Elexis: tapering fluoxetine / Prozac - did I come off too fast?

[Elexis]

On 5/28/2020 at 11:55 PM, ChessieCat said:

 

You might want to reconsider how long you stay on this drug combination.

 

From https://reference.medscape.com/drug-interactionchecker

 

 

23 hours ago, Elexis said:

I took zoplicone for 1st time on thur, didnt take any on fri, then took on saturday & sunday 

Last nite (sunday) didnt work very well (tolerance alreaady building?) Do i need to taper or can i just stop now before i get hooked?

 

didnt take any zoplicone monday nite - was that the right move?

[Elexis]

I  took zoplicone 8mg for 1st time on thursday, didnt take any on fri, then took on saturday & sunday 

Sunday night didnt work very well (tolerance alreaady building?) so didnt take any zoplicone  on monday nite (last nite)

Do i need to taper or can i just stop now before i get hooked?

 

thanks!

[Altostrata]

You don't need to taper it if you take it only a few times.

 

Did you go off the promethazine?

[Elexis]

54 minutes ago, Altostrata said:

You don't need to taper it if you take it only a few times.

 

Did you go off the promethazine?

I'm down to 15mg, reducing by 25% every 3 days, sleep unchanged so far

[Elexis]

On 6/2/2020 at 5:27 PM, Altostrata said:

You don't need to taper it if you take it only a few times.

 

Did you go off the promethazine?

I took a zolpidem thurs nite (last took a z-drug 3 nites previous & have only taken them 4 nites total), then started 4mg melatonin on friday nite. Sleep's great but quite dizzy/nauseous since saturday.

Is there any possibility this is z-drug withdrawal?

[Altostrata]

53 minutes ago, Elexis said:

Is there any possibility this is z-drug withdrawal?

 

Possibly. What other changes have you made in your drugs recently? You'll have to list them again, I can't keep up.

[Elexis]

On 6/8/2020 at 5:58 AM, Altostrata said:

 

Possibly. What other changes have you made in your drugs recently? You'll have to list them again, I can't keep up.

only recent change is promethazine taper, I'm down to 15mg, reducing by 25% every 3 days but haven't changed it for past 3 days, I paused the taper while trying out melatonin. Other than that my drugs are:

 

Amitriptyline - 60mg, since 2011

Lyrica - 200mg since 2014

Prozac - 25mg/day 9 months in 2015. 1mg day since 2016.

5htp - 50mg April 4th-21st. reinstated at 25mg april 27th

l-tryptophan - 40mg April 4th-21st. reinstated at 20mg april 27th

 

Melatonin 4mg since 6th June

Zoplicone 8mg on 28th, 30th and 31st May

Zoplidem 10mg on 4th June

 

Edited June 21, 2020 by ChessieCat
reduced font size

[Altostrata]

A rule of thumb is don't make any sudden drug changes. I don't believe we told you to quit zolpidem.

 

If you want to discuss emergence of symptoms, we have to know the last drug change and your daily symptom pattern. Please keep daily notes of times of day you take your drugs, their dosages, and your symptoms throughout the day. Post 24 hours of notes at a time in this topic, in a simple list format with time of day on the left and notation (symptom or drug and dosage) on the right.

[Elexis]

39 minutes ago, Altostrata said:

A rule of thumb is don't make any sudden drug changes. I don't believe we told you to quit zolpidem

I only took zolpidem one night, didn't think I had to taper

 

zoplicone was taken for 3 nights but was told no need to taper. (and stopped taking it & was okay)

 

is it because they are similar drugs?

[Elexis]

going to bed soon - was planning not to take melatonin as only been on 2 days & it could be causing the nausea. guessing reinstating a z-drug would be a bad move too.

[Altostrata]

Sorry, thought you were one of our chronic zolpidem users.

 

When you have a symptom, we need the context -- what drug you took before the symptom, for example. You are taking 3 drugs which interact and may cause symptoms. Please keep daily notes of times of day you take your drugs, their dosages, and your symptoms throughout the day. Post 24 hours of notes at a time in this topic, in a simple list format with time of day on the left and notation (symptom or drug and dosage) on the right.

[Elexis]

14 minutes ago, Altostrata said:

Sorry, thought you were one of our chronic zolpidem users.

