast tapered in 2019 

Xanax 0.5 mg as needed 2002 - 2019, up to 3x weekly 

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  • 4 months later...

Hi All,

 

I've had an issue that's been touched on quite a few times. But, nothing specific enough with what I'm experiencing so I thought I'd ask here.

 

I also read in various places in the forum that anti-depressant solutions can be kept in the fridge for 3-4 days. I recently switched over from oral suspension to oral solution, so that it is possible for me to dilute and handle smaller doses much more easily.

 

What I didn't realise is that, the doses I've been taking have until the past week been at least a little inaccurate. And perhaps coming with containing degraded medication. As, I noticed the problem mentioned elsewhere of crystals forming and a possible precipitation issue.

 

The problem is, this is happening almost immediately. The water turns cloudy from my sertraline oral solution syrup (and according the to information booklet this is expected) and when I come back to the homemade solution the day after, there's "sediment" settled in the bottom which I then have to shake in order to suspend. This is defeating the purpose of my original issue when using pills to taper down.

 

Does anyone have any experience with why this might be? The prevailing thought from what I've research on the forum, is that the precipitation shouldn't become an issue until 3-5 days after the making of the solution.

 

What's exactly happening to cause the sediment? Is the water causing a reaction with the drug? Or is it the dissolved minerals in the water, e.g. calcium and magnesium salts that are reacting? If so, would perhaps distilled water fix the issue?

 

In terms of its effect on my symptoms. I'm having more frequent tension headaches but my main concern is the extremely loose and water dirrhoea that has very suddenly become a morning routine (I take my dose just before bed so this seems to fit).

 

Any thoughts you all might have on how I can make this whole thing more practical is very much appreciated. The oral solution 100mg/5ml is so concentrated that without diluting it, it essentially becomes inaccurate and difficult to at my current dose (29mg).

 

 

 

 

October 2013 - Started 40mg citalopram
2015 - Tapered off of citalopram slowly over six months against Doctor's advice by cutting up pills until I could not longer cut them any smaller.
2015 later - Doctor convinced I had a relapse of depression rather than discontinuation. Placed on sertraline 100mg.
2022 - Diagnosed with ADHD & began lisdexamphetamine as required.
16/10/2022 - Tapered to 10% reduction using pills and pestle and mortar.

02/02/2023 - Tapered to 50mg and held for 9 months due to withdrawal symptoms from inaccuracy of pestle and mortar method and GP unwilling to prescribe oral suspension/solution.

15/11/2023 - Tapering 10% reduction every 4 weeks using oral suspension sertraline - minimal symptoms.

28/02/2024 - Switched to oral solution as easier to dilute to smaller dose (now at 29mg Sertraline)

 

 

 

 

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