Guest Posted October 20, 2020 Share Posted October 20, 2020 On 10/17/2020 at 3:43 PM, Altostrata said: merged similar topics No, there is no way to upregulate your receptors. Let them recover on their own. Thanks for replying, i see why youve concluded this based on your experiences and on reading. The last thing ill say is that i just read a paper which said agonists downregulate and antagonists upregulate as a universal rule...knowing that ssris are agonists, wouldnt it make sense to add in an antagonist like cyproheptadine? Or is the logic behind agonist and antagonists also completely flawed Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted October 21, 2020 Administrator Share Posted October 21, 2020 Yes, we know chemicals can upregulate and downregulate receptors. What a psychotropic has done to your receptors and nervous system is complex. It's not a simple matter of turning a switch on and off. We do not advise trying to correct the upregulation or downregulation with other drugs. Let them recover on their own. 1 This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Guest Posted October 21, 2020 Share Posted October 21, 2020 42 minutes ago, Altostrata said: Yes, we know chemicals can upregulate and downregulate receptors. What a psychotropic has done to your receptors and nervous system is complex. It's not a simple matter of turning a switch on and off. We do not advise trying to correct the upregulation or downregulation with other drugs. Let them recover on their own. thank you Link to comment Share on other sites More sharing options...
gardenlady Posted October 23, 2020 Share Posted October 23, 2020 On 1/29/2015 at 12:32 PM, Rhiannon said: In general I do think a brain that was on psych drugs for 20 plus years (like mine) will never be the same as it would have been without the drugs, Very frightening. 2016-Aug-Prescribed 2 mg Ativan & 10 mg Ambien; Oct-c/o from 20 mg Lexapro to 60 mg Cymbalta; Nov-Dec-Tapered off 10 mg Ambien 2017-Jan-Feb c/o from 1.75 mg Ativan to 13 mg Valium & begin daily liquid micro taper; May-taper Cymbalta 60 mg to 48 mg with severe withdrawals. Begin 11 month Cymbalta hold. 2018-Jan 11 completed Valium taper; Apr-Resume Cymbalta taper. Interval dose progress: Apr 43 mg; May 40 mg; Jul 35 mg; Sep 29 mg; Dec 21 mg; 2019- Apr 14 mg; Jun 11 mg; Aug 9 mg; Oct 7 mg; Nov 6 mg 2020-Jan 5.2 mg; Feb 4.8 mg; Mar 4.3 mg; Apr 3.9 mg; May 3.5 mg; Jun 3.3 mg; Jul 2.9 mg; Aug 2.7 mg; 28 Sep 2.4 mg/12 beads; 25 Oct 2.2 mg/11 beads; 22 Nov 2.0 mg/10 beads; 20 Dec 1.8 mg/9 beads 2021- 17 Jan 1.6 mg/8 beads; 14 Feb 1.4 mg/7 beads; 18 Mar 1.2 mg/6 beads; 18 Apr 1.0 mg/5 beads; 16 May 0.8 mg/4 beads; 13 Jun 0.6 mg/3 beads; 11 Jul 0.5 mg/2 beads; 8 Aug .03 mg/1 bead; 5 Sep 0 mg. Brutal, agonizing, slow 4.5 year Cymbalta taper completed as of 5 Sep 2021. 100% psych drug free. Link to comment Share on other sites More sharing options...
Guest Posted February 4, 2021 Share Posted February 4, 2021 So the downregulation theory is incomplete, got it...i just want that feeling of what 5htp does to me, all day long, without having the side effects, theres gotta be a way todo that Link to comment Share on other sites More sharing options...
Nivsch Posted February 20, 2021 Share Posted February 20, 2021 On 1/29/2015 at 12:14 AM, WiggleIt said: Tanit, I know you have a better grasp of brain science than the rest of us here, but don't forget that the errors of science are what landed all of us in this support group. So, it's perfectly well possible that science is in error when it says neurotransmitters can't heal. The reductionistic science of today is deeply in the dark ages and far less advanced than what it thinks. There is no way to understand such a complex, God-like, systems with this gross reductionistic method which provide only a delusional sense of "understanding" to the doctors and scientists. Science with is arrogancy thinks it got nature and understand nature, the brain and the human body, and the more it thinks so, the more fool it is. 2010-2015 Cipramil 20-40mg. half-year break in the middle which was tough. 2015-2020 Venlafaxine 150-225 mg. Venlafaxine duloxetine cross taper details 150 for half-year then 225 for a period than stabilized in ~187.5 (1.25 pills) for 2 years than reduced to ~168.5 (1.125 pills). 3.2020 - Duloxetine 60mg. 19.05.2020 - started to taper - 59! 20.5 - 58.5. June 2020: 57. end of June - 55.5 Summer 2020: 5.7 - 54, 9.7 - 52, 12.7 - updose to 53+, 19.7 - 52.3, 26.7 - 51.8, 4.8 - 51.3, 11.8 - 50.8, 15.8 - updose to 51.0, 17.8 - 50.5, 19.8 - 50.3, 19.9 - 49.3 Autumn-winter: 7.10 - 46.8, 1.12 - 45.8, 17.12 - 44.4, 30.12 - 42.4, 21.1 - 40.8. 17.2 - 40.1, end of feb - 38.6, spring: mid march updose to 40.1, 28.3 - 38.6, 15.4 - 37.5, 14.5 - 36.8, end of may 37.5+ and after a week 39 Summer 2021: mid of june again to 36.7, end of july 39.5. 11.10.2021 - 40.7 📌 Link to comment Share on other sites More sharing options...
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