 

When you have a symptom, we need the context -- what drug you took before the symptom, for example. You are taking 3 drugs which interact and may cause symptoms. Please keep daily notes of times of day you take your drugs, their dosages, and your symptoms throughout the day. Post 24 hours of notes at a time in this topic, in a simple list format with time of day on the left and notation (symptom or drug and dosage) on the right.

ok, thanks, will post the first drug diary tomorrow. I'm freaking out a bit that it could be z-drug withdrawal, really hoping it's something else. 

[Altostrata]

Probablyy not, you've takine z-drugs so seldom. Have you skipped doses of anything?

[Elexis]

15 hours ago, Altostrata said:

Probablyy not, you've takine z-drugs so seldom. Have you skipped doses of anything?

Dont think so. Seem a bit better since not taking melatonin last nite

[Elexis]

been on 2mg melatonin for 10 days - do i need to taper to stop?

[ChessieCat]

  

On 5/8/2012 at 12:20 PM, Altostrata said:

Just wanted to note that I have been taking 2mg melatonin nightly for 3 years with no ill effects.

 

I do not believe it causes physical dependency -- half-life is only a few hours -- but I intend to taper off when my sleep is stable.

 

Melatonin does not downregulate any receptors.

 

If it was me I wouldn't want to risk it; I'd be doing a fast taper off it.  Perhaps reduce to 1.5mg then 1mg, then 0.5mg for a few days at each dose.

 

Even if it isn't necessary just from a mental perspective it would probably help to lessen any anxiety you have about going off it.

[Elexis]

12 hours ago, ChessieCat said:

  

 

If it was me I wouldn't want to risk it; I'd be doing a fast taper off it.  Perhaps reduce to 1.5mg then 1mg, then 0.5mg for a few days at each dose.

 

Even if it isn't necessary just from a mental perspective it would probably help to lessen any anxiety you have about going off it.

Will do - thanks! The side effects are awful but I worry about withdrawal effects if I CT.

[Altostrata]

16 hours ago, ChessieCat said:

Even if it isn't necessary just from a mental perspective it would probably help to lessen any anxiety you have about going off it.

 

Very wise, @ChessieCat

[Elexis]

10 days ago i made a 25% decrease in 5HTP  then 2 days later took a zoplicone. PGAD has spiked badly ever since. Should I return to my previous 5-htp dose or just hold everything steady?

[Altostrata]

As you made 2 changes at once, hard to tell what caused your PGAD problem. I wouldn't change your 5-HTP taper, if it isn't helping, probably best you gradually go off it and remove it from cluttering up the situation.

 

My guess is you've found when you make a drastic drug change, such as adding zopiclone, you can expect an aggravation of your symptoms.

[Elexis]

Ok thanks, i'll continue the taper, (going to taper melatonin before I resume the 5htp taper but that won't take long ) is 25% every 3 days gradual enough for 5htp?

i've got away with taking zoplicone in the past but never took it while also tapering something else or maybe I was just lucky before, will try to avoid in future 

[Elexis]

for tapering melatonin is it okay to switch from prolonged release tablets to instant release liquid ?

[Elexis]

I finished tapering 5htp (reducing 25% every 3 days), came off on 19th august at 10% of my original dose. 4 days later & PGAD spiked, it's been bad for 3 days now.

Unsure whether to reinstate at my final dose & taper more slowly or just ride it out?

[ChessieCat]

To me it seems silly to try to ride it out when a small reinstatement might help.

 

Q:  Are you able to reinstate 1/2 of your last dose?

 

5htp:  10% of original dose of 50mg?  So your last dose was 5mg?  And you were reducing every 3 days? 

 

I'd try 2.5mg.

 

You've already been off 1 week.  Your brain will have already made some adaptations.  When taking ADs it takes about 4 days for a dose change to get to full effect in the blood and a bit longer for it to register in the brain.  Seems like the 5htp might be similar.

 

 

 

 

[Elexis]

16 hours ago, ChessieCat said:

To me it seems silly to try to ride it out when a small reinstatement might help.

 

Q:  Are you able to reinstate 1/2 of your last dose?

 

5htp:  10% of original dose of 50mg?  So your last dose was 5mg?  And you were reducing every 3 days? 

