Jump to content
Sign in to follow this  

Roose, 2016 Selective Serotonin Reuptake Inhibitors and Operative Bleeding Risk: A Review of the Literature.

Recommended Posts


J Clin Psychopharmacol. 2016 Sep 28. [Epub ahead of print]

Selective Serotonin Reuptake Inhibitors and Operative Bleeding Risk: A Review of the Literature.
Roose SP1, Rutherford BR.

Abstract at https://www.ncbi.nlm.nih.gov/pubmed/27684291

This study aimed to review the data on the effect of selective serotonin reuptake inhibitors (SSRIs) on bleeding during or after operative procedures and to offer guidelines for clinical management.

Search of PubMed and MEDLINE for all articles in English from 1990-2016 with key words depression, antidepressants, bleeding, platelets, and operation.

Studies were included if they reported information on bleeding complications during operative or childbirth procedures in patients taking antidepressants.

Because of the limited number and heterogeneity of studies with respect to the range of operative procedures and definition of bleeding complications, a qualitative approach was taken to summarize results rather than abstracting and aggregating data.

The weight of the evidence is that SSRI use increases the risk of bleeding complications during and immediately after surgery. However, given the limited data, we cannot estimate the risk for a given patient having a given procedure.

Clinicians must consider the risk-to-benefit ratio of discontinuing an SSRI before an elective operative procedure. Discontinuing SSRI medications may result in discontinuation syndrome, symptom recrudescence, or relapse of depression, whereas continuing an SSRI during surgery exposes patients to significant bleeding risks. Antidepressant prescribers must be cognizant of and take responsibility for discussing this potential problem and considering different options. This issue must also be the responsibility of the doctor performing the procedure, but, frequently, it will be the prescribing physician who alerts the surgeon to the potential bleeding risk associated with SSRIs.

Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
Sign in to follow this  


Important Information

By using this site, you agree to our Terms of Use.