 

I'd try 2.5mg.

 

You've already been off 1 week.  Your brain will have already made some adaptations.  When taking ADs it takes about 4 days for a dose change to get to full effect in the blood and a bit longer for it to register in the brain.  Seems like the 5htp might be similar.

 

 

 

 

Thanks for the reply - Yes, 5mg after reducing every 3 days. taper itself was fine until I jumped off so maybe I jumped too high? Will try 2.5mg.

[Elexis]

On 8/26/2020 at 11:52 PM, ChessieCat said:

To me it seems silly to try to ride it out when a small reinstatement might help.

 

Q:  Are you able to reinstate 1/2 of your last dose?

 

5htp:  10% of original dose of 50mg?  So your last dose was 5mg?  And you were reducing every 3 days? 

 

I'd try 2.5mg.

 

You've already been off 1 week.  Your brain will have already made some adaptations.  When taking ADs it takes about 4 days for a dose change to get to full effect in the blood and a bit longer for it to register in the brain.  Seems like the 5htp might be similar.

 

 

 

 

Been 5 days on the reinstated dose and the PGAD has calmed significantly - so that was wise advice!  How long do you think I should stay on this dose before tapering again? should I taper more slowly than last time? Thank you!

[Elexis]

Spoke too soon, the PGAD is fluctuating a lot. still it's not constant anymore so that's an improvement!

[Elexis]

Hi, my reinstatement of 2.5mg was doing fine so I resumed my taper - a week ago I dropped 25% and the PGAD has got worse, waking me up nearly every night :(  I'm thinking 25% decreases may be too much for me. Considering an updose - what do you think?

 

Thank you!

[Elexis]

20 hours ago, Elexis said:

Hi, my reinstatement of 2.5mg 5-HTP was doing fine so I resumed my taper - a week ago I dropped 25% and the PGAD has got worse, waking me up nearly every night :(  I'm thinking 25% decreases may be too much for me.  Also think I should have waited to stabilise completely before resuming my taper...

 

Considering an updose - what do you think?

 

Thank you!

Edit - added some detail. ^

[Elexis]

Updosing Query

 

Hi, my reinstatement of 2.5mg 5-HTP was doing fine so I resumed my taper - on 29th September I dropped 25% and the PGAD has got worse, waking me up nearly every night  I'm thinking 25% decreases may be too much for me.  Also think I should have waited to stabilise completely before resuming my taper...

 

Considering an updose - what do you think?

 

Thank you!

 

(apologies if I've posted in the wrong place - not sure if my posts to my updates thread were seen)

Edited October 15, 2020 by manymoretodays
merged from tapering, title added

[manymoretodays]

Hi Elexis,

And hmmm, I'm having difficulty getting your post that you quoted above moved from tapering.

Okay, got your most recent post moved here.  So, it's been about 2 weeks.

When did the PGAD start?

 

What did you decrease to? Have you had PGAD before?

It looks like you've been with us for awhile, I'll have to read through your introduction further when I have time.

 

And I'd probably HOLD with the decrease, as it's only been a week, so far.  2 Weeks!!!!

If I did decide to updose, I wouldn't go all the way back to 2.5 mg of 5-HTP, maybe only half way or less. 

I'll put the HTP link here too, I'm not seeing it on this page.  I know it's not a tapering topic, but you might find something there that helps.

5- HTP(5-hydroxytryptophan) and l-tryptophan

 

And try and use non-drug coping. 

Here's our PGAD topic:

https://www.survivingantidepressants.org/topic/4587-persistent-genital-arousal-disorder-pgad/

and I'm seeing a link to some coping strategies, in the first post ^

 

Are you taking other drugs or supplements now Elexis?

And any other symptoms right now?

 

Thanks,

L, P, H, and G,

mmt

 

Edited October 15, 2020 by manymoretodays
corrections, after I got recent post merged, links

[Elexis]

On 10/15/2020 at 6:54 PM, manymoretodays said:

Hi Elexis,

And hmmm, I'm having difficulty getting your post that you quoted above moved from tapering.

Okay, got your most recent post moved here.  So, it's been about 2 weeks.

When did the PGAD start?

 

What did you decrease to? Have you had PGAD before?

It looks like you've been with us for awhile, I'll have to read through your introduction further when I have time.

 

And I'd probably HOLD with the decrease, as it's only been a week, so far.  2 Weeks!!!!

If I did decide to updose, I wouldn't go all the way back to 2.5 mg of 5-HTP, maybe only half way or less. 

I'll put the HTP link here too, I'm not seeing it on this page.  I know it's not a tapering topic, but you might find something there that helps.

5- HTP(5-hydroxytryptophan) and l-tryptophan

 

And try and use non-drug coping. 

Here's our PGAD topic:

https://www.survivingantidepressants.org/topic/4587-persistent-genital-arousal-disorder-pgad/

and I'm seeing a link to some coping strategies, in the first post ^

 

Are you taking other drugs or supplements now Elexis?

And any other symptoms right now?

 

Thanks,

L, P, H, and G,

mmt

 

Hi there, :) 

I decreased to 1.9mg from 2.5mg, been holding for 3 weeks now. PGAD has improved slightly, still waking me at night but less bothersome during the day. 

PGAD is my only withdrawal symptom &  I'm only taking the other drugs that are in my signicture .

 

Thanks!

[manymoretodays]

Hey Elexis,

So you are referring to the 5 HTP?  I am assuming so.  And then good, that a little improvement of your PGAD.  I would not go any higher, if it was me, with the 5HTP.

 

Would you just list your current drug(s) here, on your introduction page.  It's looking like you might be on 3-4 prescription drugs, and then some supplements as well, and stuff that you can just purchase without a prescription.

 

List the times you take them, and the name and dosage of all current drug(s) or supplements.

 

And then, go ahead and do a interaction check here:  Drug.com- Drug Interactions

Copy and paste here, or leave a link back to your interactions please.

 

I'll check back.  I haven't gotten back to read your full intro.  But am interested.

 

Thanks for checking back.

L, P, H, and G,

mmt

Edited October 21, 2020 by manymoretodays
spelling, grammar

[Elexis]

 

Current drugs & supplements:

Amitriptyline - 60mg, since 2011, take at 11pm

Lyrica - 200mg since 2014, 100mg taken at 11am, 100mg at 11pm

Prozac - 25mg/day 9 months in 2015. 1mg day since 2016. take at 11pm

Promethazine - 25mg, since 17 April 2020, 11pm

Herbal Nytol  (70mg Hops, 60mg Valerian and 36mg Passionflower) - since 2018, 11pm

Alverine Citrate - 120mg twice a day since 2012. 60mg 11am, 60mg 11pm.

5htp - 50mg April 4th-21st. reinstated at 25mg May 27th. Off at 5mg 19th August. Reinstate 2.5mg 26th Aug. 11pm

 

 

Interactions:

Drug Interaction Report

This report displays the potential drug interactions for the following 6 drugs:

• Valerian Root (valerian)
• Prozac (fluoxetine)
• promethazine
• Lyrica (pregabalin)
• amitriptyline
• 5-HTP (5-hydroxytryptophan)

Edit list (add/remove drugs)

• Consumer
• Professional
• Email this report

Major (3)

 

Moderate (9)

 

Minor (0)

 

Food (3)

 

Therapeutic Duplication (2)

Interactions between your drugs

Major

amitriptyline  FLUoxetine

Applies to: amitriptyline, Prozac (fluoxetine)

Talk to your doctor before using amitriptyline and FLUoxetine. This combination may cause sedation, dry mouth, blurred vision, constipation, and urinary retention. You could also have high levels of FLUoxetine which include altered consciousness, confusion, poor muscle coordination, abdominal cramping, shivering, dilation of the pupils, sweating, high blood pressure, and increased heart beat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

Switch to professional interaction data

Major

FLUoxetine  5-hydroxytryptophan

Applies to: Prozac (fluoxetine), 5-HTP (5-hydroxytryptophan)

Using 5-hydroxytryptophan together with FLUoxetine is generally not recommended. Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should contact your doctor immediately if you experience these symptoms while taking the medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Major

amitriptyline  5-hydroxytryptophan

Applies to: amitriptyline, 5-HTP (5-hydroxytryptophan)

Using amitriptyline together with 5-hydroxytryptophan can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should seek immediate medical attention if you experience these symptoms while taking the medications. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

amitriptyline  promethazine

Applies to: amitriptyline, promethazine

Before taking amitriptyline, tell your doctor if you also use promethazine. You may need dose adjustments or special tests in order to safely take both medications together. This combination should be used with caution, particularly in the elderly. You should notify your doctor promptly if you have signs of bladder problems, dry mouth, stomach pain, fever, blurred vision, confusion, dizziness, or reduced heart rate. You should avoid driving until you know how these medications will affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

Switch to professional interaction data

Moderate

FLUoxetine  promethazine

Applies to: Prozac (fluoxetine), promethazine

FLUoxetine may increase the blood levels and effects of promethazine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

amitriptyline  valerian

Applies to: amitriptyline, Valerian Root (valerian)

Using amitriptyline together with valerian may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

promethazine  valerian

Applies to: promethazine, Valerian Root (valerian)

Using promethazine together with valerian may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

FLUoxetine  valerian

Applies to: Prozac (fluoxetine), Valerian Root (valerian)

Using FLUoxetine together with valerian may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

amitriptyline  pregabalin

Applies to: amitriptyline, Lyrica (pregabalin)

Using amitriptyline together with pregabalin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

promethazine  pregabalin

Applies to: promethazine, Lyrica (pregabalin)

Using promethazine together with pregabalin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

FLUoxetine  pregabalin

Applies to: Prozac (fluoxetine), Lyrica (pregabalin)

Treatment with FLUoxetine may occasionally cause blood sodium levels to get too low, a condition known as hyponatremia, and using it with pregabalin can increase that risk. In addition, FLUoxetine can cause seizures in susceptible patients, which may reduce the effectiveness of medications that are used to control seizures such as pregabalin. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek medical attention if you experience nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness or unsteadiness, as these may be symptoms of hyponatremia. More severe cases may lead to hallucination, fainting, seizure, coma, and even death. Also let your doctor know if you develop seizures or experience an increase in seizures during treatment with FLUoxetine. Additionally, because these medications may cause dizziness, drowsiness, and impairment in judgment, reaction speed and motor coordination, you should avoid driving or operating hazardous machinery until you know how they affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

valerian  pregabalin

Applies to: Valerian Root (valerian), Lyrica (pregabalin)

Using valerian together with pregabalin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

No other interactions were found between your selected drugs. This does not necessarily mean no other interactions exist. Always consult your healthcare provider.

Drug and food interactions

Moderate

FLUoxetine  food

Applies to: Prozac (fluoxetine)

Alcohol can increase the nervous system side effects of FLUoxetine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with FLUoxetine. Do not use more than the recommended dose of FLUoxetine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Switch to professional interaction data

Moderate

pregabalin  food

Applies to: Lyrica (pregabalin)

Alcohol can increase the nervous system side effects of pregabalin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with pregabalin. Do not use more than the recommended dose of pregabalin, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Switch to professional interaction data

Moderate

valerian  food

Applies to: Valerian Root (valerian)

Alcohol can increase the nervous system side effects of valerian such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with valerian. Do not use more than the recommended dose of valerian, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Switch to professional interaction data

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Central Nervous System (CNS) Drugs

Therapeutic duplication

The recommended maximum number of medicines in the 'Central Nervous System (CNS) Drugs' category to be taken concurrently is usually three. Your list includes five medicines belonging to the 'Central Nervous System (CNS) Drugs' category:

• Prozac (fluoxetine)
• promethazine
• Lyrica (pregabalin)
• amitriptyline
• 5-HTP (5-hydroxytryptophan)

Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

Duplication

Antidepressants

Therapeutic duplication

The recommended maximum number of medicines in the 'antidepressants' category to be taken concurrently is usually one. Your list includes three medicines belonging to the 'antidepressants' category:

• Prozac (fluoxetine)
• amitriptyline
• 5-HTP (5-hydroxytryptophan)

[Elexis]

Hi folks,

On 25th feb I took 10mg valium before a medical procedure. first and only time I've taken it. 8 days later my PGAD has spiked. I know valium can take 10 days to leave body - could that be a cause?

Unsure if anything I can do - would any sort of 'reinstatement' be inappropriate as only took it once?

 

thanks!